GREMLIN Database
GLOX - Glycine oxidase
UniProt: O31616 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (338)
Sequences: 28810 (21204)
Seq/√Len: 1153.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_A166_A5.6871.00
5_Y31_A4.0481.00
35_S173_P3.7601.00
8_V186_I3.4621.00
173_P189_P3.3401.00
6_E196_N3.2961.00
6_E29_N3.1991.00
176_H187_K3.0821.00
8_V195_A2.9691.00
31_A169_F2.9671.00
178_E187_K2.7021.00
178_E185_F2.6791.00
121_S124_E2.6621.00
8_V33_F2.6301.00
230_W293_K2.5731.00
29_N167_E2.4951.00
24_A164_L2.4691.00
33_F193_V2.4591.00
74_K92_N2.4221.00
68_H340_A2.4051.00
7_A23_L2.3841.00
25_K79_E2.2911.00
24_A166_A2.2901.00
118_S124_E2.2101.00
28_K347_M2.1791.00
7_A28_K2.1231.00
19_I199_V2.1131.00
8_V193_V2.0721.00
188_T191_G2.0031.00
175_L189_P1.9911.00
105_V138_G1.9481.00
26_E347_M1.9221.00
125_V139_A1.9211.00
22_Y340_A1.9201.00
124_E127_E1.8961.00
17_S158_V1.8891.00
12_G38_M1.8691.00
24_A161_A1.8661.00
38_M170_E1.8521.00
22_Y339_G1.8501.00
197_H322_L1.8451.00
75_G79_E1.8241.00
17_S154_C1.8001.00
276_E280_K1.7941.00
116_S144_D1.7941.00
158_V162_K1.7861.00
21_Y160_A1.7781.00
344_D349_K1.7691.00
324_A338_T1.7651.00
327_H338_T1.7581.00
175_L187_K1.7171.00
224_G302_R1.7071.00
5_Y167_E1.6641.00
187_K192_D1.6601.00
206_S325_A1.6541.00
199_V346_I1.6461.00
25_K164_L1.6461.00
188_T193_V1.6421.00
322_L346_I1.6391.00
38_M158_V1.6351.00
174_V186_I1.6331.00
185_F192_D1.6261.00
158_V168_I1.6111.00
179_R184_L1.6031.00
185_F194_W1.5981.00
37_T171_H1.5951.00
172_T188_T1.5901.00
322_L342_I1.5721.00
89_R152_F1.5701.00
26_E349_K1.5661.00
106_L109_R1.5661.00
200_V206_S1.5641.00
22_Y26_E1.5641.00
109_R113_D1.5601.00
21_Y25_K1.5581.00
122_K126_L1.5481.00
12_G32_L1.5341.00
159_K162_K1.5251.00
160_A163_M1.5221.00
197_H346_I1.5191.00
169_F172_T1.5091.00
5_Y8_V1.5021.00
324_A342_I1.4991.00
160_A164_L1.4481.00
118_S143_Q1.4451.00
6_E31_A1.4411.00
229_V232_D1.4341.00
159_K163_M1.4311.00
26_E344_D1.4281.00
72_L75_G1.4271.00
33_F195_A1.4271.00
195_A198_V1.4131.00
7_A197_H1.4091.00
339_G343_S1.4021.00
31_A193_V1.3751.00
8_V31_A1.3711.00
19_I324_A1.3681.00
15_I324_A1.3671.00
37_T170_E1.3661.00
18_A22_Y1.3651.00
72_L340_A1.3531.00
109_R119_W1.3521.00
33_F169_F1.3501.00
68_H71_R1.3411.00
73_Y153_V1.3341.00
15_I327_H1.3271.00
182_E185_F1.3161.00
6_E28_K1.3041.00
14_I335_A1.3021.00
200_V323_F1.2981.00
120_Y124_E1.2961.00
149_E152_F1.2931.00
22_Y25_K1.2841.00
23_L343_S1.2801.00
200_V321_I1.2731.00
180_D183_A1.2671.00
21_Y164_L1.2661.00
32_L168_I1.2631.00
105_V109_R1.2611.00
272_L276_E1.2491.00
26_E343_S1.2391.00
71_R75_G1.2091.00
94_G141_F1.1991.00
10_I202_S1.1911.00
177_V198_V1.1881.00
17_S161_A1.1871.00
