RSGI - BACSU - GREMLIN Contacts

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RSGI - Anti-sigma-I factor RsgI

UniProt:	O31655	Sequences: MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSETRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEMALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILISTVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIKSNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQKEEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYHRDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	381 (340)
Sequences:	280 (261)
Seq/√Len:	14.2

BACSU - RSGI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
115_P	120_G	4.270	1.00
116_L	212_S	4.063	1.00
130_W	138_V	4.024	1.00
110_V	138_V	3.984	1.00
91_Y	203_R	3.939	1.00
95_D	99_S	3.421	0.99
15_T	92_M	3.405	0.99
98_P	119_E	3.378	0.99
199_D	202_T	3.305	0.99
97_N	119_E	3.160	0.98
96_I	146_C	3.075	0.98
100_V	142_I	2.925	0.97
17_L	21_G	2.888	0.97
98_P	151_Y	2.848	0.96
98_P	117_N	2.837	0.96
93_T	213_T	2.632	0.94
10_N	92_M	2.544	0.93
91_Y	101_E	2.503	0.93
99_S	117_N	2.471	0.92
98_P	120_G	2.307	0.89
18_T	90_A	2.282	0.89
198_S	213_T	2.268	0.88
89_Y	94_I	2.233	0.88
100_V	120_G	2.225	0.87
113_L	138_V	2.192	0.87
14_V	214_G	2.188	0.86
90_A	106_S	2.076	0.83
89_Y	146_C	2.074	0.83
288_D	318_D	2.069	0.83
93_T	214_G	2.057	0.83
8_E	15_T	2.030	0.82
17_L	199_D	2.010	0.81
83_F	105_N	2.001	0.81
14_V	33_Y	2.000	0.81
102_M	142_I	1.984	0.80
9_K	26_A	1.981	0.80
13_F	25_K	1.973	0.80
39_I	73_M	1.949	0.79
163_V	198_S	1.922	0.78
113_L	130_W	1.915	0.78
18_T	24_L	1.903	0.77
161_S	196_L	1.861	0.76
16_L	26_A	1.813	0.74
91_Y	213_T	1.780	0.72
217_I	220_N	1.774	0.72
93_T	161_S	1.768	0.72
162_T	214_G	1.725	0.70
4_G	15_T	1.712	0.69
9_K	214_G	1.706	0.69
101_E	203_R	1.700	0.69
14_V	213_T	1.696	0.69
219_S	230_D	1.696	0.69
158_I	298_E	1.684	0.68
19_P	38_E	1.677	0.68
211_V	214_G	1.653	0.66
96_I	119_E	1.635	0.66
21_G	120_G	1.632	0.65
184_T	191_Y	1.621	0.65
119_E	172_Y	1.605	0.64
38_E	91_Y	1.584	0.63
203_R	213_T	1.581	0.63
93_T	212_S	1.574	0.63
101_E	213_T	1.565	0.62
195_S	216_Y	1.562	0.62
4_G	90_A	1.553	0.61
95_D	212_S	1.550	0.61
238_E	241_Q	1.536	0.61
99_S	212_S	1.530	0.60
95_D	117_N	1.512	0.59
76_I	114_T	1.497	0.59
348_S	352_D	1.475	0.57
163_V	213_T	1.465	0.57
108_Y	138_V	1.457	0.56
102_M	138_V	1.442	0.56
4_G	38_E	1.436	0.55
66_I	70_T	1.411	0.54
4_G	18_T	1.405	0.54
118_D	161_S	1.383	0.52
67_F	72_I	1.381	0.52
99_S	214_G	1.359	0.51
97_N	117_N	1.357	0.51
114_T	161_S	1.356	0.51
123_V	126_D	1.351	0.51
72_I	265_E	1.337	0.50
