GREMLIN Database
MANA1 - Mannose-6-phosphate isomerase ManA
UniProt: O31646 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (289)
Sequences: 3142 (2369)
Seq/√Len: 139.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_E155_R4.3691.00
7_F291_D3.5081.00
121_D160_P3.0401.00
58_F66_H2.9851.00
158_V178_I2.8171.00
142_T146_R2.7931.00
125_D157_K2.7351.00
117_W179_L2.5951.00
15_R35_G2.5621.00
50_V63_L2.4941.00
277_R305_E2.4371.00
171_V193_L2.4241.00
277_R284_V2.4031.00
102_Y216_V2.3951.00
21_A24_D2.3891.00
127_E157_K2.3871.00
101_E105_I2.3631.00
141_T145_E2.3511.00
197_D205_L2.3161.00
165_Y244_C2.2191.00
20_T24_D2.1981.00
251_K309_E2.1711.00
58_F62_E2.1691.00
275_E288_K2.1581.00
59_T62_E2.1471.00
148_E151_E2.1371.00
20_T23_A2.0751.00
171_V217_I2.0681.00
273_E309_E2.0641.00
125_D159_K2.0411.00
279_I284_V2.0171.00
277_R286_P2.0121.00
47_Q61_S2.0071.00
9_K51_Q1.9991.00
100_D111_L1.9651.00
43_H46_G1.9641.00
52_N56_K1.9541.00
136_T139_E1.9431.00
110_E189_T1.9361.00
276_G308_A1.9291.00
107_E212_K1.9061.00
102_Y106_H1.9011.00
273_E289_K1.8841.00
287_F293_M1.8571.00
288_K291_D1.8541.00
285_Y293_M1.7781.00
45_N188_D1.7551.00
93_S192_R1.7501.00
16_I205_L1.7221.00
212_K215_E1.7211.00
9_K49_V1.7131.00
181_L270_S1.6891.00
100_D104_N1.6851.00
62_E66_H1.6791.00
49_V59_T1.6781.00
99_N102_Y1.6731.00
275_E286_P1.6701.00
270_S292_H1.6361.00
280_S283_Y1.6271.00
253_N309_E1.6201.00
191_Y216_V1.5991.00
83_T183_T1.5881.00
279_I303_K1.5671.00
63_L70_L1.5661.00
304_L308_A1.5601.00
133_N154_R1.5401.00
257_S305_E1.5401.00
20_T32_Q1.5341.00
29_I34_T1.4881.00
271_V274_G1.4871.00
61_S65_E1.4851.00
39_A292_H1.4741.00
100_D112_G1.4731.00
10_P292_H1.4401.00
279_I305_E1.4401.00
267_L302_F1.4401.00
276_G293_M1.4341.00
96_V216_V1.4031.00
296_P299_L1.3971.00
147_G197_D1.3921.00
7_F285_Y1.3791.00
95_Q190_T1.3731.00
255_S307_Y1.3551.00
83_T181_L1.3391.00
159_K162_D1.3201.00
118_Y249_V1.3141.00
64_W71_F1.3141.00
62_E65_E1.3091.00
114_T168_S1.2901.00
96_V217_I1.2781.00
36_E84_K1.2611.00
13_K46_G1.2611.00
141_T214_I1.2591.00
121_D179_L1.2581.00
93_S206_R1.2581.00
39_A268_L1.2571.00
78_R110_E1.2411.00
259_S301_E1.2391.00
261_K301_E1.2361.00
55_Y63_L1.2341.00
19_G87_D1.2331.00
114_T165_Y1.2281.00
16_I90_Q1.2191.00
11_V46_G1.2181.00
101_E104_N1.2131.00
140_L219_V1.2071.00
128_I164_F1.1991.00
120_I272_I1.1991.00
43_H186_N1.1941.00
102_Y215_E1.1891.00
137_K215_E1.1821.00
129_I155_R1.1731.00
21_A25_F1.1721.00
112_G185_Q1.1590.99
10_P37_C1.1560.99
23_A34_T1.1520.99
85_I181_L1.1500.99
134_A139_E1.1430.99
78_R111_L1.1410.99
9_K57_G1.1190.99
20_T31_S1.1080.99
37_C292_H1.1080.99
239_T251_K1.1060.99
116_C249_V1.1050.99
257_S303_K1.1040.99
183_T249_V1.1030.99
237_L250_G1.0950.99
82_L184_Q1.0880.99
140_L193_L1.0760.99
6_L63_L1.0690.99
137_K141_T1.0680.99
104_N110_E1.0670.99
193_L217_I1.0640.99
276_G287_F1.0600.99
193_L213_S1.0590.99
162_D228_V1.0500.99
87_D179_L1.0410.99
184_Q190_T1.0370.99
119_I178_I1.0350.99
167_P170_T1.0320.99
21_A179_L1.0310.99
158_V164_F1.0280.99
90_Q176_K1.0230.99
271_V287_F1.0210.99
132_H217_I1.0170.99
