GREMLIN Database
METC - Cystathionine beta-lyase MetC
UniProt: O31632 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 390 (377)
Sequences: 10611 (5839)
Seq/√Len: 300.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_R188_D3.3611.00
95_H122_T3.1431.00
133_A167_E3.0201.00
269_Q284_D3.0001.00
70_G214_A2.9971.00
69_G188_D2.9091.00
378_E382_K2.8481.00
9_E369_H2.7961.00
275_K307_E2.6791.00
262_Q266_E2.6761.00
7_T369_H2.5761.00
95_H137_K2.5171.00
64_I212_L2.4311.00
322_P333_S2.4231.00
348_K352_E2.3821.00
159_K293_S2.3371.00
159_K163_Q2.3291.00
276_R305_E2.3241.00
288_A292_K2.2481.00
142_V173_F2.2271.00
11_Q66_A2.2051.00
267_F374_E2.1981.00
267_F378_E2.1341.00
255_E259_Q2.1121.00
183_L258_S2.1001.00
162_V172_T1.9961.00
129_R160_A1.9841.00
156_T161_V1.9291.00
58_T62_E1.9171.00
236_G239_D1.9161.00
166_K192_D1.9131.00
128_D131_E1.9051.00
120_E137_K1.8941.00
9_E251_Q1.8841.00
305_E359_G1.8821.00
60_L243_V1.8461.00
198_A210_S1.8431.00
94_D141_K1.8301.00
264_L374_E1.8201.00
256_K259_Q1.8171.00
201_F300_A1.8001.00
337_Y340_T1.7931.00
91_S116_R1.7911.00
174_L191_V1.7881.00
163_Q167_E1.7701.00
122_T137_K1.7211.00
166_K172_T1.6881.00
351_R358_D1.6821.00
348_K358_D1.6751.00
8_L182_A1.6721.00
73_G214_A1.6691.00
257_A300_A1.6681.00
370_A374_E1.6541.00
263_R370_A1.6531.00
260_T370_A1.6471.00
130_N133_A1.6451.00
39_S43_E1.6131.00
263_R374_E1.6071.00
57_R240_C1.6011.00
218_E222_K1.5991.00
124_V135_S1.5911.00
98_V110_V1.5831.00
266_E283_A1.5811.00
305_E357_T1.5771.00
95_H120_E1.5771.00
76_F85_T1.5661.00
70_G187_L1.5641.00
143_I161_V1.5541.00
319_V335_L1.5461.00
129_R164_L1.5431.00
68_E196_H1.5401.00
47_Y53_G1.5381.00
263_R266_E1.5361.00
318_N383_E1.5321.00
185_R296_T1.5311.00
314_K318_N1.5291.00
172_T191_V1.5231.00
7_T371_D1.5131.00
86_A173_F1.5101.00
133_A168_N1.4941.00
306_L315_L1.4671.00
309_K313_K1.4671.00
143_I165_A1.4651.00
347_P350_E1.4491.00
320_S379_Q1.4421.00
160_A163_Q1.4291.00
95_H140_T1.4211.00
15_N66_A1.4191.00
267_F271_H1.4161.00
275_K359_G1.4161.00
263_R371_D1.4071.00
210_S235_L1.4071.00
264_L365_V1.4051.00
178_F328_L1.4001.00
65_A73_G1.3931.00
32_H238_Q1.3891.00
198_A243_V1.3821.00
309_K358_D1.3791.00
72_R221_G1.3731.00
60_L75_A1.3731.00
322_P377_F1.3581.00
7_T375_H1.3561.00
136_I170_C1.3551.00
136_I143_I1.3501.00
73_G212_L1.3491.00
198_A212_L1.3451.00
83_I144_Y1.3421.00
95_H139_N1.3401.00
283_A288_A1.3381.00
