GREMLIN Database
YJBM - GTP pyrophosphokinase YjbM
UniProt: O31611 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (180)
Sequences: 5146 (3183)
Seq/√Len: 237.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_F85_D3.6161.00
81_Q145_L3.2791.00
79_M145_L2.6751.00
44_T148_N2.5431.00
55_E59_R2.5291.00
28_R32_E2.5181.00
85_D88_I2.4671.00
42_F145_L2.4431.00
34_E37_H2.4391.00
100_T124_L2.3301.00
5_Q8_R2.3001.00
8_R12_P2.2131.00
41_E81_Q2.1531.00
80_C89_V2.1491.00
94_F104_Q2.0841.00
174_Q178_E2.0511.00
17_V47_V1.9921.00
21_K25_K1.9821.00
31_Y93_L1.9701.00
12_P67_I1.9431.00
17_V21_K1.8371.00
186_E191_R1.8361.00
34_E96_R1.8351.00
7_E10_L1.8311.00
123_V140_I1.8201.00
81_Q85_D1.8071.00
84_D88_I1.7941.00
27_I138_V1.7531.00
90_K94_F1.7261.00
22_V26_G1.7091.00
118_S143_R1.6711.00
124_L135_H1.6521.00
10_L50_V1.6461.00
87_Q109_A1.6191.00
11_V15_Q1.5741.00
26_G134_K1.5711.00
187_M191_R1.5481.00
62_I70_M1.5281.00
94_F121_L1.5231.00
90_K104_Q1.4821.00
29_T33_Y1.4731.00
90_K119_Y1.4731.00
145_L149_F1.4671.00
71_Q137_L1.4641.00
167_E171_L1.4461.00
175_R179_A1.4421.00
63_P68_E1.4381.00
87_Q91_E1.4261.00
148_N152_T1.4251.00
35_D89_V1.4211.00
54_L58_R1.4111.00
170_K177_S1.3901.00
16_A19_E1.3791.00
13_Y50_V1.3721.00
62_I69_T1.3701.00
90_K121_L1.3541.00
174_Q177_S1.3441.00
53_I70_M1.3421.00
169_V179_A1.3331.00
9_F50_V1.3151.00
32_E36_D1.3131.00
15_Q136_V1.2891.00
33_Y37_H1.2871.00
168_K171_L1.2791.00
169_V175_R1.2741.00
52_S160_K1.2621.00
91_E94_F1.2511.00
93_L140_I1.2491.00
7_E11_V1.2381.00
25_K28_R1.2331.00
175_R182_R1.2221.00
172_R186_E1.2151.00
34_E92_M1.2051.00
174_Q181_S1.2021.00
30_L97_K1.1931.00
29_T32_E1.1821.00
93_L123_V1.1681.00
123_V138_V1.1631.00
87_Q106_D1.1531.00
117_R150_W1.1381.00
89_V92_M1.1341.00
51_A55_E1.1221.00
103_D122_V1.1201.00
10_L14_R1.1101.00
158_N170_K1.0921.00
46_R75_G1.0821.00
77_R141_Q1.0701.00
94_F101_V1.0691.00
172_R178_E1.0471.00
169_V177_S1.0441.00
23_K125_Y1.0431.00
6_W10_L1.0421.00
146_A149_F1.0191.00
11_V14_R1.0191.00
182_R186_E1.0151.00
14_R29_T1.0121.00
24_L45_G1.0061.00
167_E170_K1.0001.00
34_E38_S0.9851.00
30_L96_R0.9821.00
188_S192_G0.9811.00
170_K175_R0.9791.00
32_E42_F0.9741.00
18_E21_K0.9601.00
124_L137_L0.9581.00
48_K141_Q0.9511.00
26_G30_L0.9501.00
38_S92_M0.9331.00
105_R122_V0.9141.00
77_R143_R0.9141.00
169_V173_L0.9121.00
27_I76_L0.9111.00
169_V176_A0.9071.00
31_Y140_I0.9041.00
170_K179_A0.9001.00
88_I91_E0.8961.00
100_T104_Q0.8920.99
107_Y112_K0.8850.99
116_Y120_H0.8680.99
48_K77_R0.8680.99
115_G150_W0.8620.99
46_R160_K0.8570.99
175_R181_S0.8530.99
104_Q121_L0.8430.99
48_K75_G0.8330.99
171_L174_Q0.8320.99
78_I142_I0.8290.99
80_C85_D0.8240.99
25_K29_T0.8110.99
174_Q179_A0.8070.99
74_A138_V0.8060.99
170_K174_Q0.7930.99
168_K172_R0.7840.99
172_R179_A0.7830.99
176_A179_A0.7830.99
88_I92_M0.7780.99
186_E190_I0.7770.99
56_K141_Q0.7670.98
179_A183_L0.7610.98
18_E25_K0.7600.98
26_G29_T0.7600.98
48_K56_K0.7590.98
23_K74_A0.7500.98
