GREMLIN Database
COXX1 - Protoheme IX farnesyltransferase 1
UniProt: O31652 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (278)
Sequences: 8141 (5691)
Seq/√Len: 341.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_Y111_P4.2791.00
90_R111_P4.2591.00
26_D108_K3.5371.00
87_Y115_L3.4621.00
23_T113_M3.3451.00
110_P113_M3.1091.00
80_S122_G3.0981.00
29_K108_K2.9041.00
230_H234_I2.8931.00
97_A100_R2.8901.00
92_M220_V2.4081.00
112_A116_T2.3751.00
136_T179_C2.3151.00
134_P138_F2.3031.00
290_W294_M2.2821.00
27_F113_M2.2581.00
276_K280_K2.2351.00
133_N136_T2.2131.00
212_K216_R2.1561.00
213_E216_R2.1021.00
186_S189_A2.0981.00
36_I75_A2.0881.00
83_V121_L2.0501.00
47_F67_M2.0461.00
77_V125_G2.0251.00
69_T131_S1.9571.00
94_A105_V1.9241.00
44_F71_M1.8211.00
266_A308_I1.7721.00
129_L132_L1.7641.00
251_P263_Y1.7581.00
69_T128_M1.7541.00
25_Y29_K1.7461.00
292_K296_V1.7241.00
138_F142_A1.6911.00
260_S312_D1.6831.00
231_V234_I1.6661.00
116_T120_V1.6441.00
109_M114_I1.6371.00
63_F66_T1.6291.00
216_R225_V1.6251.00
269_V273_I1.6191.00
104_S114_I1.6061.00
227_K231_V1.6051.00
122_G144_F1.5631.00
83_V117_Y1.5521.00
90_R94_A1.5311.00
87_Y114_I1.5191.00
273_I276_K1.5181.00
241_A245_P1.5181.00
119_S123_I1.5181.00
88_F153_V1.5091.00
31_A83_V1.5001.00
76_F125_G1.4861.00
185_F189_A1.4611.00
146_F169_P1.4581.00
130_Y137_A1.4471.00
150_I165_V1.4181.00
83_V118_G1.4181.00
31_A79_A1.4131.00
145_I149_I1.4101.00
126_L129_L1.4091.00
115_L119_S1.4061.00
30_L109_M1.4061.00
178_Y182_T1.4011.00
168_F193_Y1.3951.00
266_A270_L1.3901.00
31_A121_L1.3891.00
292_K295_F1.3631.00
115_L118_G1.3441.00
284_T287_D1.3331.00
28_I31_A1.3321.00
76_F124_A1.3121.00
90_R104_S1.2971.00
289_K293_D1.2961.00
212_K229_N1.2951.00
114_I118_G1.2891.00
155_V158_T1.2861.00
231_V235_K1.2801.00
125_G129_L1.2731.00
229_N233_K1.2671.00
212_K225_V1.2671.00
135_L179_C1.2611.00
265_L269_V1.2591.00
79_A121_L1.2591.00
28_I33_P1.2591.00
280_K283_K1.2571.00
31_A117_Y1.2511.00
273_I277_K1.2351.00
293_D296_V1.2331.00
299_L303_C1.2321.00
84_Y118_G1.2281.00
135_L139_L1.2261.00
198_L239_Y1.2221.00
296_V299_L1.2151.00
295_F299_L1.2111.00
277_K281_G1.2111.00
298_S302_F1.2081.00
43_A74_T1.2021.00
117_Y121_L1.2001.00
234_I238_Q1.1991.00
50_A178_Y1.1911.00
89_D157_R1.1891.00
174_P177_G1.1771.00
209_I231_V1.1731.00
43_A70_A1.1641.00
190_V194_T1.1611.00
65_M69_T1.1601.00
114_I117_Y1.1581.00
291_A295_F1.1521.00
127_A131_S1.1481.00
296_V300_I1.1421.00
77_V140_G1.1411.00
162_S222_L1.1391.00
195_I246_V1.1371.00
209_I229_N1.1371.00
30_L83_V1.1371.00
68_V72_L1.1351.00
291_A294_M1.1331.00
87_Y118_G1.1291.00
38_S203_H1.1211.00
243_L247_T1.1041.00
27_F117_Y1.1011.00
166_G170_G1.0721.00
185_F190_V1.0681.00
237_M241_A1.0681.00
83_V109_M1.0551.00
211_R215_Y1.0501.00
124_A128_M1.0501.00
275_I278_S1.0491.00
308_I312_D1.0481.00
91_H95_K1.0431.00
155_V165_V1.0421.00
171_A197_F1.0371.00
171_A200_Q1.0321.00
286_D289_K1.0271.00
300_I304_L1.0191.00
204_F207_I1.0161.00
109_M117_Y1.0141.00
194_T198_L1.0111.00
