HTPX - BACSU - GREMLIN Contacts

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HTPX - Protease HtpX homolog

UniProt:	O31657	Sequences: MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDPMALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSRSAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHITNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILGSLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGKKRSSLFSTHPDLDERIRRLEAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	298 (257)
Sequences:	4940 (3696)
Seq/√Len:	230.6

ECOLI - HTPX LOIP YCAL BEPA
BACSU - HTPX YHFN YXKI
HALSA - HTPX Q9HSA2 Q9HS47
SULSO - HTPX2 HTPX1 Q97VD5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
251_R	296_E	4.608	1.00
99_R	150_E	4.388	1.00
158_A	236_G	4.273	1.00
148_A	252_T	4.166	1.00
116_R	138_S	3.984	1.00
147_A	243_K	3.379	1.00
154_A	237_G	3.327	1.00
92_Q	146_D	3.313	1.00
81_P	98_H	3.133	1.00
136_V	153_L	2.998	1.00
238_A	295_L	2.937	1.00
231_F	290_E	2.912	1.00
128_S	131_R	2.732	1.00
235_R	239_D	2.632	1.00
96_R	150_E	2.526	1.00
94_V	109_M	2.438	1.00
237_G	241_A	2.394	1.00
254_K	289_D	2.329	1.00
26_L	30_T	2.312	1.00
247_I	292_I	2.296	1.00
104_A	240_L	2.234	1.00
148_A	248_H	2.191	1.00
251_R	292_I	2.155	1.00
76_V	113_G	2.147	1.00
53_V	57_V	2.116	1.00
26_L	29_V	2.113	1.00
164_D	232_H	2.063	1.00
145_D	248_H	1.987	1.00
290_E	293_R	1.979	1.00
254_K	288_L	1.965	1.00
97_V	112_V	1.963	1.00
145_D	252_T	1.950	1.00
77_R	116_R	1.862	1.00
98_H	102_R	1.852	1.00
191_S	194_V	1.802	1.00
287_D	290_E	1.766	1.00
143_Q	256_Y	1.751	1.00
57_V	61_T	1.740	1.00
78_V	111_E	1.735	1.00
98_H	109_M	1.718	1.00
68_W	72_T	1.642	1.00
91_Q	94_V	1.616	1.00
123_F	135_A	1.558	1.00
138_S	142_E	1.556	1.00
80_N	89_E	1.532	1.00
164_D	229_R	1.523	1.00
24_S	27_S	1.522	1.00
96_R	146_D	1.516	1.00
151_G	246_M	1.511	1.00
184_R	188_W	1.508	1.00
144_M	253_L	1.508	1.00
235_R	294_R	1.478	1.00
140_L	149_V	1.463	1.00
95_D	99_R	1.460	1.00
185_I	188_W	1.443	1.00
219_S	223_F	1.441	1.00
78_V	113_G	1.440	1.00
51_S	180_V	1.424	1.00
25_V	28_S	1.417	1.00
113_G	133_L	1.409	1.00
195_K	198_L	1.390	1.00
183_S	186_A	1.358	1.00
118_P	142_E	1.354	1.00
163_G	166_V	1.353	1.00
280_S	290_E	1.352	1.00
132_S	160_I	1.351	1.00
22_V	26_L	1.351	1.00
94_V	98_H	1.346	1.00
90_E	114_I	1.336	1.00
25_V	30_T	1.331	1.00
92_Q	95_D	1.324	1.00
247_I	296_E	1.320	1.00
159_H	230_E	1.318	1.00
95_D	98_H	1.306	1.00
100_L	157_V	1.305	1.00
124_A	134_V	1.299	1.00
162_N	232_H	1.289	1.00
141_L	149_V	1.286	1.00