109_G189_T1.0140.99
275_E307_Y1.0130.99
25_F28_T1.0100.98
279_I282_E1.0070.98
132_H219_V1.0040.98
31_S34_T1.0010.98
170_T218_E0.9980.98
295_L302_F0.9970.98
269_I293_M0.9940.98
114_T185_Q0.9940.98
306_G309_E0.9800.98
116_C183_T0.9740.98
14_E32_Q0.9730.98
23_A32_Q0.9690.98
8_F294_L0.9680.98
165_Y247_F0.9660.98
116_C163_F0.9590.98
83_T249_V0.9530.98
53_G57_G0.9500.98
17_W93_S0.9470.98
43_H47_Q0.9420.98
192_R206_R0.9410.98
280_S299_L0.9390.98
191_Y212_K0.9330.97
287_F308_A0.9300.97
19_G178_I0.9260.97
129_I175_G0.9260.97
278_M293_M0.9190.97
86_L174_I0.9180.97
9_K56_K0.9150.97
10_P39_A0.9150.97
27_Y37_C0.9110.97
106_H212_K0.9100.97
52_N55_Y0.9010.97
38_W48_S0.8980.97
88_A174_I0.8960.97
55_Y58_F0.8940.97
130_Y153_L0.8930.97
14_E31_S0.8930.97
135_T152_L0.8890.97
36_E82_L0.8740.96
70_L294_L0.8650.96
85_I120_I0.8610.96
107_E191_Y0.8590.96
106_H215_E0.8570.96
42_A78_R0.8560.96
273_E307_Y0.8540.96
139_E143_M0.8490.96
70_L296_P0.8480.96
130_Y166_V0.8410.95
38_W84_K0.8400.95
112_G246_Y0.8370.95
138_E142_T0.8330.95
53_G56_K0.8260.95
226_H229_H0.8230.95
118_Y163_F0.8200.95
198_R206_R0.8160.95
50_V53_G0.8160.95
68_R74_L0.8160.95
240_T250_G0.8150.95
27_Y292_H0.8100.94
14_E33_R0.8080.94
25_F289_K0.8080.94
294_L297_Y0.8080.94
232_Q236_L0.8040.94
15_R188_D0.8030.94
233_I236_L0.8020.94
41_A47_Q0.8020.94
47_Q59_T0.8010.94
100_D185_Q0.7990.94
128_I175_G0.7910.94
276_G286_P0.7900.94
23_A28_T0.7870.93
211_K215_E0.7870.93
91_D176_K0.7870.93
58_F63_L0.7830.93
259_S303_K0.7820.93
128_I158_V0.7800.93
84_K184_Q0.7760.93
65_E77_D0.7750.93
145_E214_I0.7660.93
86_L189_T0.7620.92
114_T244_C0.7620.92
13_K45_N0.7600.92
55_Y67_H0.7590.92
38_W41_A0.7590.92
27_Y39_A0.7580.92
99_N218_E0.7570.92
102_Y105_I0.7560.92
160_P273_E0.7540.92
93_S198_R0.7480.92
83_T270_S0.7470.92
69_H298_G0.7420.91
121_D125_D0.7420.91
84_K187_S0.7410.91
93_S190_T0.7410.91
64_W67_H0.7390.91
21_A178_I0.7390.91
271_V276_G0.7330.91
142_T145_E0.7320.91
130_Y168_S0.7310.91
52_N57_G0.7290.91
64_W79_F0.7270.90
10_P48_S0.7270.90
254_L306_G0.7270.90
127_E176_K0.7240.90
252_W269_I0.7240.90
96_V193_L0.7210.90
108_N190_T0.7180.90
296_P300_G0.7160.90
206_R209_H0.7130.90
240_T243_E0.7100.89
94_V153_L0.7100.89
286_P291_D0.7080.89
21_A87_D0.7060.89
140_L144_I0.7040.89
15_R33_R0.6970.89
22_L25_F0.6970.89
143_M152_L0.6970.89
92_L115_E0.6960.88
6_L294_L0.6940.88
112_G184_Q0.6930.88
166_V170_T0.6930.88
7_F51_Q0.6890.88
138_E141_T0.6880.88
27_Y34_T0.6840.88
17_W192_R0.6840.88
237_L252_W0.6840.88
96_V170_T0.6820.87
278_M304_L0.6820.87
141_T211_K0.6800.87
163_F242_I0.6790.87
89_D176_K0.6770.87
254_L308_A0.6760.87
96_V191_Y0.6720.87
87_D178_I0.6690.86
190_T206_R0.6690.86
129_I153_L0.6680.86
102_Y212_K0.6680.86
239_T242_I0.6640.86
38_W43_H0.6630.86
12_F34_T0.6620.86
97_H115_E0.6610.86
102_Y107_E0.6590.86
273_E277_R0.6570.85
8_F11_V0.6570.85
133_N137_K0.6520.85
155_R175_G0.6500.85
105_I215_E0.6470.85
30_P34_T0.6440.84
113_K188_D0.6440.84
116_C270_S0.6440.84
12_F37_C0.6430.84
163_F249_V0.6420.84
235_D239_T0.6410.84
269_I295_L0.6400.84
68_R72_G0.6390.84
93_S204_K0.6390.84
