METI - BACSU - GREMLIN Contacts

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METI - Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase

UniProt:	O31631	Sequences: MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGFDYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIARITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLYPGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (361)
Sequences:	10451 (5693)
Seq/√Len:	299.6

ECOLI - METB METC
BACSU - METI METC MCCB
HALSA - Q9HQG7 Q9HR98 Q9HMR3
SULSO - Q97W69

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
182_R	185_E	3.494	1.00
92_E	119_H	3.272	1.00
67_G	211_V	3.145	1.00
130_R	164_E	3.124	1.00
66_N	185_E	2.895	1.00
359_K	363_C	2.891	1.00
6_E	350_H	2.881	1.00
259_Q	263_A	2.818	1.00
92_E	134_T	2.706	1.00
272_S	288_Q	2.590	1.00
303_I	314_S	2.580	1.00
61_I	209_L	2.460	1.00
4_H	350_H	2.400	1.00
139_A	170_I	2.398	1.00
273_D	286_R	2.391	1.00
156_E	160_R	2.382	1.00
329_E	333_I	2.380	1.00
264_F	355_K	2.291	1.00
180_L	255_Q	2.270	1.00
8_K	63_N	2.202	1.00
252_R	256_A	2.140	1.00
264_F	359_K	2.137	1.00
159_A	169_L	2.068	1.00
153_A	158_I	2.026	1.00
233_P	236_D	1.993	1.00
125_D	128_C	1.974	1.00
318_Y	321_T	1.966	1.00
286_R	340_R	1.962	1.00
117_T	134_T	1.962	1.00
126_E	157_H	1.950	1.00
195_A	207_A	1.947	1.00
163_K	189_D	1.935	1.00
198_Y	281_G	1.921	1.00
57_V	240_L	1.910	1.00
55_Q	59_D	1.904	1.00
6_E	248_S	1.902	1.00
91_D	138_K	1.899	1.00
261_L	355_K	1.892	1.00
171_V	188_A	1.856	1.00
253_Q	256_A	1.824	1.00
119_H	134_T	1.812	1.00
163_K	169_L	1.797	1.00
88_K	113_K	1.796	1.00
160_R	164_E	1.767	1.00
254_H	281_G	1.766	1.00
70_G	211_V	1.751	1.00
5_V	179_V	1.739	1.00
351_A	355_K	1.720	1.00
332_R	339_N	1.695	1.00
127_D	130_R	1.695	1.00
257_N	351_A	1.679	1.00
329_E	339_N	1.663	1.00
54_R	237_S	1.657	1.00
260_E	351_A	1.654	1.00
65_E	193_H	1.653	1.00
169_L	188_A	1.628	1.00
300_L	316_I	1.627	1.00
260_E	263_A	1.620	1.00
260_E	355_K	1.619	1.00
92_E	117_T	1.615	1.00
126_E	161_I	1.615	1.00
95_V	107_F	1.613	1.00
140_V	158_I	1.610	1.00
44_F	50_K	1.599	1.00
286_R	338_C	1.593	1.00
92_E	137_T	1.572	1.00
295_P	299_A	1.570	1.00
67_G	184_L	1.569	1.00
121_D	132_K	1.562	1.00
140_V	162_T	1.535	1.00
287_L	296_F	1.532	1.00
299_A	364_Q	1.502	1.00
215_E	219_E	1.497	1.00
175_F	309_L	1.493	1.00
328_P	331_I	1.484	1.00
207_A	232_L	1.483	1.00
261_L	346_V	1.477	1.00
301_K	360_Q	1.473	1.00
92_E	136_N	1.461	1.00
264_F	268_Q	1.459	1.00
12_I	63_N	1.454	1.00
272_S	340_R	1.451	1.00
130_R	165_H	1.450	1.00
195_A	240_L	1.447	1.00
157_H	160_R	1.444	1.00
29_L	235_F	1.442	1.00
62_A	70_G	1.440	1.00
57_V	72_A	1.439	1.00
260_E	352_E	1.437	1.00
195_A	209_L	1.425	1.00
303_I	358_L	1.413	1.00
70_G	209_L	1.392	1.00
