GREMLIN Database
NADK1 - NAD kinase 1
UniProt: O31612 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (226)
Sequences: 4212 (2807)
Seq/√Len: 186.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_D237_Q4.0651.00
99_E244_R3.9191.00
208_M233_S3.8601.00
140_K205_H3.5671.00
136_D210_K3.2411.00
177_R203_S3.1711.00
208_M235_R3.1111.00
89_A94_P3.0431.00
164_N182_A2.9781.00
135_A209_I2.9441.00
104_E237_Q2.8811.00
210_K233_S2.8371.00
104_E117_R2.7181.00
106_I235_R2.6891.00
48_L245_F2.5591.00
138_E143_L2.4561.00
206_D235_R2.4401.00
172_I180_Q2.3771.00
99_E242_K2.3231.00
138_E210_K2.2971.00
141_G208_M2.1751.00
131_G134_V2.1391.00
82_E85_K2.1361.00
181_L201_L2.1001.00
138_E208_M2.0481.00
88_L92_K2.0191.00
100_Y158_S1.8901.00
105_V124_C1.8741.00
137_V181_L1.8571.00
142_Q252_P1.8451.00
106_I117_R1.8291.00
39_V55_Y1.8261.00
110_H232_K1.8161.00
98_V247_R1.7231.00
124_C219_V1.7221.00
126_I209_I1.7191.00
119_L239_A1.6801.00
53_H224_L1.6781.00
141_G206_D1.6751.00
139_I207_C1.6751.00
48_L66_G1.6691.00
97_T244_R1.6591.00
108_T114_R1.6361.00
167_L182_A1.6141.00
42_V69_T1.5841.00
106_I237_Q1.5771.00
102_L243_V1.5531.00
161_T171_I1.5411.00
139_I205_H1.5151.00
108_T233_S1.4821.00
57_D60_D1.4701.00
143_L146_T1.4551.00
167_L185_A1.4441.00
170_A180_Q1.4431.00
103_L179_I1.4251.00
154_L209_I1.3891.00
137_V152_L1.3751.00
77_D247_R1.3731.00
78_W86_L1.3491.00
136_D146_T1.3141.00
48_L76_A1.3111.00
123_E153_C1.2831.00
110_H115_E1.2771.00
104_E239_A1.2681.00
120_A221_I1.2581.00
40_I87_V1.2091.00
172_I200_L1.2061.00
170_A200_L1.1981.00
108_T235_R1.1971.00
201_L207_C1.1901.00
142_Q255_K1.1801.00
124_C236_C1.1751.00
102_L239_A1.1721.00
173_H202_P1.1701.00
253_F257_V1.1641.00
124_C221_I1.1631.00
72_L187_I1.1591.00
172_I178_A1.1531.00
68_H73_G1.1501.00
61_K244_R1.1491.00
114_R117_R1.1431.00
173_H254_W1.1301.00
38_I90_I1.1291.00
155_S180_Q1.1261.00
57_D241_E1.1081.00
154_L181_L1.1061.00
203_S238_V1.1031.00
104_E240_S1.1021.00
102_L242_K1.1011.00
150_D163_Y1.0901.00
52_F64_F1.0891.00
153_C167_L1.0861.00
105_V221_I1.0751.00
34_N60_D1.0681.00
85_K89_A1.0671.00
61_K241_E1.0631.00
154_L179_I1.0581.00
211_P217_F1.0421.00
94_P249_R1.0371.00
65_V90_I1.0331.00
177_R242_K1.0311.00
100_Y103_L1.0231.00
255_K259_D1.0161.00
38_I246_A1.0030.99
101_P177_R0.9970.99
90_I95_Y0.9950.99
229_K232_K0.9860.99
136_D143_L0.9860.99
101_P203_S0.9800.99
216_D229_K0.9780.99
138_E141_G0.9760.99
67_V78_W0.9720.99
201_L205_H0.9650.99
165_K190_R0.9610.99
