MANR - BACSU - GREMLIN Contacts

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MANR - Transcriptional regulator ManR

UniProt:	O31644	Sequences: MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLKVIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIAYDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNERNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFESLLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAVYLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIHLNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTLHFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDYIKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQMLNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGIAIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLSEQPAFVQKLTKETNVMTFLSHLDY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	648 (623)
Sequences:	2258 (1982)
Seq/√Len:	79.4

ECOLI - FRVR
BACSU - MANR LICR MTLR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
7_R	42_D	5.668	1.00
160_E	229_R	4.640	1.00
97_R	131_D	4.215	1.00
324_D	400_R	3.975	1.00
357_K	384_E	3.970	1.00
34_C	39_I	3.910	1.00
410_K	437_A	3.814	1.00
43_L	47_E	3.546	1.00
144_L	158_G	3.478	1.00
353_L	388_A	3.471	1.00
104_D	120_R	3.457	1.00
206_K	257_A	3.377	1.00
123_V	128_I	3.375	1.00
160_E	164_R	3.222	1.00
638_N	641_T	3.220	1.00
522_E	587_K	3.198	1.00
143_D	162_N	3.137	1.00
123_V	131_D	3.109	1.00
586_L	589_P	3.001	1.00
412_V	442_I	2.886	1.00
598_S	634_T	2.821	1.00
531_E	548_A	2.752	1.00
415_C	418_G	2.727	1.00
314_S	320_D	2.708	1.00
514_P	640_M	2.688	1.00
534_A	548_A	2.688	1.00
142_F	169_R	2.672	1.00
136_E	148_S	2.639	1.00
144_L	156_V	2.604	1.00
375_N	381_H	2.567	1.00
426_R	430_E	2.565	1.00
164_R	274_E	2.469	1.00
123_V	127_S	2.431	1.00
38_T	42_D	2.382	1.00
465_A	475_V	2.349	1.00
307_G	328_I	2.311	1.00
515_F	540_K	2.297	1.00
517_V	639_V	2.279	1.00
14_L	23_L	2.251	1.00
576_I	604_A	2.237	1.00
164_R	229_R	2.233	1.00
34_C	42_D	2.217	1.00
324_D	397_A	2.185	1.00
14_L	28_F	2.127	1.00
525_H	528_K	2.092	1.00
47_E	58_L	2.091	1.00
159_N	162_N	2.080	1.00
247_K	272_E	2.072	1.00
425_L	463_T	2.071	1.00
523_A	532_Q	2.066	1.00
411_A	461_I	2.061	1.00
47_E	60_R	2.060	1.00
413_I	429_I	2.042	1.00
533_L	584_A	2.009	1.00
222_H	281_H	1.999	1.00
28_F	39_I	1.982	1.00
533_L	602_M	1.981	1.00
368_I	384_E	1.979	1.00
530_I	548_A	1.976	1.00
591_E	594_N	1.976	1.00
423_Q	426_R	1.958	1.00
147_V	157_E	1.955	1.00
529_L	584_A	1.952	1.00
529_L	600_V	1.930	1.00
102_A	135_V	1.929	1.00
357_K	364_F	1.914	1.00
589_P	598_S	1.910	1.00
351_P	385_E	1.896	1.00
98_M	135_V	1.895	1.00
59_I	69_H	1.892	1.00
411_A	436_I	1.884	1.00
367_I	391_T	1.879	1.00
538_F	543_V	1.868	1.00
306_V	335_L	1.863	1.00
551_A	602_M	1.844	1.00
36_E	40_R	1.843	1.00
535_T	539_E	1.842	1.00
202_S	261_R	1.833	1.00
350_N	388_A	1.822	1.00
316_L	369_D	1.822	1.00
415_C	422_S	1.810	1.00
