GREMLIN Database
THIF - Sulfur carrier protein ThiS adenylyltransferase
UniProt: O31619 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (283)
Sequences: 2131 (1503)
Seq/√Len: 89.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_E94_S3.9441.00
119_I202_A3.8511.00
50_S97_D3.7631.00
86_E90_R3.7311.00
120_I137_A3.4901.00
77_K87_R3.4361.00
29_I40_A3.3551.00
32_A53_I3.3411.00
26_R50_S3.3181.00
70_Y84_A3.2931.00
166_C169_C3.2721.00
121_V202_A3.1881.00
44_V96_V3.0241.00
73_D91_S2.9281.00
86_E100_G2.9261.00
50_S99_T2.8101.00
89_L98_V2.8041.00
166_C238_C2.7251.00
37_T69_L2.6731.00
201_D204_K2.6681.00
238_C241_C2.5351.00
39_S121_V2.5261.00
14_I18_G2.4901.00
169_C238_C2.4591.00
56_R104_D2.4141.00
52_K117_A2.3811.00
80_P102_V2.2841.00
69_L85_A2.2291.00
147_G194_V2.2241.00
6_S10_L2.1961.00
71_T91_S2.0781.00
8_Q65_Q2.0671.00
257_A261_C2.0631.00
124_A133_V2.0441.00
166_C241_C2.0121.00
71_T88_R1.9141.00
5_Y93_N1.9071.00
26_R52_K1.8921.00
30_I133_V1.8361.00
44_V89_L1.8251.00
52_K101_L1.8131.00
135_D168_H1.8111.00
101_L117_A1.8031.00
83_A102_V1.7901.00
28_V114_I1.7781.00
124_A129_T1.7761.00
82_A102_V1.7231.00
74_D77_K1.7121.00
116_D142_I1.6981.00
279_E282_A1.6591.00
22_L203_L1.6351.00
25_A206_L1.6101.00
111_F140_E1.6001.00
105_V110_I1.5971.00
40_A53_I1.5601.00
14_I207_T1.5351.00
169_C241_C1.5321.00
145_L202_A1.5301.00
20_K24_E1.5201.00
86_E98_V1.5071.00
115_R140_E1.4670.99
282_A286_R1.4430.99
257_A260_L1.4400.99
111_F139_K1.4370.99
93_N96_V1.4320.99
54_A105_V1.4290.99
40_A85_A1.4140.99
156_T197_F1.4040.99
32_A70_Y1.4000.99
245_D248_F1.3970.99
137_A144_F1.3680.99
158_T205_L1.3300.99
30_I105_V1.3230.99
44_V98_V1.3180.99
197_F225_R1.3160.99
42_M192_L1.2920.99
23_K95_D1.2870.99
126_N129_T1.2820.99
40_A89_L1.2800.99
82_A100_G1.2710.99
277_D280_A1.2680.98
44_V51_V1.2500.98
59_V84_A1.2480.98
80_P83_A1.2480.98
69_L89_L1.2460.98
110_I136_A1.2430.98
147_G198_Q1.2400.98
214_V227_E1.2340.98
119_I206_L1.2300.98
88_R91_S1.2220.98
114_I137_A1.2210.98
28_V117_A1.2000.98
242_G245_D1.2000.98
192_L196_V1.1950.98
63_N81_K1.1900.98
21_K24_E1.1800.98
74_D88_R1.1780.98
261_C265_T1.1690.97
256_K260_L1.1690.97
257_A262_G1.1560.97
5_Y96_V1.1520.97
131_L172_D1.1510.97
161_P164_T1.1300.97
28_V54_A1.1290.97
105_V114_I1.1260.97
11_F152_S1.1250.97
261_C266_V1.1160.97
66_R81_K1.1000.96
280_A284_Q1.0910.96
219_D222_K1.0870.96
39_S123_A1.0840.96
284_Q288_A1.0820.96
216_R225_R1.0810.96
262_G266_V1.0790.96
246_F250_S1.0730.96
193_Q200_T1.0710.96
38_A41_E1.0640.96
138_V159_V1.0630.96
154_G194_V1.0510.95
263_R266_V1.0510.95
280_A287_Q1.0500.95
74_D84_A1.0460.95
281_L285_L1.0430.95
158_T204_K1.0400.95
38_A195_A1.0390.95
275_E278_L1.0370.95
149_C190_A1.0340.95
200_T218_F1.0330.95
70_Y74_D1.0320.95
121_V147_G1.0270.95
245_D250_S1.0250.95
111_F136_A1.0210.94
103_M112_E1.0190.94
278_L281_L1.0170.94
136_A140_E1.0150.94
189_P196_V1.0140.94
32_A82_A1.0120.94
63_N66_R1.0080.94
114_I120_I1.0030.94
267_Q271_S1.0030.94
195_A199_V0.9930.94
247_P250_S0.9900.93
68_Q192_L0.9870.93
