GREMLIN Database
HTPX - Protease HtpX homolog
UniProt: O31657 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (257)
Sequences: 4940 (3696)
Seq/√Len: 230.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_R296_E4.6081.00
99_R150_E4.3881.00
158_A236_G4.2731.00
148_A252_T4.1661.00
116_R138_S3.9841.00
147_A243_K3.3791.00
154_A237_G3.3271.00
92_Q146_D3.3131.00
81_P98_H3.1331.00
136_V153_L2.9981.00
238_A295_L2.9371.00
231_F290_E2.9121.00
128_S131_R2.7321.00
235_R239_D2.6321.00
96_R150_E2.5261.00
94_V109_M2.4381.00
237_G241_A2.3941.00
254_K289_D2.3291.00
26_L30_T2.3121.00
247_I292_I2.2961.00
104_A240_L2.2341.00
148_A248_H2.1911.00
251_R292_I2.1551.00
76_V113_G2.1471.00
53_V57_V2.1161.00
26_L29_V2.1131.00
164_D232_H2.0631.00
145_D248_H1.9871.00
290_E293_R1.9791.00
254_K288_L1.9651.00
97_V112_V1.9631.00
145_D252_T1.9501.00
77_R116_R1.8621.00
98_H102_R1.8521.00
191_S194_V1.8021.00
287_D290_E1.7661.00
143_Q256_Y1.7511.00
57_V61_T1.7401.00
78_V111_E1.7351.00
98_H109_M1.7181.00
68_W72_T1.6421.00
91_Q94_V1.6161.00
123_F135_A1.5581.00
138_S142_E1.5561.00
80_N89_E1.5321.00
164_D229_R1.5231.00
24_S27_S1.5221.00
96_R146_D1.5161.00
151_G246_M1.5111.00
184_R188_W1.5081.00
144_M253_L1.5081.00
235_R294_R1.4781.00
140_L149_V1.4631.00
95_D99_R1.4601.00
185_I188_W1.4431.00
219_S223_F1.4411.00
78_V113_G1.4401.00
51_S180_V1.4241.00
25_V28_S1.4171.00
113_G133_L1.4091.00
195_K198_L1.3901.00
183_S186_A1.3581.00
118_P142_E1.3541.00
163_G166_V1.3531.00
280_S290_E1.3521.00
132_S160_I1.3511.00
22_V26_L1.3511.00
94_V98_H1.3461.00
90_E114_I1.3361.00
25_V30_T1.3311.00
92_Q95_D1.3241.00
247_I296_E1.3201.00
159_H230_E1.3181.00
95_D98_H1.3061.00
100_L157_V1.3051.00
124_A134_V1.2991.00
162_N232_H1.2891.00
141_L149_V1.2861.00
155_H230_E1.2771.00
168_M229_R1.2631.00
162_N236_G1.2451.00
27_S30_T1.2361.00
24_S28_S1.2211.00
187_A190_A1.2131.00
156_E230_E1.2091.00
203_H206_A1.1811.00
66_S71_K1.1771.00
283_S287_D1.1771.00
61_T65_I1.1661.00
147_A248_H1.1521.00
24_S30_T1.1451.00
100_L240_L1.1431.00
228_H232_H1.1381.00
155_H159_H1.1301.00
56_F173_G1.1291.00
77_R89_E1.1221.00
91_Q95_D1.1171.00
65_I69_M1.1161.00
147_A245_K1.1151.00
231_F294_R1.1121.00
181_F184_R1.1091.00
232_H236_G1.1011.00
246_M295_L1.0961.00
118_P138_S1.0951.00
194_V198_L1.0951.00
293_R296_E1.0821.00
181_F185_I1.0761.00
152_V249_A1.0731.00
95_D146_D1.0651.00
207_M211_Q1.0581.00
201_I204_F1.0451.00
186_A189_I1.0391.00
289_D293_R1.0371.00
229_R232_H1.0371.00
35_Y38_A1.0281.00
245_K296_E1.0231.00
106_L157_V1.0211.00
71_K123_F1.0151.00
253_L274_N1.0041.00
199_A202_V1.0001.00
221_V225_Y0.9931.00
59_S62_S0.9911.00
150_E243_K0.9761.00
90_E94_V0.9751.00
90_E93_L0.9681.00
210_F213_V0.9671.00
248_H252_T0.9611.00
204_F207_M0.9591.00
127_P131_R0.9581.00
93_L136_V0.9521.00
