GREMLIN Database
RSGI - Anti-sigma-I factor RsgI
UniProt: O31655 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 381 (340)
Sequences: 280 (261)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_P120_G4.2701.00
116_L212_S4.0631.00
130_W138_V4.0241.00
110_V138_V3.9841.00
91_Y203_R3.9391.00
95_D99_S3.4210.99
15_T92_M3.4050.99
98_P119_E3.3780.99
199_D202_T3.3050.99
97_N119_E3.1600.98
96_I146_C3.0750.98
100_V142_I2.9250.97
17_L21_G2.8880.97
98_P151_Y2.8480.96
98_P117_N2.8370.96
93_T213_T2.6320.94
10_N92_M2.5440.93
91_Y101_E2.5030.93
99_S117_N2.4710.92
98_P120_G2.3070.89
18_T90_A2.2820.89
198_S213_T2.2680.88
89_Y94_I2.2330.88
100_V120_G2.2250.87
113_L138_V2.1920.87
14_V214_G2.1880.86
90_A106_S2.0760.83
89_Y146_C2.0740.83
288_D318_D2.0690.83
93_T214_G2.0570.83
8_E15_T2.0300.82
17_L199_D2.0100.81
83_F105_N2.0010.81
14_V33_Y2.0000.81
102_M142_I1.9840.80
9_K26_A1.9810.80
13_F25_K1.9730.80
39_I73_M1.9490.79
163_V198_S1.9220.78
113_L130_W1.9150.78
18_T24_L1.9030.77
161_S196_L1.8610.76
16_L26_A1.8130.74
91_Y213_T1.7800.72
217_I220_N1.7740.72
93_T161_S1.7680.72
162_T214_G1.7250.70
4_G15_T1.7120.69
9_K214_G1.7060.69
101_E203_R1.7000.69
14_V213_T1.6960.69
219_S230_D1.6960.69
158_I298_E1.6840.68
19_P38_E1.6770.68
211_V214_G1.6530.66
96_I119_E1.6350.66
21_G120_G1.6320.65
184_T191_Y1.6210.65
119_E172_Y1.6050.64
38_E91_Y1.5840.63
203_R213_T1.5810.63
93_T212_S1.5740.63
101_E213_T1.5650.62
195_S216_Y1.5620.62
4_G90_A1.5530.61
95_D212_S1.5500.61
238_E241_Q1.5360.61
99_S212_S1.5300.60
95_D117_N1.5120.59
76_I114_T1.4970.59
348_S352_D1.4750.57
163_V213_T1.4650.57
108_Y138_V1.4570.56
102_M138_V1.4420.56
4_G38_E1.4360.55
66_I70_T1.4110.54
4_G18_T1.4050.54
118_D161_S1.3830.52
67_F72_I1.3810.52
99_S214_G1.3590.51
97_N117_N1.3570.51
114_T161_S1.3560.51
123_V126_D1.3510.51
72_I265_E1.3370.50
4_G219_S1.3340.50
332_Q349_S1.3220.49
91_Y162_T1.3190.49
18_T38_E1.3090.48
210_G213_T1.3080.48
7_V28_N1.3080.48
21_G35_I1.3050.48
4_G36_G1.2990.48
161_S194_E1.2920.47
101_E161_S1.2870.47
159_L212_S1.2860.47
93_T116_L1.2860.47
120_G213_T1.2790.47
103_A161_S1.2720.46
105_N111_I1.2680.46
21_G36_G1.2630.46
5_I21_G1.2520.45
23_F38_E1.2490.45
161_S218_K1.2450.45
6_I14_V1.2400.45
6_I37_E1.2380.44
264_N321_N1.2360.44
17_L74_L1.2240.44
75_F158_I1.2220.44
335_R346_R1.2200.44
111_I175_A1.2150.43
8_E28_N1.2110.43
172_Y193_M1.2090.43
18_T22_Q1.1970.42
41_L132_K1.1960.42
101_E162_T1.1920.42
26_A81_P1.1920.42
146_C213_T1.1920.42
310_Q329_G1.1920.42
118_D148_E1.1810.41
317_Q328_K1.1800.41
4_G41_L1.1770.41
117_N120_G1.1720.41
293_I297_D1.1720.41
215_S222_K1.1670.41
9_K14_V1.1630.40
26_A33_Y1.1570.40
246_N265_E1.1550.40
90_A203_R1.1500.40
