GREMLIN Database
YJCL - Uncharacterized membrane protein YjcL
UniProt: O31634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (373)
Sequences: 620 (448)
Seq/√Len: 23.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_V53_V6.5461.00
261_S383_Y6.2261.00
105_T348_V4.3951.00
116_L317_I4.3741.00
132_A144_M4.1461.00
101_S347_T4.1131.00
176_I179_L3.9011.00
329_A333_F3.6651.00
100_I325_V3.6391.00
20_W46_G3.4311.00
275_E278_N3.1891.00
330_G340_I2.8370.99
128_G389_G2.7990.99
324_A332_L2.6200.99
323_L327_L2.5070.98
147_K386_T2.4320.98
15_G230_A2.3900.98
99_L380_I2.3570.98
258_V262_L2.3190.97
101_S104_G2.2410.97
130_I133_S2.2350.97
385_G388_M2.2000.96
133_S138_G2.1870.96
235_V258_V2.1820.96
148_F389_G2.1590.96
28_E39_G2.0930.95
74_A288_I2.0860.95
342_L370_I2.0540.95
106_V384_V1.9680.93
107_L237_G1.9260.92
14_W62_V1.9230.92
296_G355_A1.8960.92
140_N377_G1.8920.92
349_G354_A1.8700.91
184_R334_R1.8570.91
32_K35_S1.8550.91
345_N357_M1.8540.91
336_R339_E1.8030.90
223_G227_A1.7940.89
328_A332_L1.7510.88
27_L34_A1.7460.88
148_F390_N1.7030.87
327_L341_L1.7010.87
84_V99_L1.6850.86
322_N344_V1.6720.86
387_F391_W1.6300.84
134_Y166_M1.6260.84
189_P192_E1.6030.83
83_N86_Q1.5810.82
89_K184_R1.5770.82
144_M385_G1.5750.82
316_F320_I1.5690.82
112_A317_I1.5690.82
98_F350_G1.5650.82
88_F95_L1.5590.81
300_D303_L1.5570.81
84_V264_V1.5450.81
66_V290_L1.5450.81
16_F20_W1.5320.80
265_L269_L1.5220.80
50_F55_V1.5180.80
97_I335_V1.5110.79
265_L313_L1.5070.79
135_I318_I1.5050.79
211_K217_D1.4990.79
195_K198_G1.4870.78
144_M382_N1.4810.78
56_L297_I1.4800.78
84_V324_A1.4770.78
132_A388_M1.4770.78
150_T155_V1.4750.78
98_F135_I1.4570.77
84_V325_V1.4550.77
77_L225_A1.4530.76
134_Y159_V1.4510.76
111_L321_S1.4410.76
234_K238_Y1.4350.76
228_L262_L1.4310.75
386_T390_N1.4250.75
88_F92_R1.4240.75
169_L344_V1.4210.75
323_L348_V1.4150.75
165_M316_F1.4120.74
232_S259_L1.4070.74
197_D276_R1.4010.74
271_P276_R1.3970.74
264_V380_I1.3950.73
76_P228_L1.3850.73
28_E55_V1.3800.73
133_S159_V1.3750.72
184_R187_A1.3700.72
134_Y315_V1.3630.72
104_G325_V1.3610.72
321_S348_V1.3540.71
173_L378_Y1.3450.71
103_V258_V1.3420.70
349_G353_T1.3410.70
383_Y387_F1.3340.70
108_G322_N1.3290.70
327_L348_V1.3280.70
181_W184_R1.3060.68
177_P356_A1.2980.68
184_R324_A1.2960.68
353_T356_A1.2940.68
372_L376_L1.2860.67
105_T345_N1.2850.67
158_T312_L1.2850.67
162_D346_A1.2820.67
164_F311_I1.2810.67
91_S169_L1.2800.67
130_I158_T1.2670.66
84_V220_F1.2600.65
292_F363_W1.2550.65
157_A301_L1.2530.65
12_V107_L1.2500.65
145_A152_G1.2440.64
224_A274_F1.2370.64
284_G288_I1.2350.64
170_F345_N1.2270.63
178_A331_K1.2250.63
31_F34_A1.2240.63
263_T326_S1.2210.63
85_R89_K1.2180.63
38_S361_K1.2130.62
80_F263_T1.2040.62
274_F305_V1.1910.61
151_P312_L1.1850.61
111_L225_A1.1830.60
44_L67_W1.1800.60
242_I271_P1.1760.60
90_E373_V1.1660.59
225_A287_L1.1630.59
133_S295_I1.1620.59
99_L102_S1.1620.59
32_K331_K1.1620.59
219_A286_F1.1570.59
55_V83_N1.1500.58
228_L259_L1.1500.58