263_E	269_R	1.805	1.00
90_R	96_E	1.802	1.00
7_R	38_T	1.790	1.00
477_S	484_E	1.785	1.00
371_L	390_L	1.773	1.00
56_A	70_I	1.769	1.00
544_D	577_K	1.758	1.00
630_V	634_T	1.731	1.00
321_F	394_F	1.729	1.00
341_R	386_E	1.722	1.00
149_R	152_L	1.705	1.00
312_R	373_D	1.689	1.00
542_Y	578_Q	1.684	1.00
22_Y	67_Y	1.683	1.00
549_V	553_M	1.682	1.00
534_A	602_M	1.676	1.00
522_E	588_E	1.671	1.00
313_V	366_L	1.670	1.00
526_R	592_W	1.666	1.00
14_L	31_R	1.663	1.00
579_S	606_K	1.647	1.00
138_W	166_A	1.647	1.00
542_Y	580_A	1.642	1.00
520_Q	585_T	1.641	1.00
43_L	58_L	1.636	1.00
62_P	65_G	1.632	1.00
350_N	385_E	1.632	1.00
223_T	278_L	1.624	1.00
158_G	163_K	1.603	1.00
338_V	342_L	1.602	1.00
313_V	394_F	1.598	1.00
363_L	391_T	1.598	1.00
14_L	32_V	1.580	1.00
308_H	377_T	1.578	1.00
409_K	492_I	1.573	1.00
327_L	331_L	1.563	1.00
93_S	96_E	1.562	1.00
5_N	8_Q	1.551	0.99
531_E	552_V	1.542	0.99
519_L	585_T	1.537	0.99
43_L	66_V	1.535	0.99
168_A	222_H	1.533	0.99
61_K	64_L	1.531	0.99
334_H	393_H	1.531	0.99
484_E	487_K	1.528	0.99
567_A	597_V	1.524	0.99
8_Q	45_V	1.521	0.99
415_C	464_I	1.519	0.99
218_S	281_H	1.505	0.99
349_A	385_E	1.505	0.99
135_V	146_L	1.495	0.99
327_L	397_A	1.493	0.99
111_P	155_K	1.492	0.99
313_V	367_I	1.492	0.99
461_I	476_V	1.482	0.99
565_G	598_S	1.482	0.99
203_L	258_C	1.471	0.99
317_K	366_L	1.466	0.99
512_T	583_I	1.462	0.99
25_V	66_V	1.460	0.99
200_I	220_L	1.460	0.99
26_Q	36_E	1.455	0.99
207_H	257_A	1.454	0.99
144_L	163_K	1.453	0.99
314_S	324_D	1.440	0.99
443_A	446_D	1.439	0.99
310_I	328_I	1.432	0.99
461_I	474_I	1.426	0.99
543_V	547_Y	1.425	0.99
516_L	540_K	1.424	0.99
97_R	127_S	1.420	0.99
524_E	528_K	1.414	0.99
251_E	279_T	1.413	0.99
309_L	394_F	1.404	0.99
523_A	529_L	1.398	0.99
581_I	601_F	1.397	0.99
433_Y	489_S	1.393	0.99
12_L	46_I	1.389	0.99
637_T	641_T	1.389	0.99
521_Q	584_A	1.386	0.99
8_Q	42_D	1.386	0.99
115_K	125_R	1.386	0.99
457_I	471_V	1.385	0.99
408_H	437_A	1.384	0.99
218_S	222_H	1.381	0.99
331_L	390_L	1.381	0.99
527_Y	531_E	1.381	0.99
518_F	536_A	1.379	0.99
22_Y	65_G	1.370	0.99
538_F	548_A	1.361	0.99
256_F	275_A	1.357	0.99
534_A	551_A	1.354	0.99
326_D	400_R	1.348	0.99
561_N	592_W	1.346	0.98
252_Y	279_T	1.344	0.98
462_S	475_V	1.343	0.98
520_Q	587_K	1.341	0.98
554_R	560_T	1.337	0.98
102_A	139_L	1.336	0.98
168_A	225_L	1.331	0.98
145_T	157_E	1.322	0.98
480_L	488_L	1.316	0.98
321_F	397_A	1.313	0.98
440_A	457_I	1.311	0.98
11_I	28_F	1.308	0.98
488_L	492_I	1.306	0.98
26_Q	30_D	1.303	0.98
350_N	389_Y	1.298	0.98
548_A	552_V	1.297	0.98
101_I	135_V	1.289	0.98
37_K	41_N	1.289	0.98
29_A	39_I	1.288	0.98
533_L	582_A	1.287	0.98
94_D	131_D	1.277	0.98
338_V	341_R	1.272	0.98
59_I	67_Y	1.272	0.98
98_M	131_D	1.270	0.98
526_R	593_G	1.269	0.98
327_L	400_R	1.268	0.98
551_A	560_T	1.262	0.98
599_L	634_T	1.259	0.98
417_M	421_M	1.258	0.98
560_T	569_P	1.249	0.98
15_L	68_L	1.249	0.98
469_I	472_P	1.248	0.98
541_G	577_K	1.248	0.98