4_G	219_S	1.334	0.50
332_Q	349_S	1.322	0.49
91_Y	162_T	1.319	0.49
18_T	38_E	1.309	0.48
210_G	213_T	1.308	0.48
7_V	28_N	1.308	0.48
21_G	35_I	1.305	0.48
4_G	36_G	1.299	0.48
161_S	194_E	1.292	0.47
101_E	161_S	1.287	0.47
159_L	212_S	1.286	0.47
93_T	116_L	1.286	0.47
120_G	213_T	1.279	0.47
103_A	161_S	1.272	0.46
105_N	111_I	1.268	0.46
21_G	36_G	1.263	0.46
5_I	21_G	1.252	0.45
23_F	38_E	1.249	0.45
161_S	218_K	1.245	0.45
6_I	14_V	1.240	0.45
6_I	37_E	1.238	0.44
264_N	321_N	1.236	0.44
17_L	74_L	1.224	0.44
75_F	158_I	1.222	0.44
335_R	346_R	1.220	0.44
111_I	175_A	1.215	0.43
8_E	28_N	1.211	0.43
172_Y	193_M	1.209	0.43
18_T	22_Q	1.197	0.42
41_L	132_K	1.196	0.42
101_E	162_T	1.192	0.42
26_A	81_P	1.192	0.42
146_C	213_T	1.192	0.42
310_Q	329_G	1.192	0.42
118_D	148_E	1.181	0.41
317_Q	328_K	1.180	0.41
4_G	41_L	1.177	0.41
117_N	120_G	1.172	0.41
293_I	297_D	1.172	0.41
215_S	222_K	1.167	0.41
9_K	14_V	1.163	0.40
26_A	33_Y	1.157	0.40
246_N	265_E	1.155	0.40
90_A	203_R	1.150	0.40
337_W	351_R	1.142	0.39
217_I	222_K	1.134	0.39
10_N	35_I	1.131	0.39
315_D	325_G	1.131	0.39
139_I	150_G	1.122	0.38
143_I	146_C	1.118	0.38
166_N	186_K	1.112	0.38
104_L	151_Y	1.111	0.38
325_G	338_N	1.109	0.38
71_A	74_L	1.099	0.37
91_Y	103_A	1.094	0.37
90_A	104_L	1.094	0.37
351_R	354_A	1.089	0.37
24_L	41_L	1.087	0.37
41_L	177_K	1.084	0.36
90_A	93_T	1.077	0.36
34_E	203_R	1.070	0.36
88_A	103_A	1.058	0.35
15_T	63_K	1.054	0.35
15_T	80_L	1.052	0.35
113_L	297_D	1.047	0.35
332_Q	353_N	1.046	0.35
5_I	15_T	1.045	0.34
345_N	348_S	1.043	0.34
68_T	71_A	1.038	0.34
120_G	179_Q	1.034	0.34
340_G	354_A	1.030	0.34
159_L	217_I	1.027	0.34
8_E	35_I	1.027	0.34
317_Q	324_N	1.024	0.33
121_Q	137_K	1.024	0.33
156_K	236_S	1.023	0.33
281_D	301_N	1.020	0.33
158_I	176_V	1.020	0.33
199_D	220_N	1.012	0.33
341_E	348_S	1.006	0.33
4_G	142_I	1.005	0.33
105_N	109_E	1.001	0.32
151_Y	240_D	0.990	0.32
101_E	160_I	0.990	0.32
24_L	67_F	0.990	0.32
4_G	101_E	0.987	0.32
90_A	102_M	0.983	0.31
33_Y	213_T	0.979	0.31
15_T	19_P	0.969	0.31
85_N	90_A	0.968	0.31
321_N	330_Q	0.968	0.31
321_N	341_E	0.966	0.31
202_T	217_I	0.965	0.31
278_E	284_I	0.962	0.30
91_Y	210_G	0.960	0.30
301_N	310_Q	0.958	0.30
14_V	93_T	0.955	0.30
14_V	198_S	0.952	0.30
89_Y	160_I	0.949	0.30
105_N	212_S	0.946	0.30
312_P	329_G	0.942	0.30
202_T	220_N	0.940	0.29
4_G	108_Y	0.937	0.29
7_V	200_M	0.934	0.29
5_I	265_E	0.930	0.29
33_Y	214_G	0.930	0.29
202_T	216_Y	0.925	0.29
165_E	214_G	0.922	0.29
110_V	124_V	0.921	0.29
16_L	92_M	0.921	0.29
102_M	110_V	0.920	0.29
116_L	234_K	0.918	0.28
326_A	330_Q	0.915	0.28