258_A261_C0.9760.93
38_A192_L0.9730.93
61_W75_V0.9670.93
158_T201_D0.9490.92
262_G265_T0.9470.92
90_R96_V0.9450.92
165_P213_P0.9430.92
45_R65_Q0.9420.92
27_A119_I0.9340.91
37_T41_E0.9320.91
114_I140_E0.9250.91
58_Y80_P0.9230.91
193_Q197_F0.9140.90
30_I120_I0.9130.90
203_L207_T0.9100.90
114_I136_A0.9060.90
69_L84_A0.9020.90
161_P212_E0.8990.90
38_A68_Q0.8920.89
57_D66_R0.8910.89
164_T212_E0.8910.89
200_T220_L0.8910.89
8_Q19_Q0.8900.89
246_F249_L0.8890.89
282_A289_G0.8800.89
282_A287_Q0.8700.88
83_A100_G0.8550.87
260_L263_R0.8500.87
119_I145_L0.8500.87
119_I205_L0.8410.86
285_L288_A0.8340.86
138_V240_S0.8330.86
269_R274_K0.8280.85
256_K261_C0.8230.85
256_K262_G0.8210.85
29_I43_L0.8180.85
189_P203_L0.8170.85
156_T194_V0.8150.85
236_D243_T0.8140.84
134_N138_V0.8100.84
192_L195_A0.8090.84
84_A88_R0.8090.84
83_A87_R0.8030.84
63_N67_Q0.8010.84
118_S142_I0.7980.83
192_L199_V0.7970.83
41_E92_I0.7920.83
172_D235_H0.7920.83
17_S20_K0.7910.83
55_D82_A0.7830.82
245_D249_L0.7830.82
244_K247_P0.7830.82
37_T144_F0.7830.82
42_M199_V0.7820.82
66_R125_D0.7810.82
275_E279_E0.7800.82
21_K208_G0.7780.82
260_L265_T0.7760.82
272_I275_E0.7760.82
74_D87_R0.7750.81
81_K125_D0.7740.81
77_K83_A0.7710.81
280_A286_R0.7700.81
277_D282_A0.7690.81
46_A203_L0.7690.81
41_E68_Q0.7660.81
121_V145_L0.7650.81
191_V196_V0.7640.81
160_V163_S0.7630.80
143_P206_L0.7630.80
205_L212_E0.7620.80
4_R72_E0.7620.80
241_C244_K0.7560.80
131_L168_H0.7540.80
69_L88_R0.7500.79
255_T260_L0.7500.79
42_M68_Q0.7440.79
73_D77_K0.7400.78
266_V269_R0.7390.78
137_A140_E0.7370.78
281_L286_R0.7350.78
160_V164_T0.7320.78
188_S192_L0.7290.77
260_L266_V0.7280.77
279_E287_Q0.7270.77
9_E16_P0.7240.77
49_G93_N0.7220.77
27_A202_A0.7220.77
6_S9_E0.7210.77
156_T216_R0.7210.77
53_I59_V0.7200.76
193_Q220_L0.7170.76
15_G143_P0.7150.76
284_Q287_Q0.7140.76
26_R99_T0.7120.76
261_C267_Q0.7110.76
165_P169_C0.7110.76
129_T133_V0.7070.75
278_L284_Q0.7070.75
276_A279_E0.7040.75
145_L205_L0.7000.74
238_C242_G0.7000.74
133_V144_F0.6970.74
211_C214_V0.6950.74
234_K238_C0.6940.74
277_D281_L0.6900.73
151_G184_A0.6890.73
148_A186_I0.6860.73
57_D81_K0.6860.73
193_Q196_V0.6860.73
273_T276_A0.6830.73
30_I54_A0.6810.72
120_I142_I0.6760.72
113_L140_E0.6740.72
271_S276_A0.6720.71
28_V101_L0.6710.71
212_E216_R0.6710.71
77_K84_A0.6680.71
112_E115_R0.6650.71
278_L282_A0.6620.70
126_N130_R0.6610.70
271_S274_K0.6570.70
30_I110_I0.6560.70
244_K250_S0.6550.69
279_E286_R0.6520.69
243_T247_P0.6520.69
32_A40_A0.6490.69
197_F216_R0.6490.69
152_S220_L0.6490.69
254_Q258_A0.6460.68
263_R267_Q0.6460.68
146_Y191_V0.6440.68
132_I168_H0.6430.68
62_S68_Q0.6430.68
10_L37_T0.6410.68
216_R219_D0.6370.67
241_C250_S0.6370.67
23_K94_S0.6350.67
141_G163_S0.6350.67
22_L207_T0.6340.67
99_T116_D0.6320.67
52_K99_T0.6320.67
282_A285_L0.6280.66
83_A86_E0.6240.66
34_A57_D0.6220.66
40_A69_L0.6200.65
283_G286_R0.6200.65
125_D130_R0.6190.65
271_S284_Q0.6180.65
235_H238_C0.6170.65
75_V91_S0.6170.65
234_K240_S0.6140.65
160_V212_E0.6140.65
63_N125_D0.6140.65
