GREMLIN Database
MTNA - Methylthioribose-1-phosphate isomerase
UniProt: O31662 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (299)
Sequences: 3138 (2107)
Seq/√Len: 121.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_T325_I3.4881.00
255_Y264_F3.2821.00
106_R127_E3.1481.00
42_F93_S2.8111.00
258_A324_L2.7611.00
43_D47_T2.6871.00
37_T40_D2.5851.00
159_I192_C2.5711.00
283_C286_D2.5701.00
178_Y211_G2.5111.00
67_A86_I2.4751.00
263_A324_L2.4471.00
150_F234_A2.4031.00
48_L197_V2.3981.00
154_D234_A2.3861.00
87_K108_S2.3571.00
142_I271_A2.3401.00
87_K104_L2.3251.00
224_A256_G2.2791.00
64_L87_K2.2531.00
151_K154_D2.2401.00
263_A323_D2.2061.00
106_R134_E2.1581.00
236_I271_A2.1251.00
188_H216_T2.1231.00
191_A215_V2.1121.00
237_V254_T2.0751.00
65_A125_V2.0571.00
33_L49_K2.0501.00
62_F132_Q2.0361.00
217_L310_V2.0201.00
219_T222_M1.9981.00
91_N105_E1.9741.00
91_N101_S1.9521.00
116_S119_E1.9521.00
42_F89_Y1.9101.00
242_I272_A1.9081.00
39_E89_Y1.8921.00
84_E108_S1.8751.00
107_L124_L1.8621.00
122_T126_H1.8481.00
75_N78_E1.8411.00
235_V261_A1.8311.00
157_M192_C1.8241.00
304_R308_S1.8191.00
147_L183_K1.7841.00
155_R233_S1.7701.00
215_V310_V1.7531.00
144_Q179_L1.7521.00
155_R188_H1.7411.00
205_A217_L1.7351.00
282_K286_D1.7351.00
222_M315_P1.7241.00
157_M232_I1.7191.00
249_A287_I1.7101.00
190_Y232_I1.7081.00
35_L41_V1.6931.00
43_D49_K1.6801.00
217_L306_A1.6701.00
133_V137_E1.6401.00
291_E313_F1.6141.00
62_F129_I1.6031.00
141_L144_Q1.5921.00
269_F327_G1.5871.00
228_K285_A1.5841.00
101_S105_E1.5791.00
237_V268_F1.5651.00
247_D322_H1.5491.00
267_P326_S1.5471.00
137_E141_L1.5201.00
155_R190_Y1.5091.00
239_A272_A1.4831.00
154_D233_S1.4671.00
152_K186_G1.4601.00
239_A242_I1.4601.00
176_P271_A1.4561.00
127_E130_Q1.4541.00
219_T297_V1.4491.00
237_V270_V1.4251.00
83_L111_V1.4091.00
277_F335_M1.4071.00
179_L182_Q1.4061.00
84_E112_E1.3941.00
248_T270_V1.3861.00
188_H214_D1.3821.00
226_T313_F1.3811.00
254_T320_T1.3671.00
295_E298_R1.3521.00
126_H130_Q1.3481.00
46_V89_Y1.3441.00
157_M257_L1.3321.00
88_Q92_S1.3301.00
36_T40_D1.3151.00
91_N104_L1.3121.00
294_P312_V1.3001.00
41_V59_T1.2991.00
274_L331_E1.2961.00
298_R309_N1.2921.00
214_D311_P1.2691.00
179_L183_K1.2611.00
295_E299_Q1.2591.00
135_D139_C1.2510.99
148_Q183_K1.2420.99
147_L185_L1.2370.99
197_V202_R1.2310.99
71_I82_R1.2280.99
129_I132_Q1.2240.99
64_L107_L1.2140.99
150_F154_D1.2130.99
144_Q148_Q1.2130.99