33_Y	210_G	0.915	0.28
94_I	132_K	0.914	0.28
204_E	208_K	0.911	0.28
66_I	72_I	0.909	0.28
176_V	232_S	0.905	0.28
88_A	105_N	0.904	0.28
6_I	16_L	0.902	0.28
342_Q	346_R	0.896	0.28
77_F	100_V	0.888	0.27
18_T	41_L	0.884	0.27
78_I	120_G	0.883	0.27
347_S	350_R	0.881	0.27
17_L	33_Y	0.878	0.27
79_V	118_D	0.873	0.27
332_Q	338_N	0.873	0.27
94_I	162_T	0.873	0.27
146_C	218_K	0.871	0.26
270_A	284_I	0.870	0.26
102_M	213_T	0.870	0.26
109_E	134_D	0.869	0.26
163_V	218_K	0.867	0.26
86_N	89_Y	0.865	0.26
39_I	152_V	0.864	0.26
163_V	217_I	0.863	0.26
68_T	345_N	0.862	0.26
282_D	287_S	0.860	0.26
81_P	147_S	0.852	0.26
150_G	195_S	0.851	0.26
196_L	214_G	0.851	0.26
112_E	123_V	0.850	0.26
277_E	302_T	0.849	0.26
329_G	335_R	0.849	0.26
287_S	302_T	0.843	0.25
344_K	348_S	0.842	0.25
18_T	91_Y	0.842	0.25
334_H	350_R	0.842	0.25
347_S	354_A	0.841	0.25
92_M	113_L	0.839	0.25
196_L	212_S	0.838	0.25
126_D	183_V	0.836	0.25
148_E	178_K	0.833	0.25
160_I	176_V	0.830	0.25
333_Y	340_G	0.829	0.25
265_E	293_I	0.827	0.25
65_G	112_E	0.827	0.25
136_K	213_T	0.821	0.24
6_I	20_D	0.820	0.24
163_V	194_E	0.820	0.24
90_A	142_I	0.818	0.24
16_L	93_T	0.816	0.24
39_I	87_K	0.814	0.24
19_P	33_Y	0.813	0.24
92_M	135_F	0.811	0.24
215_S	230_D	0.806	0.24
147_S	191_Y	0.806	0.24
138_V	157_E	0.806	0.24
100_V	271_D	0.805	0.24
26_A	43_S	0.803	0.24
337_W	347_S	0.803	0.24
191_Y	214_G	0.800	0.24
28_N	218_K	0.798	0.23
10_N	191_Y	0.796	0.23
16_L	188_K	0.796	0.23
110_V	222_K	0.795	0.23
66_I	143_I	0.795	0.23
263_D	319_K	0.792	0.23
23_F	36_G	0.788	0.23
176_V	297_D	0.786	0.23
21_G	33_Y	0.783	0.23
18_T	88_A	0.779	0.23
258_D	261_Q	0.776	0.23
17_L	71_A	0.774	0.23
23_F	138_V	0.774	0.23
5_I	8_E	0.773	0.22
267_L	279_K	0.769	0.22
80_L	152_V	0.767	0.22
103_A	164_Y	0.767	0.22
19_P	213_T	0.767	0.22
135_F	235_P	0.766	0.22
6_I	36_G	0.766	0.22
216_Y	219_S	0.763	0.22
92_M	111_I	0.763	0.22
275_Q	282_D	0.762	0.22
42_P	109_E	0.761	0.22
150_G	215_S	0.751	0.22
283_Q	299_N	0.751	0.22
290_D	310_Q	0.748	0.22
71_A	89_Y	0.747	0.22
127_I	133_T	0.747	0.22
92_M	162_T	0.745	0.21
226_K	242_K	0.743	0.21
160_I	214_G	0.742	0.21
339_N	344_K	0.742	0.21
268_N	294_K	0.742	0.21
89_Y	234_K	0.741	0.21
265_E	288_D	0.741	0.21
26_A	42_P	0.738	0.21
3_R	102_M	0.736	0.21
79_V	108_Y	0.735	0.21
120_G	307_D	0.734	0.21
284_I	289_K	0.733	0.21
120_G	210_G	0.732	0.21
322_E	335_R	0.731	0.21
10_N	156_K	0.730	0.21
96_I	99_S	0.730	0.21
280_A	295_E	0.728	0.21
29_D	214_G	0.727	0.21
303_E	307_D	0.725	0.21
251_T	263_D	0.725	0.21
41_L	138_V	0.724	0.21
6_I	249_E	0.724	0.21
17_L	213_T	0.724	0.21