256_F	272_E	1.246	0.97
29_A	36_E	1.245	0.97
399_E	428_K	1.245	0.97
537_L	543_V	1.241	0.97
418_G	421_M	1.240	0.97
363_L	395_Q	1.239	0.97
34_C	38_T	1.239	0.97
474_I	484_E	1.237	0.97
37_K	395_Q	1.236	0.97
547_Y	604_A	1.236	0.97
117_I	128_I	1.236	0.97
271_P	274_E	1.233	0.97
150_Q	153_G	1.232	0.97
363_L	367_I	1.232	0.97
412_V	457_I	1.232	0.97
98_M	134_A	1.226	0.97
543_V	604_A	1.217	0.97
585_T	599_L	1.215	0.97
528_K	531_E	1.213	0.97
374_I	382_I	1.205	0.97
534_A	538_F	1.204	0.97
113_S	153_G	1.203	0.97
113_S	116_D	1.202	0.97
60_R	66_V	1.202	0.97
606_K	609_D	1.199	0.97
639_V	643_L	1.196	0.97
521_Q	587_K	1.195	0.97
581_I	616_L	1.194	0.97
579_S	605_V	1.192	0.97
591_E	596_K	1.190	0.97
353_L	384_E	1.189	0.97
416_H	464_I	1.184	0.97
410_K	456_D	1.182	0.97
100_H	121_H	1.180	0.97
29_A	34_C	1.179	0.97
556_K	559_A	1.176	0.96
204_Q	211_F	1.168	0.96
415_C	420_G	1.167	0.96
8_Q	46_I	1.167	0.96
11_I	46_I	1.163	0.96
538_F	545_K	1.152	0.96
255_T	275_A	1.147	0.96
517_V	585_T	1.147	0.96
393_H	396_A	1.146	0.96
249_K	252_Y	1.146	0.96
147_V	155_K	1.145	0.96
512_T	516_L	1.144	0.96
114_A	125_R	1.144	0.96
418_G	422_S	1.142	0.96
586_L	598_S	1.138	0.96
530_I	551_A	1.136	0.96
553_M	556_K	1.135	0.96
432_K	489_S	1.131	0.96
4_I	8_Q	1.130	0.96
94_D	134_A	1.126	0.95
14_L	18_E	1.124	0.95
555_E	558_S	1.122	0.95
639_V	642_F	1.119	0.95
230_I	274_E	1.119	0.95
125_R	153_G	1.119	0.95
195_F	265_V	1.117	0.95
530_I	534_A	1.111	0.95
636_E	641_T	1.109	0.95
317_K	321_F	1.105	0.95
550_H	575_F	1.101	0.95
199_E	203_L	1.099	0.95
327_L	370_V	1.097	0.95
557_M	560_T	1.097	0.95
115_K	119_A	1.089	0.95
255_T	279_T	1.089	0.95
429_I	436_I	1.087	0.94
122_F	592_W	1.085	0.94
364_F	384_E	1.079	0.94
309_L	367_I	1.079	0.94
520_Q	586_L	1.078	0.94
512_T	517_V	1.074	0.94
196_V	224_L	1.073	0.94
491_F	495_L	1.069	0.94
396_A	400_R	1.068	0.94
351_P	389_Y	1.068	0.94
555_E	560_T	1.068	0.94
38_T	41_N	1.067	0.94
127_S	131_D	1.065	0.94
555_E	559_A	1.062	0.94
302_L	306_V	1.059	0.94
523_A	586_L	1.059	0.94
330_G	400_R	1.056	0.94
58_L	61_K	1.054	0.94
230_I	270_F	1.049	0.93
126_S	129_K	1.048	0.93
35_S	38_T	1.046	0.93
592_W	600_V	1.046	0.93
334_H	570_H	1.044	0.93
100_H	120_R	1.043	0.93
310_I	327_L	1.043	0.93
411_A	492_I	1.043	0.93
518_F	532_Q	1.041	0.93
560_T	592_W	1.040	0.93
160_E	274_E	1.036	0.93
128_I	131_D	1.035	0.93
613_T	617_F	1.031	0.93
102_A	170_I	1.031	0.93
252_Y	275_A	1.019	0.92
397_A	400_R	1.018	0.92
367_I	370_V	1.015	0.92
222_H	226_M	1.014	0.92
571_A	604_A	1.013	0.92
5_N	45_V	1.008	0.92
592_W	597_V	1.006	0.92
364_F	368_I	1.001	0.92
428_K	479_L	0.998	0.92
433_Y	485_E	0.997	0.91
97_R	123_V	0.997	0.91
118_A	128_I	0.995	0.91
148_S	154_L	0.995	0.91
310_I	313_V	0.994	0.91
162_N	165_K	0.992	0.91
530_I	552_V	0.992	0.91
572_N	605_V	0.991	0.91
41_N	45_V	0.989	0.91
567_A	592_W	0.988	0.91
537_L	580_A	0.986	0.91
309_L	370_V	0.986	0.91
425_L	480_L	0.986	0.91
255_T	282_I	0.983	0.91
