GREMLIN Database
YJCR - Uncharacterized protein YjcR
UniProt: O31640 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 175 (167)
Sequences: 183 (153)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_R155_D4.0890.99
137_I166_R4.0610.99
18_Y33_K3.3240.98
18_Y30_N3.1980.97
135_E166_R3.1310.96
34_S38_R3.1200.96
29_V33_K2.6890.92
104_R112_D2.3280.85
160_S166_R2.3250.85
19_K30_N2.2700.83
161_F164_W2.2350.82
30_N33_K2.2130.81
8_A16_M2.1710.80
78_Q81_V2.1630.80
135_E160_S2.1460.79
142_K157_L2.1300.79
73_A79_N2.0600.76
109_M113_Q2.0580.76
8_A12_Y1.9660.73
5_H39_H1.8750.69
55_T60_Q1.8400.67
136_M160_S1.8190.67
64_K67_L1.7900.65
31_T38_R1.7680.64
6_I10_K1.7500.63
141_K157_L1.7290.62
12_Y15_G1.6960.61
19_K33_K1.6840.60
12_Y34_S1.6760.60
55_T59_G1.6460.58
66_A71_G1.6250.57
137_I160_S1.6060.57
21_L32_I1.5780.55
18_Y29_V1.5760.55
136_M166_R1.4720.50
9_Y12_Y1.4510.49
161_F165_F1.4030.46
58_G63_N1.3890.46
8_A15_G1.3740.45
33_K38_R1.3670.45
85_F101_I1.3500.44
16_M24_K1.3250.43
5_H9_Y1.3230.43
31_T34_S1.3120.42
120_A123_R1.3040.42
157_L160_S1.2750.40
132_D135_E1.2690.40
33_K37_Q1.2520.39
30_N37_Q1.1860.36
157_L162_S1.1750.35
141_K162_S1.1740.35
138_K141_K1.1740.35
7_Q11_D1.1690.35
5_H14_K1.1640.35
135_E139_E1.1570.35
9_Y13_V1.1570.35
30_N34_S1.1540.35
18_Y37_Q1.1460.34
16_M30_N1.1430.34
5_H12_Y1.1330.34
58_G65_N1.1270.33
9_Y34_S1.1210.33
21_L25_Y1.1140.33
8_A39_H1.1060.32
12_Y30_N1.0980.32
15_G30_N1.0950.32
136_M139_E1.0940.32
21_L35_W1.0930.32
33_K42_E1.0880.32
166_R169_L1.0880.32
27_V32_I1.0870.32
142_K155_D1.0800.31
159_I164_W1.0740.31
140_L160_S1.0740.31
67_L72_G1.0620.31
159_I165_F1.0600.30
12_Y31_T1.0580.30
18_Y34_S1.0520.30
109_M119_A1.0430.30
120_A174_N1.0320.29
146_L155_D1.0300.29
65_N68_G1.0180.29
15_G39_H1.0130.28
89_F110_I1.0020.28
22_A32_I0.9980.28
18_Y42_E0.9890.28
15_G34_S0.9840.27
123_R128_M0.9810.27
25_Y33_K0.9770.27
19_K29_V0.9740.27
11_D28_S0.9670.27
115_Q119_A0.9650.27
65_N74_P0.9650.27
19_K38_R0.9620.26
28_S31_T0.9590.26
141_K159_I0.9540.26
18_Y36_K0.9480.26
142_K160_S0.9350.25
8_A18_Y0.9260.25
34_S39_H0.9230.25
60_Q65_N0.9230.25
12_Y18_Y0.9200.25
18_Y27_V0.9170.25
5_H25_Y0.9040.24
66_A69_N0.9000.24
161_F168_R0.8900.24
155_D160_S0.8740.23
149_E155_D0.8700.23
140_L157_L0.8690.23
137_I141_K0.8690.23
86_F118_Y0.8640.23
25_Y39_H0.8640.23
97_I106_P0.8600.23
141_K144_R0.8530.22
66_A72_G0.8520.22
158_V162_S0.8490.22
7_Q16_M0.8450.22
136_M157_L0.8440.22
12_Y33_K0.8380.22
28_S37_Q0.8320.22
147_I155_D0.8260.22
136_M162_S0.8240.21
35_W39_H0.8200.21
31_T47_A0.8180.21
19_K42_E0.8080.21
138_K162_S0.8060.21
136_M141_K0.8040.21
17_K34_S0.7980.21
24_K34_S0.7960.21
135_E146_L0.7950.21
17_K20_D0.7840.20
30_N47_A0.7770.20
93_E98_M0.7670.20