152_K185_L1.2050.99
243_A281_V1.2020.99
255_Y321_P1.1920.99
110_S127_E1.1920.99
104_L108_S1.1800.99
181_K186_G1.1570.99
138_T274_L1.1520.99
78_E82_R1.1510.99
140_R144_Q1.1440.99
148_Q334_I1.1410.99
82_R85_D1.1290.99
154_D185_L1.1270.99
259_I263_A1.1220.99
223_A257_L1.1210.99
182_Q211_G1.1200.99
225_H228_K1.1180.99
125_V129_I1.1130.99
42_F92_S1.1100.99
218_I226_T1.1050.99
335_M339_Y1.1020.99
191_A204_T1.1010.99
234_A327_G1.0990.99
153_G186_G1.0990.99
101_S104_L1.0970.99
31_E34_E1.0940.99
262_N265_D1.0930.99
102_W275_S1.0920.99
189_I208_L1.0880.99
79_F121_K1.0840.99
149_L327_G1.0780.98
192_C223_A1.0670.98
206_W210_Q1.0650.98
224_A259_I1.0640.98
241_R278_D1.0620.98
129_I133_V1.0610.98
147_L179_L1.0490.98
180_A234_A1.0490.98
140_R179_L1.0480.98
197_V316_A1.0470.98
336_T339_Y1.0470.98
81_R85_D1.0430.98
89_Y92_S1.0430.98
223_A256_G1.0420.98
209_M310_V1.0410.98
93_S101_S1.0400.98
227_M235_V1.0390.98
154_D180_A1.0360.98
227_M261_A1.0280.98
297_V312_V1.0270.98
84_E88_Q1.0260.98
327_G334_I1.0250.98
140_R182_Q1.0110.98
143_G179_L1.0070.98
192_C257_L1.0040.98
58_I132_Q0.9960.97
180_A187_L0.9900.97
145_N148_Q0.9810.97
127_E131_I0.9800.97
225_H313_F0.9750.97
69_K125_V0.9750.97
38_K89_Y0.9720.97
117_V121_K0.9690.97
155_R187_L0.9630.97
177_F187_L0.9550.97
247_D319_I0.9500.97
114_A123_N0.9430.96
292_R296_E0.9330.96
127_E134_E0.9330.96
224_A260_L0.9320.96
64_L108_S0.9280.96
162_A215_V0.9240.96
58_I139_C0.9230.96
143_G175_A0.9170.96
38_K86_I0.9140.96
335_M338_N0.9100.96
177_F213_I0.9030.95
274_L332_K0.9020.95
224_A264_F0.8980.95
159_I257_L0.8950.95
181_K214_D0.8870.95
153_G187_L0.8850.95
242_I328_I0.8840.95
269_F326_S0.8820.95
281_V286_D0.8810.95
60_A100_L0.8770.95
42_F46_V0.8760.95
226_T232_I0.8760.95
162_A276_T0.8750.95
189_I213_I0.8680.94
256_G260_L0.8670.94
154_D187_L0.8660.94
300_I305_T0.8600.94
227_M266_I0.8580.94
269_F329_I0.8550.94
188_H215_V0.8540.94
262_N323_D0.8520.94
298_R312_V0.8380.93
197_V222_M0.8370.93
235_V257_L0.8360.93
224_A255_Y0.8320.93
150_F156_I0.8270.93
141_L145_N0.8220.93
292_R316_A0.8190.92
193_E220_D0.8190.92
299_Q304_R0.8160.92
298_R304_R0.8110.92
176_P236_I0.8030.92
156_I186_G0.8000.92
270_V325_I0.7990.91
130_Q134_E0.7980.91
109_H112_E0.7960.91
109_H113_N0.7940.91
231_Q313_F0.7930.91
209_M215_V0.7930.91
221_S297_V0.7920.91
247_D284_G0.7910.91
115_I119_E0.7890.91
216_T311_P0.7880.91
105_E109_H0.7880.91
174_L177_F0.7870.91
