GREMLIN Database
THID - Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
UniProt: O31620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (252)
Sequences: 6220 (4401)
Seq/√Len: 277.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_D132_R3.2701.00
88_E128_L2.9401.00
24_I34_G2.9001.00
153_S156_D2.7751.00
50_H66_A2.7361.00
53_H56_T2.7001.00
149_M163_Q2.6941.00
30_L222_Q2.6231.00
222_Q227_D2.5581.00
173_I215_F2.5491.00
228_S231_Q2.5041.00
65_D93_K2.3771.00
81_L90_V2.2541.00
143_A174_I2.2181.00
61_R92_R2.1431.00
78_T104_V2.1231.00
41_V59_T2.1101.00
32_V221_A2.0961.00
115_S119_D2.0601.00
196_M230_H2.0591.00
158_K195_F2.0081.00
27_F221_A1.9701.00
60_L86_M1.9661.00
6_A32_V1.9551.00
222_Q225_K1.9281.00
41_V55_L1.9231.00
51_G62_Q1.9161.00
123_A127_E1.9141.00
27_F34_G1.9051.00
95_D128_L1.8971.00
8_T36_S1.8771.00
12_S21_Q1.8511.00
101_R134_Y1.8271.00
27_F32_V1.8211.00
110_A114_A1.8121.00
184_H199_T1.8091.00
54_P82_W1.7221.00
171_H229_I1.7201.00
144_E150_T1.7161.00
61_R89_E1.7121.00
227_D235_V1.7071.00
154_L197_Q1.6981.00
64_I93_K1.6511.00
219_L233_F1.6461.00
93_K96_E1.6401.00
151_I160_A1.5831.00
152_S156_D1.5761.00
237_A241_R1.5691.00
222_Q235_V1.5501.00
6_A27_F1.5251.00
94_I102_V1.5251.00
61_R93_K1.5191.00
8_T27_F1.5161.00
65_D69_E1.5131.00
185_I237_A1.5121.00
87_I125_L1.4971.00
37_A64_I1.4881.00
241_R245_E1.4871.00
21_Q36_S1.4801.00
57_V89_E1.4761.00
5_K74_D1.4741.00
161_A174_I1.4701.00
165_V190_F1.4641.00
50_H69_E1.4531.00
78_T102_V1.4531.00
242_E245_E1.4431.00
104_V133_S1.4381.00
84_A120_E1.4261.00
201_P245_E1.4261.00
136_I164_L1.4011.00
186_T197_Q1.3851.00
117_L121_S1.3771.00
147_T164_L1.3561.00
158_K197_Q1.3521.00
20_I38_I1.3431.00
5_K35_M1.3291.00
198_I234_E1.3031.00
144_E151_I1.2871.00
190_F195_F1.2801.00
54_P83_N1.2581.00
53_H59_T1.2541.00
12_S42_T1.2431.00
161_A190_F1.2361.00
5_K71_L1.2331.00
200_H237_A1.2241.00
68_A96_E1.2191.00
149_M159_K1.2161.00
92_R128_L1.2151.00
134_Y170_Q1.2101.00
5_K72_R1.1961.00
227_D231_Q1.1871.00
115_S122_V1.1851.00
196_M234_E1.1841.00
68_A73_P1.1681.00
55_L59_T1.1641.00
58_E62_Q1.1561.00
200_H241_R1.1541.00
103_I220_T1.1531.00
26_T214_T1.1441.00
83_N86_M1.1441.00
57_V85_D1.1441.00
37_A60_L1.1401.00
6_A224_A1.1371.00
46_T70_D1.1331.00
188_L197_Q1.1291.00
144_E160_A1.1291.00
43_A62_Q1.1231.00
163_Q166_K1.1221.00
171_H191_D1.1181.00
65_D96_E1.1121.00
223_T229_I1.1111.00
81_L87_I1.1031.00
126_K167_M1.1011.00
162_E166_K1.0961.00
30_L218_A1.0911.00
158_K162_E1.0831.00
135_A229_I1.0781.00
87_I124_T1.0721.00
147_T163_Q1.0671.00
231_Q234_E1.0661.00
230_H234_E1.0561.00
126_K146_L1.0541.00
124_T128_L1.0521.00
43_A59_T1.0411.00
89_E92_R1.0351.00
30_L221_A1.0321.00
130_I136_I1.0311.00
