GREMLIN Database
KTRD - Ktr system potassium uptake protein D
UniProt: O31658 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 449 (408)
Sequences: 5128 (3844)
Seq/√Len: 190.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
368_A415_V4.3501.00
308_A314_G4.2931.00
49_D409_K3.5371.00
200_M273_L3.4431.00
48_I410_C3.2391.00
371_I411_V2.9111.00
151_Y192_D2.6781.00
288_D291_Q2.6631.00
379_S382_E2.5841.00
309_S319_T2.5431.00
182_T188_P2.5271.00
184_N188_P2.5121.00
145_G167_F2.4541.00
375_T408_G2.4101.00
84_L172_S2.3981.00
81_A168_F2.3521.00
51_L413_M2.3471.00
372_L408_G2.3461.00
264_S267_D2.3351.00
85_Q141_E2.2561.00
148_L199_T2.1721.00
375_T407_V2.1381.00
159_Y194_F2.1211.00
77_I164_L2.0781.00
48_I413_M2.0741.00
169_A180_D2.0721.00
55_V413_M2.0601.00
172_S284_L2.0331.00
196_Q270_F2.0191.00
369_T384_L2.0101.00
30_V47_F2.0101.00
196_Q271_L2.0061.00
252_F256_A2.0021.00
75_I79_I1.9941.00
279_T300_I1.9791.00
45_W71_T1.9631.00
74_T78_F1.9601.00
250_G299_F1.9521.00
239_T323_A1.9321.00
389_S401_T1.9311.00
194_F198_I1.9141.00
234_K238_I1.9091.00
204_I244_V1.9091.00
67_D70_D1.8801.00
200_M277_T1.8751.00
186_M199_T1.8551.00
207_A280_R1.8531.00
236_T240_F1.8231.00
368_A411_V1.8151.00
144_G202_L1.8141.00
64_T68_T1.7971.00
48_I406_S1.7891.00
152_F199_T1.7871.00
174_T206_G1.7821.00
204_I277_T1.7681.00
46_T49_D1.7611.00
325_N358_T1.7571.00
301_C388_C1.7461.00
266_H270_F1.7351.00
197_F201_L1.7321.00
371_I407_V1.7111.00
131_K135_F1.7061.00
34_S47_F1.7011.00
251_I296_T1.6991.00
159_Y198_I1.6751.00
158_S162_A1.6711.00
365_V388_C1.6551.00
196_Q286_T1.6501.00
244_V277_T1.6451.00
68_T71_T1.6391.00
324_L346_L1.6301.00
193_Y270_F1.6231.00
149_G166_G1.6181.00
317_I322_F1.6141.00
389_S394_T1.5961.00
182_T189_F1.5941.00
145_G170_S1.5791.00
232_F236_T1.5651.00
153_L158_S1.5461.00
281_S394_T1.5441.00
382_E398_L1.5381.00
248_A273_L1.5361.00
197_F270_F1.5151.00
330_F334_R1.5021.00
190_R271_L1.4901.00
63_L401_T1.4831.00
369_T387_V1.4771.00
306_I319_T1.4771.00
149_G163_Y1.4711.00
361_A391_F1.4701.00
203_I278_A1.4671.00
365_V391_F1.4671.00
375_T405_S1.4411.00
56_S179_F1.4281.00
203_I282_G1.4261.00
45_W72_F1.4251.00
34_S38_A1.4201.00
276_S279_T1.4201.00
197_F266_H1.4151.00
207_A240_F1.4131.00
201_L205_F1.4131.00
173_A199_T1.4051.00
38_A75_I1.4041.00
237_T241_G1.3991.00
168_F181_I1.3971.00
247_G276_S1.3911.00
410_C414_I1.3901.00
77_I81_A1.3881.00
161_E195_V1.3831.00
234_K240_F1.3811.00
53_T65_V1.3801.00
48_I409_K1.3651.00
256_A268_I1.3621.00
227_Y230_T1.3541.00
242_S246_F1.3511.00
19_A417_F1.3471.00
84_L177_G1.3421.00
378_H400_I1.3391.00