85_K88_L0.9530.99
104_E119_L0.9460.99
96_H250_P0.9400.99
106_I114_R0.9390.99
180_Q200_L0.9380.99
89_A248_F0.9340.99
108_T232_K0.9330.99
123_E127_K0.9320.99
177_R238_V0.9280.99
52_F243_V0.9240.99
119_L241_E0.9200.99
101_P238_V0.9150.99
158_S174_P0.9090.99
125_T153_C0.9080.99
173_H205_H0.9070.99
154_L236_C0.9060.99
129_I132_S0.9060.99
74_F254_W0.9030.99
65_V246_A0.8980.99
179_I207_C0.8900.99
100_Y174_P0.8850.99
165_K187_I0.8820.99
175_S202_P0.8820.99
68_H260_S0.8800.99
108_T115_E0.8740.99
84_E88_L0.8720.99
32_D36_P0.8710.99
39_V64_F0.8690.98
173_H253_F0.8690.98
216_D227_L0.8660.98
189_N223_H0.8640.98
238_V242_K0.8630.98
57_D61_K0.8610.98
251_F256_R0.8600.98
139_I201_L0.8590.98
67_V83_I0.8590.98
110_H229_K0.8520.98
135_A149_G0.8480.98
140_K206_D0.8420.98
38_I65_V0.8410.98
135_A152_L0.8400.98
65_V78_W0.8350.98
177_R204_H0.8260.98
101_P157_P0.8250.98
165_K170_A0.8250.98
152_L181_L0.8240.98
110_H113_E0.8200.98
108_T111_E0.8170.98
202_P205_H0.8150.98
41_S51_A0.8100.98
118_Y221_I0.8060.98
121_L243_V0.8050.98
111_E114_R0.7970.97
86_L248_F0.7970.97
144_F254_W0.7970.97
101_P179_I0.7960.97
190_R193_R0.7940.97
98_V175_S0.7940.97
46_G70_G0.7910.97
42_V67_V0.7850.97
36_P166_A0.7840.97
252_P255_K0.7830.97
105_V234_I0.7780.97
139_I144_F0.7770.97
90_I93_T0.7740.97
56_S239_A0.7710.97
52_F121_L0.7640.97
254_W257_V0.7640.97
137_V209_I0.7630.97
154_L207_C0.7630.97
217_F222_D0.7590.96
31_L34_N0.7490.96
182_A198_P0.7460.96
77_D248_F0.7440.96
77_D162_A0.7300.96
218_Q227_L0.7280.96
101_P105_V0.7270.96
175_S204_H0.7260.95
191_V198_P0.7180.95
189_N236_C0.7140.95
33_E36_P0.7140.95
123_E224_L0.7120.95
147_F171_I0.7070.95
86_L90_I0.7060.95
101_P178_A0.7030.95
137_V147_F0.7030.95
209_I236_C0.6980.94
165_K261_F0.6970.94
85_K250_P0.6960.94
151_G184_M0.6940.94
96_H247_R0.6910.94
253_F256_R0.6890.94
71_H148_R0.6860.94
108_T112_N0.6850.94
186_S189_N0.6850.94
140_K204_H0.6790.94
121_L158_S0.6760.93
32_D35_E0.6730.93
252_P256_R0.6720.93
144_F201_L0.6700.93
134_V148_R0.6700.93
107_V228_H0.6690.93
167_L184_M0.6660.93
103_L120_A0.6660.93
48_L64_F0.6650.93
33_E55_Y0.6640.93
83_I86_L0.6620.93
133_L162_A0.6620.93
77_D251_F0.6590.93
102_L121_L0.6550.92
55_Y64_F0.6540.92
152_L209_I0.6530.92
174_P253_F0.6530.92
228_H234_I0.6520.92
40_I65_V0.6470.92
63_A244_R0.6460.92
55_Y62_T0.6390.91
98_V107_V0.6380.91
56_S102_L0.6360.91
107_V234_I0.6350.91
82_E86_L0.6350.91
175_S225_T0.6300.91
50_Y224_L0.6280.91
103_L158_S0.6270.91
178_A200_L0.6240.90