340_A344_D1.1841.00
17_S32_L1.1841.00
12_G34_E1.1831.00
5_Y29_N1.1591.00
279_M283_K1.1591.00
36_G40_G1.1541.00
230_W295_D1.1361.00
31_A167_E1.1341.00
322_L345_L1.1271.00
124_E128_K1.1231.00
19_I201_A1.1141.00
120_Y128_K1.1131.00
275_L297_F1.1101.00
180_D185_F1.1071.00
75_G78_E1.1061.00
74_K78_E1.1051.00
9_V20_A1.1041.00
315_H323_F1.1031.00
60_D64_D1.1031.00
123_E127_E1.0981.00
9_V19_I1.0971.00
20_A30_T1.0951.00
10_I198_V1.0881.00
110_Q113_D1.0831.00
209_F212_Q1.0821.00
341_L344_D1.0721.00
20_A166_A1.0711.00
152_F155_K1.0701.00
19_I339_G1.0681.00
33_F174_V1.0681.00
90_Q146_V1.0671.00
161_A168_I1.0661.00
20_A32_L1.0581.00
45_A298_W1.0521.00
202_S206_S1.0491.00
94_G143_Q1.0431.00
36_G41_R1.0421.00
39_G154_C1.0321.00
18_A339_G1.0131.00
182_E319_S1.0111.00
17_S168_I1.0011.00
176_H212_Q0.9981.00
102_E137_F0.9971.00
177_V183_A0.9971.00
177_V186_I0.9871.00
76_L80_L0.9801.00
151_Y155_K0.9781.00
169_F193_V0.9781.00
30_T166_A0.9581.00
281_K284_T0.9581.00
18_A157_Y0.9561.00
197_H200_V0.9551.00
324_A327_H0.9521.00
153_V332_I0.9521.00
102_E106_L0.9521.00
172_T190_S0.9511.00
38_M168_I0.9511.00
172_T193_V0.9501.00
101_S104_D0.9451.00
5_Y196_N0.9401.00
283_K290_Q0.9351.00
183_A194_W0.9351.00
184_L320_R0.9351.00
118_S128_K0.9341.00
73_Y77_G0.9331.00
69_S73_Y0.9311.00
70_Q74_K0.9311.00
118_S141_F0.9301.00
197_H314_R0.9261.00
280_K284_T0.9251.00
202_S209_F0.9191.00
184_L321_I0.9181.00
148_V153_V0.9131.00
201_A324_A0.9111.00
148_V332_I0.9101.00
314_R319_S0.9041.00
23_L28_K0.9021.00
280_K283_K0.8921.00
77_G88_I0.8871.00
343_S346_I0.8851.00
153_V336_P0.8841.00
33_F188_T0.8721.00
198_V320_R0.8671.00
106_L110_Q0.8641.00
271_D274_G0.8611.00
111_M115_D0.8611.00
156_A160_A0.8521.00
175_L188_T0.8521.00
99_A108_L0.8511.00
112_D140_S0.8481.00
208_M211_K0.8471.00
10_I174_V0.8451.00
178_E192_D0.8451.00
257_V282_A0.8421.00
282_A286_L0.8381.00
6_E194_W0.8271.00
49_M55_E0.8241.00
312_I338_T0.8241.00
275_L279_M0.8231.00
73_Y335_A0.8181.00
10_I200_V0.8171.00
62_F66_A0.8161.00
158_V170_E0.8141.00
245_C248_V0.8141.00
123_E126_L0.8141.00
229_V257_V0.8131.00
48_G150_P0.8121.00
20_A161_A0.8111.00
197_H320_R0.8101.00
21_Y157_Y0.8091.00
52_A55_E0.8091.00
18_A336_P0.8071.00
310_P313_G0.8041.00
18_A335_A0.8031.00
228_S256_V0.8021.00
200_V210_F0.8021.00
68_H72_L0.8011.00
68_H337_A0.8011.00
26_E340_A0.8001.00
162_K167_E0.7981.00
112_D119_W0.7911.00
188_T192_D0.7901.00
256_V259_A0.7891.00
15_I201_A0.7871.00
252_S257_V0.7871.00
318_D321_I0.7861.00
183_A198_V0.7861.00
183_A196_N0.7851.00
314_R320_R0.7811.00
105_V119_W0.7801.00
64_D67_M0.7791.00
161_A165_G0.7781.00
86_V156_A0.7751.00
67_M71_R0.7671.00
105_V137_F0.7661.00
169_F192_D0.7631.00