40_S43_E1.3371.00
47_Y58_T1.3351.00
252_V367_V1.3341.00
275_K305_E1.3331.00
84_S88_L1.3251.00
271_H378_E1.3231.00
28_V59_A1.3221.00
159_K294_Q1.3111.00
60_L212_L1.3101.00
235_L240_C1.3101.00
162_V166_K1.3061.00
91_S94_D1.3041.00
87_F110_V1.2941.00
87_F142_V1.2811.00
145_M158_I1.2741.00
86_A193_I1.2691.00
98_V102_V1.2681.00
264_L377_F1.2671.00
254_L257_A1.2661.00
130_N134_R1.2631.00
145_M172_T1.2561.00
157_D160_A1.2501.00
136_I164_L1.2461.00
90_L96_V1.2451.00
120_E139_N1.2431.00
8_L185_R1.2301.00
71_T218_E1.2271.00
184_Q189_L1.2261.00
322_P373_L1.2251.00
292_K298_A1.2181.00
335_L361_L1.2161.00
162_V191_V1.2131.00
74_F221_G1.2111.00
173_F195_L1.2071.00
85_T233_A1.2061.00
40_S317_E1.1991.00
363_L377_F1.1981.00
76_F213_A1.1971.00
64_I214_A1.1911.00
86_A213_A1.1891.00
260_T367_V1.1771.00
321_L373_L1.1771.00
303_S360_L1.1701.00
264_L373_L1.1681.00
81_A233_A1.1681.00
251_Q255_E1.1651.00
208_V243_V1.1641.00
261_A265_A1.1621.00
269_Q282_L1.1601.00
258_S297_G1.1581.00
159_K189_L1.1581.00
281_G298_A1.1571.00
110_V121_H1.1541.00
265_A282_L1.1501.00
37_H323_V1.1491.00
153_L280_P1.1371.00
289_E292_K1.1361.00
213_A224_L1.1341.00
111_T123_F1.1341.00
256_K260_T1.1341.00
198_A202_L1.1331.00
12_L251_Q1.1301.00
288_A298_A1.1251.00
203_S208_V1.1221.00
331_V367_V1.1201.00
97_L135_S1.1171.00
132_V161_V1.1151.00
202_L247_L1.1071.00
171_L220_L1.1071.00
42_E317_E1.1051.00
100_E154_G1.0971.00
136_I168_N1.0871.00
165_A172_T1.0831.00
215_V221_G1.0831.00
266_E269_Q1.0821.00
287_G290_T1.0781.00
208_V239_D1.0761.00
87_F90_L1.0751.00
163_Q166_K1.0731.00
259_Q263_R1.0711.00
64_I202_L1.0671.00
207_D245_R1.0671.00
74_F225_Y1.0661.00
131_E134_R1.0571.00
374_E378_E1.0511.00
291_H298_A1.0501.00
111_T115_T1.0501.00
72_R218_E1.0481.00
153_L302_L1.0461.00
133_A164_L1.0451.00
143_I170_C1.0451.00
42_E313_K1.0381.00
195_L213_A1.0311.00
264_L370_A1.0301.00
210_S243_V1.0241.00
26_V323_V1.0231.00
183_L297_G1.0181.00
350_E353_K1.0171.00
252_V256_K1.0151.00
63_T244_L1.0151.00
72_R225_Y1.0071.00
58_T61_E1.0061.00
85_T227_L1.0011.00
375_H378_E0.9991.00
308_S311_A0.9981.00
41_F317_E0.9961.00
127_T287_G0.9961.00
90_L94_D0.9941.00
63_T247_L0.9931.00
265_A277_V0.9901.00
289_E293_S0.9881.00
84_S109_M0.9841.00
74_F224_L0.9761.00
238_Q242_L0.9761.00
258_S262_Q0.9751.00
311_A359_G0.9711.00
52_S229_N0.9701.00
288_A291_H0.9691.00
278_Y305_E0.9611.00
71_T217_D0.9611.00
83_I195_L0.9591.00
