GREMLIN Database
METI - Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase
UniProt: O31631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (361)
Sequences: 10451 (5693)
Seq/√Len: 299.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_R185_E3.4941.00
92_E119_H3.2721.00
67_G211_V3.1451.00
130_R164_E3.1241.00
66_N185_E2.8951.00
359_K363_C2.8911.00
6_E350_H2.8811.00
259_Q263_A2.8181.00
92_E134_T2.7061.00
272_S288_Q2.5901.00
303_I314_S2.5801.00
61_I209_L2.4601.00
4_H350_H2.4001.00
139_A170_I2.3981.00
273_D286_R2.3911.00
156_E160_R2.3821.00
329_E333_I2.3801.00
264_F355_K2.2911.00
180_L255_Q2.2701.00
8_K63_N2.2021.00
252_R256_A2.1401.00
264_F359_K2.1371.00
159_A169_L2.0681.00
153_A158_I2.0261.00
233_P236_D1.9931.00
125_D128_C1.9741.00
318_Y321_T1.9661.00
286_R340_R1.9621.00
117_T134_T1.9621.00
126_E157_H1.9501.00
195_A207_A1.9471.00
163_K189_D1.9351.00
198_Y281_G1.9211.00
57_V240_L1.9101.00
55_Q59_D1.9041.00
6_E248_S1.9021.00
91_D138_K1.8991.00
261_L355_K1.8921.00
171_V188_A1.8561.00
253_Q256_A1.8241.00
119_H134_T1.8121.00
163_K169_L1.7971.00
88_K113_K1.7961.00
160_R164_E1.7671.00
254_H281_G1.7661.00
70_G211_V1.7511.00
5_V179_V1.7391.00
351_A355_K1.7201.00
332_R339_N1.6951.00
127_D130_R1.6951.00
257_N351_A1.6791.00
329_E339_N1.6631.00
54_R237_S1.6571.00
260_E351_A1.6541.00
65_E193_H1.6531.00
169_L188_A1.6281.00
300_L316_I1.6271.00
260_E263_A1.6201.00
260_E355_K1.6191.00
92_E117_T1.6151.00
126_E161_I1.6151.00
95_V107_F1.6131.00
140_V158_I1.6101.00
44_F50_K1.5991.00
286_R338_C1.5931.00
92_E137_T1.5721.00
295_P299_A1.5701.00
67_G184_L1.5691.00
121_D132_K1.5621.00
140_V162_T1.5351.00
287_L296_F1.5321.00
299_A364_Q1.5021.00
215_E219_E1.4971.00
175_F309_L1.4931.00
328_P331_I1.4841.00
207_A232_L1.4831.00
261_L346_V1.4771.00
301_K360_Q1.4731.00
92_E136_N1.4611.00
264_F268_Q1.4591.00
12_I63_N1.4541.00
272_S340_R1.4511.00
130_R165_H1.4501.00
195_A240_L1.4471.00
157_H160_R1.4441.00
29_L235_F1.4421.00
62_A70_G1.4401.00
57_V72_A1.4391.00
260_E352_E1.4371.00
195_A209_L1.4251.00
303_I358_L1.4131.00
70_G209_L1.3921.00
272_S286_R1.3911.00
159_A163_K1.3901.00
133_I167_L1.3821.00
249_L348_I1.3681.00
44_F55_Q1.3671.00
251_M254_H1.3591.00
133_I140_V1.3581.00
80_I141_F1.3511.00
4_H352_E1.3461.00
232_L237_S1.3441.00
181_Q186_L1.3441.00
154_D157_H1.3421.00
25_A56_L1.3391.00
88_K91_D1.3341.00
57_V209_L1.3301.00
73_F210_V1.3291.00
95_V99_L1.3271.00
268_Q359_K1.3271.00
156_E186_L1.3171.00
261_L358_L1.3131.00
142_V169_L1.3081.00
142_V155_I1.3001.00
117_T136_N1.2981.00
133_I161_I1.2941.00
257_N348_I1.2761.00
303_I354_L1.2711.00
316_I342_L1.2651.00
266_E279_K1.2631.00
344_F358_L1.2481.00
127_D131_S1.2391.00
170_I192_I1.2391.00
37_G298_K1.2341.00
87_F93_L1.2331.00
159_A188_A1.2321.00
78_A230_A1.2291.00
216_R220_E1.2271.00
150_M277_P1.2161.00
284_S341_L1.2101.00
205_L240_L1.2071.00
258_A262_A1.2071.00