147_G154_G0.6110.64
90_R98_V0.6100.64
133_V173_A0.6070.64
72_E196_V0.6070.64
272_I276_A0.6060.64
149_C186_I0.6060.64
33_G125_D0.6040.63
32_A51_V0.6040.63
163_S209_E0.6030.63
266_V270_S0.6010.63
216_R220_L0.6010.63
275_E280_A0.6010.63
244_K249_L0.6000.63
259_V262_G0.6000.63
134_N166_C0.5960.62
38_A42_M0.5960.62
19_Q22_L0.5950.62
12_A151_G0.5950.62
275_E281_L0.5940.62
217_S220_L0.5940.62
54_A113_L0.5930.62
4_R8_Q0.5930.62
39_S199_V0.5930.62
217_S228_V0.5930.62
33_G81_K0.5920.62
265_T270_S0.5900.61
123_A179_A0.5890.61
105_V109_N0.5880.61
271_S288_A0.5860.61
8_Q190_A0.5860.61
152_S221_W0.5850.61
8_Q45_R0.5820.60
258_A262_G0.5810.60
105_V257_A0.5750.60
28_V52_K0.5750.60
281_L287_Q0.5730.59
35_L147_G0.5710.59
271_S277_D0.5710.59
127_F167_L0.5680.59
284_Q289_G0.5680.59
174_L177_G0.5680.59
161_P166_C0.5670.58
41_E45_R0.5650.58
31_G36_G0.5650.58
62_S66_R0.5640.58
194_V222_K0.5620.58
282_A288_A0.5600.58
274_K278_L0.5590.57
17_S21_K0.5580.57
45_R152_S0.5580.57
122_D185_G0.5570.57
181_C185_G0.5560.57
90_R97_D0.5560.57
196_V200_T0.5560.57
241_C245_D0.5540.57
42_M188_S0.5530.57
118_S141_G0.5530.57
280_A283_G0.5520.56
148_A167_L0.5520.56
143_P203_L0.5510.56
146_Y198_Q0.5510.56
57_D63_N0.5510.56
33_G66_R0.5500.56
57_D125_D0.5470.56
35_L67_Q0.5470.56
264_N267_Q0.5470.56
25_A208_G0.5460.56
37_T84_A0.5450.55
213_P219_D0.5430.55
29_I208_G0.5430.55
16_P20_K0.5430.55
283_G288_A0.5430.55
187_I220_L0.5430.55
276_A282_A0.5420.55
32_A85_A0.5390.55
13_P18_G0.5380.55
252_E259_V0.5370.54
57_D64_L0.5370.54
277_D286_R0.5360.54
87_R91_S0.5350.54
150_V184_A0.5330.54
34_A155_L0.5310.54
253_N257_A0.5290.53
25_A118_S0.5250.53
106_T109_N0.5220.52
42_M45_R0.5220.52
24_E97_D0.5210.52
127_F149_C0.5210.52
8_Q191_V0.5200.52
157_F186_I0.5190.52
11_F216_R0.5180.52
243_T249_L0.5180.52
272_I279_E0.5180.52
275_E287_Q0.5170.52
26_R97_D0.5170.52
14_I22_L0.5160.52
261_C270_S0.5160.52
256_K259_V0.5160.52
273_T284_Q0.5150.51
278_L286_R0.5150.51
146_Y159_V0.5150.51
273_T288_A0.5130.51
264_N269_R0.5130.51
122_D146_Y0.5130.51
179_A184_A0.5130.51
33_G36_G0.5120.51
265_T269_R0.5120.51
186_I191_V0.5110.51
128_E182_D0.5100.51
214_V219_D0.5090.51
155_L167_L0.5090.51
69_L74_D0.5070.50
254_Q257_A0.5070.50
40_A166_C0.5070.50
24_E209_E0.5070.50
149_C179_A0.5060.50
146_Y160_V0.5050.50
83_A264_N0.5040.50
54_A114_I0.5040.50
123_A127_F0.5040.50
260_L268_I0.5030.50
265_T268_I0.5030.50
251_Y254_Q0.5010.49
111_F115_R0.5000.49
186_I190_A0.5000.49
217_S222_K0.5000.49
253_N256_K0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zud1 2 0.6964 100 0.355 Contact Map
3ruiA 2 0.8125 100 0.36 Contact Map
4gslA 2 0.7768 100 0.364 Contact Map
3h8vA 2 0.631 100 0.365 Contact Map
1jw9B 2 0.6875 100 0.368 Contact Map
1tt5B 1 0.9077 100 0.383 Contact Map
2nvuB 1 0.9524 100 0.395 Contact Map
3h5nA 3 0.6964 100 0.411 Contact Map
1y8qB 1 0.9375 100 0.418 Contact Map
4ii2A 1 0.9286 100 0.439 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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