GREMLIN Database
YKRP - Putative membrane-bound acyltransferase YkrP
UniProt: O31660 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 340 (298)
Sequences: 15156 (13317)
Seq/√Len: 771.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_K262_R3.6051.00
5_R10_D3.5581.00
304_S308_S3.3831.00
21_V266_V3.2691.00
16_L50_A3.1941.00
269_L306_L3.1891.00
311_V314_V3.0751.00
60_K171_F3.0401.00
72_A76_I3.0291.00
10_D261_T2.6681.00
299_T303_T2.6561.00
68_V124_Y2.6271.00
14_F260_G2.4751.00
262_R304_S2.4131.00
112_F116_L2.3851.00
258_K304_S2.3391.00
79_Y110_L2.3171.00
25_I274_I2.1611.00
82_F269_L2.1511.00
76_I80_L2.1491.00
49_P166_M2.1271.00
308_S312_K2.0101.00
61_G174_N1.9991.00
311_V315_A1.9371.00
44_Y47_H1.9261.00
57_Y177_H1.9021.00
58_F61_G1.8971.00
11_N252_K1.8741.00
14_F263_T1.8421.00
258_K308_S1.8271.00
10_D257_T1.7991.00
69_K73_V1.7831.00
52_I115_S1.7771.00
14_F259_W1.7731.00
199_V203_G1.7391.00
305_V309_N1.7231.00
108_W271_G1.7051.00
227_S231_R1.7001.00
17_I266_V1.6871.00
193_V197_V1.6761.00
12_A50_A1.6631.00
313_T316_Q1.6421.00
142_A146_G1.6401.00
184_K187_K1.6271.00
313_T317_P1.6271.00
82_F268_L1.6261.00
60_K123_L1.6111.00
200_I204_I1.6031.00
53_L173_L1.5961.00
78_P268_L1.5831.00
23_G44_Y1.5781.00
20_V48_M1.5651.00
62_F65_A1.5621.00
239_F243_F1.5531.00
9_F58_F1.5241.00
142_A145_I1.5171.00
197_V201_C1.5041.00
146_G149_D1.5011.00
190_A194_L1.4811.00
163_F166_M1.4761.00
258_K261_T1.4751.00
9_F54_V1.4691.00
194_L198_F1.4621.00
257_T261_T1.4231.00
266_V299_T1.3971.00
58_F62_F1.3961.00
141_I145_I1.3921.00
63_K123_L1.3901.00
235_Y238_A1.3851.00
248_L251_Q1.3831.00
133_W136_F1.3701.00
55_S116_L1.3691.00
238_A242_T1.3441.00
266_V303_T1.3431.00
308_S313_T1.3381.00
114_V118_F1.3311.00
315_A318_F1.3241.00
265_Y306_L1.3141.00
66_G70_K1.3121.00
297_L301_A1.3111.00
59_A123_L1.3081.00
253_R256_F1.3041.00
314_V317_P1.3021.00
236_V239_F1.2941.00
123_L167_F1.2931.00
262_R266_V1.2881.00
235_Y239_F1.2841.00
265_Y307_S1.2821.00
14_F18_F1.2771.00
138_S142_A1.2761.00
237_L240_G1.2761.00
16_L47_H1.2621.00
161_F165_P1.2621.00
61_G64_R1.2601.00
107_Q110_L1.2601.00
71_L120_N1.2561.00
57_Y174_N1.2551.00
192_G196_A1.2511.00
236_V240_G1.2481.00
262_R265_Y1.2471.00
143_V146_G1.2451.00
255_F259_W1.2421.00
86_Y272_F1.2361.00
228_G231_R1.2321.00
191_L195_A1.2291.00
6_D57_Y1.2191.00
303_T307_S1.2151.00
116_L120_N1.2091.00
59_A120_N1.2091.00