302_T354_L1.2051.00
34_R304_C1.1931.00
61_I211_V1.1921.00
261_L354_L1.1901.00
108_E120_Y1.1881.00
129_L158_I1.1841.00
83_I139_A1.1781.00
68_A215_E1.1701.00
195_A199_L1.1681.00
97_S151_Q1.1671.00
253_Q257_N1.1641.00
312_V348_I1.1621.00
39_G298_K1.1601.00
9_L248_S1.1591.00
160_R163_K1.1581.00
107_F118_F1.1581.00
199_L244_M1.1551.00
200_G205_L1.1521.00
248_S252_R1.1411.00
4_H356_E1.1381.00
162_T169_L1.1341.00
263_A266_E1.1301.00
204_D242_R1.1271.00
150_M283_L1.1251.00
94_I132_K1.1241.00
71_L218_G1.1181.00
205_L236_D1.1171.00
262_A279_K1.1141.00
55_Q58_E1.0961.00
145_P181_Q1.0901.00
256_A260_E1.0891.00
192_I210_V1.0871.00
61_I199_L1.0861.00
140_V167_L1.0781.00
23_V304_C1.0731.00
207_A240_L1.0721.00
261_L351_A1.0701.00
355_K359_K1.0701.00
262_A274_V1.0641.00
216_R221_M1.0611.00
38_I298_K1.0551.00
39_G294_N1.0511.00
128_C131_S1.0491.00
71_L222_F1.0491.00
203_N311_G1.0441.00
69_R218_G1.0421.00
155_I188_A1.0411.00
73_F225_Q1.0411.00
69_R215_E1.0381.00
168_L217_L1.0301.00
130_R161_I1.0281.00
60_A244_M1.0261.00
81_Q106_L1.0241.00
108_E112_K1.0211.00
249_L253_Q1.0181.00
289_K292_W1.0171.00
178_P193_H1.0141.00
60_A241_M1.0141.00
212_V218_G1.0121.00
49_T226_N1.0121.00
87_F91_D1.0111.00
255_Q259_Q1.0081.00
142_V171_V1.0061.00
296_F342_L0.9951.00
356_E359_K0.9921.00
119_H132_K0.9871.00
75_S206_L0.9861.00
77_M80_I0.9841.00
285_F344_F0.9821.00
200_G240_L0.9791.00
184_L191_V0.9771.00
10_A348_I0.9731.00
290_E340_R0.9721.00
133_I165_H0.9681.00
296_F316_I0.9671.00
141_F170_I0.9651.00
82_T170_I0.9641.00
95_V120_Y0.9631.00
235_F239_L0.9631.00
80_I192_I0.9631.00
179_V252_R0.9611.00
66_N182_R0.9611.00
69_R222_F0.9601.00
175_F282_M0.9601.00
248_S253_Q0.9571.00
68_A214_D0.9551.00
296_F358_L0.9541.00
17_D20_T0.9531.00
357_D360_Q0.9531.00
331_I334_A0.9511.00
291_E295_P0.9491.00
245_K313_E0.9491.00
104_Y108_E0.9451.00
54_R232_L0.9411.00
264_F362_L0.9401.00
320_A332_R0.9371.00
155_I159_A0.9371.00
98_D151_Q0.9331.00
275_L286_R0.9331.00
27_I235_F0.9321.00
210_V221_M0.9281.00
142_V153_A0.9231.00
297_L316_I0.9211.00
162_T167_L0.9211.00
15_R59_D0.9171.00
72_A209_L0.9171.00
292_W340_R0.9091.00
259_Q266_E0.9081.00
123_F129_L0.9081.00
196_T206_L0.9081.00
219_E223_Q0.9061.00
270_E288_Q0.9051.00
265_L285_F0.9051.00
155_I181_Q0.9041.00
303_I344_F0.9041.00
270_E362_L0.9021.00
261_L344_F0.8991.00
258_A276_Y0.8971.00
122_D128_C0.8961.00
47_V54_R0.8901.00
95_V118_F0.8851.00
352_E356_E0.8841.00
268_Q362_L0.8841.00
195_A232_L0.8831.00
54_R72_A0.8821.00
217_L220_E0.8811.00
6_E253_Q0.8761.00
141_F192_I0.8701.00
21_G36_R0.8681.00
142_V158_I0.8681.00
73_F78_A0.8661.00
273_D340_R0.8621.00
259_Q276_Y0.8591.00
87_F139_A0.8581.00
216_R219_E0.8571.00
360_Q364_Q0.8561.00
83_I87_F0.8531.00
294_N298_K0.8521.00
158_I169_L0.8521.00
139_A168_L0.8461.00
94_I121_D0.8451.00
155_I186_L0.8431.00
179_V251_M0.8421.00
27_I238_W0.8381.00
81_Q228_I0.8381.00