229_V288_I1.1480.58
284_G311_I1.1420.58
32_K119_H1.1420.58
21_A62_V1.1340.57
20_W106_V1.1330.57
132_A174_I1.1310.57
126_I158_T1.1270.57
319_A348_V1.1180.56
122_Y125_K1.1160.56
48_M299_A1.1120.56
168_L219_A1.1110.56
133_S162_D1.1090.55
99_L347_T1.1080.55
268_F372_L1.1020.55
130_I315_V1.0960.55
49_V98_F1.0880.54
325_V329_A1.0880.54
78_L170_F1.0860.54
107_L250_G1.0850.54
129_M141_F1.0810.53
33_W103_V1.0800.53
369_P373_V1.0700.53
78_L312_L1.0700.53
142_A315_V1.0650.52
103_V114_F1.0600.52
115_L317_I1.0560.52
116_L310_L1.0480.51
148_F386_T1.0450.51
18_A290_L1.0430.51
218_I283_L1.0400.51
130_I164_F1.0380.50
322_N326_S1.0370.50
115_L231_V1.0300.50
171_F336_R1.0260.50
304_I372_L1.0250.50
66_V294_V1.0220.49
14_W66_V1.0210.49
192_E235_V1.0200.49
323_L345_N1.0190.49
135_I384_V1.0180.49
83_N238_Y1.0150.49
141_F392_F1.0080.48
139_V353_T1.0080.48
346_A380_I1.0080.48
94_L104_G1.0050.48
115_L334_R1.0050.48
134_Y352_T1.0020.48
108_G112_A1.0020.48
35_S115_L0.9970.48
160_V379_L0.9910.47
78_L177_P0.9910.47
18_A22_A0.9890.47
132_A343_A0.9880.47
53_V312_L0.9860.47
235_V238_Y0.9850.47
112_A135_I0.9840.47
84_V222_A0.9840.47
104_G166_M0.9830.47
281_Q349_G0.9790.46
110_I392_F0.9750.46
92_R95_L0.9750.46
193_K365_E0.9720.46
82_I368_A0.9630.45
343_A354_A0.9610.45
78_L289_Y0.9600.45
177_P312_L0.9590.45
351_P375_T0.9580.45
51_T58_V0.9560.45
59_E387_F0.9540.45
182_F337_L0.9520.44
180_K223_G0.9490.44
18_A301_L0.9440.44
129_M142_A0.9400.44
151_P154_Y0.9390.44
127_G314_F0.9370.43
156_S217_D0.9280.43
138_G160_V0.9280.43
387_F390_N0.9250.43
168_L329_A0.9200.42
33_W192_E0.9170.42
98_F342_L0.9160.42
221_N283_L0.9160.42
41_I65_T0.9160.42
214_S306_T0.9130.42
55_V305_V0.9120.42
112_A393_S0.9080.41
313_L389_G0.9070.41
145_A296_G0.9050.41
125_K148_F0.9050.41
313_L348_V0.9030.41
122_Y215_L0.9020.41
207_Y325_V0.8980.41
79_L148_F0.8970.41
345_N353_T0.8910.40
114_F365_E0.8910.40
231_V234_K0.8910.40
115_L332_L0.8890.40
129_M134_Y0.8830.40
102_S128_G0.8800.40
45_A325_V0.8760.39
261_S382_N0.8740.39
205_E222_A0.8740.39
54_G83_N0.8690.39
52_N57_P0.8670.39
381_G385_G0.8660.39
262_L266_I0.8650.39
97_I333_F0.8630.38
313_L316_F0.8610.38
109_S318_I0.8580.38
205_E208_W0.8570.38
169_L353_T0.8560.38
145_A355_A0.8560.38
9_D234_K0.8550.38
13_L33_W0.8550.38
49_V184_R0.8540.38
111_L317_I0.8540.38
264_V379_L0.8530.38
72_P372_L0.8520.38
104_G108_G0.8510.38
120_I310_L0.8480.37
169_L341_L0.8470.37
108_G317_I0.8470.37
292_F353_T0.8460.37
101_S295_I0.8460.37
322_N349_G0.8450.37
103_V332_L0.8450.37
103_V204_A0.8430.37
351_P374_G0.8420.37
231_V235_V0.8400.37
96_F235_V0.8390.37
16_F224_A0.8380.37
16_F107_L0.8380.37
42_I138_G0.8360.37
125_K150_T0.8350.37
44_L355_A0.8330.37
56_L160_V0.8320.36
160_V163_N0.8280.36
346_A350_G0.8240.36
16_F304_I0.8230.36
110_I265_L0.8230.36
174_I260_T0.8230.36
310_L313_L0.8220.36
324_A328_A0.8190.36
76_P169_L0.8190.36
9_D283_L0.8170.35
323_L357_M0.8140.35
23_V107_L0.8090.35
134_Y338_E0.8080.35
258_V317_I0.8060.35