80_P84_E0.6240.90
259_D262_I0.6240.90
187_I190_R0.6230.90
50_Y53_H0.6190.90
150_D185_A0.6180.90
49_L164_N0.6170.90
51_A133_L0.6160.90
125_T223_H0.6120.90
220_T223_H0.6080.89
39_V62_T0.6050.89
113_E232_K0.6050.89
132_S135_A0.6040.89
73_G76_A0.6040.89
61_K102_L0.6040.89
218_Q222_D0.6020.89
64_F243_V0.5970.88
95_Y246_A0.5970.88
77_D256_R0.5970.88
56_S241_E0.5960.88
111_E115_E0.5950.88
227_L230_D0.5950.88
114_R240_S0.5900.88
106_I115_E0.5880.88
44_G70_G0.5880.88
129_I134_V0.5870.87
105_V219_V0.5870.87
130_E133_L0.5840.87
102_L119_L0.5820.87
33_E60_D0.5820.87
102_L105_V0.5800.87
145_E162_A0.5720.86
128_S131_G0.5710.86
110_H234_I0.5700.86
48_L75_Y0.5680.86
65_V86_L0.5680.86
56_S61_K0.5670.86
164_N180_Q0.5640.85
165_K186_S0.5600.85
214_E219_V0.5600.85
178_A198_P0.5590.85
217_F223_H0.5590.85
123_E166_A0.5590.85
47_T100_Y0.5550.84
66_G73_G0.5550.84
134_V146_T0.5530.84
79_V82_E0.5530.84
67_V86_L0.5510.84
176_I203_S0.5510.84
36_P62_T0.5510.84
150_D182_A0.5510.84
125_T149_G0.5500.84
100_Y253_F0.5490.84
31_L35_E0.5490.84
53_H56_S0.5490.84
95_Y99_E0.5470.84
246_A256_R0.5440.83
123_E155_S0.5420.83
192_F261_F0.5400.83
41_S48_L0.5400.83
80_P152_L0.5400.83
95_Y248_F0.5390.83
64_F171_I0.5390.83
166_A240_S0.5380.83
131_G220_T0.5380.83
90_I248_F0.5370.82
79_V253_F0.5360.82
115_E118_Y0.5360.82
68_H153_C0.5360.82
48_L225_T0.5350.82
56_S119_L0.5340.82
102_L107_V0.5330.82
135_A211_P0.5320.82
85_K91_A0.5320.82
38_I41_S0.5320.82
97_T102_L0.5310.82
219_V228_H0.5290.82
39_V65_V0.5250.81
161_T183_E0.5240.81
258_Q261_F0.5230.81
123_E220_T0.5230.81
128_S184_M0.5200.80
94_P98_V0.5200.80
192_F198_P0.5190.80
127_K218_Q0.5190.80
126_I217_F0.5170.80
145_E256_R0.5130.80
55_Y60_D0.5120.79
107_V232_K0.5100.79
49_L121_L0.5090.79
30_E115_E0.5080.79
36_P39_V0.5080.79
204_H238_V0.5080.79
77_D98_V0.5060.79
147_F183_E0.5060.79
78_W125_T0.5060.79
69_T180_Q0.5020.78
112_N233_S0.5010.78
44_G73_G0.5010.78
89_A95_Y0.5000.78
64_F167_L0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfnA 4 0.9586 100 0.177 Contact Map
3afoA 4 0.9737 100 0.208 Contact Map
2i2cA 3 0.9925 100 0.285 Contact Map
2an1A 4 0.9474 100 0.322 Contact Map
1u0tA 4 0.9699 100 0.334 Contact Map
1yt5A 4 0.9248 100 0.336 Contact Map
1z0sA 4 0.8947 100 0.346 Contact Map
2qv7A 2 0.9098 100 0.647 Contact Map
3s40A 3 0.8835 99.9 0.671 Contact Map
4werA 2 0.8571 99.9 0.68 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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