GREMLIN Database
YJCH - Uncharacterized protein YjcH
UniProt: O31630 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (211)
Sequences: 8766 (6538)
Seq/√Len: 450.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_A149_I3.7361.00
111_D123_R3.3031.00
14_F21_E3.1551.00
204_K208_E2.8051.00
151_M154_P2.7521.00
117_Y122_G2.6881.00
109_F113_E2.6311.00
100_R104_H2.5721.00
90_P100_R2.5481.00
206_L210_K2.3761.00
111_D116_T2.3711.00
217_E234_P2.3031.00
41_I71_S2.2751.00
152_Q235_A2.2331.00
99_K142_Y2.2331.00
12_K21_E2.1591.00
31_N70_R2.1451.00
72_I116_T2.1441.00
204_K214_Y2.1111.00
201_R218_P1.9971.00
99_K138_T1.9911.00
150_I235_A1.9881.00
38_Y72_I1.9531.00
42_I123_R1.9221.00
107_V123_R1.9161.00
41_I126_I1.9121.00
40_V74_I1.9081.00
32_Y115_P1.8951.00
124_T148_N1.8461.00
43_A126_I1.8041.00
74_I110_A1.7991.00
14_F19_N1.7871.00
26_V74_I1.7791.00
178_Q231_L1.7491.00
13_F101_F1.6721.00
197_T201_R1.6141.00
54_R57_R1.5921.00
32_Y38_Y1.5911.00
99_K141_D1.5871.00
181_T220_D1.5851.00
103_A142_Y1.5761.00
10_E23_T1.5691.00
42_I107_V1.5301.00
28_L72_I1.5161.00
110_A116_T1.5081.00
12_K23_T1.4951.00
11_K24_L1.4611.00
101_F106_L1.4461.00
42_I111_D1.4291.00
36_Y70_R1.4291.00
204_K216_F1.4271.00
61_E65_K1.3861.00
205_Q208_E1.3561.00
205_Q209_K1.3531.00
201_R205_Q1.3381.00
84_R87_T1.3371.00
24_L106_L1.3281.00
204_K218_P1.3191.00
62_L233_T1.3071.00
107_V145_M1.3051.00
233_T237_K1.3031.00
41_I73_I1.2871.00
202_E205_Q1.2821.00
168_D172_H1.2801.00
136_L156_V1.2721.00
137_M141_D1.2691.00
125_L135_S1.2651.00
59_V73_I1.2521.00
104_H108_P1.2411.00
50_F75_G1.2301.00
27_Y60_E1.2291.00
44_Q134_V1.2271.00
154_P200_N1.2231.00
126_I150_I1.2221.00
104_H142_Y1.2221.00
128_D228_W1.2171.00
44_Q98_Y1.2091.00
148_N174_S1.2051.00
69_D236_L1.1741.00
168_D171_K1.1661.00
10_E25_L1.1621.00
17_E105_E1.1621.00
180_G183_E1.1581.00
103_A145_M1.1561.00
123_R145_M1.1201.00
38_Y115_P1.1191.00
17_E104_H1.1161.00
207_L214_Y1.1161.00
135_S149_I1.1161.00
206_L209_K1.1151.00
153_S228_W1.1141.00
17_E100_R1.1111.00
40_V116_T1.1041.00
24_L109_F1.1021.00
37_K115_P1.0751.00
99_K103_A1.0731.00
136_L151_M1.0571.00
142_Y145_M1.0561.00
42_I74_I1.0481.00
208_E214_Y1.0421.00
15_S105_E1.0421.00
49_Y53_G1.0411.00
54_R58_Q1.0351.00
107_V111_D1.0341.00
103_A138_T1.0331.00
126_I152_Q1.0291.00
101_F105_E1.0181.00
72_I114_Y1.0111.00
109_F112_D1.0051.00
132_A151_M1.0001.00
42_I110_A0.9911.00
122_G147_G0.9911.00
198_E202_E0.9891.00
63_L70_R0.9881.00
53_G225_W0.9881.00
43_A75_G0.9861.00
102_I138_T0.9801.00
55_I58_Q0.9771.00
149_I175_I0.9771.00
176_Y217_E0.9761.00
37_K117_Y0.9611.00
69_D237_K0.9601.00
31_N38_Y0.9571.00
111_D118_Q0.9541.00
24_L101_F0.9431.00
179_I183_E0.9421.00
203_L207_L0.9411.00
135_S151_M0.9391.00
133_T137_M0.9341.00
181_T218_P0.9341.00
162_E165_K0.9331.00
129_S223_H0.9281.00
22_M101_F0.9221.00
11_K109_F0.9141.00
125_L138_T0.9121.00
219_F231_L0.9031.00
170_I173_L0.8971.00
159_H162_E0.8941.00
177_H204_K0.8911.00
44_Q125_L0.8911.00
185_D196_F0.8891.00
11_K113_E0.8871.00
156_V203_L0.8851.00
16_K105_E0.8851.00
39_H71_S0.8741.00
231_L234_P0.8721.00
152_Q228_W0.8711.00
163_A166_Q0.8641.00
62_L237_K0.8631.00
18_L22_M0.8581.00
28_L32_Y0.8521.00
90_P95_F0.8511.00
103_A146_F0.8471.00
15_S18_L0.8461.00
157_D160_V0.8441.00
219_F227_Y0.8341.00
160_V163_A0.8281.00
38_Y70_R0.8231.00
84_R90_P0.8181.00
107_V146_F0.8131.00
76_V102_I0.8121.00
162_E166_Q0.8061.00
103_A108_P0.8051.00
42_I146_F0.8021.00
88_Y134_V0.7991.00