126_M132_V0.9541.00
310_E314_K0.9541.00
187_L194_V0.9531.00
145_M174_L0.9501.00
267_F381_L0.9491.00
206_S330_A0.9481.00
78_S209_L0.9461.00
285_H288_A0.9441.00
315_L361_L0.9431.00
158_I191_V0.9421.00
98_V123_F0.9391.00
57_R235_L0.9351.00
203_S243_V0.9341.00
179_M295_S0.9341.00
315_L377_F0.9341.00
88_L117_F0.9311.00
69_G185_R0.9311.00
219_E223_Q0.9251.00
107_F111_T0.9251.00
80_M83_I0.9231.00
76_F228_Q0.9211.00
315_L335_L0.9191.00
304_F363_L0.9161.00
181_P196_H0.9161.00
24_G39_S0.9131.00
178_F301_V0.9121.00
145_M156_T0.9111.00
376_D379_Q0.9111.00
144_Y173_F0.9101.00
339_A351_R0.9071.00
251_Q256_K0.9061.00
13_V367_V0.9041.00
101_D154_G0.9021.00
122_T135_S0.9011.00
158_I162_V0.8941.00
125_D131_E0.8901.00
322_P363_L0.8891.00
264_L363_L0.8871.00
199_T209_L0.8861.00
98_V121_H0.8811.00
273_A307_E0.8791.00
165_A170_C0.8781.00
182_A255_E0.8771.00
30_I238_Q0.8701.00
75_A212_L0.8691.00
261_A279_Y0.8671.00
158_I184_Q0.8671.00
271_H381_L0.8631.00
18_K62_E0.8611.00
268_F304_F0.8561.00
57_R75_A0.8561.00
379_Q383_E0.8551.00
266_E282_L0.8551.00
9_E256_K0.8531.00
158_I189_L0.8511.00
115_T120_E0.8511.00
216_K219_E0.8501.00
50_S57_R0.8491.00
155_I287_G0.8461.00
248_K332_E0.8461.00
142_V171_L0.8421.00
161_V172_T0.8361.00
89_L220_L0.8351.00
371_D375_H0.8331.00
20_D23_T0.8331.00
316_V335_L0.8281.00
313_K317_E0.8271.00
116_R223_Q0.8271.00
145_M161_V0.8271.00
28_V244_L0.8231.00
262_Q297_G0.8231.00
86_A195_L0.8231.00
144_Y195_L0.8221.00
198_A235_L0.8201.00
273_A381_L0.8151.00
182_A254_L0.8121.00
262_Q279_Y0.8101.00
129_R133_A0.8091.00
84_S231_F0.8081.00
276_R359_G0.8041.00
148_P184_Q0.8031.00
251_Q369_H0.8021.00
318_N380_A0.8021.00
310_E313_K0.8011.00
11_Q15_N0.7981.00
271_H382_K0.7971.00
193_I213_A0.7941.00
30_I241_W0.7900.99
76_F81_A0.7870.99
10_T321_L0.7860.99
322_P335_L0.7850.99
184_Q294_Q0.7840.99
90_L142_V0.7840.99
112_E226_K0.7800.99
90_L119_I0.7780.99
302_L363_L0.7760.99
164_L168_N0.7750.99
86_A89_L0.7700.99
155_I290_T0.7670.99
260_T264_L0.7660.99
97_L124_V0.7640.99
126_M156_T0.7630.99
148_P294_Q0.7590.99
311_A314_K0.7580.99
193_I215_V0.7580.99
202_L243_V0.7560.99
96_V142_V0.7550.99
266_E270_K0.7540.99
263_R267_F0.7530.99
371_D374_E0.7490.99
262_Q269_Q0.7480.99
25_A31_Q0.7460.99
91_S141_K0.7420.99
348_K351_R0.7420.99
196_H214_A0.7410.99
8_L11_Q0.7380.99
259_Q370_A0.7350.99
193_I220_L0.7340.99
278_Y285_H0.7310.99
260_T365_V0.7300.99