146_A176_P0.7830.91
68_A79_F0.7820.91
175_A179_L0.7810.91
41_V63_G0.7800.90
144_Q183_K0.7760.90
108_S111_V0.7700.90
93_S104_L0.7700.90
108_S112_E0.7680.90
106_R131_I0.7680.90
80_R112_E0.7660.90
301_S305_T0.7560.89
239_A248_T0.7470.88
201_S217_L0.7460.88
175_A178_Y0.7450.88
43_D46_V0.7450.88
64_L111_V0.7450.88
199_Q251_K0.7430.88
248_T328_I0.7400.88
178_Y213_I0.7370.88
80_R111_V0.7370.88
162_A176_P0.7350.88
150_F185_L0.7340.88
56_I103_A0.7340.88
145_N333_G0.7300.87
235_V268_F0.7290.87
146_A271_A0.7270.87
146_A329_I0.7260.87
35_L40_D0.7190.87
68_A71_I0.7190.87
273_P276_T0.7190.87
150_F187_L0.7140.86
65_A121_K0.7140.86
64_L104_L0.7110.86
102_W106_R0.7110.86
302_G305_T0.7090.86
160_C251_K0.7070.86
177_F181_K0.7060.86
174_L178_Y0.7040.85
223_A260_L0.7020.85
41_V66_L0.7010.85
138_T142_I0.6970.85
227_M264_F0.6940.85
130_Q133_V0.6920.84
152_K187_L0.6890.84
196_P220_D0.6890.84
239_A328_I0.6880.84
277_F330_T0.6870.84
46_V92_S0.6850.84
119_E122_T0.6840.84
295_E304_R0.6840.84
245_N284_G0.6800.83
190_Y231_Q0.6780.83
259_I264_F0.6760.83
174_L207_E0.6750.83
86_I93_S0.6740.83
205_A307_P0.6740.83
40_D43_D0.6730.83
234_A269_F0.6730.83
226_T231_Q0.6730.83
63_G66_L0.6720.83
60_A103_A0.6700.82
156_I234_A0.6700.82
177_F189_I0.6670.82
118_N122_T0.6660.82
160_C199_Q0.6660.82
103_A107_L0.6650.82
73_T78_E0.6620.82
262_N324_L0.6620.82
197_V314_N0.6610.82
42_F104_L0.6600.82
105_E280_K0.6580.81
217_L315_P0.6570.81
157_M235_V0.6540.81
142_I176_P0.6530.81
71_I79_F0.6520.81
149_L269_F0.6510.81
191_A217_L0.6490.80
80_R84_E0.6480.80
240_D317_F0.6470.80
65_A70_D0.6470.80
56_I60_A0.6470.80
255_Y259_I0.6460.80
240_D251_K0.6450.80
299_Q305_T0.6450.80
41_V56_I0.6450.80
38_K67_A0.6440.80
33_L43_D0.6430.80
81_R84_E0.6400.79
117_V120_A0.6360.79
65_A69_K0.6350.79
174_L208_L0.6320.79
136_E140_R0.6320.79
190_Y218_I0.6300.78
55_A59_T0.6290.78
121_K125_V0.6280.78
160_C250_N0.6270.78
50_V59_T0.6270.78
57_G102_W0.6270.78
151_K185_L0.6260.78
151_K233_S0.6240.78
294_P311_P0.6200.77
90_L104_L0.6190.77
79_F117_V0.6160.77
160_C194_T0.6150.77
209_M307_P0.6150.77
76_V80_R0.6150.77
191_A205_A0.6150.77
234_A267_P0.6140.77
39_E43_D0.6100.76
58_I131_I0.6100.76
176_P179_L0.6100.76
74_D78_E0.6080.76
329_I334_I0.6080.76
87_K91_N0.6080.76
68_A121_K0.6070.76
293_D298_R0.6040.75
64_L83_L0.6040.75
132_Q136_E0.6020.75
256_G259_I0.6010.75
245_N282_K0.5990.75
88_Q91_N0.5980.75
153_G185_L0.5980.75