337_W351_R1.1420.39
217_I222_K1.1340.39
10_N35_I1.1310.39
315_D325_G1.1310.39
139_I150_G1.1220.38
143_I146_C1.1180.38
166_N186_K1.1120.38
104_L151_Y1.1110.38
325_G338_N1.1090.38
71_A74_L1.0990.37
91_Y103_A1.0940.37
90_A104_L1.0940.37
351_R354_A1.0890.37
24_L41_L1.0870.37
41_L177_K1.0840.36
90_A93_T1.0770.36
34_E203_R1.0700.36
88_A103_A1.0580.35
15_T63_K1.0540.35
15_T80_L1.0520.35
113_L297_D1.0470.35
332_Q353_N1.0460.35
5_I15_T1.0450.34
345_N348_S1.0430.34
68_T71_A1.0380.34
120_G179_Q1.0340.34
340_G354_A1.0300.34
159_L217_I1.0270.34
8_E35_I1.0270.34
317_Q324_N1.0240.33
121_Q137_K1.0240.33
156_K236_S1.0230.33
281_D301_N1.0200.33
158_I176_V1.0200.33
199_D220_N1.0120.33
341_E348_S1.0060.33
4_G142_I1.0050.33
105_N109_E1.0010.32
151_Y240_D0.9900.32
101_E160_I0.9900.32
24_L67_F0.9900.32
4_G101_E0.9870.32
90_A102_M0.9830.31
33_Y213_T0.9790.31
15_T19_P0.9690.31
85_N90_A0.9680.31
321_N330_Q0.9680.31
321_N341_E0.9660.31
202_T217_I0.9650.31
278_E284_I0.9620.30
91_Y210_G0.9600.30
301_N310_Q0.9580.30
14_V93_T0.9550.30
14_V198_S0.9520.30
89_Y160_I0.9490.30
105_N212_S0.9460.30
312_P329_G0.9420.30
202_T220_N0.9400.29
4_G108_Y0.9370.29
7_V200_M0.9340.29
5_I265_E0.9300.29
33_Y214_G0.9300.29
202_T216_Y0.9250.29
165_E214_G0.9220.29
110_V124_V0.9210.29
16_L92_M0.9210.29
102_M110_V0.9200.29
116_L234_K0.9180.28
326_A330_Q0.9150.28
33_Y210_G0.9150.28
94_I132_K0.9140.28
204_E208_K0.9110.28
66_I72_I0.9090.28
176_V232_S0.9050.28
88_A105_N0.9040.28
6_I16_L0.9020.28
342_Q346_R0.8960.28
77_F100_V0.8880.27
18_T41_L0.8840.27
78_I120_G0.8830.27
347_S350_R0.8810.27
17_L33_Y0.8780.27
79_V118_D0.8730.27
332_Q338_N0.8730.27
94_I162_T0.8730.27
146_C218_K0.8710.26
270_A284_I0.8700.26
102_M213_T0.8700.26
109_E134_D0.8690.26
163_V218_K0.8670.26
86_N89_Y0.8650.26
39_I152_V0.8640.26
163_V217_I0.8630.26
68_T345_N0.8620.26
282_D287_S0.8600.26
81_P147_S0.8520.26
150_G195_S0.8510.26
196_L214_G0.8510.26
112_E123_V0.8500.26
277_E302_T0.8490.26
329_G335_R0.8490.26
287_S302_T0.8430.25
344_K348_S0.8420.25
18_T91_Y0.8420.25
334_H350_R0.8420.25
347_S354_A0.8410.25
92_M113_L0.8390.25
196_L212_S0.8380.25
126_D183_V0.8360.25
148_E178_K0.8330.25
160_I176_V0.8300.25
333_Y340_G0.8290.25
265_E293_I0.8270.25
65_G112_E0.8270.25
136_K213_T0.8210.24
6_I20_D0.8200.24
163_V194_E0.8200.24
90_A142_I0.8180.24
16_L93_T0.8160.24
39_I87_K0.8140.24
19_P33_Y0.8130.24
92_M135_F0.8110.24
215_S230_D0.8060.24
147_S191_Y0.8060.24
138_V157_E0.8060.24
100_V271_D0.8050.24
26_A43_S0.8030.24
337_W347_S0.8030.24
191_Y214_G0.8000.24
28_N218_K0.7980.23
10_N191_Y0.7960.23
16_L188_K0.7960.23
110_V222_K0.7950.23
66_I143_I0.7950.23
263_D319_K0.7920.23
23_F36_G0.7880.23