160_V303_L0.8050.35
209_K212_D0.8050.35
79_L145_A0.8040.35
348_V365_E0.8030.35
115_L153_E0.8010.34
35_S239_F0.8000.34
48_M301_L0.7970.34
55_V203_S0.7960.34
129_M144_M0.7900.34
341_L345_N0.7900.34
20_W158_T0.7900.34
235_V305_V0.7900.34
45_A150_T0.7890.34
76_P91_S0.7890.34
225_A229_V0.7880.34
30_R333_F0.7850.33
26_G111_L0.7830.33
35_S290_L0.7810.33
235_V276_R0.7810.33
42_I312_L0.7810.33
156_S376_L0.7810.33
57_P297_I0.7780.33
35_S333_F0.7770.33
125_K131_S0.7740.33
166_M349_G0.7740.33
48_M173_L0.7710.33
221_N277_L0.7710.33
74_A296_G0.7700.33
76_P80_F0.7690.32
47_A293_V0.7690.32
204_A208_W0.7690.32
149_E274_F0.7690.32
134_Y291_F0.7670.32
71_V229_V0.7670.32
302_R348_V0.7670.32
139_V163_N0.7670.32
142_A386_T0.7660.32
150_T332_L0.7660.32
127_G392_F0.7630.32
75_I158_T0.7620.32
124_D389_G0.7610.32
113_F375_T0.7610.32
173_L260_T0.7590.32
103_V321_S0.7590.32
300_D376_L0.7580.32
292_F374_G0.7560.32
45_A153_E0.7540.32
287_L290_L0.7530.31
54_G321_S0.7510.31
78_L160_V0.7500.31
51_T300_D0.7500.31
131_S317_I0.7480.31
97_I340_I0.7450.31
261_S380_I0.7440.31
37_V331_K0.7420.31
148_F319_A0.7410.31
155_V262_L0.7400.31
172_I319_A0.7390.31
210_R214_S0.7370.31
145_A380_I0.7350.30
91_S361_K0.7350.30
210_R391_W0.7320.30
75_I266_I0.7320.30
113_F392_F0.7270.30
204_A329_A0.7250.30
77_L221_N0.7250.30
327_L340_I0.7240.30
274_F342_L0.7190.29
133_S315_V0.7190.29
21_A44_L0.7170.29
263_T356_A0.7160.29
168_L392_F0.7140.29
264_V304_I0.7140.29
82_I268_F0.7130.29
270_F348_V0.7110.29
147_K254_D0.7100.29
142_A176_I0.7080.29
32_K164_F0.7070.29
100_I320_I0.7050.29
256_Y389_G0.7040.29
175_S179_L0.7030.29
92_R236_S0.6930.28
101_S357_M0.6930.28
172_I283_L0.6920.28
113_F117_K0.6910.28
38_S254_D0.6870.28
196_A200_S0.6870.28
264_V329_A0.6830.27
231_V332_L0.6820.27
103_V224_A0.6810.27
17_I110_I0.6810.27
70_V370_I0.6790.27
322_N347_T0.6780.27
168_L324_A0.6780.27
345_N363_W0.6770.27
125_K360_A0.6750.27
32_K184_R0.6720.27
82_I372_L0.6700.27
170_F357_M0.6670.27
38_S368_A0.6640.26
168_L228_L0.6640.26
98_F102_S0.6620.26
19_V23_V0.6620.26
24_S34_A0.6620.26
361_K369_P0.6600.26
23_V262_L0.6600.26
129_M288_I0.6590.26
32_K187_A0.6570.26
14_W35_S0.6570.26
164_F168_L0.6540.26
26_G231_V0.6520.26
18_A283_L0.6520.26
57_P127_G0.6510.26
18_A234_K0.6440.25
111_L324_A0.6430.25
231_V262_L0.6420.25
67_W294_V0.6420.25
196_A320_I0.6410.25
156_S186_Y0.6410.25
44_L134_Y0.6390.25
317_I321_S0.6370.25
80_F274_F0.6370.25
139_V352_T0.6360.25
343_A349_G0.6360.25
323_L340_I0.6350.25
70_V290_L0.6330.25
169_L323_L0.6330.25
15_G316_F0.6320.25
37_V300_D0.6320.25
196_A258_V0.6310.25
74_A138_G0.6270.24
257_L379_L0.6270.24
193_K333_F0.6240.24
162_D381_G0.6220.24
53_V283_L0.6220.24
160_V340_I0.6190.24
249_T386_T0.6170.24
93_R309_P0.6170.24
76_P294_V0.6160.24
132_A338_E0.6150.24
162_D295_I0.6140.24
330_G333_F0.6140.24
75_I268_F0.6130.24
85_R287_L0.6120.24
234_K321_S0.6120.24
98_F346_A0.6120.24
384_V391_W0.6120.24
95_L391_W0.6110.24
292_F356_A0.6100.24
93_R339_E0.6080.23