45_W66_V1.3341.00
55_V417_F1.3281.00
165_H182_T1.3251.00
151_Y198_I1.3221.00
289_I300_I1.3211.00
69_A183_G1.3201.00
159_Y195_V1.3181.00
159_Y163_Y1.3161.00
51_L410_C1.3121.00
161_E165_H1.2991.00
197_F273_L1.2971.00
410_C413_M1.2951.00
251_I300_I1.2901.00
368_A387_V1.2881.00
229_F233_T1.2721.00
47_F51_L1.2691.00
246_F250_G1.2671.00
169_A181_I1.2621.00
40_K73_S1.2611.00
233_T236_T1.2591.00
275_Q286_T1.2521.00
180_D183_G1.2511.00
163_Y167_F1.2501.00
378_H383_L1.2401.00
197_F269_L1.2311.00
187_I285_A1.2301.00
30_V51_L1.2281.00
245_L248_A1.2251.00
173_A284_L1.2231.00
57_S179_F1.2231.00
301_C384_L1.2221.00
297_L398_L1.2181.00
74_T164_L1.2121.00
302_A306_I1.2091.00
30_V55_V1.2031.00
148_L202_L1.1941.00
37_A83_V1.1921.00
248_A252_F1.1891.00
190_R193_Y1.1861.00
193_Y196_Q1.1841.00
324_L351_L1.1841.00
72_F80_L1.1841.00
54_A83_V1.1801.00
196_Q200_M1.1711.00
49_D65_V1.1681.00
68_T183_G1.1641.00
306_I322_F1.1641.00
43_A73_S1.1611.00
289_I292_L1.1591.00
184_N187_I1.1571.00
267_D271_L1.1511.00
244_V279_T1.1461.00
81_A164_L1.1461.00
215_E230_T1.1421.00
414_I418_I1.1411.00
173_A202_L1.1371.00
151_Y159_Y1.1361.00
328_A355_L1.1351.00
365_V369_T1.1321.00
271_L275_Q1.1291.00
153_L162_A1.1241.00
305_F365_V1.1231.00
46_T406_S1.1191.00
369_T383_L1.1181.00
252_F255_E1.1171.00
404_L412_I1.1161.00
243_L247_G1.1131.00
153_L163_Y1.1081.00
187_I288_D1.1061.00
137_I141_E1.1001.00
148_L152_F1.0981.00
263_K271_L1.0951.00
265_W269_L1.0941.00
51_L55_V1.0941.00
190_R196_Q1.0931.00
387_V415_V1.0931.00
140_I205_F1.0921.00
301_C385_F1.0911.00
293_S296_T1.0901.00
252_F272_S1.0901.00
30_V34_S1.0801.00
151_Y194_F1.0741.00
66_V72_F1.0741.00
197_F200_M1.0711.00
81_A167_F1.0641.00
25_A58_V1.0561.00
203_I277_T1.0541.00
310_P320_T1.0531.00
148_L195_V1.0531.00
371_I375_T1.0491.00
241_G245_L1.0431.00
200_M248_A1.0431.00
135_F139_W1.0401.00
324_L354_S1.0381.00
233_T237_T1.0371.00
289_I398_L1.0361.00
227_Y232_F1.0341.00
338_A345_E1.0331.00
234_K342_F1.0321.00
252_F268_I1.0311.00
404_L408_G1.0291.00
271_L287_I1.0231.00
147_I194_F1.0201.00
229_F232_F1.0191.00
78_F82_F1.0191.00
33_L54_A1.0121.00
111_R125_G0.9980.99
149_G159_Y0.9950.99
37_A75_I0.9880.99
297_L382_E0.9880.99
85_Q145_G0.9870.99
40_K77_I0.9870.99
332_F352_M0.9850.99
149_G162_A0.9820.99
74_T77_I0.9810.99
53_T68_T0.9780.99
204_I240_F0.9740.99
372_L387_V0.9740.99
358_T362_I0.9740.99
248_A276_S0.9720.99
238_I342_F0.9720.99
65_V68_T0.9680.99
348_P352_M0.9670.99
369_T380_L0.9650.99
39_H45_W0.9630.99
169_A182_T0.9610.99
231_L234_K0.9590.99
405_S408_G0.9550.99
386_E397_S0.9530.99
248_A272_S0.9490.99