270_H274_I1.2051.00
60_K175_K1.1951.00
262_R303_T1.1901.00
237_L241_A1.1861.00
145_I149_D1.1681.00
68_V117_F1.1621.00
279_Q283_E1.1621.00
277_L281_G1.1601.00
301_A305_V1.1591.00
52_I116_L1.1581.00
85_I269_L1.1561.00
254_Y258_K1.1471.00
312_K316_Q1.1461.00
273_I302_L1.1401.00
77_I81_I1.1381.00
76_I117_F1.1371.00
78_P306_L1.1341.00
19_L47_H1.1251.00
109_S271_G1.1181.00
312_K315_A1.1181.00
82_F110_L1.1161.00
119_W167_F1.1161.00
121_L124_Y1.1151.00
240_G244_S1.1131.00
82_F86_Y1.1121.00
11_N256_F1.1091.00
66_G69_K1.1001.00
187_K191_L1.0951.00
247_A250_P1.0901.00
65_A70_K1.0901.00
295_L299_T1.0901.00
14_F256_F1.0831.00
239_F242_T1.0831.00
149_D152_S1.0821.00
201_C204_I1.0811.00
73_V76_I1.0771.00
67_Y120_N1.0701.00
286_L289_Y1.0671.00
159_R162_V1.0621.00
179_D183_S1.0611.00
60_K174_N1.0611.00
140_G144_L1.0611.00
234_W238_A1.0561.00
84_I88_V1.0541.00
135_L138_S1.0481.00
145_I148_L1.0261.00
155_L159_R1.0231.00
274_I295_L1.0181.00
59_A62_F1.0181.00
134_A137_V1.0161.00
264_F268_L1.0111.00
246_L250_P1.0101.00
49_P163_F1.0071.00
231_R235_Y1.0061.00
293_V297_L1.0051.00
226_V230_S1.0001.00
228_G232_I0.9981.00
277_L295_L0.9971.00
289_Y293_V0.9891.00
72_A117_F0.9881.00
111_W115_S0.9881.00
147_Y150_F0.9811.00
180_L183_S0.9781.00
123_L171_F0.9671.00
88_V92_I0.9631.00
17_I112_F0.9611.00
269_L272_F0.9601.00
179_D182_R0.9581.00
198_F202_W0.9571.00
44_Y48_M0.9561.00
302_L306_L0.9491.00
11_N253_R0.9431.00
79_Y264_F0.9411.00
115_S163_F0.9411.00
307_S311_V0.9371.00
185_R188_Q0.9341.00
165_P168_L0.9341.00
78_P265_Y0.9321.00
109_S267_Y0.9291.00
252_K255_F0.9171.00
23_G45_T0.9131.00
146_G150_F0.9071.00
134_A138_S0.9051.00
254_Y257_T0.9031.00
75_L120_N0.9031.00
34_H37_L0.9021.00
167_F171_F0.8961.00
300_A303_T0.8951.00
229_L233_G0.8931.00
21_V270_H0.8851.00
168_L171_F0.8841.00
110_L268_L0.8841.00
113_L268_L0.8821.00
20_V47_H0.8811.00
14_F17_I0.8781.00
231_R243_F0.8721.00
200_I203_G0.8681.00
8_Y11_N0.8671.00
148_L151_V0.8651.00
10_D260_G0.8631.00
259_W300_A0.8621.00
79_Y83_Q0.8611.00
67_Y71_L0.8581.00
273_I277_L0.8571.00
55_S167_F0.8541.00
10_D13_K0.8541.00
238_A241_A0.8531.00
245_F248_L0.8511.00
195_A199_V0.8501.00
306_L309_N0.8481.00
234_W237_L0.8481.00
307_S312_K0.8441.00
187_K190_A0.8411.00
6_D61_G0.8371.00
17_I51_F0.8341.00
230_S234_W0.8311.00
124_Y128_K0.8311.00
33_N37_L0.8281.00
292_L295_L0.8261.00
191_L194_L0.8241.00
125_P129_L0.8221.00