12_S38_I1.0271.00
186_T199_T1.0271.00
159_K163_Q1.0261.00
234_E238_N1.0181.00
157_R188_L1.0131.00
26_T218_A1.0121.00
68_A99_F1.0051.00
26_T30_L1.0041.00
154_L158_K1.0021.00
91_A132_R0.9991.00
51_G59_T0.9971.00
189_L198_I0.9901.00
84_A88_E0.9871.00
165_V172_V0.9861.00
126_K148_G0.9861.00
32_V225_K0.9821.00
9_I90_V0.9781.00
76_V99_F0.9721.00
115_S145_T0.9711.00
88_E124_T0.9681.00
135_A219_L0.9671.00
35_M73_P0.9641.00
59_T62_Q0.9641.00
103_I223_T0.9611.00
198_I233_F0.9561.00
84_A124_T0.9541.00
109_I145_T0.9521.00
194_M230_H0.9521.00
4_Y74_D0.9471.00
47_L252_S0.9451.00
135_A173_I0.9421.00
75_A220_T0.9401.00
159_K162_E0.9381.00
35_M71_L0.9331.00
156_D159_K0.9291.00
40_A80_M0.9281.00
85_D88_E0.9151.00
165_V169_A0.9151.00
214_T257_T0.9081.00
82_W86_M0.9081.00
15_G42_T0.9051.00
219_L236_A0.9011.00
188_L195_F0.9001.00
5_K73_P0.8971.00
68_A93_K0.8941.00
87_I117_L0.8931.00
208_T244_V0.8911.00
240_V257_T0.8901.00
242_E246_N0.8831.00
165_V192_G0.8831.00
122_V126_K0.8821.00
136_I172_V0.8771.00
162_E195_F0.8771.00
134_Y171_H0.8761.00
171_H189_L0.8751.00
122_V145_T0.8741.00
12_S36_S0.8711.00
134_Y229_I0.8681.00
149_M156_D0.8661.00
30_L225_K0.8621.00
92_R96_E0.8491.00
203_I241_R0.8491.00
198_I237_A0.8381.00
203_I244_V0.8321.00
135_A171_H0.8261.00
154_L186_T0.8190.99
214_T239_F0.8180.99
218_A239_F0.8170.99
14_S42_T0.8160.99
207_H249_G0.8140.99
14_S36_S0.8100.99
163_Q167_M0.8060.99
189_L233_F0.8000.99
123_A126_K0.7920.99
78_T81_L0.7910.99
184_H201_P0.7890.99
32_V224_A0.7890.99
94_I99_F0.7870.99
205_T255_G0.7860.99
223_T226_G0.7840.99
62_Q66_A0.7830.99
57_V61_R0.7770.99
157_R179_Q0.7770.99
50_H62_Q0.7750.99
238_N242_E0.7710.99
62_Q65_D0.7680.99
17_G209_H0.7670.99
154_L188_L0.7620.99
111_K254_H0.7610.99
173_I189_L0.7610.99
207_H255_G0.7600.99
165_V171_H0.7580.99
227_D232_A0.7550.99
6_A221_A0.7520.99
155_D158_K0.7510.99
77_K217_A0.7500.99
11_G39_T0.7480.99
135_A233_F0.7460.99
124_T127_E0.7430.99
35_M67_V0.7410.99
61_R65_D0.7410.99
14_S43_A0.7370.99
27_F220_T0.7320.99
27_F217_A0.7300.99
174_I188_L0.7250.99
223_T232_A0.7250.99
140_V179_Q0.7230.99
7_L35_M0.7220.99
140_V144_E0.7120.99
231_Q235_V0.7040.98
46_T251_G0.7010.98
15_G71_L0.7010.98
21_Q24_I0.6960.98
91_A129_L0.6960.98
189_L229_I0.6910.98
88_E127_E0.6900.98
76_V102_V0.6900.98
187_D237_A0.6890.98
141_P178_H0.6880.98
40_A54_P0.6870.98
68_A97_Y0.6820.98
143_A160_A0.6800.98
60_L89_E0.6790.98
225_K235_V0.6760.98
139_N142_E0.6740.98
10_A23_D0.6720.98
57_V60_L0.6720.98
130_I169_A0.6690.98
240_V244_V0.6660.98
83_N118_R0.6620.98
77_K216_A0.6600.98
191_D194_M0.6600.98
12_S41_V0.6590.98
8_T216_A0.6590.98
78_T216_A0.6580.98
22_A214_T0.6580.98
12_S20_I0.6560.97
78_T94_I0.6550.97
205_T208_T0.6530.97
