GREMLIN Database
THIG - Thiazole synthase
UniProt: O31618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (250)
Sequences: 1816 (713)
Seq/√Len: 45.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_S148_V5.2181.00
86_R125_E4.9831.00
95_D128_I3.8701.00
82_V121_Q3.5241.00
225_L228_E3.3831.00
16_L39_I3.3571.00
133_T140_A2.9761.00
167_P195_Y2.9751.00
215_D218_K2.8741.00
5_T8_G2.8301.00
117_K120_E2.6961.00
120_E124_E2.6291.00
17_L210_V2.5871.00
189_S238_R2.5771.00
9_K67_T2.5271.00
11_F39_I2.4881.00
225_L232_L2.4421.00
112_P139_L2.4411.00
231_R235_E2.3921.00
182_I203_G2.3781.00
114_E117_K2.3521.00
231_R234_Y2.3161.00
99_V119_S2.2511.00
26_D30_E2.2511.00
221_R232_L2.1751.00
130_L150_A2.1101.00
161_G239_I2.1031.00
155_A196_A2.0450.99
128_I149_H2.0440.99
218_K232_L2.0340.99
116_L139_L2.0260.99
5_T10_S1.9870.99
123_L146_L1.9770.99
192_D195_Y1.9510.99
221_R225_L1.9060.99
164_I196_A1.8960.99
144_E178_K1.8610.99
15_L227_V1.8550.99
218_K225_L1.7650.98
78_A114_E1.7610.98
121_Q125_E1.7350.98
224_K228_E1.7220.98
17_L37_S1.7180.98
3_M10_S1.6480.97
171_S243_Q1.6300.97
171_S175_E1.5920.97
16_L182_I1.5840.97
221_R228_E1.5710.96
174_I201_A1.5650.96
78_A82_V1.5580.96
162_Q168_L1.5440.96
189_S233_S1.5410.96
214_D237_G1.5240.96
12_Q38_D1.5140.96
119_S146_L1.5120.96
232_L235_E1.4850.95
78_A121_Q1.4600.95
113_V139_L1.4400.94
88_A97_I1.4250.94
134_S169_N1.4230.94
144_E177_A1.3970.93
162_Q241_L1.3780.93
23_P27_I1.3740.93
7_G128_I1.3530.92
218_K235_E1.3520.92
192_D241_L1.3380.92
29_K33_A1.3340.91
34_V217_V1.3270.91
212_G239_I1.3190.91
130_L149_H1.3170.91
11_F67_T1.3080.91
32_V40_L1.2960.90
208_T212_G1.2850.90
119_S123_L1.2790.90
142_K145_E1.2700.89
190_P233_S1.2670.89
15_L210_V1.2560.89
144_E179_V1.2450.88
135_D166_N1.2380.88
124_E145_E1.2370.88
62_D65_K1.2190.87
135_D169_N1.2170.87
30_E33_A1.2170.87
6_I16_L1.1980.86
79_E121_Q1.1910.86
117_K121_Q1.1820.86
28_Q40_L1.1690.85
112_P133_T1.1640.85
36_E228_E1.1540.84
191_K198_E1.1520.84
16_L205_L1.1330.83
103_G138_V1.1310.83
113_V120_E1.1300.83
218_K221_R1.1280.83
34_V221_R1.1240.83
141_R144_E1.1210.82
120_E142_K1.1070.82
27_I217_V1.1050.81
39_I67_T1.1050.81
206_L210_V1.0970.81
111_D157_P1.0920.81
75_A84_I1.0890.80
173_I177_A1.0850.80
218_K236_A1.0640.79
6_I182_I1.0630.79
181_V201_A1.0480.78
131_P148_V1.0470.78
7_G96_M1.0410.77
79_E86_R1.0400.77
77_T80_E1.0370.77
156_S192_D1.0360.77
137_V177_A1.0350.77
221_R224_K1.0330.77
78_A101_V1.0330.77
83_R86_R1.0290.77
113_V142_K1.0290.77
207_N211_S1.0230.76
92_G249_S1.0230.76
36_E224_K1.0170.76
17_L32_V1.0170.76
33_A66_Y1.0140.75
33_A65_K1.0130.75
174_I181_V1.0040.75
107_S135_D1.0040.75
170_L201_A1.0010.75
173_I181_V1.0000.74