390_A412_I0.9490.99
193_Y197_F0.9480.99
364_L418_I0.9460.99
20_L24_L0.9440.99
400_I403_D0.9400.99
231_L236_T0.9360.99
372_L412_I0.9350.99
38_A73_S0.9340.99
81_A171_I0.9340.99
387_V412_I0.9310.99
235_I323_A0.9310.99
193_Y266_H0.9300.99
177_G281_S0.9280.99
78_F164_L0.9270.99
89_I138_L0.9260.99
38_A47_F0.9200.99
21_Y91_I0.9190.99
181_I189_F0.9190.99
326_L330_F0.9170.99
180_D185_S0.9170.99
234_K255_E0.9170.99
373_T383_L0.9160.99
271_L286_T0.9070.99
295_S370_L0.9060.99
125_G128_N0.9040.99
148_L173_A0.9030.99
67_D183_G0.8990.99
145_G163_Y0.8980.99
186_M195_V0.8970.99
23_F417_F0.8960.99
305_F361_A0.8960.99
81_A84_L0.8950.99
149_G167_F0.8940.99
364_L415_V0.8920.99
389_S397_S0.8890.99
140_I213_L0.8870.99
227_Y231_L0.8800.99
235_I240_F0.8770.99
235_I238_I0.8760.99
244_V273_L0.8760.99
304_M394_T0.8750.99
290_S297_L0.8730.99
228_P232_F0.8720.99
236_T255_E0.8720.99
150_T153_L0.8700.99
237_T240_F0.8670.99
235_I239_T0.8550.98
232_F238_I0.8540.98
407_V411_V0.8510.98
294_D381_L0.8490.98
68_T80_L0.8480.98
227_Y236_T0.8470.98
239_T319_T0.8420.98
147_I198_I0.8390.98
254_L296_T0.8370.98
310_P319_T0.8370.98
386_E401_T0.8330.98
29_A83_V0.8290.98
55_V426_F0.8290.98
70_D183_G0.8260.98
53_T80_L0.8180.98
139_W143_F0.8180.98
144_G198_I0.8180.98
162_A166_G0.8160.98
230_T234_K0.8140.98
205_F213_L0.8130.98
276_S303_L0.8120.98
39_H44_D0.8110.98
57_S80_L0.8110.98
26_V58_V0.8080.98
391_F415_V0.8070.98
235_I327_L0.8040.98
192_D196_Q0.8030.98
243_L319_T0.8030.98
106_I127_V0.8030.98
327_L339_V0.8010.98
149_G153_L0.7990.98
66_V69_A0.7960.98
248_A269_L0.7940.97
200_M204_I0.7920.97
251_I276_S0.7900.97
35_L39_H0.7890.97
162_A165_H0.7890.97
144_G174_T0.7880.97
68_T72_F0.7880.97
327_L341_V0.7880.97
408_G412_I0.7870.97
190_R263_K0.7840.97
254_L374_I0.7820.97
239_T326_L0.7820.97
329_L360_M0.7750.97
290_S398_L0.7740.97
247_G303_L0.7740.97
299_F370_L0.7700.97
207_A308_A0.7700.97
248_A251_I0.7690.97
81_A172_S0.7690.97
266_H269_L0.7660.97
328_A351_L0.7650.97
275_Q289_I0.7640.97
275_Q300_I0.7600.97
403_D406_S0.7570.97
331_H339_V0.7570.97
47_F410_C0.7560.97
304_M389_S0.7560.97
373_T380_L0.7540.97
388_C392_G0.7500.96
31_I51_L0.7470.96
360_M424_L0.7460.96
247_G299_F0.7450.96
141_E145_G0.7430.96
35_L75_I0.7430.96
146_L150_T0.7380.96
176_N280_R0.7380.96
236_T239_T0.7370.96
152_F186_M0.7370.96
168_F172_S0.7370.96
262_G268_I0.7350.96
89_I137_I0.7310.96
292_L296_T0.7290.96
153_L159_Y0.7290.96
24_L28_V0.7290.96
215_E233_T0.7280.96
192_D195_V0.7260.96
136_L140_I0.7250.96
67_D402_A0.7230.96
158_S161_E0.7220.96
273_L277_T0.7210.96
148_L170_S0.7200.96
385_F396_L0.7190.95