103_V117_K0.6080.23
108_G321_S0.6080.23
94_L289_Y0.6070.23
173_L214_S0.6070.23
295_I338_E0.6070.23
226_F256_Y0.6060.23
184_R340_I0.6060.23
86_Q379_L0.6040.23
17_I346_A0.6030.23
341_L357_M0.6030.23
202_N324_A0.6020.23
176_I337_L0.6020.23
274_F277_L0.6010.23
205_E209_K0.5980.23
132_A165_M0.5980.23
77_L104_G0.5980.23
345_N361_K0.5970.23
223_G236_S0.5960.23
75_I142_A0.5950.23
17_I297_I0.5950.23
266_I387_F0.5940.23
41_I299_A0.5940.23
96_F99_L0.5920.23
166_M357_M0.5890.23
142_A337_L0.5870.22
87_I337_L0.5870.22
122_Y151_P0.5860.22
39_G356_A0.5860.22
285_T348_V0.5840.22
150_T154_Y0.5810.22
92_R96_F0.5800.22
259_L384_V0.5800.22
213_I280_S0.5790.22
386_T389_G0.5770.22
256_Y290_L0.5760.22
16_F286_F0.5760.22
97_I262_L0.5760.22
196_A325_V0.5760.22
71_V295_I0.5750.22
305_V376_L0.5720.22
138_G354_A0.5710.22
63_Y177_P0.5710.22
26_G55_V0.5700.22
190_F195_K0.5690.22
30_R45_A0.5660.21
237_G241_S0.5640.21
67_W134_Y0.5630.21
292_F354_A0.5590.21
216_K220_F0.5570.21
241_S312_L0.5550.21
228_L283_L0.5540.21
237_G283_L0.5540.21
26_G264_V0.5530.21
102_S347_T0.5510.21
33_W325_V0.5510.21
100_I340_I0.5500.21
166_M170_F0.5490.21
135_I260_T0.5460.20
41_I166_M0.5460.20
107_L233_M0.5450.20
133_S349_G0.5440.20
264_V372_L0.5430.20
163_N173_L0.5420.20
292_F326_S0.5420.20
165_M171_F0.5400.20
168_L208_W0.5400.20
338_E361_K0.5400.20
141_F355_A0.5380.20
50_F232_S0.5360.20
305_V327_L0.5350.20
186_Y330_G0.5340.20
356_A369_P0.5340.20
15_G155_V0.5340.20
342_L366_L0.5340.20
105_T356_A0.5330.20
89_K114_F0.5330.20
224_A227_A0.5330.20
206_S222_A0.5330.20
81_Q111_L0.5320.20
342_L357_M0.5320.20
202_N367_V0.5300.20
23_V46_G0.5300.20
103_V241_S0.5290.20
217_D313_L0.5280.20
155_V270_F0.5270.20
152_G298_P0.5260.20
313_L380_I0.5250.20
22_A142_A0.5250.20
111_L265_L0.5240.20
177_P277_L0.5230.19
174_I289_Y0.5230.19
80_F221_N0.5210.19
211_K283_L0.5190.19
336_R341_L0.5170.19
259_L275_E0.5170.19
13_L57_P0.5170.19
102_S132_A0.5160.19
9_D302_R0.5160.19
129_M322_N0.5150.19
170_F370_I0.5140.19
342_L371_M0.5130.19
388_M391_W0.5130.19
52_N261_S0.5130.19
323_L341_L0.5110.19
263_T355_A0.5110.19
229_V381_G0.5100.19
55_V370_I0.5090.19
41_I146_A0.5080.19
88_F265_L0.5080.19
240_K389_G0.5080.19
157_A160_V0.5070.19
13_L44_L0.5060.19
274_F383_Y0.5060.19
105_T127_G0.5050.19
144_M155_V0.5050.19
182_F379_L0.5040.19
106_V391_W0.5030.19
148_F182_F0.5030.19
16_F219_A0.5030.19
213_I217_D0.5030.19
112_A314_F0.5030.19
37_V206_S0.5000.18
115_L265_L0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cz8A 2 0.8712 98 0.917 Contact Map
4czbA 2 0.8712 98 0.918 Contact Map
4bwzA 2 0.8939 97.7 0.923 Contact Map
3zuxA 1 0.7576 94.7 0.944 Contact Map
4n7wA 2 0.7399 92.9 0.948 Contact Map
1pw4A 1 0.8384 42.4 0.967 Contact Map
1zcdA 1 0.4419 25.2 0.971 Contact Map
3qapA 1 0.4571 14.6 0.974 Contact Map
3o7qA 1 0.899 11.6 0.975 Contact Map
2cfqA 1 0.846 8.9 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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