517_V	642_F	0.982	0.91
113_S	152_L	0.980	0.91
277_Y	351_P	0.977	0.91
211_F	282_I	0.973	0.90
601_F	620_L	0.973	0.90
139_L	144_L	0.971	0.90
532_Q	536_A	0.970	0.90
259_L	263_E	0.969	0.90
312_R	315_E	0.964	0.90
616_L	620_L	0.964	0.90
367_I	371_L	0.963	0.90
32_V	39_I	0.961	0.90
468_N	472_P	0.960	0.90
229_R	274_E	0.960	0.90
279_T	283_L	0.959	0.90
328_I	332_N	0.956	0.90
587_K	637_T	0.954	0.90
203_L	261_R	0.954	0.90
106_L	166_A	0.953	0.90
547_Y	571_A	0.952	0.90
636_E	642_F	0.949	0.89
447_L	469_I	0.949	0.89
571_A	575_F	0.948	0.89
135_V	139_L	0.946	0.89
543_V	548_A	0.945	0.89
550_H	553_M	0.942	0.89
599_L	630_V	0.939	0.89
393_H	420_G	0.938	0.89
371_L	382_I	0.935	0.89
311_N	315_E	0.931	0.88
339_L	343_S	0.924	0.88
251_E	283_L	0.923	0.88
243_M	276_V	0.922	0.88
565_G	634_T	0.922	0.88
530_I	602_M	0.921	0.88
547_Y	551_A	0.921	0.88
142_F	166_A	0.921	0.88
609_D	612_M	0.920	0.88
546_D	549_V	0.917	0.88
309_L	373_D	0.916	0.88
284_G	337_T	0.916	0.88
24_V	65_G	0.915	0.88
212_T	286_K	0.915	0.88
199_E	258_C	0.911	0.87
626_Q	629_F	0.911	0.87
548_A	551_A	0.909	0.87
255_T	258_C	0.905	0.87
526_R	552_V	0.904	0.87
306_V	332_N	0.903	0.87
197_T	217_E	0.902	0.87
417_M	420_G	0.901	0.87
409_K	459_L	0.900	0.87
355_D	359_M	0.900	0.87
529_L	533_L	0.899	0.87
550_H	571_A	0.897	0.87
201_K	216_F	0.897	0.87
311_N	322_H	0.896	0.86
536_A	582_A	0.894	0.86
462_S	473_H	0.894	0.86
411_A	438_V	0.892	0.86
421_M	464_I	0.892	0.86
335_L	338_V	0.887	0.86
370_V	373_D	0.886	0.86
432_K	485_E	0.885	0.86
523_A	584_A	0.883	0.86
228_R	232_M	0.882	0.86
259_L	278_L	0.879	0.85
399_E	402_Q	0.877	0.85
440_A	450_Y	0.875	0.85
213_D	443_A	0.875	0.85
188_F	224_L	0.872	0.85
337_T	341_R	0.872	0.85
583_I	642_F	0.870	0.85
160_E	233_K	0.867	0.85
385_E	388_A	0.865	0.84
306_V	328_I	0.864	0.84
517_V	583_I	0.863	0.84
118_A	154_L	0.863	0.84
537_L	582_A	0.860	0.84
330_G	396_A	0.860	0.84
363_L	398_I	0.859	0.84
527_Y	552_V	0.858	0.84
158_G	164_R	0.857	0.84
6_T	10_E	0.857	0.84
561_N	597_V	0.857	0.84
132_L	136_E	0.851	0.83
106_L	144_L	0.850	0.83
338_V	382_I	0.847	0.83
438_V	457_I	0.846	0.83
18_E	23_L	0.845	0.83
310_I	394_F	0.842	0.83
24_V	29_A	0.841	0.83
554_R	559_A	0.840	0.83
561_N	614_K	0.837	0.82
492_I	496_G	0.835	0.82
415_C	463_T	0.835	0.82
532_Q	535_T	0.833	0.82
372_E	375_N	0.832	0.82
516_L	582_A	0.831	0.82
513_T	516_L	0.826	0.82
132_L	135_V	0.825	0.82
350_N	357_K	0.824	0.81
197_T	216_F	0.822	0.81
128_I	135_V	0.822	0.81
518_F	582_A	0.821	0.81
285_G	338_V	0.821	0.81
189_L	192_E	0.820	0.81
112_V	117_I	0.819	0.81
341_R	348_V	0.819	0.81
514_P	639_V	0.816	0.81
480_L	485_E	0.814	0.81
312_R	370_V	0.809	0.80
564_S	592_W	0.809	0.80
11_I	23_L	0.801	0.80
413_I	426_R	0.800	0.80
236_I	277_Y	0.800	0.80
283_L	340_Q	0.799	0.79
435_Q	489_S	0.799	0.79
563_G	595_E	0.797	0.79
415_C	419_I	0.796	0.79
7_R	34_C	0.795	0.79
390_L	420_G	0.795	0.79
306_V	309_L	0.794	0.79
331_L	393_H	0.794	0.79