303_I316_I0.8381.00
190_I212_V0.8371.00
299_A361_A0.8291.00
123_F153_A0.8291.00
126_E130_R0.8271.00
213_K216_R0.8271.00
283_L344_F0.8221.00
268_Q363_C0.8191.00
112_K117_T0.8181.00
199_L240_L0.8151.00
25_A241_M0.8151.00
190_I210_V0.8141.00
257_N261_L0.8061.00
248_S350_H0.8031.00
91_D136_N0.8001.00
93_L139_A0.8001.00
217_L221_M0.8001.00
8_K12_I0.7971.00
264_F358_L0.7961.00
255_Q281_G0.7961.00
303_I346_V0.7930.99
88_K138_K0.7860.99
260_E264_F0.7840.99
113_K220_E0.7800.99
232_L240_L0.7780.99
291_E294_N0.7780.99
81_Q84_M0.7780.99
74_S230_A0.7760.99
86_L217_L0.7710.99
263_A279_K0.7710.99
297_L342_L0.7690.99
180_L251_M0.7680.99
87_F116_L0.7670.99
352_E355_K0.7650.99
193_H211_V0.7610.99
57_V199_L0.7600.99
163_K167_L0.7590.99
7_T302_T0.7590.99
161_I165_H0.7570.99
71_L221_M0.7570.99
257_N346_V0.7570.99
292_W295_P0.7560.99
94_I137_T0.7550.99
276_Y283_L0.7520.99
109_N223_Q0.7510.99
263_A267_E0.7500.99
314_S344_F0.7500.99
296_F300_L0.7480.99
126_E129_L0.7470.99
57_V195_A0.7470.99
119_H136_N0.7410.99
256_A351_A0.7400.99
239_L242_R0.7390.99
103_T141_F0.7380.99
259_Q279_K0.7380.99
65_E191_V0.7350.99
73_F230_A0.7350.99
235_F238_W0.7320.99
190_I217_L0.7310.99
22_T28_Y0.7310.99
219_E222_F0.7300.99
61_I72_A0.7290.99
270_E292_W0.7270.99
121_D128_C0.7270.99
361_A364_Q0.7250.99
146_T151_Q0.7240.99
329_E332_R0.7230.99
93_L107_F0.7190.99
146_T149_L0.7170.99
5_V8_K0.7170.99
271_I285_F0.7130.99
5_V182_R0.7100.99
199_L247_L0.7050.99
68_A213_K0.7050.99
86_L170_I0.7020.99
45_D49_T0.7000.99
173_N193_H0.6990.99
68_A212_V0.6990.99
29_L205_L0.6970.99
173_N183_P0.6930.99
24_S238_W0.6920.99
69_R212_V0.6880.99
261_L264_F0.6870.99
270_E363_C0.6870.99
275_L284_S0.6870.99
29_L238_W0.6860.99
72_A232_L0.6860.99
128_C132_K0.6850.99
130_R157_H0.6840.99
61_I195_A0.6840.99
131_S135_P0.6830.99
356_E360_Q0.6830.99
75_S231_V0.6810.98
285_F342_L0.6800.98
32_A308_S0.6780.98
92_E135_P0.6770.98
71_L210_V0.6770.98
5_V9_L0.6760.98
214_D218_G0.6750.98
155_I169_L0.6740.98
144_T173_N0.6730.98
271_I362_L0.6690.98
129_L140_V0.6690.98
140_V163_K0.6670.98
162_T165_H0.6630.98
212_V217_L0.6620.98
50_K55_Q0.6620.98
98_D146_T0.6590.98
58_E72_A0.6580.98
93_L118_F0.6580.98
121_D129_L0.6580.98
218_G222_F0.6580.98
358_L362_L0.6560.98
216_R222_F0.6550.98
87_F138_K0.6550.98
157_H161_I0.6540.98
89_S115_G0.6540.98
17_D28_Y0.6530.98
178_P199_L0.6530.98
133_I137_T0.6520.98
59_D63_N0.6510.98
198_Y282_M0.6500.98
254_H257_N0.6490.98
296_F362_L0.6490.98
270_E287_L0.6490.98
170_I190_I0.6480.98
107_F141_F0.6470.98
307_E317_T0.6470.98
299_A360_Q0.6420.98
74_S231_V0.6390.98
173_N176_Y0.6390.98
145_P176_Y0.6360.98
262_A283_L0.6340.98
316_I344_F0.6340.98
296_F361_A0.6310.98
217_L222_F0.6300.97
124_S151_Q0.6290.97
111_W116_L0.6290.97
125_D131_S0.6270.97
276_Y279_K0.6230.97
205_L243_G0.6210.97
140_V161_I0.6200.97
295_P298_K0.6190.97
80_I103_T0.6190.97
282_M309_L0.6190.97
