GLOX - BACSU - GREMLIN Contacts

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GLOX - Glycine oxidase

UniProt:	O31616	Sequences: MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTSAAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSEEDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKAAKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNAFLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLESVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILLAPATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	369 (338)
Sequences:	28810 (21204)
Seq/√Len:	1153.3

ECOLI - PUUB LHGO MTOX DADA MNMC GLPA GLPD MQO
BACSU - GLOX YURR YHFW GLPD
HALSA - Q9HSD9 Q9HNS4
SULSO - Q980U0 Q97VT4 Q97ZD5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
161_A	166_A	5.687	1.00
5_Y	31_A	4.048	1.00
35_S	173_P	3.760	1.00
8_V	186_I	3.462	1.00
173_P	189_P	3.340	1.00
6_E	196_N	3.296	1.00
6_E	29_N	3.199	1.00
176_H	187_K	3.082	1.00
8_V	195_A	2.969	1.00
31_A	169_F	2.967	1.00
178_E	187_K	2.702	1.00
178_E	185_F	2.679	1.00
121_S	124_E	2.662	1.00
8_V	33_F	2.630	1.00
230_W	293_K	2.573	1.00
29_N	167_E	2.495	1.00
24_A	164_L	2.469	1.00
33_F	193_V	2.459	1.00
74_K	92_N	2.422	1.00
68_H	340_A	2.405	1.00
7_A	23_L	2.384	1.00
25_K	79_E	2.291	1.00
24_A	166_A	2.290	1.00
118_S	124_E	2.210	1.00
28_K	347_M	2.179	1.00
7_A	28_K	2.123	1.00
19_I	199_V	2.113	1.00
8_V	193_V	2.072	1.00
188_T	191_G	2.003	1.00
175_L	189_P	1.991	1.00
105_V	138_G	1.948	1.00
26_E	347_M	1.922	1.00
125_V	139_A	1.921	1.00
22_Y	340_A	1.920	1.00
124_E	127_E	1.896	1.00
17_S	158_V	1.889	1.00
12_G	38_M	1.869	1.00
24_A	161_A	1.866	1.00
38_M	170_E	1.852	1.00
22_Y	339_G	1.850	1.00
197_H	322_L	1.845	1.00
75_G	79_E	1.824	1.00
17_S	154_C	1.800	1.00
276_E	280_K	1.794	1.00
116_S	144_D	1.794	1.00
158_V	162_K	1.786	1.00
21_Y	160_A	1.778	1.00
344_D	349_K	1.769	1.00
324_A	338_T	1.765	1.00
327_H	338_T	1.758	1.00
175_L	187_K	1.717	1.00
224_G	302_R	1.707	1.00
5_Y	167_E	1.664	1.00
187_K	192_D	1.660	1.00
206_S	325_A	1.654	1.00
199_V	346_I	1.646	1.00
25_K	164_L	1.646	1.00
188_T	193_V	1.642	1.00
322_L	346_I	1.639	1.00
38_M	158_V	1.635	1.00
174_V	186_I	1.633	1.00
185_F	192_D	1.626	1.00
158_V	168_I	1.611	1.00
179_R	184_L	1.603	1.00
185_F	194_W	1.598	1.00
37_T	171_H	1.595	1.00
172_T	188_T	1.590	1.00
322_L	342_I	1.572	1.00
89_R	152_F	1.570	1.00
26_E	349_K	1.566	1.00
106_L	109_R	1.566	1.00
200_V	206_S	1.564	1.00
22_Y	26_E	1.564	1.00
109_R	113_D	1.560	1.00
21_Y	25_K	1.558	1.00
122_K	126_L	1.548	1.00
12_G	32_L	1.534	1.00
159_K	162_K	1.525	1.00
160_A	163_M	1.522	1.00