156_A159_K0.7631.00
72_L76_L0.7581.00
23_L346_I0.7561.00
225_E262_K0.7481.00
128_K141_F0.7471.00
42_T204_V0.7451.00
7_A199_V0.7421.00
120_Y125_V0.7411.00
105_V108_L0.7411.00
179_R320_R0.7401.00
277_S280_K0.7391.00
314_R345_L0.7391.00
178_E184_L0.7371.00
96_F125_V0.7361.00
61_A66_A0.7331.00
222_V304_G0.7331.00
80_L160_A0.7321.00
29_N196_N0.7261.00
254_R295_D0.7231.00
290_Q293_K0.7221.00
28_K197_H0.7191.00
237_T240_L0.7181.00
210_F213_L0.7171.00
69_S337_A0.7141.00
51_G333_L0.7121.00
69_S72_L0.7121.00
153_V157_Y0.7121.00
34_E170_E0.7101.00
253_G257_V0.7091.00
116_S143_Q0.7091.00
185_F198_V0.7091.00
73_Y80_L0.7071.00
14_I43_T0.7061.00
228_S296_R0.7061.00
24_A29_N0.7041.00
310_P314_R0.7041.00
312_I342_I0.7001.00
22_Y72_L0.6991.00
63_F67_M0.6971.00
330_N333_L0.6971.00
174_V177_V0.6971.00
122_K125_V0.6951.00
19_I346_I0.6941.00
77_G80_L0.6941.00
227_L294_V0.6931.00
89_R149_E0.6921.00
179_R182_E0.6911.00
177_V184_L0.6871.00
258_G263_P0.6871.00
184_L198_V0.6851.00
173_P208_M0.6841.00
183_A320_R0.6821.00
196_N320_R0.6811.00
305_T326_G0.6791.00
86_V89_R0.6791.00
277_S281_K0.6781.00
243_D249_P0.6761.00
257_V260_T0.6751.00
245_C249_P0.6741.00
108_L112_D0.6741.00
336_P339_G0.6721.00
185_F188_T0.6711.00
129_E237_T0.6711.00
110_Q114_L0.6711.00
179_R185_F0.6671.00
45_A300_G0.6651.00
33_F172_T0.6631.00
66_A70_Q0.6621.00
32_L166_A0.6621.00
344_D351_V0.6611.00
41_R45_A0.6611.00
26_E348_N0.6601.00
205_W208_M0.6601.00
109_R112_D0.6591.00
32_L161_A0.6591.00
246_Y258_G0.6591.00
43_T46_A0.6591.00
154_C158_V0.6571.00
223_K262_K0.6571.00
25_K160_A0.6561.00
177_V213_L0.6551.00
72_L79_E0.6541.00
18_A153_V0.6511.00
179_R183_A0.6501.00
64_D68_H0.6501.00
51_G330_N0.6501.00
220_L263_P0.6481.00
335_A339_G0.6461.00
210_F323_F0.6451.00
300_G303_P0.6431.00
8_V198_V0.6431.00
172_T189_P0.6411.00
343_S347_M0.6371.00
21_Y161_A0.6371.00
236_L239_T0.6361.00
175_L190_S0.6341.00
14_I332_I0.6331.00
178_E194_W0.6331.00
27_N30_T0.6331.00
276_E279_M0.6331.00
49_M52_A0.6311.00
49_M53_H0.6311.00
34_E37_T0.6301.00
308_G313_G0.6291.00
162_K168_I0.6291.00
51_G55_E0.6291.00
14_I154_C0.6271.00
327_H335_A0.6271.00
96_F139_A0.6261.00
255_L259_A0.6251.00
281_K285_M0.6241.00
41_R44_S0.6241.00
312_I315_H0.6221.00
6_E195_A0.6211.00
199_V342_I0.6211.00
175_L178_E0.6181.00
19_I342_I0.6171.00
24_A30_T0.6171.00
180_D194_W0.6171.00
253_G258_G0.6151.00
230_W233_D0.6141.00
227_L278_V0.6141.00
243_D248_V0.6121.00
61_A64_D0.6121.00
73_Y76_L0.6101.00
125_V136_I0.6071.00
66_A69_S0.6051.00
260_T263_P0.6051.00
172_T191_G0.6051.00
51_G54_A0.6041.00
287_P290_Q0.6021.00
226_C298_W0.6021.00
126_L133_S0.6011.00
71_R74_K0.6011.00
142_I145_D0.5991.00