198_S	217_I	0.721	0.21
14_V	29_D	0.718	0.20
282_D	289_K	0.717	0.20
201_Q	302_T	0.713	0.20
271_D	275_Q	0.712	0.20
290_D	297_D	0.711	0.20
150_G	160_I	0.708	0.20
6_I	161_S	0.708	0.20
330_Q	346_R	0.707	0.20
329_G	341_E	0.707	0.20
5_I	130_W	0.707	0.20
73_M	104_L	0.704	0.20
331_S	341_E	0.703	0.20
267_L	293_I	0.701	0.20
91_Y	160_I	0.699	0.20
320_G	350_R	0.697	0.20
327_D	351_R	0.694	0.20
227_D	232_S	0.693	0.20
41_L	130_W	0.692	0.20
23_F	163_V	0.692	0.20
146_C	215_S	0.692	0.20
61_P	176_V	0.691	0.20
279_K	321_N	0.691	0.20
116_L	180_L	0.688	0.19
91_Y	165_E	0.682	0.19
286_D	290_D	0.681	0.19
103_A	139_I	0.679	0.19
10_N	15_T	0.679	0.19
34_E	37_E	0.677	0.19
339_N	347_S	0.674	0.19
100_V	152_V	0.673	0.19
105_N	219_S	0.673	0.19
279_K	289_K	0.672	0.19
328_K	332_Q	0.671	0.19
336_D	347_S	0.669	0.19
15_T	212_S	0.667	0.19
104_L	146_C	0.667	0.19
105_N	108_Y	0.666	0.19
7_V	143_I	0.665	0.19
326_A	345_N	0.663	0.19
23_F	110_V	0.663	0.19
87_K	218_K	0.662	0.19
199_D	212_S	0.661	0.19
37_E	159_L	0.656	0.18
137_K	158_I	0.655	0.18
26_A	164_Y	0.655	0.18
312_P	317_Q	0.652	0.18
151_Y	172_Y	0.651	0.18
61_P	163_V	0.650	0.18
329_G	354_A	0.649	0.18
346_R	351_R	0.648	0.18
14_V	19_P	0.647	0.18
15_T	218_K	0.645	0.18
314_Q	321_N	0.645	0.18
40_M	135_F	0.644	0.18
30_R	231_D	0.643	0.18
162_T	184_T	0.642	0.18
252_D	265_E	0.642	0.18
206_A	216_Y	0.642	0.18
249_E	283_Q	0.641	0.18
234_K	243_S	0.639	0.18
280_A	303_E	0.639	0.18
94_I	108_Y	0.637	0.18
334_H	347_S	0.636	0.18
300_T	341_E	0.636	0.18
305_D	315_D	0.634	0.18
98_P	115_P	0.633	0.18
74_L	257_Q	0.631	0.18
130_W	157_E	0.630	0.18
98_P	214_G	0.630	0.18
303_E	329_G	0.630	0.18
264_N	276_K	0.629	0.17
320_G	338_N	0.627	0.17
331_S	334_H	0.627	0.17
119_E	151_Y	0.625	0.17
259_S	341_E	0.625	0.17
187_Y	208_K	0.623	0.17
264_N	271_D	0.623	0.17
98_P	116_L	0.622	0.17
330_Q	337_W	0.622	0.17
225_N	230_D	0.622	0.17
253_Q	293_I	0.621	0.17
283_Q	286_D	0.620	0.17
18_T	104_L	0.617	0.17
35_I	260_K	0.615	0.17
105_N	154_K	0.609	0.17
248_D	261_Q	0.609	0.17
300_T	324_N	0.608	0.17
19_P	113_L	0.607	0.17
23_F	116_L	0.606	0.17
15_T	33_Y	0.605	0.17
71_A	288_D	0.605	0.17
214_G	218_K	0.604	0.17
19_P	22_Q	0.604	0.17
74_L	244_D	0.603	0.17
151_Y	214_G	0.601	0.17
94_I	210_G	0.600	0.17
41_L	164_Y	0.599	0.17
16_L	218_K	0.599	0.17
26_A	40_M	0.598	0.17
25_K	28_N	0.598	0.17
64_M	143_I	0.596	0.16
121_Q	201_Q	0.596	0.16
161_S	213_T	0.595	0.16
82_V	180_L	0.595	0.16
321_N	342_Q	0.594	0.16
37_E	105_N	0.594	0.16
18_T	150_G	0.593	0.16
132_K	165_E	0.593	0.16
344_K	352_D	0.590	0.16
110_V	309_E	0.589	0.16