185_I202_Y0.6520.97
165_V170_Q0.6510.97
91_A95_D0.6500.97
89_E93_K0.6480.97
133_S136_I0.6460.97
125_L130_I0.6460.97
113_G116_L0.6450.97
26_T239_F0.6440.97
87_I121_S0.6420.97
110_A116_L0.6420.97
39_T86_M0.6420.97
6_A220_T0.6410.97
165_V191_D0.6400.97
93_K97_Y0.6370.97
80_M116_L0.6370.97
91_A128_L0.6330.97
13_D19_G0.6310.97
29_E239_F0.6310.97
237_A240_V0.6290.97
167_M170_Q0.6270.97
97_Y100_N0.6200.96
92_R95_D0.6180.96
186_T190_F0.6170.96
56_T59_T0.6170.96
25_K33_F0.6150.96
226_G232_A0.6140.96
69_E97_Y0.6120.96
191_D195_F0.6110.96
76_V94_I0.6110.96
82_W118_R0.6100.96
5_K250_I0.6100.96
165_V168_G0.6070.96
149_M160_A0.6060.96
104_V129_L0.6040.96
151_I157_R0.6030.96
9_I64_I0.6000.96
71_L74_D0.5980.96
65_D97_Y0.5980.96
146_L164_L0.5980.96
15_G33_F0.5970.96
44_Q209_H0.5940.96
140_V151_I0.5940.96
30_L235_V0.5920.95
23_D77_K0.5890.95
45_N50_H0.5880.95
46_T253_G0.5860.95
91_A104_V0.5830.95
66_A69_E0.5790.95
228_S232_A0.5780.95
44_Q66_A0.5760.95
173_I233_F0.5760.95
108_M117_L0.5750.95
8_T34_G0.5750.95
235_V238_N0.5730.95
20_I36_S0.5710.94
103_I135_A0.5680.94
161_A172_V0.5660.94
239_F243_A0.5650.94
68_A76_V0.5630.94
162_E165_V0.5630.94
47_L50_H0.5620.94
143_A164_L0.5620.94
105_D139_N0.5610.94
105_D138_P0.5610.94
7_L37_A0.5600.94
154_L199_T0.5570.94
151_I156_D0.5530.93
75_A216_A0.5520.93
18_A209_H0.5510.93
51_G58_E0.5500.93
244_V257_T0.5490.93
178_H202_Y0.5490.93
141_P144_E0.5480.93
87_I129_L0.5460.93
102_V132_R0.5460.93
236_A240_V0.5450.93
37_A67_V0.5450.93
162_E190_F0.5430.93
135_A236_A0.5410.93
88_E92_R0.5410.93
198_I230_H0.5410.93
104_V125_L0.5390.93
109_I115_S0.5380.93
189_L230_H0.5360.92
155_D159_K0.5360.92
214_T243_A0.5350.92
38_I41_V0.5330.92
173_I219_L0.5320.92
25_K28_Q0.5280.92
147_T172_V0.5280.92
45_N66_A0.5270.92
233_F236_A0.5270.92
72_R100_N0.5240.92
211_T240_V0.5200.91
11_G18_A0.5200.91
98_G101_R0.5200.91
75_A224_A0.5190.91
143_A151_I0.5180.91
5_K33_F0.5180.91
67_V73_P0.5160.91
109_I114_A0.5140.91
40_A82_W0.5120.91
215_F236_A0.5120.91
201_P241_R0.5090.90
138_P142_E0.5040.90
119_D145_T0.5040.90
107_V138_P0.5020.90
170_Q192_G0.5020.90
13_D18_A0.5010.90
15_G44_Q0.5010.90
152_S180_P0.5010.90
128_L132_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i5bA 2 0.9889 100 0.33 Contact Map
3rm5A 2 0.9594 100 0.347 Contact Map
3h74A 2 0.9705 100 0.394 Contact Map
1ub0A 2 0.9077 100 0.396 Contact Map
4yl5A 2 0.8339 100 0.399 Contact Map
1jxhA 2 0.9004 100 0.407 Contact Map
3pzsA 2 0.9926 100 0.407 Contact Map
2ddmA 2 0.9483 100 0.412 Contact Map
2yxtA 3 0.9889 100 0.413 Contact Map
3mbhA 5 0.9852 100 0.414 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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