235_L243_V0.7290.99
267_F377_F0.7270.99
333_S363_L0.7230.99
96_V110_V0.7220.99
316_V361_L0.7210.99
94_D139_N0.7210.99
183_L254_L0.7180.99
166_K170_C0.7160.99
129_R132_V0.7140.99
97_L140_T0.7130.99
157_D293_S0.7090.99
149_S154_G0.7080.99
258_S300_A0.7070.99
322_P365_V0.7050.99
315_L319_V0.7050.99
60_L198_A0.7030.99
77_S233_A0.7020.99
32_H208_V0.7000.99
95_H138_P0.7000.99
219_E222_K0.6980.99
124_V131_E0.6980.99
131_E135_S0.6970.99
68_E194_V0.6950.99
295_S298_A0.6950.99
72_R215_V0.6930.99
48_D52_S0.6930.99
273_A311_A0.6910.99
189_L294_Q0.6890.99
106_T144_Y0.6890.99
223_Q226_K0.6880.99
238_Q241_W0.6870.99
60_L202_L0.6860.99
202_L250_L0.6850.99
90_L141_K0.6850.99
262_Q281_G0.6820.99
64_I75_A0.6800.98
274_V304_F0.6790.98
155_I291_H0.6770.98
71_T216_K0.6760.98
71_T215_V0.6750.98
85_T213_A0.6730.98
242_L245_R0.6730.98
75_A235_L0.6730.98
149_S152_T0.6710.98
279_Y302_L0.6670.98
176_N186_P0.6650.98
154_G287_G0.6620.98
92_Q118_G0.6620.98
375_H379_Q0.6600.98
64_I198_A0.6540.98
273_A382_K0.6520.98
110_V144_Y0.6510.98
88_L231_F0.6510.98
264_L267_F0.6510.98
53_G58_T0.6500.98
183_L296_T0.6490.98
176_N179_M0.6460.98
8_L12_L0.6450.98
176_N196_H0.6440.98
122_T139_N0.6440.98
74_F213_A0.6430.98
160_A164_L0.6400.98
32_H241_W0.6400.98
76_F233_A0.6370.98
127_T154_G0.6340.98
27_S241_W0.6340.98
173_F193_I0.6340.98
258_S298_A0.6330.98
158_I172_T0.6320.98
147_T176_N0.6310.98
124_V132_V0.6310.98
349_E353_K0.6310.98
62_E66_A0.6300.98
278_Y303_S0.6300.98
89_L173_F0.6300.98
315_L381_L0.6290.97
380_A383_E0.6280.97
273_A306_L0.6280.97
148_P179_M0.6280.97
314_K317_E0.6270.97
290_T293_S0.6270.97
304_F361_L0.6260.97
290_T294_Q0.6250.97
377_F381_L0.6240.97
96_V121_H0.6230.97
274_V381_L0.6220.97
155_I285_H0.6220.97
20_D31_Q0.6210.97
143_I166_K0.6200.97
35_T327_S0.6200.97
20_D25_A0.6170.97
77_S234_V0.6170.97
78_S234_V0.6160.97
59_A244_L0.6160.97
132_V143_I0.6150.97
23_T31_Q0.6140.97
318_N379_Q0.6130.97
99_T126_M0.6130.97
108_R112_E0.6130.97
235_L239_D0.6110.97
339_A358_D0.6100.97
101_D149_S0.6100.97
133_A160_A0.6090.97
265_A302_L0.6040.97
181_P202_L0.6040.97
33_A36_F0.6030.97
143_I164_L0.6020.97
314_K383_E0.6000.97
83_I106_T0.5990.97
128_D134_R0.5970.97
315_L380_A0.5970.97
221_G225_Y0.5960.97
352_E357_T0.5950.96
307_E311_A0.5950.96
61_E225_Y0.5940.96
259_Q297_G0.5940.96
61_E75_A0.5920.96
312_V359_G0.5920.96
209_L234_V0.5900.96
60_L244_L0.5880.96
335_L363_L0.5880.96