220_E223_Q0.6180.97
232_L236_D0.6170.97
320_A339_N0.6170.97
317_T322_Q0.6160.97
314_S354_L0.6140.97
259_Q278_G0.6140.97
108_E331_I0.6130.97
212_V221_M0.6130.97
330_E334_A0.6130.97
20_T28_Y0.6100.97
295_P364_Q0.6100.97
333_I339_N0.6090.97
301_K364_Q0.6090.97
8_K66_N0.6090.97
57_V241_M0.6080.97
29_L233_P0.6080.97
144_T181_Q0.6070.97
206_L231_V0.6070.97
245_K312_V0.6070.97
73_F82_T0.6070.97
85_A224_H0.6070.97
82_T86_L0.6070.97
287_L362_L0.6060.97
286_R341_L0.6050.97
333_I338_C0.6030.97
300_L303_I0.6010.97
85_A221_M0.6000.97
30_S33_Y0.6000.97
58_E70_G0.5980.97
134_T137_T0.5980.97
56_L241_M0.5970.97
32_A306_A0.5970.97
17_D22_T0.5960.96
193_H209_L0.5950.96
5_V248_S0.5950.96
259_Q262_A0.5940.96
55_Q69_R0.5940.96
327_I331_I0.5930.96
155_I171_V0.5930.96
293_V340_R0.5910.96
314_S358_L0.5900.96
288_Q292_W0.5890.96
272_S287_L0.5880.96
96_S123_F0.5880.96
104_Y120_Y0.5860.96
11_Q304_C0.5840.96
110_E227_A0.5830.96
328_P332_R0.5820.96
267_E359_K0.5810.96
202_H242_R0.5800.96
94_I123_F0.5770.96
163_K166_G0.5760.96
176_Y181_Q0.5760.96
316_I358_L0.5730.96
38_I294_N0.5720.96
290_E339_N0.5710.96
252_R255_Q0.5660.95
97_S122_D0.5660.95
225_Q231_V0.5660.95
36_R42_T0.5620.95
156_E185_E0.5620.95
213_K217_L0.5610.95
53_T241_M0.5610.95
306_A315_F0.5590.95
255_Q258_A0.5580.95
294_N321_T0.5570.95
4_H8_K0.5570.95
83_I107_F0.5560.95
101_G324_H0.5550.95
287_L292_W0.5550.95
23_V34_R0.5550.95
150_M282_M0.5540.95
110_E224_H0.5520.95
216_R223_Q0.5510.95
100_Y308_S0.5490.94
40_E43_G0.5480.94
105_R109_N0.5420.94
20_T44_F0.5420.94
198_Y254_H0.5410.94
256_A259_Q0.5390.94
150_M284_S0.5380.94
51_N54_R0.5370.94
135_P138_K0.5370.94
179_V248_S0.5350.94
32_A307_E0.5340.94
110_E228_I0.5340.94
71_L225_Q0.5340.94
330_E333_I0.5340.94
161_I164_E0.5330.94
293_V318_Y0.5300.93
84_M114_Y0.5300.93
94_I140_V0.5300.93
94_I119_H0.5280.93
62_A69_R0.5280.93
270_E364_Q0.5230.93
14_N60_A0.5230.93
80_I106_L0.5230.93
264_F351_A0.5230.93
59_D62_A0.5230.93
257_N260_E0.5220.93
264_F267_E0.5220.93
298_K305_F0.5210.93
83_I210_V0.5200.93
290_E293_V0.5200.93
32_A315_F0.5180.93
327_I335_N0.5170.93
68_A218_G0.5160.92
57_V244_M0.5140.92
97_S334_A0.5130.92
122_D125_D0.5130.92
203_N313_E0.5120.92
246_T249_L0.5120.92
214_D217_L0.5110.92
24_S30_S0.5110.92
82_T210_V0.5090.92
301_K357_D0.5080.92
184_L211_V0.5040.92
272_S285_F0.5030.92
87_F170_I0.5020.91
69_R214_D0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibjA 4 0.9759 100 0.389 Contact Map
1qgnA 4 0.9759 100 0.418 Contact Map
3cogA 4 0.9893 100 0.437 Contact Map
3ri6A 4 0.8472 100 0.445 Contact Map
4iy7A 4 0.9705 100 0.447 Contact Map
4kamA 4 0.9062 100 0.467 Contact Map
4itxA 4 0.9678 100 0.47 Contact Map
1e5eA 4 0.9732 100 0.474 Contact Map
3ndnA 4 0.9678 100 0.493 Contact Map
4oc9A 5 0.9705 100 0.5 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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