554_R	569_P	0.793	0.79
226_M	230_I	0.792	0.79
426_R	441_C	0.790	0.79
11_I	42_D	0.790	0.79
533_L	536_A	0.790	0.79
641_T	644_S	0.789	0.79
339_L	380_L	0.787	0.78
516_L	542_Y	0.787	0.78
631_Q	634_T	0.787	0.78
476_V	480_L	0.785	0.78
25_V	65_G	0.783	0.78
560_T	617_F	0.783	0.78
552_V	559_A	0.782	0.78
60_R	65_G	0.781	0.78
199_E	261_R	0.781	0.78
5_N	42_D	0.780	0.78
68_L	84_T	0.779	0.78
631_Q	635_K	0.778	0.78
371_L	387_A	0.778	0.78
222_H	393_H	0.778	0.78
125_R	420_G	0.777	0.78
442_I	450_Y	0.777	0.78
255_T	259_L	0.777	0.78
306_V	310_I	0.777	0.78
113_S	125_R	0.777	0.78
571_A	576_I	0.777	0.78
41_N	44_K	0.775	0.77
302_L	332_N	0.774	0.77
469_I	473_H	0.774	0.77
633_L	642_F	0.773	0.77
554_R	570_H	0.770	0.77
111_P	153_G	0.768	0.77
284_G	393_H	0.767	0.77
15_L	66_V	0.767	0.77
91_Q	100_H	0.764	0.76
366_L	370_V	0.764	0.76
305_V	309_L	0.763	0.76
428_K	432_K	0.761	0.76
249_K	279_T	0.759	0.76
524_E	588_E	0.757	0.76
252_Y	283_L	0.757	0.76
213_D	445_A	0.757	0.76
476_V	484_E	0.756	0.76
246_V	276_V	0.755	0.75
522_E	539_E	0.754	0.75
640_M	644_S	0.752	0.75
252_Y	272_E	0.752	0.75
113_S	149_R	0.752	0.75
418_G	424_L	0.747	0.75
393_H	400_R	0.746	0.75
551_A	571_A	0.745	0.75
338_V	383_P	0.745	0.75
252_Y	255_T	0.744	0.74
47_E	66_V	0.739	0.74
450_Y	457_I	0.739	0.74
158_G	229_R	0.739	0.74
111_P	152_L	0.739	0.74
70_I	78_L	0.737	0.74
342_L	386_E	0.737	0.74
334_H	386_E	0.736	0.74
330_G	423_Q	0.735	0.74
533_L	551_A	0.734	0.73
526_R	561_N	0.734	0.73
414_V	466_L	0.733	0.73
348_V	389_Y	0.730	0.73
351_P	356_I	0.729	0.73
37_K	42_D	0.727	0.73
418_G	464_I	0.726	0.73
278_L	281_H	0.726	0.73
580_A	604_A	0.725	0.73
104_D	121_H	0.724	0.72
460_V	469_I	0.724	0.72
586_L	590_L	0.724	0.72
121_H	128_I	0.724	0.72
603_L	621_S	0.724	0.72
63_G	95_K	0.723	0.72
547_Y	569_P	0.723	0.72
415_C	421_M	0.723	0.72
605_V	617_F	0.721	0.72
417_M	422_S	0.720	0.72
4_I	171_S	0.718	0.72
303_P	332_N	0.718	0.72
356_I	388_A	0.718	0.72
550_H	572_N	0.717	0.72
68_L	600_V	0.715	0.71
93_S	97_R	0.714	0.71
271_P	281_H	0.713	0.71
342_L	383_P	0.713	0.71
40_R	621_S	0.711	0.71
478_P	484_E	0.711	0.71
536_A	584_A	0.709	0.71
342_L	380_L	0.709	0.71
125_R	129_K	0.706	0.71
415_C	443_A	0.706	0.71
561_N	593_G	0.705	0.70
334_H	389_Y	0.704	0.70
537_L	542_Y	0.704	0.70
472_P	491_F	0.703	0.70
425_L	485_E	0.702	0.70
15_L	29_A	0.701	0.70
37_K	66_V	0.700	0.70
164_R	226_M	0.700	0.70
560_T	605_V	0.699	0.70
533_L	592_W	0.698	0.70
572_N	614_K	0.698	0.70
203_L	257_A	0.697	0.70
547_Y	552_V	0.697	0.70
632_K	635_K	0.696	0.69
350_N	387_A	0.695	0.69
524_E	586_L	0.695	0.69
583_I	601_F	0.693	0.69
325_Q	329_N	0.692	0.69
139_L	156_V	0.692	0.69
518_F	533_L	0.692	0.69
312_R	316_L	0.691	0.69
410_K	439_M	0.689	0.69
324_D	399_E	0.688	0.69
247_K	252_Y	0.688	0.69
348_V	385_E	0.688	0.69
562_I	623_L	0.687	0.68
480_L	484_E	0.687	0.68
102_A	156_V	0.686	0.68
113_S	150_Q	0.686	0.68
345_D	380_L	0.686	0.68
184_I	187_K	0.685	0.68