272_I309_E0.6390.84
96_V118_Y0.6390.84
150_D155_R0.6360.84
143_M146_R0.6360.84
243_E248_S0.6350.83
192_R198_R0.6340.83
24_D28_T0.6310.83
232_Q235_D0.6280.83
61_S78_R0.6280.83
43_H187_S0.6270.83
130_Y164_F0.6210.82
143_M148_E0.6200.82
109_G187_S0.6190.82
92_L95_Q0.6190.82
132_H149_W0.6160.82
39_A83_T0.6150.81
15_R86_L0.6140.81
85_I270_S0.6110.81
23_A30_P0.6090.81
298_G302_F0.6090.81
44_Q78_R0.6080.81
12_F39_A0.6040.80
132_H220_P0.6010.80
95_Q192_R0.5980.80
278_M284_V0.5970.80
64_W68_R0.5970.80
149_W152_L0.5960.79
42_A61_S0.5940.79
236_L255_S0.5940.79
118_Y170_T0.5940.79
278_M285_Y0.5930.79
118_Y251_K0.5920.79
175_G178_I0.5910.79
11_V48_S0.5910.79
6_L50_V0.5900.79
99_N169_G0.5890.79
143_M151_E0.5890.79
184_Q209_H0.5890.79
191_Y206_R0.5860.78
263_Q267_L0.5850.78
92_L173_A0.5830.78
287_F291_D0.5820.78
63_L67_H0.5810.78
142_T279_I0.5790.77
133_N153_L0.5790.77
17_W206_R0.5780.77
111_L185_Q0.5770.77
41_A48_S0.5770.77
82_L187_S0.5760.77
281_G301_E0.5750.77
68_R71_F0.5730.77
233_I237_L0.5720.77
73_Q264_K0.5720.77
103_A109_G0.5720.77
35_G188_D0.5710.76
211_K214_I0.5710.76
23_A31_S0.5690.76
277_R280_S0.5680.76
224_E228_V0.5680.76
258_A304_L0.5680.76
150_D197_D0.5680.76
234_E237_L0.5670.76
158_V175_G0.5650.76
117_W164_F0.5650.76
6_L60_L0.5610.75
38_W82_L0.5610.75
112_G244_C0.5600.75
190_T198_R0.5600.75
233_I307_Y0.5600.75
80_P187_S0.5580.75
103_A189_T0.5580.75
261_K303_K0.5570.75
82_L188_D0.5570.75
206_R213_S0.5550.74
68_R77_D0.5520.74
299_L302_F0.5520.74
116_C181_L0.5510.74
114_T246_Y0.5500.74
298_G303_K0.5500.74
21_A121_D0.5460.73
39_A120_I0.5460.73
174_I184_Q0.5460.73
254_L276_G0.5460.73
45_N181_L0.5440.73
51_Q291_D0.5420.73
39_A85_I0.5410.73
181_L249_V0.5390.72
146_R151_E0.5390.72
204_K207_E0.5370.72
91_D175_G0.5350.72
21_A28_T0.5340.72
14_E34_T0.5320.71
275_E282_E0.5320.71
164_F175_G0.5310.71
239_T248_S0.5310.71
86_L188_D0.5310.71
99_N168_S0.5310.71
88_A175_G0.5300.71
220_P223_P0.5290.71
260_L303_K0.5290.71
93_S209_H0.5270.71
6_L52_N0.5250.70
91_D271_V0.5220.70
96_V169_G0.5220.70
79_F268_L0.5210.70
118_Y181_L0.5200.70
71_F75_E0.5180.69
37_C85_I0.5180.69
7_F293_M0.5170.69
23_A29_I0.5160.69
9_K28_T0.5160.69
106_H109_G0.5140.69
25_F85_I0.5120.68
144_I151_E0.5110.68
99_N110_E0.5110.68
36_E41_A0.5110.68
236_L256_G0.5100.68
129_I156_V0.5100.68
128_I190_T0.5100.68
86_L92_L0.5080.68
204_K209_H0.5070.68
88_A178_I0.5070.68
119_I179_L0.5070.68
222_I225_R0.5060.68
36_E187_S0.5060.68
272_I289_K0.5050.67
261_K302_F0.5050.67
188_D268_L0.5050.67
238_T241_L0.5010.67
12_F15_R0.5000.67
41_A186_N0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qwrA 1 0.9968 100 0.13 Contact Map
1zx5A 1 0.9143 100 0.208 Contact Map
2wfpA 1 0.9365 100 0.214 Contact Map
1pmiA 1 0.9492 100 0.241 Contact Map
3rnsA 1 0.6349 99.7 0.809 Contact Map
3bu7A 3 0.8032 99.5 0.838 Contact Map
3nw4A 3 0.8825 99 0.87 Contact Map
3myxA 1 0.7143 98.9 0.874 Contact Map
3h7jA 1 0.6667 98.7 0.882 Contact Map
1y3tA 2 0.7556 98.7 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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