197_H	346_I	1.519	1.00
169_F	172_T	1.509	1.00
5_Y	8_V	1.502	1.00
324_A	342_I	1.499	1.00
160_A	164_L	1.448	1.00
118_S	143_Q	1.445	1.00
6_E	31_A	1.441	1.00
229_V	232_D	1.434	1.00
159_K	163_M	1.431	1.00
26_E	344_D	1.428	1.00
72_L	75_G	1.427	1.00
33_F	195_A	1.427	1.00
195_A	198_V	1.413	1.00
7_A	197_H	1.409	1.00
339_G	343_S	1.402	1.00
31_A	193_V	1.375	1.00
8_V	31_A	1.371	1.00
19_I	324_A	1.368	1.00
15_I	324_A	1.367	1.00
37_T	170_E	1.366	1.00
18_A	22_Y	1.365	1.00
72_L	340_A	1.353	1.00
109_R	119_W	1.352	1.00
33_F	169_F	1.350	1.00
68_H	71_R	1.341	1.00
73_Y	153_V	1.334	1.00
15_I	327_H	1.327	1.00
182_E	185_F	1.316	1.00
6_E	28_K	1.304	1.00
14_I	335_A	1.302	1.00
200_V	323_F	1.298	1.00
120_Y	124_E	1.296	1.00
149_E	152_F	1.293	1.00
22_Y	25_K	1.284	1.00
23_L	343_S	1.280	1.00
200_V	321_I	1.273	1.00
180_D	183_A	1.267	1.00
21_Y	164_L	1.266	1.00
32_L	168_I	1.263	1.00
105_V	109_R	1.261	1.00
272_L	276_E	1.249	1.00
26_E	343_S	1.239	1.00
71_R	75_G	1.209	1.00
94_G	141_F	1.199	1.00
10_I	202_S	1.191	1.00
177_V	198_V	1.188	1.00
17_S	161_A	1.187	1.00
340_A	344_D	1.184	1.00
17_S	32_L	1.184	1.00
12_G	34_E	1.183	1.00
5_Y	29_N	1.159	1.00
279_M	283_K	1.159	1.00
36_G	40_G	1.154	1.00
230_W	295_D	1.136	1.00
31_A	167_E	1.134	1.00
322_L	345_L	1.127	1.00
124_E	128_K	1.123	1.00
19_I	201_A	1.114	1.00
120_Y	128_K	1.113	1.00
275_L	297_F	1.110	1.00
180_D	185_F	1.107	1.00
75_G	78_E	1.106	1.00
74_K	78_E	1.105	1.00
9_V	20_A	1.104	1.00
315_H	323_F	1.103	1.00
60_D	64_D	1.103	1.00
123_E	127_E	1.098	1.00
9_V	19_I	1.097	1.00
20_A	30_T	1.095	1.00
10_I	198_V	1.088	1.00
110_Q	113_D	1.083	1.00
209_F	212_Q	1.082	1.00
341_L	344_D	1.072	1.00
20_A	166_A	1.071	1.00
152_F	155_K	1.070	1.00
19_I	339_G	1.068	1.00
33_F	174_V	1.068	1.00
90_Q	146_V	1.067	1.00
161_A	168_I	1.066	1.00
20_A	32_L	1.058	1.00
45_A	298_W	1.052	1.00
202_S	206_S	1.049	1.00
94_G	143_Q	1.043	1.00
36_G	41_R	1.042	1.00
39_G	154_C	1.032	1.00
18_A	339_G	1.013	1.00
182_E	319_S	1.011	1.00
17_S	168_I	1.001	1.00
176_H	212_Q	0.998	1.00
102_E	137_F	0.997	1.00
177_V	183_A	0.997	1.00
177_V	186_I	0.987	1.00
76_L	80_L	0.980	1.00
151_Y	155_K	0.978	1.00
169_F	193_V	0.978	1.00
30_T	166_A	0.958	1.00
281_K	284_T	0.958	1.00
18_A	157_Y	0.956	1.00
197_H	200_V	0.955	1.00
324_A	327_H	0.952	1.00
153_V	332_I	0.952	1.00
102_E	106_L	0.952	1.00
172_T	190_S	0.951	1.00
38_M	168_I	0.951	1.00
172_T	193_V	0.950	1.00
101_S	104_D	0.945	1.00
5_Y	196_N	0.940	1.00
283_K	290_Q	0.935	1.00
183_A	194_W	0.935	1.00
184_L	320_R	0.935	1.00
118_S	128_K	0.934	1.00
73_Y	77_G	0.933	1.00
69_S	73_Y	0.931	1.00
