GREMLIN Database
PRPE - Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical]
UniProt: O31614 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (197)
Sequences: 4271 (3178)
Seq/√Len: 226.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_K55_E5.7281.00
209_T218_T3.6791.00
17_T59_F3.0931.00
14_D52_K2.9641.00
13_Y55_E2.9311.00
13_Y17_T2.9261.00
39_V70_R2.7501.00
73_P78_N2.5791.00
42_F60_V2.3951.00
13_Y59_F2.3781.00
5_I137_V2.3661.00
221_R224_E2.3491.00
9_I56_V2.3151.00
70_R128_D2.3131.00
23_L219_G2.2871.00
41_V137_V2.2321.00
16_M42_F2.1901.00
43_A137_V2.1421.00
19_L219_G2.1101.00
85_K122_E2.0971.00
61_A117_F2.0181.00
78_N82_R1.9571.00
135_L222_F1.9431.00
4_D221_R1.9351.00
12_C212_V1.8621.00
190_Y204_T1.8131.00
187_W205_I1.7961.00
58_R117_F1.7771.00
190_Y206_N1.7691.00
4_D23_L1.7451.00
189_V207_I1.7441.00
63_A69_V1.7381.00
9_I16_M1.7351.00
61_A120_L1.6891.00
12_C15_E1.6841.00
25_Y38_R1.6751.00
148_G151_T1.6711.00
115_E119_K1.6701.00
207_I220_F1.5941.00
205_I220_F1.5861.00
46_L56_V1.5491.00
16_M59_F1.5291.00
41_V128_D1.5061.00
61_A116_Q1.4901.00
5_I189_V1.4801.00
147_I150_Y1.4791.00
46_L71_Y1.4601.00
20_I59_F1.4391.00
40_L63_A1.4271.00
46_L60_V1.4201.00
47_T77_C1.4171.00
189_V220_F1.4061.00
71_Y124_A1.3961.00
102_L117_F1.3761.00
54_I58_R1.3751.00
138_A188_V1.3641.00
127_Y136_V1.3521.00
221_R228_V1.3461.00
16_M56_V1.3221.00
54_I101_E1.3181.00
120_L124_A1.2941.00
57_I121_Y1.2921.00
15_E211_C1.2811.00
26_T36_E1.2711.00
187_W225_I1.2671.00
12_C211_C1.2621.00
42_F71_Y1.2591.00
73_P81_Y1.2521.00
43_A72_V1.2491.00
195_V198_P1.2331.00
135_L187_W1.2241.00
42_F69_V1.1971.00
98_T102_L1.1691.00
194_P212_V1.1481.00
48_D98_T1.1481.00
46_L72_V1.1361.00
125_P128_D1.1331.00
84_L118_M1.1161.00
174_I178_W1.1021.00
3_Y39_V1.0751.00
131_H186_A1.0531.00
59_F63_A1.0511.00
90_K94_G1.0411.00
62_G66_K1.0291.00
5_I135_L1.0231.00
194_P213_F1.0201.00
79_K93_H1.0181.00
118_M122_E1.0161.00
168_Y172_R1.0021.00
129_I186_A0.9981.00
20_I42_F0.9971.00
98_T101_E0.9881.00
95_L98_T0.9791.00
136_V188_V0.9791.00
58_R116_Q0.9751.00
73_P124_A0.9681.00
100_A104_E0.9601.00
96_E100_A0.9601.00
216_Q229_S0.9591.00
43_A207_I0.9541.00
39_V68_A0.9511.00
9_I42_F0.9451.00
176_R180_A0.9431.00
25_Y35_E0.9431.00
134_E186_A0.9391.00
13_Y52_K0.9331.00
15_E214_G0.9311.00
57_I117_F0.9271.00
212_V215_N0.9211.00
48_D76_H0.9181.00
47_T57_I0.9171.00
210_G213_F0.9161.00
7_S218_T0.9120.99
59_F62_G0.9110.99
224_E228_V0.9110.99
81_Y121_Y0.9080.99
18_A21_Q0.9060.99
58_R105_L0.9010.99
60_V71_Y0.8990.99
7_S207_I0.8970.99
221_R226_E0.8960.99
119_K123_T0.8950.99
58_R61_A0.8930.99
135_L189_V0.8820.99
170_D174_I0.8770.99
42_F46_L0.8740.99
175_R193_T0.8680.99
7_S42_F0.8680.99
94_G98_T0.8610.99
174_I179_A0.8590.99
7_S209_T0.8580.99
147_I151_T0.8530.99
136_V186_A0.8470.99
5_I222_F0.8440.99
40_L69_V0.8410.99
35_E38_R0.8360.99
77_C81_Y0.8350.99
11_G53_S0.8350.99
3_Y137_V0.8350.99
184_G203_R0.8170.99
13_Y56_V0.8060.99
143_R146_D0.8060.99
194_P206_N0.8050.99
195_V206_N0.8050.99
6_I219_G0.8030.99
143_R170_D0.8000.99
189_V205_I0.7970.99
4_D228_V0.7920.99
60_V69_V0.7890.99
73_P168_Y0.7870.98
171_G174_I0.7860.98
220_F225_I0.7780.98
169_P172_R0.7760.98
130_L133_G0.7710.98
80_L90_K0.7690.98