244_V247_G0.7180.95
162_A189_F0.7150.95
64_T80_L0.7120.95
26_V55_V0.7090.95
66_V71_T0.7050.95
84_L175_T0.7050.95
58_V83_V0.7040.95
73_S76_G0.7040.95
165_H169_A0.7040.95
40_K76_G0.7030.95
372_L383_L0.7020.95
204_I241_G0.7000.95
227_Y234_K0.7000.95
48_I412_I0.7000.95
240_F255_E0.6970.95
287_I292_L0.6960.95
325_N329_L0.6960.95
236_T251_I0.6960.95
372_L375_T0.6930.94
70_D182_T0.6920.94
269_L273_L0.6920.94
228_P231_L0.6920.94
240_F244_V0.6900.94
361_A392_G0.6890.94
232_F240_F0.6890.94
301_C381_L0.6890.94
163_Y166_G0.6880.94
142_F146_L0.6860.94
298_F380_L0.6820.94
141_E144_G0.6820.94
369_T373_T0.6810.94
53_T64_T0.6800.94
250_G254_L0.6750.94
329_L356_V0.6750.94
196_Q275_Q0.6750.94
325_N355_L0.6740.94
423_I427_L0.6740.94
169_A199_T0.6730.94
295_S374_I0.6730.94
34_S44_D0.6730.94
418_I426_F0.6700.93
250_G253_A0.6700.93
31_I34_S0.6690.93
150_T166_G0.6680.93
381_L398_L0.6680.93
170_S202_L0.6640.93
256_A265_W0.6630.93
275_Q278_A0.6610.93
234_K237_T0.6610.93
254_L295_S0.6600.93
385_F397_S0.6600.93
247_G251_I0.6600.93
331_H348_P0.6600.93
39_H71_T0.6540.93
219_F226_R0.6530.93
176_N282_G0.6520.92
265_W268_I0.6520.92
372_L378_H0.6510.92
145_G149_G0.6510.92
244_V248_A0.6500.92
176_N313_V0.6500.92
231_L235_I0.6490.92
186_M189_F0.6490.92
160_Q164_L0.6480.92
69_A77_I0.6450.92
152_F195_V0.6450.92
236_T244_V0.6420.92
285_A396_L0.6400.92
176_N206_G0.6390.92
167_F170_S0.6360.92
235_I342_F0.6350.91
194_F197_F0.6340.91
208_I213_L0.6340.91
42_G45_W0.6300.91
285_A288_D0.6300.91
213_L217_K0.6290.91
380_L383_L0.6290.91
238_I255_E0.6280.91
302_A366_F0.6280.91
124_S128_N0.6280.91
263_K267_D0.6280.91
63_L389_S0.6270.91
211_P311_S0.6260.91
164_L168_F0.6250.91
252_F265_W0.6240.91
27_T30_V0.6240.91
263_K268_I0.6230.91
327_L330_F0.6230.91
84_L284_L0.6230.91
134_L138_L0.6230.91
30_V54_A0.6220.91
406_S409_K0.6210.91
317_I358_T0.6200.91
233_T240_F0.6170.90
233_T238_I0.6170.90
252_F269_L0.6170.90
329_L359_M0.6160.90
150_T194_F0.6150.90
144_G206_G0.6130.90
18_I21_Y0.6110.90
298_F302_A0.6070.90
149_G170_S0.6050.89
23_F27_T0.6020.89
117_D120_Q0.6020.89
325_N359_M0.6000.89
186_M196_Q0.5990.89
250_G295_S0.5980.89
187_I190_R0.5970.89
138_L142_F0.5960.89
238_I242_S0.5960.89
236_T309_S0.5950.89
26_V59_S0.5940.89
50_A54_A0.5940.89
313_V318_R0.5940.89
409_K413_M0.5920.88
63_L390_A0.5910.88
94_L138_L0.5870.88
348_P351_L0.5860.88
244_V276_S0.5830.88
401_T404_L0.5830.88
375_T411_V0.5810.87
64_T69_A0.5800.87
378_H404_L0.5780.87
49_D402_A0.5780.87
84_L171_I0.5760.87
31_I245_L0.5760.87
31_I47_F0.5730.87
23_F426_F0.5730.87
38_A50_A0.5710.87
185_S286_T0.5700.86