187_I223_M0.9930.74
242_K246_T0.9860.73
139_L143_L0.9820.73
123_L148_V0.9800.73
139_L142_K0.9750.73
101_V253_G0.9690.72
11_F96_M0.9640.72
24_S27_I0.9600.71
193_A227_V0.9530.71
247_A252_E0.9490.70
155_A164_I0.9410.70
17_L31_A0.9360.69
177_A181_V0.9350.69
4_L202_D0.9340.69
14_R231_R0.9330.69
86_R121_Q0.9250.68
79_E117_K0.9220.68
11_F130_L0.9200.68
166_N169_N0.9200.68
168_L171_S0.9170.68
45_R253_G0.9150.68
6_I130_L0.9140.68
30_E217_V0.9050.67
144_E151_I0.9020.67
156_S165_L0.8830.65
16_L119_S0.8730.64
197_M231_R0.8710.64
165_L168_L0.8690.64
160_S244_Y0.8590.63
22_Y211_S0.8560.62
138_V142_K0.8530.62
88_A91_S0.8520.62
189_S192_D0.8430.61
7_G150_A0.8380.61
32_V66_Y0.8340.60
205_L216_P0.8300.60
162_Q165_L0.8290.60
76_S105_S0.8170.59
164_I187_I0.8160.59
9_K130_L0.8130.58
187_I227_V0.8120.58
194_A229_A0.8120.58
83_R92_G0.8110.58
151_I179_V0.8100.58
175_E244_Y0.8060.58
102_I253_G0.7980.57
56_N59_E0.7970.57
9_K96_M0.7920.56
73_A161_G0.7870.56
107_S172_F0.7830.56
28_Q31_A0.7790.55
32_V165_L0.7770.55
145_E173_I0.7770.55
90_A93_L0.7740.55
78_A117_K0.7730.55
137_V173_I0.7730.55
111_D142_K0.7700.54
22_Y40_L0.7680.54
8_G233_S0.7650.54
103_G107_S0.7640.54
116_L137_V0.7630.54
113_V116_L0.7610.53
69_L130_L0.7560.53
84_I102_I0.7560.53
123_L129_V0.7560.53
192_D238_R0.7520.53
161_G212_G0.7510.52
22_Y207_N0.7490.52
204_V227_V0.7450.52
141_R176_Q0.7440.52
55_P59_E0.7410.52
5_T9_K0.7390.51
197_M230_G0.7360.51
225_L229_A0.7310.51
96_M130_L0.7290.50
187_I195_Y0.7290.50
107_S169_N0.7250.50
28_Q32_V0.7240.50
21_K28_Q0.7210.50
228_E232_L0.7190.49
190_P238_R0.7190.49
17_L40_L0.7110.49
112_P162_Q0.7100.48
42_F68_L0.7060.48
167_P199_L0.7050.48
183_V207_N0.7030.48
106_R244_Y0.7010.48
82_V86_R0.6980.47
25_F60_Q0.6980.47
140_A173_I0.6970.47
182_I206_L0.6950.47
29_K63_L0.6930.47
116_L120_E0.6920.47
102_I248_S0.6890.46
155_A170_L0.6830.46
8_G128_I0.6820.46
156_S208_T0.6790.45
76_S133_T0.6770.45
32_V57_F0.6760.45
162_Q187_I0.6740.45
142_K146_L0.6710.45
96_M131_P0.6700.45
218_K233_S0.6700.45
37_S199_L0.6690.45
190_P223_M0.6670.44
161_G238_R0.6660.44
155_A212_G0.6660.44
69_L99_V0.6630.44
247_A251_G0.6630.44
104_C176_Q0.6540.43
85_A94_C0.6480.43
60_Q148_V0.6460.42
68_L94_C0.6430.42
17_L66_Y0.6400.42
73_A239_I0.6390.42
81_A101_V0.6370.41
22_Y31_A0.6360.41
17_L22_Y0.6350.41
38_D65_K0.6320.41
144_E174_I0.6300.41
58_L92_G0.6250.40
13_S224_K0.6240.40
144_E176_Q0.6230.40
29_K64_S0.6230.40
243_Q246_T0.6210.40
31_A220_A0.6210.40
9_K38_D0.6200.40
75_A99_V0.6200.40
187_I192_D0.6180.40
172_F243_Q0.6170.40
79_E92_G0.6170.40
170_L174_I0.6150.39
157_P162_Q0.6140.39
103_G135_D0.6130.39
237_G240_P0.6130.39
7_G149_H0.6120.39
45_R84_I0.6110.39
128_I131_P0.6080.39