158_K163_A0.7991.00
23_T77_P0.7961.00
97_A100_R0.7941.00
117_Y121_Y0.7931.00
63_L69_D0.7891.00
174_S213_D0.7871.00
48_D225_W0.7771.00
207_L212_S0.7731.00
25_L77_P0.7651.00
34_P115_P0.7631.00
107_V110_A0.7611.00
232_I236_L0.7601.00
83_E86_N0.7601.00
60_E64_S0.7561.00
227_Y231_L0.7541.00
82_K86_N0.7541.00
26_V114_Y0.7511.00
177_H200_N0.7491.00
43_A232_I0.7491.00
40_V123_R0.7481.00
61_E64_S0.7481.00
108_P112_D0.7471.00
160_V165_K0.7441.00
161_L165_K0.7421.00
125_L149_I0.7401.00
84_R88_Y0.7401.00
28_L38_Y0.7391.00
201_R204_K0.7391.00
99_K137_M0.7381.00
234_P237_K0.7371.00
59_V63_L0.7341.00
44_Q76_V0.7261.00
136_L154_P0.7211.00
30_S64_S0.7191.00
61_E233_T0.7121.00
200_N216_F0.7111.00
10_E51_R0.7081.00
33_S115_P0.7081.00
219_F234_P0.7071.00
39_H70_R0.7041.00
198_E201_R0.7021.00
40_V72_I0.6981.00
123_R147_G0.6971.00
85_R130_L0.6971.00
124_T150_I0.6931.00
40_V73_I0.6931.00
56_G60_E0.6911.00
152_Q178_Q0.6831.00
74_I106_L0.6791.00
40_V111_D0.6761.00
111_D145_M0.6761.00
151_M177_H0.6681.00
48_D52_L0.6671.00
57_R61_E0.6661.00
230_P233_T0.6631.00
33_S37_K0.6601.00
44_Q135_S0.6561.00
108_P145_M0.6551.00
11_K114_Y0.6541.00
27_Y63_L0.6541.00
158_K161_L0.6521.00
103_A107_V0.6440.99
95_F134_V0.6440.99
90_P97_A0.6330.99
126_I232_I0.6320.99
136_L175_I0.6300.99
84_R89_H0.6280.99
169_D173_L0.6280.99
53_G57_R0.6280.99
196_F200_N0.6270.99
104_H145_M0.6260.99
62_L69_D0.6260.99
13_F24_L0.6220.99
131_G134_V0.6210.99
39_H122_G0.6190.99
171_K174_S0.6190.99
163_A167_S0.6190.99
153_S183_E0.6140.99
128_D225_W0.6100.99
62_L236_L0.6090.99
158_K166_Q0.6040.99
54_R75_G0.6040.99
83_E87_T0.5980.99
43_A49_Y0.5950.99
171_K176_Y0.5910.99
62_L65_K0.5860.99
117_Y123_R0.5820.99
159_H163_A0.5820.99
179_I182_K0.5800.99
33_S36_Y0.5790.99
181_T185_D0.5790.99
65_K69_D0.5780.99
87_T90_P0.5770.99
178_Q182_K0.5730.99
32_Y72_I0.5720.99
202_E206_L0.5710.99
161_L166_Q0.5700.99
138_T146_F0.5650.99
219_F230_P0.5650.99
111_D117_Y0.5640.99
132_A154_P0.5630.99
16_K19_N0.5620.99
224_K227_Y0.5610.99
57_R60_E0.5610.99
124_T147_G0.5600.99
178_Q227_Y0.5570.99
108_P146_F0.5560.99
58_Q61_E0.5540.98
177_H214_Y0.5540.98
47_H50_F0.5490.98
58_Q229_Q0.5470.98
152_Q231_L0.5470.98
173_L178_Q0.5440.98
179_I196_F0.5430.98
86_N90_P0.5430.98
17_E97_A0.5430.98
139_A173_L0.5420.98
52_L56_G0.5380.98
27_Y73_I0.5380.98
182_K221_G0.5340.98
169_D172_H0.5320.98
133_T155_Y0.5300.98
203_L206_L0.5290.98
171_K177_H0.5280.98
160_V164_V0.5280.98
35_L115_P0.5260.98
85_R89_H0.5230.98
71_S236_L0.5220.98
13_F109_F0.5180.98
55_I232_I0.5140.98
164_V167_S0.5130.98
26_V72_I0.5130.98
130_L134_V0.5130.98
96_S141_D0.5090.97
28_L31_N0.5090.97
159_H165_K0.5090.97
46_G129_S0.5080.97
110_A114_Y0.5070.97
197_T200_N0.5070.97
27_Y59_V0.5070.97
13_F22_M0.5060.97
178_Q219_F0.5060.97
39_H117_Y0.5060.97
28_L114_Y0.5050.97
175_I178_Q0.5050.97
157_D202_E0.5050.97
230_P234_P0.5040.97
136_L203_L0.5010.97
89_H137_M0.5000.97
96_S137_M0.5000.97
60_E63_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4w9rA 2 0.925 100 0.357 Contact Map
3c8dA 2 0.9208 100 0.399 Contact Map
1jjfA 1 0.9292 100 0.418 Contact Map
3gffA 2 0.9292 100 0.422 Contact Map
3ls2A 2 0.9417 100 0.444 Contact Map
2gzsA 1 0.9167 100 0.454 Contact Map
2uz0A 4 0.8708 100 0.467 Contact Map
4rotA 4 0.9125 100 0.469 Contact Map
2qm0A 3 0.95 100 0.471 Contact Map
3i6yA 1 0.9417 100 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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