179_M291_H0.5870.96
333_S373_L0.5870.96
201_F301_V0.5860.96
11_Q69_G0.5860.96
281_G288_A0.5860.96
113_V227_L0.5840.96
35_T325_A0.5830.96
71_T221_G0.5820.96
270_K378_E0.5820.96
85_T231_F0.5820.96
100_E125_D0.5800.96
349_E352_E0.5790.96
305_E360_L0.5770.96
196_H212_L0.5740.96
134_R138_P0.5740.96
58_T72_R0.5730.96
215_V220_L0.5730.96
113_V230_A0.5720.96
26_V37_H0.5720.96
165_A168_N0.5720.96
319_V322_P0.5720.96
107_F123_F0.5710.96
136_I140_T0.5690.95
326_V336_S0.5680.95
97_L126_M0.5680.95
257_A260_T0.5670.95
301_V328_L0.5660.95
208_V246_G0.5660.95
306_L381_L0.5650.95
114_L119_I0.5590.95
39_S45_G0.5590.95
220_L223_Q0.5570.95
88_L114_L0.5550.95
265_A281_G0.5550.95
14_H323_V0.5540.95
320_S383_E0.5530.95
158_I174_L0.5520.95
248_K331_V0.5520.95
7_T11_Q0.5510.95
147_T184_Q0.5510.95
61_E73_G0.5510.95
333_S377_F0.5500.95
313_K340_T0.5500.95
262_Q282_L0.5500.95
111_T350_E0.5500.95
32_H236_G0.5500.95
228_Q234_V0.5460.94
335_L377_F0.5460.94
255_E258_S0.5460.94
97_L122_T0.5450.94
346_M354_R0.5430.94
125_D128_D0.5420.94
41_F313_K0.5410.94
352_E358_D0.5380.94
8_L251_Q0.5370.94
282_L288_A0.5360.94
19_T37_H0.5360.94
86_A142_V0.5350.94
269_Q285_H0.5340.94
182_A251_Q0.5320.94
100_E353_K0.5300.93
89_L223_Q0.5300.93
74_F228_Q0.5300.93
347_P351_R0.5300.93
312_V337_Y0.5260.93
159_K188_D0.5250.93
275_K306_L0.5250.93
205_H245_R0.5240.93
179_M184_Q0.5240.93
166_K169_G0.5230.93
23_T47_Y0.5230.93
325_A334_I0.5220.93
164_L167_E0.5170.93
184_Q295_S0.5170.93
56_T244_L0.5160.93
83_I86_A0.5160.93
54_T57_R0.5150.92
65_A72_R0.5140.92
258_S261_A0.5120.92
153_L303_S0.5110.92
260_T263_R0.5110.92
346_M350_E0.5100.92
113_V231_F0.5090.92
122_T140_T0.5090.92
156_T290_T0.5080.92
291_H295_S0.5050.92
317_E324_F0.5030.92
267_F270_K0.5030.92
267_F370_A0.5020.92
201_F257_A0.5010.91
86_A220_L0.5010.91
306_L311_A0.5010.91
219_E224_L0.5000.91
41_F316_V0.5000.91
320_S376_D0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibjA 4 0.9744 100 0.381 Contact Map
1qgnA 4 0.9795 100 0.409 Contact Map
3ri6A 4 0.8487 100 0.428 Contact Map
3cogA 4 0.9923 100 0.429 Contact Map
4iy7A 4 0.9744 100 0.436 Contact Map
4kamA 4 0.9128 100 0.453 Contact Map
4itxA 4 0.9667 100 0.459 Contact Map
1e5eA 4 0.9795 100 0.461 Contact Map
3ndnA 4 0.9692 100 0.49 Contact Map
4oc9A 5 0.9692 100 0.493 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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