114_S117_F0.7680.98
71_Y120_L0.7650.98
26_T37_G0.7640.98
78_N172_R0.7640.98
10_H212_V0.7630.98
47_T80_L0.7550.98
129_I136_V0.7520.98
90_K95_L0.7510.98
141_G174_I0.7500.98
211_C217_L0.7490.98
194_P210_G0.7490.98
18_A22_K0.7470.98
90_K93_H0.7420.98
4_D219_G0.7410.98
146_D151_T0.7370.98
127_Y151_T0.7350.98
57_I102_L0.7240.97
133_G186_A0.7220.97
89_V93_H0.7200.97
55_E58_R0.7170.97
3_Y130_L0.7140.97
72_V137_V0.7130.97
57_I61_A0.7130.97
177_D180_A0.7090.97
81_Y122_E0.7080.97
4_D38_R0.7070.97
4_D25_Y0.7040.97
41_V70_R0.7030.97
223_P226_E0.7030.97
73_P126_L0.7020.97
17_T55_E0.7020.97
19_L217_L0.7000.97
178_W188_V0.6930.97
58_R113_V0.6900.97
3_Y223_P0.6900.97
127_Y152_R0.6890.97
20_I25_Y0.6820.96
135_L205_I0.6820.96
70_R125_P0.6710.96
197_E216_Q0.6680.96
71_Y125_P0.6670.96
20_I40_L0.6650.96
19_L23_L0.6640.96
187_W203_R0.6630.96
70_R124_A0.6620.96
22_K228_V0.6620.96
39_V132_N0.6590.96
172_R175_R0.6590.96
17_T21_Q0.6510.95
91_V94_G0.6490.95
80_L121_Y0.6410.95
58_R107_K0.6400.95
121_Y124_A0.6390.95
56_V59_F0.6370.95
21_Q122_E0.6370.95
220_F227_T0.6360.95
38_R221_R0.6340.94
218_T227_T0.6330.94
77_C121_Y0.6320.94
6_I217_L0.6300.94
168_Y171_G0.6280.94
200_K205_I0.6280.94
103_E107_K0.6280.94
6_I42_F0.6280.94
89_V92_M0.6210.94
218_T229_S0.6210.94
198_P218_T0.6190.94
95_L102_L0.6170.94
23_L38_R0.6130.93
41_V130_L0.6130.93
73_P172_R0.6130.93
144_A148_G0.6090.93
25_Y40_L0.6080.93
10_H43_A0.6040.93
59_F69_V0.6030.93
132_N137_V0.5990.93
198_P209_T0.5980.93
3_Y41_V0.5970.93
97_T101_E0.5960.92
179_A182_Y0.5840.92
6_I40_L0.5830.92
170_D173_P0.5830.92
146_D150_Y0.5820.92
9_I60_V0.5790.91
174_I177_D0.5790.91
142_I151_T0.5770.91
11_G49_R0.5670.91
63_A68_A0.5610.90
117_F120_L0.5580.90
61_A66_K0.5580.90
116_Q119_K0.5570.90
42_F219_G0.5560.90
70_R73_P0.5550.90
53_S56_V0.5540.90
12_C214_G0.5530.89
189_V222_F0.5530.89
55_E59_F0.5530.89
14_D18_A0.5520.89
46_L124_A0.5510.89
222_F225_I0.5500.89
178_W182_Y0.5500.89
131_H134_E0.5490.89
58_R62_G0.5490.89
142_I184_G0.5480.89
5_I43_A0.5480.89
91_V95_L0.5460.89
45_D76_H0.5440.89
198_P216_Q0.5420.88
48_D194_P0.5390.88
46_L77_C0.5380.88
26_T38_R0.5380.88
15_E18_A0.5380.88
198_P227_T0.5370.88
81_Y85_K0.5350.88
100_A103_E0.5340.88
80_L113_V0.5310.87
197_E209_T0.5280.87
178_W206_N0.5260.87
16_M69_V0.5240.87
7_S219_G0.5230.87
96_E99_A0.5190.86
21_Q24_G0.5190.86
94_G102_L0.5170.86
185_K203_R0.5160.86
47_T53_S0.5150.86
4_D223_P0.5150.86
54_I117_F0.5150.86
8_D11_G0.5140.86
6_I16_M0.5140.86
81_Y118_M0.5120.86
53_S98_T0.5110.85
141_G188_V0.5090.85
127_Y142_I0.5050.85
130_L135_L0.5050.85
211_C218_T0.5050.85
118_M126_L0.5040.85
48_D193_T0.5030.85
72_V128_D0.5030.85
3_Y132_N0.5030.85
14_D17_T0.5010.84
16_M60_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j6oA 1 0.9836 100 0.375 Contact Map
2dfjA 2 0.8689 100 0.376 Contact Map
2qjcA 1 0.832 100 0.401 Contact Map
2z72A 1 0.9713 100 0.464 Contact Map
1g5bA 4 0.8074 100 0.512 Contact Map
3icfA 2 0.8975 100 0.546 Contact Map
4i5lC 1 0.8811 100 0.559 Contact Map
1fjmA 1 0.8648 100 0.564 Contact Map
4il1A 1 0.8934 100 0.566 Contact Map
1auiA 1 0.8934 100 0.572 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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