65_K79_E0.6070.39
39_I96_M0.6040.38
99_V148_V0.6030.38
182_I202_D0.6000.38
42_F88_A0.6000.38
45_R133_T0.6000.38
73_A102_I0.5990.38
73_A212_G0.5980.38
144_E173_I0.5980.38
19_T205_L0.5960.38
115_T156_S0.5960.38
4_L32_V0.5950.38
7_G11_F0.5920.37
85_A112_P0.5920.37
170_L183_V0.5910.37
20_G43_A0.5910.37
27_I30_E0.5900.37
129_V198_E0.5880.37
58_L77_T0.5880.37
109_L154_G0.5840.37
37_S40_L0.5840.37
115_T174_I0.5840.37
107_S166_N0.5830.36
189_S194_A0.5820.36
15_L206_L0.5790.36
160_S187_I0.5780.36
97_I129_V0.5770.36
150_A182_I0.5760.36
4_L11_F0.5750.36
84_I99_V0.5750.36
156_S247_A0.5700.35
175_E182_I0.5700.35
116_L119_S0.5690.35
155_A183_V0.5680.35
11_F38_D0.5680.35
215_D226_A0.5680.35
109_L157_P0.5660.35
217_V224_K0.5660.35
117_K142_K0.5650.35
47_M58_L0.5620.35
43_A150_A0.5610.35
123_L145_E0.5610.35
45_R140_A0.5600.34
137_V144_E0.5580.34
111_D114_E0.5580.34
79_E83_R0.5570.34
196_A199_L0.5570.34
15_L35_S0.5560.34
189_S195_Y0.5550.34
164_I195_Y0.5550.34
104_C141_R0.5530.34
58_L208_T0.5530.34
35_S216_P0.5520.34
82_V125_E0.5500.34
45_R83_R0.5500.34
197_M227_V0.5490.33
134_S138_V0.5480.33
223_M238_R0.5480.33
58_L177_A0.5470.33
89_K95_D0.5470.33
107_S133_T0.5470.33
72_T85_A0.5450.33
10_S61_L0.5430.33
47_M56_N0.5430.33
55_P60_Q0.5420.33
195_Y199_L0.5410.33
3_M235_E0.5400.33
77_T241_L0.5380.33
17_L220_A0.5380.33
171_S213_A0.5370.32
141_R178_K0.5370.32
104_C172_F0.5370.32
66_Y90_A0.5360.32
44_V92_G0.5360.32
113_V173_I0.5350.32
84_I90_A0.5340.32
124_E228_E0.5300.32
20_G109_L0.5300.32
135_D167_P0.5290.32
151_I238_R0.5290.32
201_A233_S0.5270.32
187_I206_L0.5270.32
88_A92_G0.5260.32
67_T96_M0.5260.32
27_I215_D0.5230.31
197_M234_Y0.5220.31
19_T216_P0.5220.31
169_N203_G0.5180.31
21_K196_A0.5180.31
166_N223_M0.5170.31
26_D29_K0.5170.31
103_G174_I0.5170.31
45_R170_L0.5140.31
61_L92_G0.5140.31
179_V213_A0.5130.30
134_S166_N0.5100.30
53_S91_S0.5100.30
109_L112_P0.5090.30
133_T156_S0.5090.30
77_T232_L0.5080.30
14_R234_Y0.5080.30
106_R212_G0.5070.30
3_M179_V0.5070.30
126_G203_G0.5070.30
57_F73_A0.5070.30
219_M236_A0.5050.30
171_S199_L0.5050.30
121_Q124_E0.5030.30
22_Y251_G0.5030.30
23_P224_K0.5020.30
120_E145_E0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2htmA 3 0.9336 100 0.524 Contact Map
1wv2A 3 0.8945 100 0.533 Contact Map
1xm3A 4 0.9805 100 0.608 Contact Map
4n6fA 2 0.9297 100 0.716 Contact Map
1ep3A 2 0.9453 99.6 0.859 Contact Map
3o07A 3 0.8203 99.5 0.872 Contact Map
1f76A 1 0.8516 99.4 0.876 Contact Map
4ef8A 2 0.9336 99.4 0.877 Contact Map
4oqvA 1 0.9258 99.4 0.877 Contact Map
2h6rA 3 0.7539 99.4 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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