264_F268_L1.0041.00
251_P264_F1.0041.00
96_M214_E0.9991.00
221_P226_V0.9951.00
49_I178_Y0.9921.00
187_M190_V0.9891.00
202_P239_Y0.9881.00
302_F306_F0.9851.00
65_M68_V0.9851.00
155_V159_S0.9801.00
223_L227_K0.9771.00
141_L145_I0.9761.00
123_I127_A0.9731.00
62_A67_M0.9691.00
161_W164_F0.9671.00
40_S71_M0.9671.00
186_S190_V0.9651.00
143_A172_A0.9651.00
105_V114_I0.9641.00
87_Y104_S0.9641.00
24_I28_I0.9641.00
129_L137_A0.9571.00
156_K159_S0.9551.00
282_F285_D0.9551.00
95_K218_A0.9521.00
92_M157_R0.9521.00
272_G276_K0.9421.00
305_L308_I0.9361.00
290_W293_D0.9341.00
261_P265_L0.9301.00
172_A176_M0.9291.00
278_S282_F0.9261.00
38_S42_A0.9251.00
89_D92_M0.9231.00
76_F121_L0.9231.00
300_I303_C0.9191.00
121_L125_G0.9181.00
242_V246_V0.9131.00
276_K279_I0.9071.00
129_L140_G0.9061.00
295_F298_S0.9051.00
118_G122_G0.9021.00
266_A269_V0.8951.00
22_V25_Y0.8931.00
277_K297_Y0.8921.00
260_S270_L0.8891.00
79_A117_Y0.8861.00
259_I309_M0.8771.00
260_S263_Y0.8731.00
286_D290_W0.8701.00
146_F168_F0.8701.00
259_I312_D0.8681.00
73_G129_L0.8671.00
230_H233_K0.8631.00
48_W310_M0.8611.00
135_L138_F0.8611.00
129_L133_N0.8601.00
263_Y270_L0.8561.00
203_H207_I0.8561.00
84_Y88_F0.8521.00
208_G224_P0.8511.00
228_G232_T0.8511.00
64_L68_V0.8501.00
196_M200_Q0.8481.00
279_I282_F0.8421.00
46_G50_A0.8401.00
210_R292_K0.8401.00
262_F266_A0.8361.00
134_P137_A0.8351.00
121_L129_L0.8341.00
175_L193_Y0.8341.00
184_D188_T0.8331.00
244_V247_T0.8331.00
289_K296_V0.8321.00
104_S109_M0.8261.00
136_T176_M0.8251.00
204_F208_G0.8221.00
234_I237_M0.8141.00
61_L65_M0.8141.00
236_M240_I0.8111.00
142_A145_I0.8111.00
122_G125_G0.8101.00
178_Y181_V0.8091.00
40_S44_F0.8071.00
111_P115_L0.8041.00
270_L305_L0.8001.00
274_W278_S0.8001.00
130_Y134_P0.7961.00
60_G63_F0.7951.00
122_G126_L0.7941.00
238_Q242_V0.7931.00
72_L76_F0.7901.00
294_M297_Y0.7901.00
198_L241_A0.7891.00
23_T26_D0.7891.00
291_A296_V0.7891.00
171_A177_G0.7841.00
50_A181_V0.7841.00
244_V271_G0.7811.00
114_I121_L0.7811.00
103_A107_G0.7791.00
239_Y243_L0.7781.00
224_P232_T0.7751.00
140_G176_M0.7741.00
149_I153_V0.7691.00
63_F181_V0.7691.00
293_D297_Y0.7641.00
294_M298_S0.7641.00
266_A271_G0.7601.00
146_F150_I0.7561.00
213_E217_A0.7541.00
48_W51_F0.7531.00
78_M82_T0.7511.00
47_F181_V0.7481.00
296_V302_F0.7451.00
273_I280_K0.7451.00
298_S303_C0.7410.99
81_G148_A0.7400.99
96_M99_T0.7390.99
163_T166_G0.7340.99
171_A196_M0.7320.99
83_V114_I0.7320.99
233_K236_M0.7270.99
128_M132_L0.7270.99
283_K286_D0.7260.99
27_F109_M0.7250.99
170_G174_P0.7250.99
165_V170_G0.7250.99
304_L308_I0.7240.99
128_M131_S0.7180.99
223_L226_V0.7170.99
194_T246_V0.7150.99
207_I210_R0.7140.99
133_N139_L0.7100.99
263_Y267_A0.7060.99
163_T204_F0.7050.99
160_V226_V0.7050.99
103_A108_K0.7040.99
163_T205_W0.7020.99
290_W297_Y0.6980.99
289_K294_M0.6950.99
47_F70_A0.6900.99
91_H94_A0.6890.99
92_M218_A0.6880.99
155_V162_S0.6860.99
145_I150_I0.6820.99
270_L273_I0.6800.99
212_K224_P0.6790.99
101_S108_K0.6760.99
299_L306_F0.6680.99
87_Y90_R0.6660.99