70_Q	74_K	0.931	1.00
118_S	141_F	0.930	1.00
197_H	314_R	0.926	1.00
280_K	284_T	0.925	1.00
202_S	209_F	0.919	1.00
184_L	321_I	0.918	1.00
148_V	153_V	0.913	1.00
201_A	324_A	0.911	1.00
148_V	332_I	0.910	1.00
314_R	319_S	0.904	1.00
23_L	28_K	0.902	1.00
280_K	283_K	0.892	1.00
77_G	88_I	0.887	1.00
343_S	346_I	0.885	1.00
153_V	336_P	0.884	1.00
33_F	188_T	0.872	1.00
198_V	320_R	0.867	1.00
106_L	110_Q	0.864	1.00
271_D	274_G	0.861	1.00
111_M	115_D	0.861	1.00
156_A	160_A	0.852	1.00
175_L	188_T	0.852	1.00
99_A	108_L	0.851	1.00
112_D	140_S	0.848	1.00
208_M	211_K	0.847	1.00
10_I	174_V	0.845	1.00
178_E	192_D	0.845	1.00
257_V	282_A	0.842	1.00
282_A	286_L	0.838	1.00
6_E	194_W	0.827	1.00
49_M	55_E	0.824	1.00
312_I	338_T	0.824	1.00
275_L	279_M	0.823	1.00
73_Y	335_A	0.818	1.00
10_I	200_V	0.817	1.00
62_F	66_A	0.816	1.00
158_V	170_E	0.814	1.00
245_C	248_V	0.814	1.00
123_E	126_L	0.814	1.00
229_V	257_V	0.813	1.00
48_G	150_P	0.812	1.00
20_A	161_A	0.811	1.00
197_H	320_R	0.810	1.00
21_Y	157_Y	0.809	1.00
52_A	55_E	0.809	1.00
18_A	336_P	0.807	1.00
310_P	313_G	0.804	1.00
18_A	335_A	0.803	1.00
228_S	256_V	0.802	1.00
200_V	210_F	0.802	1.00
68_H	72_L	0.801	1.00
68_H	337_A	0.801	1.00
26_E	340_A	0.800	1.00
162_K	167_E	0.798	1.00
112_D	119_W	0.791	1.00
188_T	192_D	0.790	1.00
256_V	259_A	0.789	1.00
15_I	201_A	0.787	1.00
252_S	257_V	0.787	1.00
318_D	321_I	0.786	1.00
183_A	198_V	0.786	1.00
183_A	196_N	0.785	1.00
314_R	320_R	0.781	1.00
105_V	119_W	0.780	1.00
64_D	67_M	0.779	1.00
161_A	165_G	0.778	1.00
86_V	156_A	0.775	1.00
67_M	71_R	0.767	1.00
105_V	137_F	0.766	1.00
169_F	192_D	0.763	1.00
156_A	159_K	0.763	1.00
72_L	76_L	0.758	1.00
23_L	346_I	0.756	1.00
225_E	262_K	0.748	1.00
128_K	141_F	0.747	1.00
42_T	204_V	0.745	1.00
7_A	199_V	0.742	1.00
120_Y	125_V	0.741	1.00
105_V	108_L	0.741	1.00
179_R	320_R	0.740	1.00
277_S	280_K	0.739	1.00
314_R	345_L	0.739	1.00
178_E	184_L	0.737	1.00
96_F	125_V	0.736	1.00
61_A	66_A	0.733	1.00
222_V	304_G	0.733	1.00
80_L	160_A	0.732	1.00
29_N	196_N	0.726	1.00
254_R	295_D	0.723	1.00
290_Q	293_K	0.722	1.00
28_K	197_H	0.719	1.00
237_T	240_L	0.718	1.00
210_F	213_L	0.717	1.00
69_S	337_A	0.714	1.00
51_G	333_L	0.712	1.00
69_S	72_L	0.712	1.00
153_V	157_Y	0.712	1.00
34_E	170_E	0.710	1.00
253_G	257_V	0.709	1.00
116_S	143_Q	0.709	1.00
185_F	198_V	0.709	1.00
73_Y	80_L	0.707	1.00
14_I	43_T	0.706	1.00
228_S	296_R	0.706	1.00
24_A	29_N	0.704	1.00
310_P	314_R	0.704	1.00
312_I	342_I	0.700	1.00
22_Y	72_L	0.699	1.00
63_F	67_M	0.697	1.00
330_N	333_L	0.697	1.00
174_V	177_V	0.697	1.00
122_K	125_V	0.695	1.00