272_S	286_R	1.391	1.00
159_A	163_K	1.390	1.00
133_I	167_L	1.382	1.00
249_L	348_I	1.368	1.00
44_F	55_Q	1.367	1.00
251_M	254_H	1.359	1.00
133_I	140_V	1.358	1.00
80_I	141_F	1.351	1.00
4_H	352_E	1.346	1.00
232_L	237_S	1.344	1.00
181_Q	186_L	1.344	1.00
154_D	157_H	1.342	1.00
25_A	56_L	1.339	1.00
88_K	91_D	1.334	1.00
57_V	209_L	1.330	1.00
73_F	210_V	1.329	1.00
95_V	99_L	1.327	1.00
268_Q	359_K	1.327	1.00
156_E	186_L	1.317	1.00
261_L	358_L	1.313	1.00
142_V	169_L	1.308	1.00
142_V	155_I	1.300	1.00
117_T	136_N	1.298	1.00
133_I	161_I	1.294	1.00
257_N	348_I	1.276	1.00
303_I	354_L	1.271	1.00
316_I	342_L	1.265	1.00
266_E	279_K	1.263	1.00
344_F	358_L	1.248	1.00
127_D	131_S	1.239	1.00
170_I	192_I	1.239	1.00
37_G	298_K	1.234	1.00
87_F	93_L	1.233	1.00
159_A	188_A	1.232	1.00
78_A	230_A	1.229	1.00
216_R	220_E	1.227	1.00
150_M	277_P	1.216	1.00
284_S	341_L	1.210	1.00
205_L	240_L	1.207	1.00
258_A	262_A	1.207	1.00
302_T	354_L	1.205	1.00
34_R	304_C	1.193	1.00
61_I	211_V	1.192	1.00
261_L	354_L	1.190	1.00
108_E	120_Y	1.188	1.00
129_L	158_I	1.184	1.00
83_I	139_A	1.178	1.00
68_A	215_E	1.170	1.00
195_A	199_L	1.168	1.00
97_S	151_Q	1.167	1.00
253_Q	257_N	1.164	1.00
312_V	348_I	1.162	1.00
39_G	298_K	1.160	1.00
9_L	248_S	1.159	1.00
160_R	163_K	1.158	1.00
107_F	118_F	1.158	1.00
199_L	244_M	1.155	1.00
200_G	205_L	1.152	1.00
248_S	252_R	1.141	1.00
4_H	356_E	1.138	1.00
162_T	169_L	1.134	1.00
263_A	266_E	1.130	1.00
204_D	242_R	1.127	1.00
150_M	283_L	1.125	1.00
94_I	132_K	1.124	1.00
71_L	218_G	1.118	1.00
205_L	236_D	1.117	1.00
262_A	279_K	1.114	1.00
55_Q	58_E	1.096	1.00
145_P	181_Q	1.090	1.00
256_A	260_E	1.089	1.00
192_I	210_V	1.087	1.00
61_I	199_L	1.086	1.00
140_V	167_L	1.078	1.00
23_V	304_C	1.073	1.00
207_A	240_L	1.072	1.00
261_L	351_A	1.070	1.00
355_K	359_K	1.070	1.00
262_A	274_V	1.064	1.00
216_R	221_M	1.061	1.00
38_I	298_K	1.055	1.00
39_G	294_N	1.051	1.00
128_C	131_S	1.049	1.00
71_L	222_F	1.049	1.00
203_N	311_G	1.044	1.00
69_R	218_G	1.042	1.00
155_I	188_A	1.041	1.00
73_F	225_Q	1.041	1.00
69_R	215_E	1.038	1.00
168_L	217_L	1.030	1.00
130_R	161_I	1.028	1.00
60_A	244_M	1.026	1.00
81_Q	106_L	1.024	1.00
108_E	112_K	1.021	1.00
249_L	253_Q	1.018	1.00
289_K	292_W	1.017	1.00
178_P	193_H	1.014	1.00
60_A	241_M	1.014	1.00
212_V	218_G	1.012	1.00
49_T	226_N	1.012	1.00
87_F	91_D	1.011	1.00
255_Q	259_Q	1.008	1.00
142_V	171_V	1.006	1.00
296_F	342_L	0.995	1.00
356_E	359_K	0.992	1.00
119_H	132_K	0.987	1.00
75_S	206_L	0.986	1.00
77_M	80_I	0.984	1.00
285_F	344_F	0.982	1.00
200_G	240_L	0.979	1.00
184_L	191_V	0.977	1.00
10_A	348_I	0.973	1.00
290_E	340_R	0.972	1.00
133_I	165_H	0.968	1.00
296_F	316_I	0.967	1.00
141_F	170_I	0.965	1.00
82_T	170_I	0.964	1.00
95_V	120_Y	0.963	1.00