155_H	230_E	1.277	1.00
168_M	229_R	1.263	1.00
162_N	236_G	1.245	1.00
27_S	30_T	1.236	1.00
24_S	28_S	1.221	1.00
187_A	190_A	1.213	1.00
156_E	230_E	1.209	1.00
203_H	206_A	1.181	1.00
66_S	71_K	1.177	1.00
283_S	287_D	1.177	1.00
61_T	65_I	1.166	1.00
147_A	248_H	1.152	1.00
24_S	30_T	1.145	1.00
100_L	240_L	1.143	1.00
228_H	232_H	1.138	1.00
155_H	159_H	1.130	1.00
56_F	173_G	1.129	1.00
77_R	89_E	1.122	1.00
91_Q	95_D	1.117	1.00
65_I	69_M	1.116	1.00
147_A	245_K	1.115	1.00
231_F	294_R	1.112	1.00
181_F	184_R	1.109	1.00
232_H	236_G	1.101	1.00
246_M	295_L	1.096	1.00
118_P	138_S	1.095	1.00
194_V	198_L	1.095	1.00
293_R	296_E	1.082	1.00
181_F	185_I	1.076	1.00
152_V	249_A	1.073	1.00
95_D	146_D	1.065	1.00
207_M	211_Q	1.058	1.00
201_I	204_F	1.045	1.00
186_A	189_I	1.039	1.00
289_D	293_R	1.037	1.00
229_R	232_H	1.037	1.00
35_Y	38_A	1.028	1.00
245_K	296_E	1.023	1.00
106_L	157_V	1.021	1.00
71_K	123_F	1.015	1.00
253_L	274_N	1.004	1.00
199_A	202_V	1.000	1.00
221_V	225_Y	0.993	1.00
59_S	62_S	0.991	1.00
150_E	243_K	0.976	1.00
90_E	94_V	0.975	1.00
90_E	93_L	0.968	1.00
210_F	213_V	0.967	1.00
248_H	252_T	0.961	1.00
204_F	207_M	0.959	1.00
127_P	131_R	0.958	1.00
93_L	136_V	0.952	1.00
145_D	148_A	0.952	1.00
290_E	294_R	0.948	1.00
140_L	144_M	0.945	1.00
39_D	44_P	0.945	1.00
232_H	235_R	0.943	1.00
180_V	183_S	0.940	1.00
223_F	284_T	0.938	1.00
48_L	52_L	0.935	1.00
167_T	232_H	0.930	1.00
136_V	140_L	0.929	1.00
242_G	245_K	0.928	1.00
22_V	28_S	0.925	1.00
254_K	258_S	0.922	1.00
185_I	189_I	0.914	1.00
195_K	199_A	0.914	1.00
226_S	284_T	0.908	1.00
25_V	29_V	0.902	0.99
230_E	233_A	0.898	0.99
196_E	200_P	0.894	0.99
114_I	141_L	0.890	0.99
288_L	292_I	0.887	0.99
101_S	108_K	0.887	0.99
156_E	159_H	0.883	0.99
165_M	169_T	0.880	0.99
120_V	256_Y	0.879	0.99
167_T	229_R	0.879	0.99
35_Y	39_D	0.877	0.99
179_V	182_L	0.875	0.99
260_I	263_D	0.875	0.99
60_F	64_A	0.874	0.99
179_V	183_S	0.873	0.99
194_V	197_D	0.872	0.99
99_R	103_S	0.866	0.99
128_S	132_S	0.861	0.99
34_T	39_D	0.857	0.99
24_S	29_V	0.855	0.99
144_M	252_T	0.850	0.99
29_V	34_T	0.849	0.99
103_S	242_G	0.845	0.99
89_E	94_V	0.843	0.99
136_V	141_L	0.841	0.99
58_G	62_S	0.841	0.99
184_R	187_A	0.840	0.99
238_A	243_K	0.839	0.99
47_L	51_S	0.837	0.99
31_G	35_Y	0.836	0.99
224_A	227_R	0.833	0.99
202_V	206_A	0.830	0.99
155_H	233_A	0.826	0.99
246_M	250_L	0.823	0.99
37_T	41_G	0.823	0.99
101_S	109_M	0.821	0.99
74_M	115_Y	0.821	0.99
175_V	222_V	0.820	0.99
179_V	184_R	0.815	0.99
186_A	190_A	0.813	0.99
64_A	127_P	0.808	0.99
192_R	195_K	0.803	0.99