186_E193_E0.7480.98
9_F12_P0.7460.98
48_K139_E0.7430.98
169_V172_R0.7400.98
107_Y117_R0.7340.98
46_R159_Y0.7300.98
30_L34_E0.7290.98
185_E189_E0.7290.98
56_K75_G0.7290.98
172_R182_R0.7290.98
180_A183_L0.7290.98
48_K72_D0.7230.98
4_K7_E0.7150.98
47_V50_V0.7140.98
56_K139_E0.7110.98
175_R180_A0.7070.97
177_S180_A0.7050.97
169_V184_D0.7000.97
188_S191_R0.7000.97
52_S118_S0.6990.97
16_A20_L0.6980.97
114_S147_M0.6970.97
74_A136_V0.6940.97
46_R139_E0.6930.97
12_P16_A0.6920.97
72_D141_Q0.6910.97
87_Q108_I0.6900.97
56_K159_Y0.6850.97
175_R186_E0.6830.97
28_R76_L0.6810.97
187_M190_I0.6800.97
146_A150_W0.6720.96
57_A62_I0.6710.96
81_Q156_S0.6710.96
172_R175_R0.6700.96
172_R193_E0.6690.96
87_Q94_F0.6650.96
169_V174_Q0.6640.96
99_F109_A0.6630.96
89_V142_I0.6590.96
56_K77_R0.6580.96
52_S151_A0.6570.96
15_Q134_K0.6540.96
20_L47_V0.6510.96
59_R62_I0.6500.96
75_G141_Q0.6490.96
85_D89_V0.6410.95
56_K160_K0.6400.95
77_R159_Y0.6390.95
156_S159_Y0.6390.95
24_L47_V0.6360.95
91_E95_A0.6340.95
77_R139_E0.6340.95
169_V180_A0.6300.95
175_R183_L0.6290.95
178_E182_R0.6290.95
170_K182_R0.6280.95
172_R180_A0.6270.95
87_Q107_Y0.6260.95
23_K27_I0.6250.95
55_E58_R0.6240.95
86_I119_Y0.6200.95
91_E109_A0.6170.94
122_V137_L0.6150.94
107_Y111_H0.6120.94
63_P69_T0.6120.94
183_L187_M0.6070.94
75_G159_Y0.6050.94
98_D110_E0.6050.94
70_M137_L0.5950.93
28_R45_G0.5940.93
78_I89_V0.5940.93
185_E191_R0.5930.93
72_D77_R0.5890.93
87_Q119_Y0.5880.93
56_K72_D0.5880.93
167_E177_S0.5870.93
111_H119_Y0.5860.93
72_D75_G0.5850.93
86_I142_I0.5840.93
126_P134_K0.5830.93
4_K8_R0.5830.93
176_A182_R0.5760.92
189_E192_G0.5750.92
74_A122_V0.5730.92
38_S88_I0.5680.92
28_R43_V0.5680.92
51_A54_L0.5680.92
86_I90_K0.5660.91
23_K138_V0.5650.91
13_Y53_I0.5630.91
42_F148_N0.5560.91
61_S134_K0.5540.91
27_I137_L0.5520.90
102_V137_L0.5520.90
19_E22_V0.5510.90
92_M95_A0.5460.90
30_L33_Y0.5450.90
172_R176_A0.5450.90
8_R11_V0.5420.90
183_L186_E0.5400.89
80_C83_V0.5400.89
36_D41_E0.5350.89
175_R178_E0.5350.89
86_I108_I0.5320.89
9_F53_I0.5310.89
121_L142_I0.5310.89
17_V50_V0.5300.89
87_Q90_K0.5290.88
21_K123_V0.5270.88
57_A60_K0.5250.88
83_V117_R0.5240.88
108_I114_S0.5190.88
139_E159_Y0.5180.87
15_Q19_E0.5170.87
150_W190_I0.5140.87
8_R58_R0.5130.87
186_E189_E0.5120.87
86_I147_M0.5120.87
28_R44_T0.5110.87
106_D109_A0.5110.87
164_N168_K0.5060.86
146_A180_A0.5050.86
46_R56_K0.5020.86
44_T152_T0.5020.86
181_S185_E0.5000.86
98_D124_L0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l9dA 1 0.9289 100 0.215 Contact Map
1vj7A 1 0.7251 100 0.216 Contact Map
2be3A 2 0.9479 100 0.22 Contact Map
3f9tA 2 0.4313 12 0.951 Contact Map
3k40A 2 0.4834 11.6 0.951 Contact Map
2dgkA 3 0.5498 11.4 0.951 Contact Map
3j3wN 1 0.5498 10.6 0.952 Contact Map
3getA 2 0.4408 9.4 0.953 Contact Map
3u1kA 3 0.4265 8.9 0.954 Contact Map
1fg7A 2 0.455 8.5 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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