157_L161_F0.7640.20
66_A73_A0.7600.19
74_P79_N0.7550.19
117_Q168_R0.7500.19
33_K36_K0.7470.19
23_E26_G0.7410.19
63_N74_P0.7400.19
5_H35_W0.7400.19
120_A128_M0.7360.19
24_K38_R0.7360.19
145_S156_G0.7280.18
32_I35_W0.7270.18
16_M20_D0.7230.18
17_K33_K0.7200.18
96_E100_E0.7190.18
104_R113_Q0.7190.18
5_H21_L0.7160.18
8_A32_I0.7160.18
112_D126_K0.7080.18
17_K38_R0.7080.18
81_V87_S0.7070.18
123_R174_N0.7060.18
128_M168_R0.6970.18
66_A74_P0.6960.17
3_E17_K0.6920.17
19_K34_S0.6890.17
111_W121_I0.6880.17
140_L155_D0.6850.17
10_K13_V0.6840.17
15_G18_Y0.6810.17
93_E120_A0.6790.17
20_D32_I0.6750.17
128_M174_N0.6740.17
48_P51_K0.6720.17
164_W168_R0.6690.17
82_T102_Q0.6680.17
69_N72_G0.6680.17
133_K138_K0.6670.17
5_H32_I0.6670.17
121_I128_M0.6620.17
139_E166_R0.6570.16
116_I120_A0.6550.16
24_K33_K0.6540.16
11_D39_H0.6540.16
29_V34_S0.6530.16
133_K141_K0.6480.16
87_S113_Q0.6470.16
62_G76_K0.6470.16
36_K42_E0.6450.16
63_N66_A0.6440.16
78_Q87_S0.6400.16
167_Y170_Y0.6380.16
85_F144_R0.6360.16
67_L79_N0.6360.16
145_S149_E0.6360.16
86_F126_K0.6310.16
80_A93_E0.6300.16
87_S119_A0.6270.16
11_D19_K0.6180.15
83_H113_Q0.6170.15
136_M142_K0.6150.15
125_Q174_N0.6140.15
95_L112_D0.6100.15
9_Y32_I0.6010.15
100_E126_K0.6000.15
133_K137_I0.6000.15
121_I124_A0.6000.15
15_G32_I0.5990.15
53_V57_K0.5990.15
141_K155_D0.5970.15
5_H8_A0.5970.15
12_Y38_R0.5950.15
5_H15_G0.5920.15
6_I9_Y0.5910.15
133_K166_R0.5910.15
11_D18_Y0.5890.15
162_S168_R0.5890.15
14_K39_H0.5840.14
5_H33_K0.5830.14
91_P121_I0.5820.14
9_Y57_K0.5790.14
34_S45_K0.5780.14
24_K29_V0.5760.14
160_S172_E0.5710.14
18_Y25_Y0.5680.14
19_K28_S0.5670.14
6_I14_K0.5670.14
30_N53_V0.5670.14
25_Y29_V0.5650.14
45_K52_S0.5610.14
144_R159_I0.5610.14
24_K47_A0.5550.14
26_G129_F0.5450.14
22_A36_K0.5440.14
132_D166_R0.5430.13
11_D24_K0.5400.13
27_V47_A0.5390.13
20_D35_W0.5370.13
170_Y174_N0.5360.13
62_G66_A0.5330.13
8_A11_D0.5330.13
141_K160_S0.5280.13
70_N86_F0.5280.13
8_A17_K0.5270.13
17_K28_S0.5260.13
7_Q10_K0.5180.13
149_E172_E0.5170.13
11_D15_G0.5140.13
28_S54_H0.5120.13
5_H13_V0.5120.13
108_D130_V0.5080.13
111_W130_V0.5040.13
159_I162_S0.5040.13
28_S34_S0.5030.13
38_R47_A0.5030.13
131_S143_K0.5020.13
131_S137_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mzyA 1 0.3143 95.6 0.915 Contact Map
2x48A 1 0.2171 94.8 0.919 Contact Map
2lfwA 1 0.36 94.6 0.92 Contact Map
1tc3C 1 0.2571 94.2 0.922 Contact Map
1jkoC 1 0.2114 92.6 0.926 Contact Map
2m8eA 1 0.2743 92.4 0.927 Contact Map
3korA 2 0.3257 91.6 0.928 Contact Map
1pdnC 1 0.5886 90.6 0.93 Contact Map
1xsvA 2 0.4914 90.6 0.93 Contact Map
1s7oA 3 0.5029 90.3 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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