175_V	218_G	0.794	0.99
22_V	25_V	0.794	0.99
79_L	114_I	0.790	0.99
32_V	36_F	0.790	0.99
99_R	102_R	0.789	0.99
106_L	161_T	0.785	0.99
115_Y	135_A	0.780	0.98
27_S	32_V	0.779	0.98
120_V	143_Q	0.771	0.98
261_L	264_D	0.770	0.98
100_L	153_L	0.769	0.98
101_S	157_V	0.758	0.98
33_G	36_F	0.757	0.98
70_A	74_M	0.754	0.98
66_S	123_F	0.754	0.98
251_R	254_K	0.752	0.98
38_A	42_I	0.752	0.98
237_G	246_M	0.745	0.98
26_L	31_G	0.744	0.98
161_T	236_G	0.740	0.98
97_V	153_L	0.739	0.98
158_A	240_L	0.739	0.98
146_D	150_E	0.734	0.98
30_T	34_T	0.731	0.98
286_P	291_R	0.728	0.98
201_I	205_I	0.727	0.98
29_V	32_V	0.727	0.98
27_S	31_G	0.727	0.98
81_P	95_D	0.726	0.98
182_L	186_A	0.724	0.98
75_G	116_R	0.721	0.97
183_S	189_I	0.718	0.97
43_D	46_A	0.715	0.97
44_P	47_L	0.715	0.97
170_L	174_I	0.714	0.97
166_V	170_L	0.714	0.97
65_I	68_W	0.708	0.97
67_R	111_E	0.707	0.97
171_L	222_V	0.704	0.97
230_E	285_H	0.702	0.97
256_Y	259_R	0.699	0.97
28_S	33_G	0.699	0.97
23_L	26_L	0.698	0.97
79_L	93_L	0.698	0.97
253_L	257_S	0.697	0.97
46_A	50_F	0.695	0.97
252_T	255_S	0.695	0.97
213_V	217_L	0.694	0.97
52_L	59_S	0.690	0.97
41_G	45_M	0.687	0.97
115_Y	137_S	0.684	0.97
96_R	99_R	0.683	0.97
280_S	283_S	0.682	0.96
247_I	251_R	0.672	0.96
245_K	248_H	0.672	0.96
210_F	214_F	0.668	0.96
55_G	59_S	0.668	0.96
238_A	242_G	0.667	0.96
279_S	283_S	0.667	0.96
40_G	45_M	0.662	0.96
292_I	296_E	0.660	0.96
134_V	153_L	0.658	0.96
121_N	124_A	0.656	0.96
111_E	133_L	0.656	0.96
29_V	33_G	0.655	0.96
52_L	56_F	0.652	0.95
93_L	112_V	0.651	0.95
26_L	34_T	0.649	0.95
125_T	133_L	0.649	0.95
196_E	199_A	0.649	0.95
125_T	165_M	0.647	0.95
52_L	181_F	0.644	0.95
36_F	39_D	0.643	0.95
124_A	135_A	0.642	0.95
49_V	181_F	0.639	0.95
171_L	225_Y	0.639	0.95
197_D	200_P	0.639	0.95
251_R	255_S	0.638	0.95
38_A	41_G	0.638	0.95
180_V	184_R	0.635	0.95
46_A	49_V	0.631	0.95
188_W	191_S	0.629	0.95
157_V	160_I	0.627	0.94
77_R	138_S	0.626	0.94
53_V	56_F	0.625	0.94
33_G	39_D	0.621	0.94
168_M	226_S	0.621	0.94
43_D	47_L	0.619	0.94
125_T	135_A	0.617	0.94
49_V	52_L	0.617	0.94
23_L	27_S	0.617	0.94
191_S	195_K	0.616	0.94
121_N	155_H	0.615	0.94
183_S	187_A	0.614	0.94
154_A	240_L	0.614	0.94
162_N	229_R	0.613	0.94
33_G	37_T	0.612	0.94
215_S	218_G	0.611	0.94
115_Y	119_E	0.611	0.94
159_H	233_A	0.610	0.94
218_G	221_V	0.610	0.94
159_H	285_H	0.604	0.93
216_I	219_S	0.603	0.93
168_M	171_L	0.603	0.93
97_V	150_E	0.601	0.93
220_L	282_F	0.599	0.93
231_F	287_D	0.598	0.93
59_S	63_L	0.593	0.93
39_D	42_I	0.592	0.93
45_M	49_V	0.592	0.93