243_D246_Y0.5991.00
314_R322_L0.5991.00
28_K31_A0.5981.00
283_K289_I0.5981.00
107_Q110_Q0.5971.00
15_I338_T0.5961.00
70_Q73_Y0.5951.00
22_Y343_S0.5941.00
12_G158_V0.5921.00
39_G43_T0.5911.00
324_A339_G0.5911.00
12_G170_E0.5891.00
6_E193_V0.5881.00
242_H245_C0.5881.00
211_K216_N0.5881.00
316_P319_S0.5851.00
152_F156_A0.5851.00
230_W254_R0.5821.00
7_A30_T0.5811.00
96_F141_F0.5811.00
253_G259_A0.5791.00
99_A105_V0.5771.00
126_L134_G0.5771.00
136_I140_S0.5741.00
337_A340_A0.5721.00
182_E320_R0.5721.00
254_R258_G0.5711.00
174_V188_T0.5711.00
219_F303_P0.5711.00
184_L187_K0.5691.00
49_M54_A0.5691.00
261_M329_R0.5661.00
112_D117_V0.5641.00
262_K274_G0.5631.00
32_L158_V0.5621.00
223_K299_A0.5611.00
121_S127_E0.5611.00
329_R332_I0.5611.00
273_G276_E0.5591.00
24_A27_N0.5581.00
103_E106_L0.5581.00
119_W138_G0.5581.00
91_H147_H0.5561.00
242_H246_Y0.5551.00
303_P329_R0.5541.00
287_P291_N0.5541.00
54_A333_L0.5541.00
337_A341_L0.5531.00
58_E62_F0.5521.00
344_D348_N0.5521.00
73_Y336_P0.5501.00
177_V321_I0.5501.00
180_D184_L0.5481.00
92_N144_D0.5471.00
87_D152_F0.5471.00
327_H331_G0.5461.00
246_Y249_P0.5431.00
224_G260_T0.5431.00
260_T302_R0.5411.00
256_V260_T0.5401.00
95_M145_D0.5391.00
309_K312_I0.5391.00
283_K291_N0.5381.00
9_V30_T0.5371.00
155_K159_K0.5371.00
244_H248_V0.5361.00
228_S254_R0.5341.00
8_V196_N0.5341.00
186_I198_V0.5331.00
257_V262_K0.5331.00
255_L258_G0.5311.00
177_V212_Q0.5311.00
63_F66_A0.5291.00
35_S41_R0.5291.00
43_T154_C0.5271.00
49_M145_D0.5271.00
50_L90_Q0.5271.00
183_A321_I0.5251.00
221_P301_L0.5241.00
46_A49_M0.5241.00
313_G323_F0.5221.00
35_S205_W0.5201.00
47_A55_E0.5201.00
39_G44_S0.5151.00
153_V335_A0.5151.00
34_E168_I0.5151.00
125_V128_K0.5141.00
46_A55_E0.5131.00
28_K196_N0.5121.00
31_A195_A0.5111.00
133_S136_I0.5111.00
119_W140_S0.5101.00
185_F195_A0.5081.00
305_T328_F0.5081.00
108_L111_M0.5081.00
179_R194_W0.5071.00
121_S125_V0.5071.00
14_I157_Y0.5071.00
181_G185_F0.5051.00
303_P327_H0.5041.00
72_L336_P0.5031.00
282_A289_I0.5031.00
21_Y24_A0.5021.00
185_F320_R0.5021.00
5_Y28_K0.5021.00
95_M98_L0.5011.00
46_A53_H0.5011.00
129_E132_A0.5001.00
65_F341_L0.5001.00
222_V226_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ryiA 4 0.9837 100 0.238 Contact Map
4h1bA 1 0.9621 100 0.255 Contact Map
1y56B 1 0.9729 100 0.278 Contact Map
4x9mA 1 0.9675 100 0.278 Contact Map
2gagB 1 0.9756 100 0.286 Contact Map
3pvcA 1 0.9675 100 0.299 Contact Map
2gf3A 1 0.9702 100 0.3 Contact Map
3ps9A 1 0.9729 100 0.301 Contact Map
3axbA 2 0.9621 100 0.301 Contact Map
4rslA 1 0.9621 100 0.314 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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