145_D148_A0.9521.00
290_E294_R0.9481.00
140_L144_M0.9451.00
39_D44_P0.9451.00
232_H235_R0.9431.00
180_V183_S0.9401.00
223_F284_T0.9381.00
48_L52_L0.9351.00
167_T232_H0.9301.00
136_V140_L0.9291.00
242_G245_K0.9281.00
22_V28_S0.9251.00
254_K258_S0.9221.00
185_I189_I0.9141.00
195_K199_A0.9141.00
226_S284_T0.9081.00
25_V29_V0.9020.99
230_E233_A0.8980.99
196_E200_P0.8940.99
114_I141_L0.8900.99
288_L292_I0.8870.99
101_S108_K0.8870.99
156_E159_H0.8830.99
165_M169_T0.8800.99
120_V256_Y0.8790.99
167_T229_R0.8790.99
35_Y39_D0.8770.99
179_V182_L0.8750.99
260_I263_D0.8750.99
60_F64_A0.8740.99
179_V183_S0.8730.99
194_V197_D0.8720.99
99_R103_S0.8660.99
128_S132_S0.8610.99
34_T39_D0.8570.99
24_S29_V0.8550.99
144_M252_T0.8500.99
29_V34_T0.8490.99
103_S242_G0.8450.99
89_E94_V0.8430.99
136_V141_L0.8410.99
58_G62_S0.8410.99
184_R187_A0.8400.99
238_A243_K0.8390.99
47_L51_S0.8370.99
31_G35_Y0.8360.99
224_A227_R0.8330.99
202_V206_A0.8300.99
155_H233_A0.8260.99
246_M250_L0.8230.99
37_T41_G0.8230.99
101_S109_M0.8210.99
74_M115_Y0.8210.99
175_V222_V0.8200.99
179_V184_R0.8150.99
186_A190_A0.8130.99
64_A127_P0.8080.99
192_R195_K0.8030.99
175_V218_G0.7940.99
22_V25_V0.7940.99
79_L114_I0.7900.99
32_V36_F0.7900.99
99_R102_R0.7890.99
106_L161_T0.7850.99
115_Y135_A0.7800.98
27_S32_V0.7790.98
120_V143_Q0.7710.98
261_L264_D0.7700.98
100_L153_L0.7690.98
101_S157_V0.7580.98
33_G36_F0.7570.98
70_A74_M0.7540.98
66_S123_F0.7540.98
251_R254_K0.7520.98
38_A42_I0.7520.98
237_G246_M0.7450.98
26_L31_G0.7440.98
161_T236_G0.7400.98
97_V153_L0.7390.98
158_A240_L0.7390.98
146_D150_E0.7340.98
30_T34_T0.7310.98
286_P291_R0.7280.98
201_I205_I0.7270.98
29_V32_V0.7270.98
27_S31_G0.7270.98
81_P95_D0.7260.98
182_L186_A0.7240.98
75_G116_R0.7210.97
183_S189_I0.7180.97
43_D46_A0.7150.97
44_P47_L0.7150.97
170_L174_I0.7140.97
166_V170_L0.7140.97
65_I68_W0.7080.97
67_R111_E0.7070.97
171_L222_V0.7040.97
230_E285_H0.7020.97
256_Y259_R0.6990.97
28_S33_G0.6990.97
23_L26_L0.6980.97
79_L93_L0.6980.97
253_L257_S0.6970.97
46_A50_F0.6950.97
252_T255_S0.6950.97
213_V217_L0.6940.97
52_L59_S0.6900.97
41_G45_M0.6870.97
115_Y137_S0.6840.97
96_R99_R0.6830.97
280_S283_S0.6820.96
247_I251_R0.6720.96
245_K248_H0.6720.96
210_F214_F0.6680.96
55_G59_S0.6680.96
238_A242_G0.6670.96
279_S283_S0.6670.96
40_G45_M0.6620.96
292_I296_E0.6600.96
134_V153_L0.6580.96
121_N124_A0.6560.96
111_E133_L0.6560.96
29_V33_G0.6550.96
52_L56_F0.6520.95
93_L112_V0.6510.95
26_L34_T0.6490.95
125_T133_L0.6490.95
196_E199_A0.6490.95
125_T165_M0.6470.95
52_L181_F0.6440.95
36_F39_D0.6430.95
124_A135_A0.6420.95
49_V181_F0.6390.95
171_L225_Y0.6390.95
197_D200_P0.6390.95
251_R255_S0.6380.95
38_A41_G0.6380.95
180_V184_R0.6350.95
46_A49_V0.6310.95
188_W191_S0.6290.95
157_V160_I0.6270.94