247_A251_Q0.8221.00
88_V91_Y0.8171.00
115_S119_W0.8171.00
52_I112_F0.8151.00
188_Q192_G0.8151.00
139_C146_G0.8081.00
13_K54_V0.8071.00
231_R234_W0.8071.00
23_G47_H0.8051.00
253_R257_T0.8051.00
157_L163_F0.8001.00
13_K112_F0.7991.00
19_L46_F0.7961.00
11_N257_T0.7931.00
83_Q87_S0.7931.00
256_F260_G0.7921.00
226_V231_R0.7921.00
53_L166_M0.7911.00
34_H38_Y0.7871.00
196_A200_I0.7831.00
305_V308_S0.7821.00
133_W137_V0.7761.00
95_D98_M0.7761.00
136_F140_G0.7711.00
233_G236_V0.7641.00
18_F22_F0.7631.00
188_Q191_L0.7591.00
252_K257_T0.7571.00
311_V317_P0.7561.00
292_L296_L0.7531.00
21_V299_T0.7491.00
137_V141_I0.7441.00
230_S241_A0.7421.00
17_I259_W0.7421.00
48_M51_F0.7401.00
82_F107_Q0.7391.00
229_L232_I0.7361.00
143_V147_Y0.7341.00
153_S156_S0.7281.00
86_Y109_S0.7271.00
311_V316_Q0.7261.00
314_V318_F0.7241.00
194_L201_C0.7211.00
59_A167_F0.7201.00
109_S270_H0.7201.00
266_V300_A0.7201.00
286_L290_Q0.7191.00
11_N14_F0.7191.00
117_F121_L0.7181.00
21_V296_L0.7161.00
91_Y95_D0.7161.00
185_R190_A0.7071.00
270_H299_T0.7061.00
134_A142_A0.7051.00
15_L19_L0.7051.00
287_T290_Q0.7001.00
174_N177_H0.7001.00
79_Y107_Q0.6991.00
128_K132_Q0.6981.00
231_R242_T0.6981.00
71_L74_K0.6971.00
56_G171_F0.6971.00
19_L23_G0.6921.00
257_T260_G0.6921.00
52_I163_F0.6871.00
109_S272_F0.6851.00
226_V233_G0.6851.00
184_K188_Q0.6831.00
81_I311_V0.6811.00
254_Y261_T0.6791.00
262_R307_S0.6791.00
225_L228_G0.6791.00
273_I276_T0.6781.00
63_K127_S0.6771.00
12_A54_V0.6761.00
196_A199_V0.6761.00
186_G189_I0.6741.00
49_P162_V0.6731.00
115_S160_T0.6731.00
276_T279_Q0.6711.00
86_Y107_Q0.6701.00
174_N178_F0.6701.00
275_K279_Q0.6691.00
89_F93_M0.6671.00
273_I295_L0.6671.00
5_R257_T0.6651.00
301_A304_S0.6651.00
147_Y151_V0.6651.00
74_K116_L0.6621.00
67_Y124_Y0.6571.00
182_R185_R0.6571.00
226_V229_L0.6571.00
55_S59_A0.6551.00
198_F201_C0.6541.00
144_L148_L0.6531.00
148_L152_S0.6531.00
255_F258_K0.6511.00
269_L302_L0.6501.00
139_C143_V0.6501.00
197_V200_I0.6501.00
9_F57_Y0.6471.00
227_S230_S0.6451.00
192_G195_A0.6441.00
119_W163_F0.6411.00
277_L280_V0.6401.00
213_G216_P0.6391.00
191_L197_V0.6341.00
119_W124_Y0.6331.00
13_K116_L0.6291.00
86_Y90_Y0.6281.00
191_L202_W0.6281.00
75_L117_F0.6271.00
183_S186_G0.6261.00
290_Q293_V0.6261.00
186_G191_L0.6261.00
85_I89_F0.6261.00
156_S160_T0.6251.00
262_R308_S0.6251.00
17_I21_V0.6241.00
71_L116_L0.6231.00
59_A67_Y0.6211.00
