GREMLIN Database
YJBJ - Putative murein lytic transglycosylase YjbJ
UniProt: O31608 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (147)
Sequences: 3132 (2082)
Seq/√Len: 171.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_G105_M3.0891.00
155_N165_F2.8831.00
138_Y157_D2.6861.00
132_K136_D2.6361.00
64_I82_I2.6321.00
137_K157_D2.5751.00
65_K75_E2.5121.00
77_L146_L2.5071.00
78_I128_T2.3571.00
81_V131_L2.3141.00
93_V118_L2.2991.00
67_A70_K2.2241.00
99_M118_L2.2171.00
84_Q174_K2.0731.00
84_Q178_V1.9811.00
112_L133_Q1.9391.00
155_N158_R1.8921.00
104_L126_G1.8871.00
135_L145_A1.8771.00
99_M117_P1.8101.00
138_Y148_A1.7851.00
147_A172_V1.7551.00
114_V126_G1.7531.00
96_A105_M1.7471.00
104_L109_A1.7351.00
67_A125_E1.7221.00
116_N122_Q1.7101.00
151_A155_N1.6601.00
66_K121_Q1.6581.00
82_I124_V1.5691.00
108_T130_Y1.5541.00
82_I101_L1.4571.00
159_Y164_P1.4461.00
79_R88_F1.4201.00
63_A121_Q1.3761.00
71_Y132_K1.3741.00
111_S153_P1.3721.00
71_Y129_K1.3321.00
104_L114_V1.3301.00
61_D79_R1.3181.00
111_S133_Q1.2961.00
71_Y125_E1.2841.00
125_E129_K1.2751.00
122_Q126_G1.2671.00
112_L153_P1.2671.00
64_I79_R1.2441.00
170_N174_K1.2241.00
78_I102_M1.2231.00
70_K125_E1.2181.00
67_A128_T1.2051.00
134_M153_P1.2001.00
81_V102_M1.1791.00
102_M124_V1.1511.00
104_L123_N1.1241.00
83_K87_G1.1181.00
119_D122_Q1.1181.00
143_S176_T1.1121.00
73_V128_T1.1021.00
138_Y153_P1.1001.00
151_A168_T1.0911.00
71_Y128_T1.0861.00
150_N167_E1.0741.00
114_V122_Q1.0651.00
101_L120_P1.0621.00
130_Y134_M1.0611.00
133_Q137_K1.0541.00
148_A153_P1.0410.99
67_A71_Y1.0370.99
112_L130_Y1.0120.99
146_L175_I1.0100.99
89_N92_A1.0020.99
141_N144_M0.9870.99
135_L140_G0.9780.99
134_M148_A0.9730.99
64_I88_F0.9720.99
61_D65_K0.9710.99
67_A124_V0.9690.99
147_A168_T0.9590.99
82_I127_G0.9570.99
35_S39_A0.9510.99
102_M127_G0.9490.99
113_G126_G0.9480.99
99_M106_P0.9440.99
151_A165_F0.9440.99
109_A117_P0.9380.99
84_Q175_I0.9330.99
117_P126_G0.9270.99
63_A66_K0.9250.99
151_A156_V0.9190.99
64_I124_V0.9100.99
81_V175_I0.9090.99
64_I78_I0.9080.99
121_Q125_E0.9070.98
93_V99_M0.9010.98
60_I101_L0.9000.98
105_M108_T0.8980.98
107_S111_S0.8880.98
68_A128_T0.8860.98
130_Y153_P0.8860.98
42_D46_N0.8800.98
135_L142_V0.8760.98
63_A124_V0.8760.98
126_G129_K0.8670.98
60_I90_A0.8600.98
102_M123_N0.8490.98
154_G157_D0.8460.98
62_S65_K0.8460.98
78_I82_I0.8420.98
82_I102_M0.8400.98
112_L126_G0.8390.97
115_S122_Q0.8380.97
80_A175_I0.8380.97
166_Q170_N0.8290.97
68_A77_L0.8290.97
96_A99_M0.8160.97
66_K70_K0.8150.97