196_V	262_L	0.685	0.68
58_L	470_T	0.684	0.68
341_R	350_N	0.683	0.68
623_L	633_L	0.683	0.68
526_R	558_S	0.683	0.68
260_Q	263_E	0.683	0.68
330_G	393_H	0.683	0.68
252_Y	276_V	0.682	0.68
433_Y	496_G	0.680	0.68
246_V	252_Y	0.679	0.68
617_F	621_S	0.677	0.67
204_Q	445_A	0.675	0.67
531_E	549_V	0.674	0.67
18_E	27_D	0.674	0.67
563_G	592_W	0.674	0.67
4_I	49_Y	0.673	0.67
623_L	629_F	0.673	0.67
487_K	512_T	0.670	0.67
365_H	368_I	0.669	0.66
69_H	72_E	0.669	0.66
91_Q	96_E	0.668	0.66
411_A	459_L	0.667	0.66
460_V	471_V	0.667	0.66
44_K	66_V	0.666	0.66
7_R	11_I	0.666	0.66
160_E	163_K	0.664	0.66
144_L	166_A	0.663	0.66
252_Y	256_F	0.663	0.66
11_I	32_V	0.663	0.66
80_Q	84_T	0.662	0.66
352_M	389_Y	0.662	0.66
35_S	314_S	0.661	0.65
237_S	273_E	0.661	0.65
478_P	576_I	0.661	0.65
98_M	138_W	0.659	0.65
24_V	27_D	0.657	0.65
396_A	438_V	0.657	0.65
620_L	624_S	0.657	0.65
62_P	216_F	0.657	0.65
152_L	388_A	0.656	0.65
56_A	78_L	0.655	0.65
588_E	598_S	0.655	0.65
554_R	592_W	0.655	0.65
327_L	330_G	0.653	0.65
15_L	46_I	0.651	0.64
270_F	278_L	0.651	0.64
338_V	346_L	0.649	0.64
506_F	510_N	0.649	0.64
166_A	170_I	0.649	0.64
169_R	388_A	0.649	0.64
222_H	225_L	0.648	0.64
37_K	65_G	0.647	0.64
314_S	322_H	0.646	0.64
97_R	100_H	0.645	0.64
184_I	191_Y	0.645	0.64
101_I	139_L	0.643	0.63
330_G	395_Q	0.642	0.63
259_L	275_A	0.638	0.63
547_Y	606_K	0.636	0.62
113_S	129_K	0.636	0.62
520_Q	524_E	0.636	0.62
259_L	262_L	0.635	0.62
520_Q	584_A	0.634	0.62
584_A	602_M	0.633	0.62
557_M	592_W	0.633	0.62
199_E	262_L	0.633	0.62
129_K	154_L	0.633	0.62
114_A	128_I	0.632	0.62
100_H	104_D	0.630	0.62
249_K	283_L	0.629	0.62
200_I	204_Q	0.629	0.62
34_C	313_V	0.628	0.62
212_T	215_T	0.627	0.61
259_L	276_V	0.625	0.61
581_I	620_L	0.624	0.61
321_F	324_D	0.624	0.61
543_V	576_I	0.624	0.61
453_K	457_I	0.623	0.61
203_L	254_W	0.623	0.61
388_A	391_T	0.622	0.61
521_Q	586_L	0.622	0.61
146_L	383_P	0.621	0.61
554_R	602_M	0.621	0.61
113_S	151_R	0.620	0.61
118_A	123_V	0.619	0.60
508_M	515_F	0.616	0.60
551_A	592_W	0.616	0.60
78_L	81_Q	0.615	0.60
130_K	422_S	0.615	0.60
558_S	561_N	0.615	0.60
551_A	612_M	0.615	0.60
41_N	547_Y	0.615	0.60
374_I	378_F	0.614	0.60
259_L	266_F	0.613	0.60
530_I	560_T	0.611	0.59
321_F	398_I	0.611	0.59
330_G	397_A	0.611	0.59
561_N	567_A	0.610	0.59
129_K	148_S	0.610	0.59
302_L	377_T	0.609	0.59
153_G	418_G	0.609	0.59
410_K	440_A	0.608	0.59
231_K	267_A	0.608	0.59
192_E	228_R	0.608	0.59
430_E	434_H	0.607	0.59
156_V	545_K	0.606	0.59
392_L	396_A	0.606	0.59
223_T	331_L	0.605	0.59
40_R	445_A	0.605	0.59
444_K	466_L	0.602	0.58
568_I	581_I	0.602	0.58
62_P	66_V	0.602	0.58
377_T	380_L	0.602	0.58
53_H	56_A	0.600	0.58
130_K	133_Y	0.600	0.58
342_L	382_I	0.599	0.58
537_L	547_Y	0.599	0.58
132_L	154_L	0.599	0.58
525_H	531_E	0.598	0.58
25_V	60_R	0.598	0.58
486_K	588_E	0.597	0.58
429_I	461_I	0.596	0.58
98_M	121_H	0.596	0.58
576_I	580_A	0.595	0.57
485_E	496_G	0.595	0.57
397_A	401_M	0.595	0.57