94_I	150_G	0.588	0.16
142_I	210_G	0.585	0.16
7_V	79_V	0.583	0.16
71_A	162_T	0.582	0.16
33_Y	37_E	0.580	0.16
130_W	139_I	0.579	0.16
67_F	234_K	0.578	0.16
346_R	352_D	0.576	0.16
35_I	349_S	0.576	0.16
130_W	158_I	0.575	0.16
346_R	350_R	0.575	0.16
104_L	158_I	0.575	0.16
289_K	341_E	0.575	0.16
315_D	318_D	0.574	0.16
135_F	139_I	0.574	0.16
295_E	338_N	0.571	0.16
227_D	266_Q	0.569	0.16
338_N	354_A	0.567	0.16
14_V	37_E	0.566	0.16
334_H	339_N	0.566	0.16
282_D	288_D	0.564	0.16
317_Q	343_G	0.563	0.16
345_N	354_A	0.562	0.15
272_S	275_Q	0.562	0.15
78_I	94_I	0.560	0.15
8_E	117_N	0.560	0.15
28_N	162_T	0.558	0.15
162_T	216_Y	0.557	0.15
218_K	241_Q	0.557	0.15
6_I	127_I	0.556	0.15
161_S	164_Y	0.556	0.15
97_N	214_G	0.554	0.15
165_E	213_T	0.553	0.15
120_G	151_Y	0.552	0.15
215_S	238_E	0.551	0.15
199_D	205_K	0.551	0.15
148_E	239_E	0.549	0.15
113_L	323_N	0.549	0.15
222_K	233_S	0.549	0.15
299_N	307_D	0.548	0.15
269_D	308_H	0.548	0.15
27_K	146_C	0.547	0.15
25_K	44_E	0.546	0.15
294_K	336_D	0.546	0.15
311_T	314_Q	0.546	0.15
88_A	216_Y	0.545	0.15
5_I	74_L	0.545	0.15
322_E	337_W	0.544	0.15
247_E	256_T	0.544	0.15
229_K	232_S	0.543	0.15
45_T	197_E	0.538	0.15
297_D	300_T	0.538	0.15
253_Q	275_Q	0.536	0.15
4_G	83_F	0.535	0.15
115_P	203_R	0.534	0.15
213_T	218_K	0.534	0.15
95_D	98_P	0.530	0.15
339_N	343_G	0.530	0.15
10_N	26_A	0.530	0.15
147_S	189_T	0.529	0.15
24_L	92_M	0.527	0.15
228_I	232_S	0.527	0.15
75_F	78_I	0.526	0.14
3_R	7_V	0.525	0.14
108_Y	130_W	0.522	0.14
66_I	246_N	0.522	0.14
325_G	334_H	0.521	0.14
145_D	148_E	0.518	0.14
133_T	182_D	0.517	0.14
10_N	13_F	0.517	0.14
73_M	212_S	0.517	0.14
20_D	65_G	0.515	0.14
134_D	137_K	0.514	0.14
287_S	305_D	0.511	0.14
69_M	74_L	0.510	0.14
33_Y	132_K	0.510	0.14
342_Q	349_S	0.509	0.14
89_Y	148_E	0.509	0.14
113_L	124_V	0.507	0.14
93_T	194_E	0.507	0.14
249_E	304_K	0.506	0.14
134_D	282_D	0.504	0.14
319_K	323_N	0.504	0.14
70_T	315_D	0.504	0.14
21_G	37_E	0.504	0.14
8_E	23_F	0.504	0.14
130_W	199_D	0.503	0.14
86_N	142_I	0.501	0.14
265_E	268_N	0.501	0.14
347_S	352_D	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rcnA	2	0.5801	84.2	0.941	Contact Map
1ah9A	1	0.1522	65	0.95	Contact Map
4p02B	1	0.2073	64.4	0.95	Contact Map
1hr0W	1	0.1496	62.7	0.95	Contact Map
4ql5A	4	0.1522	58.5	0.951	Contact Map
2ztdA	4	0.4567	54.2	0.953	Contact Map
1t9hA	1	0.5801	47.9	0.954	Contact Map
3i4oA	1	0.1522	35.5	0.958	Contact Map
1u0lA	1	0.5722	34.3	0.958	Contact Map
1wkaA	1	0.3071	31.5	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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