235_F	239_L	0.963	1.00
80_I	192_I	0.963	1.00
179_V	252_R	0.961	1.00
66_N	182_R	0.961	1.00
69_R	222_F	0.960	1.00
175_F	282_M	0.960	1.00
248_S	253_Q	0.957	1.00
68_A	214_D	0.955	1.00
296_F	358_L	0.954	1.00
17_D	20_T	0.953	1.00
357_D	360_Q	0.953	1.00
331_I	334_A	0.951	1.00
291_E	295_P	0.949	1.00
245_K	313_E	0.949	1.00
104_Y	108_E	0.945	1.00
54_R	232_L	0.941	1.00
264_F	362_L	0.940	1.00
320_A	332_R	0.937	1.00
155_I	159_A	0.937	1.00
98_D	151_Q	0.933	1.00
275_L	286_R	0.933	1.00
27_I	235_F	0.932	1.00
210_V	221_M	0.928	1.00
142_V	153_A	0.923	1.00
297_L	316_I	0.921	1.00
162_T	167_L	0.921	1.00
15_R	59_D	0.917	1.00
72_A	209_L	0.917	1.00
292_W	340_R	0.909	1.00
259_Q	266_E	0.908	1.00
123_F	129_L	0.908	1.00
196_T	206_L	0.908	1.00
219_E	223_Q	0.906	1.00
270_E	288_Q	0.905	1.00
265_L	285_F	0.905	1.00
155_I	181_Q	0.904	1.00
303_I	344_F	0.904	1.00
270_E	362_L	0.902	1.00
261_L	344_F	0.899	1.00
258_A	276_Y	0.897	1.00
122_D	128_C	0.896	1.00
47_V	54_R	0.890	1.00
95_V	118_F	0.885	1.00
352_E	356_E	0.884	1.00
268_Q	362_L	0.884	1.00
195_A	232_L	0.883	1.00
54_R	72_A	0.882	1.00
217_L	220_E	0.881	1.00
6_E	253_Q	0.876	1.00
141_F	192_I	0.870	1.00
21_G	36_R	0.868	1.00
142_V	158_I	0.868	1.00
73_F	78_A	0.866	1.00
273_D	340_R	0.862	1.00
259_Q	276_Y	0.859	1.00
87_F	139_A	0.858	1.00
216_R	219_E	0.857	1.00
360_Q	364_Q	0.856	1.00
83_I	87_F	0.853	1.00
294_N	298_K	0.852	1.00
158_I	169_L	0.852	1.00
139_A	168_L	0.846	1.00
94_I	121_D	0.845	1.00
155_I	186_L	0.843	1.00
179_V	251_M	0.842	1.00
27_I	238_W	0.838	1.00
81_Q	228_I	0.838	1.00
303_I	316_I	0.838	1.00
190_I	212_V	0.837	1.00
299_A	361_A	0.829	1.00
123_F	153_A	0.829	1.00
126_E	130_R	0.827	1.00
213_K	216_R	0.827	1.00
283_L	344_F	0.822	1.00
268_Q	363_C	0.819	1.00
112_K	117_T	0.818	1.00
199_L	240_L	0.815	1.00
25_A	241_M	0.815	1.00
190_I	210_V	0.814	1.00
257_N	261_L	0.806	1.00
248_S	350_H	0.803	1.00
91_D	136_N	0.800	1.00
93_L	139_A	0.800	1.00
217_L	221_M	0.800	1.00
8_K	12_I	0.797	1.00
264_F	358_L	0.796	1.00
255_Q	281_G	0.796	1.00
303_I	346_V	0.793	0.99
88_K	138_K	0.786	0.99
260_E	264_F	0.784	0.99
113_K	220_E	0.780	0.99
232_L	240_L	0.778	0.99
291_E	294_N	0.778	0.99
81_Q	84_M	0.778	0.99
74_S	230_A	0.776	0.99
86_L	217_L	0.771	0.99
263_A	279_K	0.771	0.99
297_L	342_L	0.769	0.99
180_L	251_M	0.768	0.99
87_F	116_L	0.767	0.99
352_E	355_K	0.765	0.99
193_H	211_V	0.761	0.99
57_V	199_L	0.760	0.99
163_K	167_L	0.759	0.99
7_T	302_T	0.759	0.99
161_I	165_H	0.757	0.99
71_L	221_M	0.757	0.99
257_N	346_V	0.757	0.99
292_W	295_P	0.756	0.99
94_I	137_T	0.755	0.99
276_Y	283_L	0.752	0.99
109_N	223_Q	0.751	0.99
263_A	267_E	0.750	0.99
314_S	344_F	0.750	0.99
296_F	300_L	0.748	0.99
126_E	129_L	0.747	0.99
57_V	195_A	0.747	0.99