194_V	199_A	0.592	0.93
151_G	247_I	0.592	0.93
55_G	58_G	0.591	0.93
49_V	53_V	0.591	0.93
25_V	32_V	0.589	0.92
144_M	249_A	0.588	0.92
104_A	157_V	0.587	0.92
96_R	100_L	0.583	0.92
31_G	34_T	0.579	0.92
102_R	105_G	0.576	0.92
71_K	125_T	0.574	0.91
32_V	37_T	0.572	0.91
212_I	216_I	0.570	0.91
124_A	132_S	0.570	0.91
110_P	164_D	0.567	0.91
34_T	37_T	0.567	0.91
250_L	288_L	0.567	0.91
120_V	139_G	0.565	0.91
244_D	248_H	0.565	0.91
200_P	203_H	0.565	0.91
93_L	141_L	0.560	0.90
236_G	239_D	0.560	0.90
241_A	244_D	0.558	0.90
101_S	105_G	0.555	0.90
43_D	50_F	0.555	0.90
279_S	290_E	0.555	0.90
124_A	160_I	0.554	0.90
204_F	208_I	0.554	0.90
144_M	149_V	0.554	0.90
103_S	239_D	0.552	0.90
254_K	292_I	0.552	0.90
161_T	239_D	0.551	0.90
47_L	50_F	0.551	0.90
110_P	229_R	0.551	0.90
27_S	33_G	0.548	0.89
82_K	91_Q	0.548	0.89
81_P	94_V	0.548	0.89
101_S	106_L	0.548	0.89
100_L	103_S	0.548	0.89
70_A	73_M	0.547	0.89
63_L	66_S	0.547	0.89
255_S	259_R	0.547	0.89
187_A	191_S	0.546	0.89
28_S	31_G	0.546	0.89
34_T	38_A	0.546	0.89
42_I	45_M	0.545	0.89
193_F	198_L	0.544	0.89
260_I	264_D	0.544	0.89
212_I	215_S	0.540	0.89
274_N	288_L	0.540	0.89
183_S	207_M	0.540	0.89
211_Q	214_F	0.538	0.89
29_V	39_D	0.538	0.89
67_R	71_K	0.536	0.88
124_A	137_S	0.535	0.88
79_L	115_Y	0.534	0.88
117_S	138_S	0.534	0.88
208_I	212_I	0.531	0.88
31_G	38_A	0.530	0.88
23_L	33_G	0.529	0.88
184_R	190_A	0.528	0.88
224_A	228_H	0.528	0.88
253_L	288_L	0.527	0.88
213_V	216_I	0.527	0.88
277_K	280_S	0.526	0.87
119_E	257_S	0.525	0.87
144_M	152_V	0.524	0.87
39_D	43_D	0.524	0.87
248_H	251_R	0.524	0.87
71_K	76_V	0.522	0.87
79_L	133_L	0.522	0.87
283_S	288_L	0.521	0.87
285_H	291_R	0.520	0.87
71_K	79_L	0.520	0.87
56_F	60_F	0.516	0.86
160_I	163_G	0.514	0.86
223_F	283_S	0.511	0.86
136_V	160_I	0.508	0.86
188_W	192_R	0.507	0.86
51_S	55_G	0.505	0.85
151_G	250_L	0.504	0.85
71_K	133_L	0.504	0.85
114_I	138_S	0.503	0.85
52_L	177_T	0.503	0.85
156_E	285_H	0.503	0.85
41_G	46_A	0.502	0.85
35_Y	42_I	0.501	0.85
100_L	150_E	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4il3A	1	0.9295	100	0.29	Contact Map
4aw6A	2	0.9262	100	0.296	Contact Map
3c37A	1	0.6242	100	0.466	Contact Map
3cqbA	4	0.3557	99.8	0.627	Contact Map
4qhjA	2	0.3423	96.9	0.871	Contact Map
4jixA	2	0.3624	95.7	0.885	Contact Map
3dteA	2	0.4899	95.4	0.887	Contact Map
4jiuA	1	0.3389	95.2	0.889	Contact Map
4o66A	2	0.2181	33.2	0.94	Contact Map
2pnvA	5	0.0906	13.9	0.95	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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