43_A76_G0.5670.86
251_I254_L0.5660.86
231_L237_T0.5640.86
239_T243_L0.5630.86
63_L396_L0.5620.86
391_F423_I0.5600.86
146_L149_G0.5590.85
169_A284_L0.5590.85
136_L213_L0.5580.85
298_F369_T0.5580.85
363_L367_G0.5560.85
372_L390_A0.5550.85
144_G148_L0.5550.85
132_Q214_V0.5550.85
244_V251_I0.5540.85
386_E412_I0.5540.85
340_K345_E0.5530.85
185_S394_T0.5520.85
276_S300_I0.5520.85
148_L198_I0.5510.85
382_E404_L0.5510.85
281_S315_G0.5500.84
232_F235_I0.5500.84
142_F167_F0.5500.84
144_G170_S0.5480.84
139_W142_F0.5480.84
65_V409_K0.5480.84
187_I286_T0.5440.84
403_D407_V0.5440.84
165_H181_I0.5440.84
386_E396_L0.5440.84
227_Y238_I0.5430.84
114_I117_D0.5400.83
230_T236_T0.5400.83
383_L387_V0.5400.83
396_L401_T0.5400.83
71_T74_T0.5380.83
372_L411_V0.5380.83
275_Q292_L0.5380.83
60_V281_S0.5380.83
256_A261_A0.5360.83
199_T284_L0.5360.83
236_T247_G0.5360.83
364_L391_F0.5350.83
251_I255_E0.5350.83
215_E219_F0.5340.83
365_V387_V0.5330.83
372_L404_L0.5330.83
301_C398_L0.5330.83
82_F171_I0.5330.83
63_L397_S0.5320.83
64_T172_S0.5290.82
129_L312_S0.5280.82
274_F284_L0.5280.82
332_F356_V0.5270.82
269_L272_S0.5270.82
143_F147_I0.5270.82
42_G73_S0.5260.82
383_L400_I0.5260.82
14_P17_L0.5260.82
78_F81_A0.5250.82
281_S284_L0.5240.82
278_A396_L0.5230.81
50_A72_F0.5230.81
44_D65_V0.5230.81
186_M274_F0.5230.81
183_G400_I0.5220.81
279_T396_L0.5220.81
304_M392_G0.5210.81
136_L217_K0.5190.81
278_A289_I0.5190.81
333_A431_G0.5190.81
378_H382_E0.5180.81
35_L38_A0.5180.81
268_I272_S0.5170.81
214_V218_D0.5170.81
236_T248_A0.5160.81
59_S315_G0.5150.80
347_H350_D0.5150.80
171_I175_T0.5140.80
369_T388_C0.5140.80
207_A282_G0.5140.80
279_T303_L0.5130.80
236_T243_L0.5130.80
180_D184_N0.5130.80
316_G322_F0.5130.80
234_K244_V0.5130.80
234_K251_I0.5120.80
385_F389_S0.5100.80
384_L388_C0.5100.80
333_A427_L0.5100.80
142_F145_G0.5090.80
64_T183_G0.5090.80
159_Y162_A0.5090.80
59_S311_S0.5070.79
285_A289_I0.5060.79
34_S50_A0.5050.79
370_L374_I0.5040.79
324_L328_A0.5040.79
331_H334_R0.5030.79
185_S189_F0.5010.79
308_A319_T0.5010.79
226_R230_T0.5000.79
71_T183_G0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j7cI 2 0.951 100 0.167 Contact Map
3pjzA 2 0.902 100 0.198 Contact Map
3ukmA 2 0.4276 97 0.934 Contact Map
4twkA 2 0.5323 95.2 0.944 Contact Map
4bw5A 2 0.5056 94.4 0.947 Contact Map
4wfeA 2 0.4321 93.7 0.948 Contact Map
1lnqA 6 0.1938 91.7 0.951 Contact Map
2k1eA 3 0.2138 91.5 0.952 Contact Map
3effK 4 0.2227 88.7 0.955 Contact Map
4gx0A 3 0.2205 88.2 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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