176_V297_D0.7860.23
21_G33_Y0.7830.23
18_T88_A0.7790.23
258_D261_Q0.7760.23
17_L71_A0.7740.23
23_F138_V0.7740.23
5_I8_E0.7730.22
267_L279_K0.7690.22
80_L152_V0.7670.22
103_A164_Y0.7670.22
19_P213_T0.7670.22
135_F235_P0.7660.22
6_I36_G0.7660.22
216_Y219_S0.7630.22
92_M111_I0.7630.22
275_Q282_D0.7620.22
42_P109_E0.7610.22
150_G215_S0.7510.22
283_Q299_N0.7510.22
290_D310_Q0.7480.22
71_A89_Y0.7470.22
127_I133_T0.7470.22
92_M162_T0.7450.21
226_K242_K0.7430.21
160_I214_G0.7420.21
339_N344_K0.7420.21
268_N294_K0.7420.21
89_Y234_K0.7410.21
265_E288_D0.7410.21
26_A42_P0.7380.21
3_R102_M0.7360.21
79_V108_Y0.7350.21
120_G307_D0.7340.21
284_I289_K0.7330.21
120_G210_G0.7320.21
322_E335_R0.7310.21
10_N156_K0.7300.21
96_I99_S0.7300.21
280_A295_E0.7280.21
29_D214_G0.7270.21
303_E307_D0.7250.21
251_T263_D0.7250.21
41_L138_V0.7240.21
6_I249_E0.7240.21
17_L213_T0.7240.21
198_S217_I0.7210.21
14_V29_D0.7180.20
282_D289_K0.7170.20
201_Q302_T0.7130.20
271_D275_Q0.7120.20
290_D297_D0.7110.20
150_G160_I0.7080.20
6_I161_S0.7080.20
330_Q346_R0.7070.20
329_G341_E0.7070.20
5_I130_W0.7070.20
73_M104_L0.7040.20
331_S341_E0.7030.20
267_L293_I0.7010.20
91_Y160_I0.6990.20
320_G350_R0.6970.20
327_D351_R0.6940.20
227_D232_S0.6930.20
41_L130_W0.6920.20
23_F163_V0.6920.20
146_C215_S0.6920.20
61_P176_V0.6910.20
279_K321_N0.6910.20
116_L180_L0.6880.19
91_Y165_E0.6820.19
286_D290_D0.6810.19
103_A139_I0.6790.19
10_N15_T0.6790.19
34_E37_E0.6770.19
339_N347_S0.6740.19
100_V152_V0.6730.19
105_N219_S0.6730.19
279_K289_K0.6720.19
328_K332_Q0.6710.19
336_D347_S0.6690.19
15_T212_S0.6670.19
104_L146_C0.6670.19
105_N108_Y0.6660.19
7_V143_I0.6650.19
326_A345_N0.6630.19
23_F110_V0.6630.19
87_K218_K0.6620.19
199_D212_S0.6610.19
37_E159_L0.6560.18
137_K158_I0.6550.18
26_A164_Y0.6550.18
312_P317_Q0.6520.18
151_Y172_Y0.6510.18
61_P163_V0.6500.18
329_G354_A0.6490.18
346_R351_R0.6480.18
14_V19_P0.6470.18
15_T218_K0.6450.18
314_Q321_N0.6450.18
40_M135_F0.6440.18
30_R231_D0.6430.18
162_T184_T0.6420.18
252_D265_E0.6420.18
206_A216_Y0.6420.18
249_E283_Q0.6410.18
234_K243_S0.6390.18
280_A303_E0.6390.18
94_I108_Y0.6370.18
334_H347_S0.6360.18
300_T341_E0.6360.18
305_D315_D0.6340.18
98_P115_P0.6330.18
74_L257_Q0.6310.18
130_W157_E0.6300.18
98_P214_G0.6300.18
303_E329_G0.6300.18
264_N276_K0.6290.17
320_G338_N0.6270.17
331_S334_H0.6270.17
119_E151_Y0.6250.17
259_S341_E0.6250.17
187_Y208_K0.6230.17
264_N271_D0.6230.17
98_P116_L0.6220.17
330_Q337_W0.6220.17
225_N230_D0.6220.17
253_Q293_I0.6210.17
283_Q286_D0.6200.17
18_T104_L0.6170.17
35_I260_K0.6150.17
105_N154_K0.6090.17
248_D261_Q0.6090.17
300_T324_N0.6080.17
19_P113_L0.6070.17
23_F116_L0.6060.17
15_T33_Y0.6050.17
