GREMLIN Database
SPVIF - Sporulation-specific transcription factor SpoVIF
UniProt: O31625 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 84 (81)
Sequences: 153 (106)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_I53_V4.5711.00
27_L41_V3.6870.99
63_E67_S2.7080.92
32_F64_S2.1050.78
31_N82_D2.0720.76
20_V75_G1.9480.72
18_Q22_N1.9380.71
23_L35_E1.9210.71
5_F13_T1.8810.69
10_E80_M1.8510.68
31_N34_D1.7700.64
30_A37_T1.6870.60
32_F38_V1.6820.60
36_N43_N1.6590.59
16_K19_D1.5070.51
19_D40_S1.4590.49
34_D70_E1.3930.46
17_M20_V1.3880.45
23_L45_V1.3330.43
39_R73_D1.3260.42
61_I79_K1.3170.42
14_G81_M1.3130.42
28_Q51_R1.2480.39
19_D49_A1.2470.39
27_L42_I1.2380.38
15_V46_A1.2370.38
34_D37_T1.2110.37
38_V68_G1.1850.36
17_M50_N1.1550.34
41_V64_S1.1510.34
59_D62_V1.1510.34
57_L66_T1.1470.34
3_N13_T1.1400.34
9_I20_V1.1050.32
61_I70_E1.0960.32
6_F28_Q1.0820.31
57_L64_S1.0650.31
23_L80_M1.0460.30
39_R58_E1.0350.29
30_A62_V1.0260.29
10_E14_G1.0190.29
19_D26_S1.0070.28
12_K46_A0.9940.28
39_R59_D0.9680.27
56_E76_T0.9640.26
7_K22_N0.9510.26
11_K46_A0.9490.26
10_E17_M0.9430.26
10_E13_T0.9400.26
15_V45_V0.9330.25
23_L73_D0.9260.25
38_V62_V0.8970.24
28_Q77_I0.8900.24
14_G17_M0.8820.23
24_A31_N0.8750.23
57_L71_K0.8710.23
16_K73_D0.8690.23
56_E65_I0.8640.23
43_N58_E0.8600.23
36_N46_A0.8490.22
71_K81_M0.8280.22
5_F41_V0.8010.21
31_N40_S0.8000.21
27_L37_T0.7960.20
55_K58_E0.7920.20
2_D74_F0.7890.20
21_M66_T0.7840.20
48_M59_D0.7830.20
26_S37_T0.7800.20
53_V64_S0.7700.20
30_A38_V0.7700.20
71_K77_I0.7620.19
6_F10_E0.7450.19
38_V46_A0.7440.19
27_L60_K0.7420.19
46_A52_R0.7370.19
2_D52_R0.7370.19
18_Q71_K0.7340.19
68_G81_M0.7330.18
55_K63_E0.7330.18
6_F33_K0.7300.18
13_T23_L0.7180.18
45_V60_K0.7140.18
17_M81_M0.7070.18
34_D53_V0.7010.18
54_P57_L0.6950.17
17_M38_V0.6830.17
59_D63_E0.6810.17
25_G28_Q0.6810.17
14_G80_M0.6760.17
18_Q72_L0.6740.17
31_N59_D0.6730.17
5_F40_S0.6680.17
52_R63_E0.6610.16
26_S49_A0.6470.16
7_K81_M0.6230.15
48_M72_L0.6160.15
45_V49_A0.6100.15
20_V72_L0.6070.15
77_I81_M0.6020.15
46_A69_K0.5970.15
74_F78_S0.5840.14
25_G72_L0.5630.14
13_T70_E0.5620.14
52_R57_L0.5610.14
7_K14_G0.5600.14
3_N29_N0.5420.13
45_V80_M0.5400.13
5_F9_I0.5370.13
36_N61_I0.5370.13
37_T41_V0.5350.13
47_Q64_S0.5250.13
8_N74_F0.5230.13
9_I22_N0.5200.13
56_E69_K0.5200.13
38_V65_I0.5160.13
78_S82_D0.5090.13
31_N60_K0.5060.13
15_V40_S0.5030.13
15_V48_M0.5010.13
23_L42_I0.5010.13
18_Q74_F0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d23B 4 0.5714 21.2 0.913 Contact Map
2ynaA 2 0.6071 19.7 0.914 Contact Map
3tntA 2 0.6071 18.5 0.916 Contact Map
3tloA 2 0.5952 15.9 0.918 Contact Map
1lvoA 5 0.5952 15.6 0.918 Contact Map
2q6fA 2 0.5476 10.7 0.924 Contact Map
2h9aB 1 0.9286 10.2 0.925 Contact Map
2lnbA 1 0.5595 10 0.925 Contact Map
2grcA 1 0.6786 9.3 0.926 Contact Map
1h67A 1 0.5833 8.5 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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