45_V	48_D	0.595	0.57
28_F	42_D	0.593	0.57
215_T	285_G	0.593	0.57
599_L	604_A	0.593	0.57
350_N	360_Y	0.593	0.57
529_L	536_A	0.593	0.57
236_I	477_S	0.592	0.57
233_K	274_E	0.592	0.57
589_P	596_K	0.590	0.57
310_I	367_I	0.590	0.57
12_L	142_F	0.590	0.57
395_Q	419_I	0.588	0.57
446_D	449_D	0.588	0.57
368_I	558_S	0.586	0.56
18_E	22_Y	0.586	0.56
70_I	73_Q	0.586	0.56
14_L	413_I	0.585	0.56
34_C	43_L	0.585	0.56
353_L	385_E	0.584	0.56
263_E	266_F	0.583	0.56
609_D	613_T	0.583	0.56
351_P	418_G	0.582	0.56
259_L	268_I	0.582	0.56
263_E	270_F	0.582	0.56
29_A	286_K	0.582	0.56
545_K	549_V	0.582	0.56
313_V	318_M	0.581	0.56
94_D	97_R	0.580	0.55
195_F	266_F	0.580	0.55
599_L	642_F	0.579	0.55
134_A	137_E	0.579	0.55
11_I	328_I	0.579	0.55
140_K	145_T	0.579	0.55
351_P	388_A	0.578	0.55
102_A	310_I	0.577	0.55
216_F	220_L	0.577	0.55
592_W	606_K	0.576	0.55
408_H	424_L	0.576	0.55
396_A	399_E	0.575	0.55
277_Y	389_Y	0.575	0.55
410_K	458_D	0.574	0.55
557_M	561_N	0.574	0.55
632_K	641_T	0.574	0.55
317_K	576_I	0.573	0.55
337_T	340_Q	0.571	0.54
572_N	576_I	0.570	0.54
282_I	390_L	0.569	0.54
319_M	398_I	0.569	0.54
156_V	198_K	0.568	0.54
348_V	390_L	0.568	0.54
153_G	424_L	0.568	0.54
529_L	616_L	0.567	0.54
577_K	580_A	0.567	0.54
49_Y	53_H	0.565	0.54
316_L	370_V	0.564	0.53
371_L	391_T	0.564	0.53
281_H	337_T	0.564	0.53
113_S	434_H	0.564	0.53
323_K	401_M	0.564	0.53
41_N	125_R	0.563	0.53
537_L	541_G	0.563	0.53
124_N	127_S	0.562	0.53
554_R	571_A	0.562	0.53
601_F	604_A	0.560	0.53
34_C	41_N	0.560	0.53
284_G	346_L	0.560	0.53
57_Q	69_H	0.559	0.53
514_P	633_L	0.559	0.53
236_I	274_E	0.559	0.53
224_L	228_R	0.559	0.53
415_C	425_L	0.558	0.53
370_V	394_F	0.558	0.53
356_I	509_L	0.558	0.53
492_I	508_M	0.558	0.53
529_L	590_L	0.557	0.53
79_S	462_S	0.557	0.53
105_L	189_L	0.557	0.53
546_D	575_F	0.557	0.53
395_Q	399_E	0.556	0.52
419_I	422_S	0.556	0.52
200_I	258_C	0.555	0.52
113_S	337_T	0.555	0.52
255_T	278_L	0.554	0.52
115_K	152_L	0.554	0.52
107_M	163_K	0.554	0.52
356_I	391_T	0.554	0.52
536_A	539_E	0.554	0.52
433_Y	461_I	0.553	0.52
335_L	353_L	0.553	0.52
29_A	65_G	0.553	0.52
199_E	202_S	0.553	0.52
519_L	587_K	0.552	0.52
192_E	195_F	0.552	0.52
544_D	575_F	0.552	0.52
4_I	41_N	0.552	0.52
415_C	458_D	0.551	0.52
6_T	9_K	0.551	0.52
60_R	434_H	0.551	0.52
281_H	346_L	0.551	0.52
219_L	477_S	0.551	0.52
283_L	344_Y	0.550	0.52
561_N	595_E	0.549	0.52
623_L	634_T	0.549	0.52
528_K	532_Q	0.549	0.52
214_E	284_G	0.548	0.51
537_L	569_P	0.548	0.51
413_I	422_S	0.548	0.51
326_D	330_G	0.548	0.51
100_H	123_V	0.547	0.51
5_N	569_P	0.547	0.51
73_Q	78_L	0.546	0.51
462_S	468_N	0.545	0.51
145_T	354_N	0.545	0.51
68_L	78_L	0.544	0.51
324_D	393_H	0.544	0.51
105_L	146_L	0.544	0.51
569_P	599_L	0.544	0.51
532_Q	584_A	0.543	0.51
303_P	328_I	0.543	0.51
315_E	318_M	0.543	0.51
150_Q	411_A	0.543	0.51
416_H	444_K	0.542	0.51
253_Q	256_F	0.540	0.50
520_Q	523_A	0.540	0.50
168_A	281_H	0.540	0.50