71_A288_D0.6050.17
214_G218_K0.6040.17
19_P22_Q0.6040.17
74_L244_D0.6030.17
151_Y214_G0.6010.17
94_I210_G0.6000.17
41_L164_Y0.5990.17
16_L218_K0.5990.17
26_A40_M0.5980.17
25_K28_N0.5980.17
64_M143_I0.5960.16
121_Q201_Q0.5960.16
161_S213_T0.5950.16
82_V180_L0.5950.16
321_N342_Q0.5940.16
37_E105_N0.5940.16
18_T150_G0.5930.16
132_K165_E0.5930.16
344_K352_D0.5900.16
110_V309_E0.5890.16
94_I150_G0.5880.16
142_I210_G0.5850.16
7_V79_V0.5830.16
71_A162_T0.5820.16
33_Y37_E0.5800.16
130_W139_I0.5790.16
67_F234_K0.5780.16
346_R352_D0.5760.16
35_I349_S0.5760.16
130_W158_I0.5750.16
346_R350_R0.5750.16
104_L158_I0.5750.16
289_K341_E0.5750.16
315_D318_D0.5740.16
135_F139_I0.5740.16
295_E338_N0.5710.16
227_D266_Q0.5690.16
338_N354_A0.5670.16
14_V37_E0.5660.16
334_H339_N0.5660.16
282_D288_D0.5640.16
317_Q343_G0.5630.16
345_N354_A0.5620.15
272_S275_Q0.5620.15
78_I94_I0.5600.15
8_E117_N0.5600.15
28_N162_T0.5580.15
162_T216_Y0.5570.15
218_K241_Q0.5570.15
6_I127_I0.5560.15
161_S164_Y0.5560.15
97_N214_G0.5540.15
165_E213_T0.5530.15
120_G151_Y0.5520.15
215_S238_E0.5510.15
199_D205_K0.5510.15
148_E239_E0.5490.15
113_L323_N0.5490.15
222_K233_S0.5490.15
299_N307_D0.5480.15
269_D308_H0.5480.15
27_K146_C0.5470.15
25_K44_E0.5460.15
294_K336_D0.5460.15
311_T314_Q0.5460.15
88_A216_Y0.5450.15
5_I74_L0.5450.15
322_E337_W0.5440.15
247_E256_T0.5440.15
229_K232_S0.5430.15
45_T197_E0.5380.15
297_D300_T0.5380.15
253_Q275_Q0.5360.15
4_G83_F0.5350.15
115_P203_R0.5340.15
213_T218_K0.5340.15
95_D98_P0.5300.15
339_N343_G0.5300.15
10_N26_A0.5300.15
147_S189_T0.5290.15
24_L92_M0.5270.15
228_I232_S0.5270.15
75_F78_I0.5260.14
3_R7_V0.5250.14
108_Y130_W0.5220.14
66_I246_N0.5220.14
325_G334_H0.5210.14
145_D148_E0.5180.14
133_T182_D0.5170.14
10_N13_F0.5170.14
73_M212_S0.5170.14
20_D65_G0.5150.14
134_D137_K0.5140.14
287_S305_D0.5110.14
69_M74_L0.5100.14
33_Y132_K0.5100.14
342_Q349_S0.5090.14
89_Y148_E0.5090.14
113_L124_V0.5070.14
93_T194_E0.5070.14
249_E304_K0.5060.14
134_D282_D0.5040.14
319_K323_N0.5040.14
70_T315_D0.5040.14
21_G37_E0.5040.14
8_E23_F0.5040.14
130_W199_D0.5030.14
86_N142_I0.5010.14
265_E268_N0.5010.14
347_S352_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rcnA 2 0.5801 84.2 0.941 Contact Map
1ah9A 1 0.1522 65 0.95 Contact Map
4p02B 1 0.2073 64.4 0.95 Contact Map
1hr0W 1 0.1496 62.7 0.95 Contact Map
4ql5A 4 0.1522 58.5 0.951 Contact Map
2ztdA 4 0.4567 54.2 0.953 Contact Map
1t9hA 1 0.5801 47.9 0.954 Contact Map
3i4oA 1 0.1522 35.5 0.958 Contact Map
1u0lA 1 0.5722 34.3 0.958 Contact Map
1wkaA 1 0.3071 31.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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