72_E121_K0.5970.75
156_I177_F0.5940.74
78_E81_R0.5930.74
274_L277_F0.5890.74
151_K234_A0.5890.74
155_R231_Q0.5870.73
53_A240_D0.5860.73
78_E294_P0.5860.73
165_I206_W0.5860.73
249_A319_I0.5860.73
53_A98_I0.5840.73
299_Q308_S0.5830.73
258_A268_F0.5770.72
71_I121_K0.5740.72
180_A186_G0.5740.72
162_A248_T0.5730.72
245_N322_H0.5720.72
176_P269_F0.5720.72
67_A71_I0.5710.71
138_T331_E0.5710.71
38_K70_D0.5680.71
60_A90_L0.5670.71
251_K290_E0.5670.71
198_L201_S0.5660.71
194_T251_K0.5660.71
304_R307_P0.5650.71
251_K317_F0.5630.70
149_L336_T0.5630.70
147_L334_I0.5630.70
224_A263_A0.5590.70
243_A247_D0.5590.70
242_I248_T0.5570.70
300_I303_V0.5570.70
240_D250_N0.5570.70
79_F120_A0.5560.69
60_A101_S0.5550.69
200_G220_D0.5550.69
62_F125_V0.5530.69
149_L334_I0.5520.69
123_N126_H0.5510.69
103_A131_I0.5510.69
82_R295_E0.5500.69
79_F218_I0.5500.69
41_V67_A0.5480.68
319_I322_H0.5480.68
264_F324_L0.5460.68
267_P337_G0.5450.68
243_A284_G0.5430.68
82_R86_I0.5430.68
205_A310_V0.5400.67
259_I324_L0.5400.67
250_N292_R0.5370.67
34_E43_D0.5370.67
162_A216_T0.5370.67
71_I86_I0.5350.66
107_L111_V0.5330.66
196_P200_G0.5300.66
63_G67_A0.5290.66
85_D89_Y0.5290.66
162_A175_A0.5280.65
195_R198_L0.5260.65
110_S123_N0.5260.65
137_E140_R0.5250.65
231_Q315_P0.5240.65
134_E137_E0.5200.64
38_K42_F0.5200.64
193_E196_P0.5200.64
42_F86_I0.5180.64
114_A120_A0.5180.64
126_H133_V0.5170.64
31_E36_T0.5160.64
62_F65_A0.5150.64
260_L264_F0.5150.64
176_P329_I0.5140.63
221_S257_L0.5130.63
96_T292_R0.5130.63
72_E118_N0.5120.63
195_R200_G0.5110.63
57_G275_S0.5110.63
149_L180_A0.5110.63
142_I147_L0.5100.63
188_H311_P0.5090.63
181_K213_I0.5090.63
46_V93_S0.5080.62
94_R290_E0.5070.62
272_A328_I0.5070.62
244_K281_V0.5070.62
200_G204_T0.5060.62
194_T199_Q0.5050.62
54_P163_G0.5050.62
161_N203_L0.5040.62
104_L124_L0.5030.62
94_R251_K0.5020.62
143_G178_Y0.5010.61
155_R226_T0.5010.61
40_D49_K0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yvkA 2 0.9858 100 0.092 Contact Map
4ldrA 2 0.9688 100 0.1 Contact Map
1t5oA 2 0.9632 100 0.11 Contact Map
1t9kA 2 0.9688 100 0.122 Contact Map
2a0uA 2 0.9887 100 0.128 Contact Map
3a11A 4 0.8924 100 0.185 Contact Map
3ecsA 4 0.8244 100 0.302 Contact Map
1vb5A 3 0.7762 100 0.372 Contact Map
1w2wB 2 0.4703 100 0.494 Contact Map
1w2wA 1 0.5241 100 0.651 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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