119_H	136_N	0.741	0.99
256_A	351_A	0.740	0.99
239_L	242_R	0.739	0.99
103_T	141_F	0.738	0.99
259_Q	279_K	0.738	0.99
65_E	191_V	0.735	0.99
73_F	230_A	0.735	0.99
235_F	238_W	0.732	0.99
190_I	217_L	0.731	0.99
22_T	28_Y	0.731	0.99
219_E	222_F	0.730	0.99
61_I	72_A	0.729	0.99
270_E	292_W	0.727	0.99
121_D	128_C	0.727	0.99
361_A	364_Q	0.725	0.99
146_T	151_Q	0.724	0.99
329_E	332_R	0.723	0.99
93_L	107_F	0.719	0.99
146_T	149_L	0.717	0.99
5_V	8_K	0.717	0.99
271_I	285_F	0.713	0.99
5_V	182_R	0.710	0.99
199_L	247_L	0.705	0.99
68_A	213_K	0.705	0.99
86_L	170_I	0.702	0.99
45_D	49_T	0.700	0.99
173_N	193_H	0.699	0.99
68_A	212_V	0.699	0.99
29_L	205_L	0.697	0.99
173_N	183_P	0.693	0.99
24_S	238_W	0.692	0.99
69_R	212_V	0.688	0.99
261_L	264_F	0.687	0.99
270_E	363_C	0.687	0.99
275_L	284_S	0.687	0.99
29_L	238_W	0.686	0.99
72_A	232_L	0.686	0.99
128_C	132_K	0.685	0.99
130_R	157_H	0.684	0.99
61_I	195_A	0.684	0.99
131_S	135_P	0.683	0.99
356_E	360_Q	0.683	0.99
75_S	231_V	0.681	0.98
285_F	342_L	0.680	0.98
32_A	308_S	0.678	0.98
92_E	135_P	0.677	0.98
71_L	210_V	0.677	0.98
5_V	9_L	0.676	0.98
214_D	218_G	0.675	0.98
155_I	169_L	0.674	0.98
144_T	173_N	0.673	0.98
271_I	362_L	0.669	0.98
129_L	140_V	0.669	0.98
140_V	163_K	0.667	0.98
162_T	165_H	0.663	0.98
212_V	217_L	0.662	0.98
50_K	55_Q	0.662	0.98
98_D	146_T	0.659	0.98
58_E	72_A	0.658	0.98
93_L	118_F	0.658	0.98
121_D	129_L	0.658	0.98
218_G	222_F	0.658	0.98
358_L	362_L	0.656	0.98
216_R	222_F	0.655	0.98
87_F	138_K	0.655	0.98
157_H	161_I	0.654	0.98
89_S	115_G	0.654	0.98
17_D	28_Y	0.653	0.98
178_P	199_L	0.653	0.98
133_I	137_T	0.652	0.98
59_D	63_N	0.651	0.98
198_Y	282_M	0.650	0.98
254_H	257_N	0.649	0.98
296_F	362_L	0.649	0.98
270_E	287_L	0.649	0.98
170_I	190_I	0.648	0.98
107_F	141_F	0.647	0.98
307_E	317_T	0.647	0.98
299_A	360_Q	0.642	0.98
74_S	231_V	0.639	0.98
173_N	176_Y	0.639	0.98
145_P	176_Y	0.636	0.98
262_A	283_L	0.634	0.98
316_I	344_F	0.634	0.98
296_F	361_A	0.631	0.98
217_L	222_F	0.630	0.97
124_S	151_Q	0.629	0.97
111_W	116_L	0.629	0.97
125_D	131_S	0.627	0.97
276_Y	279_K	0.623	0.97
205_L	243_G	0.621	0.97
140_V	161_I	0.620	0.97
295_P	298_K	0.619	0.97
80_I	103_T	0.619	0.97
282_M	309_L	0.619	0.97
220_E	223_Q	0.618	0.97
232_L	236_D	0.617	0.97
320_A	339_N	0.617	0.97
317_T	322_Q	0.616	0.97
314_S	354_L	0.614	0.97
259_Q	278_G	0.614	0.97
108_E	331_I	0.613	0.97
212_V	221_M	0.613	0.97
330_E	334_A	0.613	0.97
20_T	28_Y	0.610	0.97
295_P	364_Q	0.610	0.97
333_I	339_N	0.609	0.97
301_K	364_Q	0.609	0.97
8_K	66_N	0.609	0.97
57_V	241_M	0.608	0.97
29_L	233_P	0.608	0.97
144_T	181_Q	0.607	0.97
206_L	231_V	0.607	0.97
245_K	312_V	0.607	0.97
73_F	82_T	0.607	0.97
85_A	224_H	0.607	0.97
82_T	86_L	0.607	0.97
287_L	362_L	0.606	0.97
286_R	341_L	0.605	0.97