19_I	346_I	0.694	1.00
77_G	80_L	0.694	1.00
227_L	294_V	0.693	1.00
89_R	149_E	0.692	1.00
179_R	182_E	0.691	1.00
177_V	184_L	0.687	1.00
258_G	263_P	0.687	1.00
184_L	198_V	0.685	1.00
173_P	208_M	0.684	1.00
183_A	320_R	0.682	1.00
196_N	320_R	0.681	1.00
305_T	326_G	0.679	1.00
86_V	89_R	0.679	1.00
277_S	281_K	0.678	1.00
243_D	249_P	0.676	1.00
257_V	260_T	0.675	1.00
245_C	249_P	0.674	1.00
108_L	112_D	0.674	1.00
336_P	339_G	0.672	1.00
185_F	188_T	0.671	1.00
129_E	237_T	0.671	1.00
110_Q	114_L	0.671	1.00
179_R	185_F	0.667	1.00
45_A	300_G	0.665	1.00
33_F	172_T	0.663	1.00
66_A	70_Q	0.662	1.00
32_L	166_A	0.662	1.00
344_D	351_V	0.661	1.00
41_R	45_A	0.661	1.00
26_E	348_N	0.660	1.00
205_W	208_M	0.660	1.00
109_R	112_D	0.659	1.00
32_L	161_A	0.659	1.00
246_Y	258_G	0.659	1.00
43_T	46_A	0.659	1.00
154_C	158_V	0.657	1.00
223_K	262_K	0.657	1.00
25_K	160_A	0.656	1.00
177_V	213_L	0.655	1.00
72_L	79_E	0.654	1.00
18_A	153_V	0.651	1.00
179_R	183_A	0.650	1.00
64_D	68_H	0.650	1.00
51_G	330_N	0.650	1.00
220_L	263_P	0.648	1.00
335_A	339_G	0.646	1.00
210_F	323_F	0.645	1.00
300_G	303_P	0.643	1.00
8_V	198_V	0.643	1.00
172_T	189_P	0.641	1.00
343_S	347_M	0.637	1.00
21_Y	161_A	0.637	1.00
236_L	239_T	0.636	1.00
175_L	190_S	0.634	1.00
14_I	332_I	0.633	1.00
178_E	194_W	0.633	1.00
27_N	30_T	0.633	1.00
276_E	279_M	0.633	1.00
49_M	52_A	0.631	1.00
49_M	53_H	0.631	1.00
34_E	37_T	0.630	1.00
308_G	313_G	0.629	1.00
162_K	168_I	0.629	1.00
51_G	55_E	0.629	1.00
14_I	154_C	0.627	1.00
327_H	335_A	0.627	1.00
96_F	139_A	0.626	1.00
255_L	259_A	0.625	1.00
281_K	285_M	0.624	1.00
41_R	44_S	0.624	1.00
312_I	315_H	0.622	1.00
6_E	195_A	0.621	1.00
199_V	342_I	0.621	1.00
175_L	178_E	0.618	1.00
19_I	342_I	0.617	1.00
24_A	30_T	0.617	1.00
180_D	194_W	0.617	1.00
253_G	258_G	0.615	1.00
230_W	233_D	0.614	1.00
227_L	278_V	0.614	1.00
243_D	248_V	0.612	1.00
61_A	64_D	0.612	1.00
73_Y	76_L	0.610	1.00
125_V	136_I	0.607	1.00
66_A	69_S	0.605	1.00
260_T	263_P	0.605	1.00
172_T	191_G	0.605	1.00
51_G	54_A	0.604	1.00
287_P	290_Q	0.602	1.00
226_C	298_W	0.602	1.00
126_L	133_S	0.601	1.00
71_R	74_K	0.601	1.00
142_I	145_D	0.599	1.00
243_D	246_Y	0.599	1.00
314_R	322_L	0.599	1.00
28_K	31_A	0.598	1.00
283_K	289_I	0.598	1.00
107_Q	110_Q	0.597	1.00
15_I	338_T	0.596	1.00
70_Q	73_Y	0.595	1.00
22_Y	343_S	0.594	1.00
12_G	158_V	0.592	1.00
39_G	43_T	0.591	1.00
324_A	339_G	0.591	1.00
12_G	170_E	0.589	1.00
6_E	193_V	0.588	1.00
242_H	245_C	0.588	1.00
211_K	216_N	0.588	1.00
316_P	319_S	0.585	1.00
152_F	156_A	0.585	1.00
230_W	254_R	0.582	1.00
7_A	30_T	0.581	1.00
96_F	141_F	0.581	1.00