80_S84_Y0.6650.99
306_F310_M0.6640.99
69_T132_L0.6630.99
109_M113_M0.6620.99
163_T201_P0.6610.99
126_L137_A0.6560.99
207_I211_R0.6560.99
30_L114_I0.6550.99
126_L130_Y0.6520.99
253_S257_G0.6520.99
73_G128_M0.6500.99
294_M302_F0.6500.99
187_M191_L0.6490.99
43_A173_P0.6480.99
84_Y149_I0.6470.99
48_W306_F0.6440.99
268_L271_G0.6430.99
39_N45_G0.6420.99
220_V225_V0.6400.99
160_V221_P0.6390.99
295_F302_F0.6380.98
307_F311_I0.6370.98
89_D220_V0.6360.98
294_M299_L0.6290.98
168_F197_F0.6280.98
166_G171_A0.6270.98
53_S60_G0.6260.98
215_Y222_L0.6260.98
132_L136_T0.6250.98
208_G211_R0.6250.98
112_A115_L0.6230.98
297_Y301_Y0.6220.98
37_I299_L0.6190.98
175_L189_A0.6180.98
302_F305_L0.6160.98
79_A83_V0.6140.98
274_W277_K0.6120.98
159_S165_V0.6040.98
47_F51_F0.6030.98
252_F264_F0.6020.98
86_N89_D0.6010.98
126_L141_L0.5990.98
299_L302_F0.5980.98
287_D291_A0.5960.98
65_M72_L0.5960.98
113_M116_T0.5950.98
209_I228_G0.5950.98
209_I233_K0.5930.98
25_Y28_I0.5880.97
266_A304_L0.5880.97
265_L268_L0.5870.97
22_V108_K0.5870.97
92_M95_K0.5850.97
39_N42_A0.5850.97
89_D152_T0.5830.97
239_Y242_V0.5820.97
161_W165_V0.5820.97
136_T139_L0.5810.97
131_S134_P0.5790.97
258_H263_Y0.5790.97
29_K103_A0.5790.97
127_A130_Y0.5790.97
177_G181_V0.5760.97
281_G294_M0.5740.97
45_G196_M0.5730.97
278_S281_G0.5720.97
91_H111_P0.5710.97
291_A299_L0.5700.97
280_K286_D0.5670.97
132_L137_A0.5670.97
275_I301_Y0.5660.97
143_A169_P0.5640.97
178_Y186_S0.5610.97
88_F152_T0.5580.97
163_T170_G0.5580.97
262_F265_L0.5580.97
259_I270_L0.5560.96
274_W297_Y0.5550.96
259_I263_Y0.5550.96
66_T132_L0.5550.96
51_F181_V0.5530.96
47_F50_A0.5520.96
201_P239_Y0.5510.96
167_S200_Q0.5500.96
22_V26_D0.5500.96
39_N143_A0.5500.96
166_G204_F0.5500.96
296_V303_C0.5460.96
41_I48_W0.5450.96
299_L305_L0.5450.96
294_M303_C0.5430.96
105_V108_K0.5430.96
167_S170_G0.5420.96
166_G200_Q0.5400.96
162_S166_G0.5400.96
160_V163_T0.5380.96
280_K284_T0.5370.96
298_S305_L0.5360.96
104_S107_G0.5340.96
23_T27_F0.5330.95
80_S149_I0.5330.95
77_V144_F0.5320.95
193_Y200_Q0.5250.95
208_G214_E0.5230.95
227_K235_K0.5210.95
170_G173_P0.5200.95
292_K298_S0.5190.95
46_G177_G0.5180.95
39_N74_T0.5150.95
135_L183_G0.5130.94
82_T86_N0.5120.94
292_K297_Y0.5120.94
97_A213_E0.5120.94
191_L253_S0.5110.94
72_L128_M0.5100.94
289_K292_K0.5080.94
39_N43_A0.5080.94
292_K303_C0.5070.94
281_G290_W0.5070.94
158_T162_S0.5050.94
295_F308_I0.5050.94
97_A101_S0.5030.94
272_G275_I0.5020.94
279_I283_K0.5010.94
120_V124_A0.5010.94
77_V148_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.8313 100 0.29 Contact Map
4tq3A 1 0.8719 100 0.355 Contact Map
4xnjA 1 0.6188 21.2 0.951 Contact Map
2cfqA 1 0.6344 17.2 0.954 Contact Map
4xp4A 1 0.3031 11 0.957 Contact Map
2xq2A 2 0.7469 10.2 0.958 Contact Map
3ze3A 4 0.3406 10.2 0.958 Contact Map
1pw4A 1 0.6031 9.6 0.959 Contact Map
3o7qA 1 0.5906 9.4 0.959 Contact Map
2kogA 1 0.1688 7.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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