333_I	338_C	0.603	0.97
300_L	303_I	0.601	0.97
85_A	221_M	0.600	0.97
30_S	33_Y	0.600	0.97
58_E	70_G	0.598	0.97
134_T	137_T	0.598	0.97
56_L	241_M	0.597	0.97
32_A	306_A	0.597	0.97
17_D	22_T	0.596	0.96
193_H	209_L	0.595	0.96
5_V	248_S	0.595	0.96
259_Q	262_A	0.594	0.96
55_Q	69_R	0.594	0.96
327_I	331_I	0.593	0.96
155_I	171_V	0.593	0.96
293_V	340_R	0.591	0.96
314_S	358_L	0.590	0.96
288_Q	292_W	0.589	0.96
272_S	287_L	0.588	0.96
96_S	123_F	0.588	0.96
104_Y	120_Y	0.586	0.96
11_Q	304_C	0.584	0.96
110_E	227_A	0.583	0.96
328_P	332_R	0.582	0.96
267_E	359_K	0.581	0.96
202_H	242_R	0.580	0.96
94_I	123_F	0.577	0.96
163_K	166_G	0.576	0.96
176_Y	181_Q	0.576	0.96
316_I	358_L	0.573	0.96
38_I	294_N	0.572	0.96
290_E	339_N	0.571	0.96
252_R	255_Q	0.566	0.95
97_S	122_D	0.566	0.95
225_Q	231_V	0.566	0.95
36_R	42_T	0.562	0.95
156_E	185_E	0.562	0.95
213_K	217_L	0.561	0.95
53_T	241_M	0.561	0.95
306_A	315_F	0.559	0.95
255_Q	258_A	0.558	0.95
294_N	321_T	0.557	0.95
4_H	8_K	0.557	0.95
83_I	107_F	0.556	0.95
101_G	324_H	0.555	0.95
287_L	292_W	0.555	0.95
23_V	34_R	0.555	0.95
150_M	282_M	0.554	0.95
110_E	224_H	0.552	0.95
216_R	223_Q	0.551	0.95
100_Y	308_S	0.549	0.94
40_E	43_G	0.548	0.94
105_R	109_N	0.542	0.94
20_T	44_F	0.542	0.94
198_Y	254_H	0.541	0.94
256_A	259_Q	0.539	0.94
150_M	284_S	0.538	0.94
51_N	54_R	0.537	0.94
135_P	138_K	0.537	0.94
179_V	248_S	0.535	0.94
32_A	307_E	0.534	0.94
110_E	228_I	0.534	0.94
71_L	225_Q	0.534	0.94
330_E	333_I	0.534	0.94
161_I	164_E	0.533	0.94
293_V	318_Y	0.530	0.93
84_M	114_Y	0.530	0.93
94_I	140_V	0.530	0.93
94_I	119_H	0.528	0.93
62_A	69_R	0.528	0.93
270_E	364_Q	0.523	0.93
14_N	60_A	0.523	0.93
80_I	106_L	0.523	0.93
264_F	351_A	0.523	0.93
59_D	62_A	0.523	0.93
257_N	260_E	0.522	0.93
264_F	267_E	0.522	0.93
298_K	305_F	0.521	0.93
83_I	210_V	0.520	0.93
290_E	293_V	0.520	0.93
32_A	315_F	0.518	0.93
327_I	335_N	0.517	0.93
68_A	218_G	0.516	0.92
57_V	244_M	0.514	0.92
97_S	334_A	0.513	0.92
122_D	125_D	0.513	0.92
203_N	313_E	0.512	0.92
246_T	249_L	0.512	0.92
214_D	217_L	0.511	0.92
24_S	30_S	0.511	0.92
82_T	210_V	0.509	0.92
301_K	357_D	0.508	0.92
184_L	211_V	0.504	0.92
272_S	285_F	0.503	0.92
87_F	170_I	0.502	0.91
69_R	214_D	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ibjA	4	0.9759	100	0.389	Contact Map
1qgnA	4	0.9759	100	0.418	Contact Map
3cogA	4	0.9893	100	0.437	Contact Map
3ri6A	4	0.8472	100	0.445	Contact Map
4iy7A	4	0.9705	100	0.447	Contact Map
4kamA	4	0.9062	100	0.467	Contact Map
4itxA	4	0.9678	100	0.47	Contact Map
1e5eA	4	0.9732	100	0.474	Contact Map
3ndnA	4	0.9678	100	0.493	Contact Map
4oc9A	5	0.9705	100	0.5	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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