151_A169_Q0.8130.97
159_Y163_P0.8040.97
53_I58_F0.8020.97
68_A75_E0.7960.97
67_A121_Q0.7920.96
154_G158_R0.7890.96
123_N127_G0.7870.96
156_V165_F0.7800.96
94_S167_E0.7720.96
104_L127_G0.7710.96
39_A42_D0.7700.96
62_S66_K0.7690.96
94_S98_A0.7520.95
47_K51_N0.7480.95
91_K118_L0.7460.95
98_A105_M0.7410.95
151_A164_P0.7400.95
104_L112_L0.7380.95
98_A106_P0.7320.95
90_A101_L0.7310.94
33_A36_T0.7300.94
144_M160_G0.7290.94
117_P122_Q0.7290.94
133_Q153_P0.7270.94
33_A38_T0.7210.94
129_K132_K0.7190.94
38_T42_D0.7140.94
36_T40_V0.7140.94
104_L117_P0.7120.94
84_Q87_G0.7080.94
82_I88_F0.7060.93
116_N119_D0.7040.93
112_L129_K0.6990.93
60_I120_P0.6940.93
128_T132_K0.6890.93
60_I63_A0.6790.92
137_K153_P0.6780.92
109_A130_Y0.6770.92
114_V117_P0.6730.92
166_Q169_Q0.6650.91
64_I68_A0.6650.91
122_Q125_E0.6640.91
98_A103_Q0.6610.91
160_G163_P0.6590.91
164_P168_T0.6580.91
71_Y78_I0.6570.91
46_N49_E0.6550.91
33_A37_E0.6480.90
133_Q136_D0.6450.90
34_E37_E0.6370.89
65_K69_D0.6370.89
39_A43_S0.6360.89
165_F168_T0.6340.89
109_A114_V0.6290.89
77_L142_V0.6230.88
107_S110_S0.6200.88
155_N164_P0.6170.88
34_E39_A0.6170.88
56_G60_I0.6160.88
117_P123_N0.6100.87
37_E41_A0.6080.87
48_H51_N0.6070.87
63_A120_P0.6050.87
134_M137_K0.6010.86
159_Y165_F0.6010.86
98_A168_T0.6000.86
32_A39_A0.5950.86
130_Y133_Q0.5940.86
32_A35_S0.5930.86
98_A167_E0.5920.86
155_N159_Y0.5910.86
34_E40_V0.5910.86
57_D62_S0.5860.85
65_K78_I0.5850.85
157_D161_G0.5800.84
36_T39_A0.5790.84
58_F62_S0.5790.84
119_D139_D0.5780.84
83_K178_V0.5740.84
41_A45_S0.5730.84
37_E40_V0.5730.84
156_V164_P0.5640.83
42_D47_K0.5640.83
87_G174_K0.5620.83
40_V50_A0.5540.82
80_A102_M0.5530.82
147_A156_V0.5480.81
73_V78_I0.5360.80
78_I81_V0.5300.79
108_T112_L0.5270.78
165_F169_Q0.5260.78
69_D121_Q0.5210.78
135_L141_N0.5190.77
104_L130_Y0.5160.77
68_A78_I0.5150.77
84_Q173_K0.5130.77
158_R162_I0.5130.77
81_V171_Y0.5120.76
49_E52_Q0.5100.76
92_A99_M0.5100.76
39_A48_H0.5070.76
75_E79_R0.5060.76
52_Q56_G0.5010.75
147_A167_E0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qsaA 1 1 100 0.243 Contact Map
4cfpA 1 0.9558 100 0.267 Contact Map
4hjzA 1 0.7735 100 0.288 Contact Map
4p0gA 1 0.9448 100 0.298 Contact Map
1gbsA 1 0.8674 100 0.347 Contact Map
3gxrA 1 0.884 100 0.354 Contact Map
4g9sA 1 0.9006 100 0.357 Contact Map
3w6bA 1 0.7514 100 0.36 Contact Map
3bkhA 1 1 100 0.447 Contact Map
4fdyA 1 0.6685 100 0.457 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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