214_E	223_T	0.539	0.50
22_Y	64_L	0.539	0.50
330_G	428_K	0.538	0.50
428_K	480_L	0.538	0.50
561_N	621_S	0.538	0.50
200_I	219_L	0.538	0.50
309_L	371_L	0.537	0.50
42_D	117_I	0.537	0.50
367_I	390_L	0.537	0.50
320_D	324_D	0.536	0.50
25_V	29_A	0.535	0.50
614_K	617_F	0.535	0.50
40_R	156_V	0.535	0.50
439_M	457_I	0.535	0.50
283_L	460_V	0.535	0.50
560_T	567_A	0.535	0.50
341_R	388_A	0.534	0.50
30_D	633_L	0.534	0.50
438_V	461_I	0.533	0.49
159_N	408_H	0.533	0.49
263_E	271_P	0.533	0.49
459_L	488_L	0.533	0.49
311_N	381_H	0.532	0.49
215_T	338_V	0.532	0.49
516_L	520_Q	0.531	0.49
539_E	640_M	0.531	0.49
37_K	249_K	0.531	0.49
24_V	594_N	0.531	0.49
77_W	486_K	0.530	0.49
605_V	613_T	0.530	0.49
200_I	623_L	0.530	0.49
613_T	616_L	0.528	0.49
42_D	620_L	0.527	0.49
601_F	623_L	0.526	0.49
476_V	485_E	0.526	0.49
284_G	480_L	0.526	0.49
88_S	528_K	0.525	0.48
341_R	345_D	0.525	0.48
104_D	117_I	0.524	0.48
132_L	146_L	0.524	0.48
215_T	218_S	0.523	0.48
123_V	363_L	0.523	0.48
160_E	234_Q	0.523	0.48
491_F	494_Q	0.523	0.48
593_G	597_V	0.522	0.48
429_I	488_L	0.522	0.48
144_L	508_M	0.522	0.48
193_V	224_L	0.521	0.48
338_V	390_L	0.521	0.48
256_F	306_V	0.521	0.48
246_V	279_T	0.521	0.48
195_F	199_E	0.521	0.48
317_K	369_D	0.521	0.48
629_F	634_T	0.521	0.48
263_E	275_A	0.520	0.48
120_R	195_F	0.520	0.48
25_V	40_R	0.520	0.48
238_L	243_M	0.519	0.48
196_V	310_I	0.518	0.48
196_V	199_E	0.518	0.48
154_L	313_V	0.517	0.47
144_L	638_N	0.517	0.47
222_H	389_Y	0.517	0.47
142_F	162_N	0.516	0.47
490_A	590_L	0.516	0.47
207_H	254_W	0.515	0.47
535_T	538_F	0.514	0.47
163_K	229_R	0.514	0.47
129_K	389_Y	0.513	0.47
316_L	366_L	0.513	0.47
254_W	416_H	0.513	0.47
413_I	461_I	0.513	0.47
338_V	348_V	0.512	0.47
421_M	557_M	0.512	0.47
105_L	156_V	0.512	0.47
460_V	472_P	0.511	0.47
592_W	602_M	0.511	0.47
164_R	277_Y	0.510	0.46
461_I	495_L	0.510	0.46
616_L	619_E	0.510	0.46
564_S	568_I	0.509	0.46
347_S	370_V	0.509	0.46
559_A	592_W	0.509	0.46
391_T	473_H	0.508	0.46
192_E	266_F	0.508	0.46
36_E	39_I	0.508	0.46
443_A	447_L	0.507	0.46
356_I	374_I	0.507	0.46
223_T	644_S	0.506	0.46
101_I	454_H	0.506	0.46
164_R	225_L	0.505	0.46
296_N	514_P	0.505	0.46
585_T	642_F	0.504	0.46
281_H	393_H	0.503	0.46
105_L	154_L	0.502	0.45
80_Q	297_L	0.502	0.45
26_Q	412_V	0.502	0.45
114_A	118_A	0.502	0.45
171_S	387_A	0.502	0.45
539_E	583_I	0.501	0.45
330_G	476_V	0.500	0.45
562_I	568_I	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4r6iA	2	0.7068	100	0.434	Contact Map
3sqnA	2	0.6991	100	0.487	Contact Map
1h99A	2	0.338	100	0.76	Contact Map
1a6jA	4	0.2315	100	0.793	Contact Map
3oxpA	2	0.2176	100	0.795	Contact Map
3bjvA	2	0.2191	100	0.797	Contact Map
2a0jA	1	0.2191	100	0.797	Contact Map
3urrA	2	0.2238	100	0.798	Contact Map
2oqtA	2	0.2207	100	0.798	Contact Map
2oq3A	1	0.2176	100	0.798	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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