77_R138_S0.6260.94
53_V56_F0.6250.94
33_G39_D0.6210.94
168_M226_S0.6210.94
43_D47_L0.6190.94
125_T135_A0.6170.94
49_V52_L0.6170.94
23_L27_S0.6170.94
191_S195_K0.6160.94
121_N155_H0.6150.94
183_S187_A0.6140.94
154_A240_L0.6140.94
162_N229_R0.6130.94
33_G37_T0.6120.94
215_S218_G0.6110.94
115_Y119_E0.6110.94
159_H233_A0.6100.94
218_G221_V0.6100.94
159_H285_H0.6040.93
216_I219_S0.6030.93
168_M171_L0.6030.93
97_V150_E0.6010.93
220_L282_F0.5990.93
231_F287_D0.5980.93
59_S63_L0.5930.93
39_D42_I0.5920.93
45_M49_V0.5920.93
194_V199_A0.5920.93
151_G247_I0.5920.93
55_G58_G0.5910.93
49_V53_V0.5910.93
25_V32_V0.5890.92
144_M249_A0.5880.92
104_A157_V0.5870.92
96_R100_L0.5830.92
31_G34_T0.5790.92
102_R105_G0.5760.92
71_K125_T0.5740.91
32_V37_T0.5720.91
212_I216_I0.5700.91
124_A132_S0.5700.91
110_P164_D0.5670.91
34_T37_T0.5670.91
250_L288_L0.5670.91
120_V139_G0.5650.91
244_D248_H0.5650.91
200_P203_H0.5650.91
93_L141_L0.5600.90
236_G239_D0.5600.90
241_A244_D0.5580.90
101_S105_G0.5550.90
43_D50_F0.5550.90
279_S290_E0.5550.90
124_A160_I0.5540.90
204_F208_I0.5540.90
144_M149_V0.5540.90
103_S239_D0.5520.90
254_K292_I0.5520.90
161_T239_D0.5510.90
47_L50_F0.5510.90
110_P229_R0.5510.90
27_S33_G0.5480.89
82_K91_Q0.5480.89
81_P94_V0.5480.89
101_S106_L0.5480.89
100_L103_S0.5480.89
70_A73_M0.5470.89
63_L66_S0.5470.89
255_S259_R0.5470.89
187_A191_S0.5460.89
28_S31_G0.5460.89
34_T38_A0.5460.89
42_I45_M0.5450.89
193_F198_L0.5440.89
260_I264_D0.5440.89
212_I215_S0.5400.89
274_N288_L0.5400.89
183_S207_M0.5400.89
211_Q214_F0.5380.89
29_V39_D0.5380.89
67_R71_K0.5360.88
124_A137_S0.5350.88
79_L115_Y0.5340.88
117_S138_S0.5340.88
208_I212_I0.5310.88
31_G38_A0.5300.88
23_L33_G0.5290.88
184_R190_A0.5280.88
224_A228_H0.5280.88
253_L288_L0.5270.88
213_V216_I0.5270.88
277_K280_S0.5260.87
119_E257_S0.5250.87
144_M152_V0.5240.87
39_D43_D0.5240.87
248_H251_R0.5240.87
71_K76_V0.5220.87
79_L133_L0.5220.87
283_S288_L0.5210.87
285_H291_R0.5200.87
71_K79_L0.5200.87
56_F60_F0.5160.86
160_I163_G0.5140.86
223_F283_S0.5110.86
136_V160_I0.5080.86
188_W192_R0.5070.86
51_S55_G0.5050.85
151_G250_L0.5040.85
71_K133_L0.5040.85
114_I138_S0.5030.85
52_L177_T0.5030.85
156_E285_H0.5030.85
41_G46_A0.5020.85
35_Y42_I0.5010.85
100_L150_E0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 0.9295 100 0.29 Contact Map
4aw6A 2 0.9262 100 0.296 Contact Map
3c37A 1 0.6242 100 0.466 Contact Map
3cqbA 4 0.3557 99.8 0.627 Contact Map
4qhjA 2 0.3423 96.9 0.871 Contact Map
4jixA 2 0.3624 95.7 0.885 Contact Map
3dteA 2 0.4899 95.4 0.887 Contact Map
4jiuA 1 0.3389 95.2 0.889 Contact Map
4o66A 2 0.2181 33.2 0.94 Contact Map
2pnvA 5 0.0906 13.9 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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