175_K178_F0.6191.00
92_I95_D0.6191.00
280_V283_E0.6181.00
232_I235_Y0.6161.00
75_L264_F0.6161.00
7_S10_D0.6131.00
75_L116_L0.6121.00
87_S90_Y0.6121.00
136_F139_C0.6101.00
5_R261_T0.6101.00
119_W123_L0.6091.00
168_L172_Y0.6091.00
225_L229_L0.6081.00
273_I298_L0.6051.00
25_I295_L0.6041.00
271_G274_I0.6011.00
172_Y176_H0.6011.00
47_H119_W0.6001.00
110_L114_V0.6001.00
155_L161_F0.6001.00
233_G237_L0.6001.00
7_S257_T0.5981.00
277_L291_S0.5981.00
189_I192_G0.5951.00
230_S233_G0.5941.00
96_E99_A0.5911.00
235_Y241_A0.5891.00
81_I85_I0.5871.00
7_S252_K0.5871.00
106_P110_L0.5861.00
232_I239_F0.5841.00
17_I263_T0.5821.00
231_R239_F0.5821.00
160_T163_F0.5821.00
159_R163_F0.5811.00
141_I146_G0.5801.00
116_L264_F0.5801.00
45_T49_P0.5791.00
23_G49_P0.5791.00
82_F272_F0.5781.00
194_L197_V0.5781.00
231_R236_V0.5751.00
231_R244_S0.5731.00
80_L117_F0.5721.00
171_F175_K0.5651.00
142_A149_D0.5621.00
259_W266_V0.5621.00
261_T271_G0.5611.00
196_A201_C0.5581.00
87_S91_Y0.5551.00
190_A193_V0.5551.00
118_F122_L0.5531.00
35_F39_L0.5521.00
135_L139_C0.5501.00
276_T280_V0.5491.00
90_Y94_Q0.5481.00
84_I87_S0.5481.00
135_L146_G0.5481.00
157_L160_T0.5471.00
172_Y175_K0.5461.00
76_I79_Y0.5441.00
19_L43_I0.5441.00
199_V202_W0.5441.00
74_K77_I0.5421.00
285_W288_D0.5421.00
272_F276_T0.5411.00
298_L301_A0.5391.00
191_L201_C0.5371.00
269_L303_T0.5361.00
227_S232_I0.5321.00
291_S295_L0.5321.00
52_I111_W0.5311.00
71_L112_F0.5311.00
230_S236_V0.5301.00
182_R187_K0.5301.00
18_F259_W0.5291.00
300_A304_S0.5291.00
81_I306_L0.5281.00
238_A246_L0.5271.00
288_D291_S0.5261.00
17_I47_H0.5201.00
71_L77_I0.5191.00
20_V112_F0.5151.00
241_A245_F0.5141.00
269_L299_T0.5131.00
236_V243_F0.5111.00
27_R30_I0.5101.00
20_V24_H0.5091.00
59_A116_L0.5081.00
189_I193_V0.5051.00
187_K192_G0.5031.00
115_S118_F0.5021.00
117_F167_F0.5021.00
162_V166_M0.5021.00
173_L177_H0.5011.00
25_I299_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3udcA 3 0.1618 4.3 0.959 Contact Map
4i0uA 4 0.1853 3.9 0.959 Contact Map
4ldsA 2 0.5588 3.9 0.96 Contact Map
2kncA 1 0.1588 3.9 0.96 Contact Map
4ev6A 3 0.1912 3.8 0.96 Contact Map
4j72A 2 0.1147 3.5 0.96 Contact Map
2kncB 1 0.1765 3.3 0.961 Contact Map
1dh3A 2 0.0735 3.2 0.961 Contact Map
2cfqA 1 0.6265 2.5 0.963 Contact Map
4i6nA 1 0.1618 2.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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