253_G	259_A	0.579	1.00
99_A	105_V	0.577	1.00
126_L	134_G	0.577	1.00
136_I	140_S	0.574	1.00
337_A	340_A	0.572	1.00
182_E	320_R	0.572	1.00
254_R	258_G	0.571	1.00
174_V	188_T	0.571	1.00
219_F	303_P	0.571	1.00
184_L	187_K	0.569	1.00
49_M	54_A	0.569	1.00
261_M	329_R	0.566	1.00
112_D	117_V	0.564	1.00
262_K	274_G	0.563	1.00
32_L	158_V	0.562	1.00
223_K	299_A	0.561	1.00
121_S	127_E	0.561	1.00
329_R	332_I	0.561	1.00
273_G	276_E	0.559	1.00
24_A	27_N	0.558	1.00
103_E	106_L	0.558	1.00
119_W	138_G	0.558	1.00
91_H	147_H	0.556	1.00
242_H	246_Y	0.555	1.00
303_P	329_R	0.554	1.00
287_P	291_N	0.554	1.00
54_A	333_L	0.554	1.00
337_A	341_L	0.553	1.00
58_E	62_F	0.552	1.00
344_D	348_N	0.552	1.00
73_Y	336_P	0.550	1.00
177_V	321_I	0.550	1.00
180_D	184_L	0.548	1.00
92_N	144_D	0.547	1.00
87_D	152_F	0.547	1.00
327_H	331_G	0.546	1.00
246_Y	249_P	0.543	1.00
224_G	260_T	0.543	1.00
260_T	302_R	0.541	1.00
256_V	260_T	0.540	1.00
95_M	145_D	0.539	1.00
309_K	312_I	0.539	1.00
283_K	291_N	0.538	1.00
9_V	30_T	0.537	1.00
155_K	159_K	0.537	1.00
244_H	248_V	0.536	1.00
228_S	254_R	0.534	1.00
8_V	196_N	0.534	1.00
186_I	198_V	0.533	1.00
257_V	262_K	0.533	1.00
255_L	258_G	0.531	1.00
177_V	212_Q	0.531	1.00
63_F	66_A	0.529	1.00
35_S	41_R	0.529	1.00
43_T	154_C	0.527	1.00
49_M	145_D	0.527	1.00
50_L	90_Q	0.527	1.00
183_A	321_I	0.525	1.00
221_P	301_L	0.524	1.00
46_A	49_M	0.524	1.00
313_G	323_F	0.522	1.00
35_S	205_W	0.520	1.00
47_A	55_E	0.520	1.00
39_G	44_S	0.515	1.00
153_V	335_A	0.515	1.00
34_E	168_I	0.515	1.00
125_V	128_K	0.514	1.00
46_A	55_E	0.513	1.00
28_K	196_N	0.512	1.00
31_A	195_A	0.511	1.00
133_S	136_I	0.511	1.00
119_W	140_S	0.510	1.00
185_F	195_A	0.508	1.00
305_T	328_F	0.508	1.00
108_L	111_M	0.508	1.00
179_R	194_W	0.507	1.00
121_S	125_V	0.507	1.00
14_I	157_Y	0.507	1.00
181_G	185_F	0.505	1.00
303_P	327_H	0.504	1.00
72_L	336_P	0.503	1.00
282_A	289_I	0.503	1.00
21_Y	24_A	0.502	1.00
185_F	320_R	0.502	1.00
5_Y	28_K	0.502	1.00
95_M	98_L	0.501	1.00
46_A	53_H	0.501	1.00
129_E	132_A	0.500	1.00
65_F	341_L	0.500	1.00
222_V	226_C	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ryiA	4	0.9837	100	0.238	Contact Map
4h1bA	1	0.9621	100	0.255	Contact Map
1y56B	1	0.9729	100	0.278	Contact Map
4x9mA	1	0.9675	100	0.278	Contact Map
2gagB	1	0.9756	100	0.286	Contact Map
3pvcA	1	0.9675	100	0.299	Contact Map
2gf3A	1	0.9702	100	0.3	Contact Map
3ps9A	1	0.9729	100	0.301	Contact Map
3axbA	2	0.9621	100	0.301	Contact Map
4rslA	1	0.9621	100	0.314	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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