GREMLIN Database
TRHBO - Group 2 truncated hemoglobin YjbI
UniProt: O31607 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (119)
Sequences: 1893 (1227)
Seq/√Len: 112.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_T85_R4.3781.00
22_D46_A3.9461.00
23_T99_H2.8831.00
94_K111_F2.6161.00
23_T27_R2.5981.00
11_A109_F2.5321.00
27_R95_D2.5211.00
23_T26_E2.4511.00
71_M74_A2.2391.00
18_S50_K2.1761.00
47_R51_Q2.0741.00
26_E46_A1.9241.00
14_E18_S1.9131.00
21_V53_L1.8981.00
27_R99_H1.8291.00
14_E50_K1.8281.00
14_E54_T1.7601.00
51_Q66_E1.7301.00
110_L114_L1.7151.00
47_R66_E1.6831.00
8_P57_L1.6781.00
51_Q67_H1.6161.00
61_P65_E1.6101.00
20_L100_V1.6071.00
88_A92_C1.5711.00
103_E106_I1.5591.00
16_L19_Q1.5431.00
11_A106_I1.5411.00
98_D107_R1.5211.00
33_L36_P1.4891.00
29_A42_L1.4641.00
86_A119_R1.4431.00
9_Y54_T1.4201.00
33_L84_E1.4061.00
37_I85_R1.4031.00
9_Y60_P1.3671.00
33_L91_S1.2630.99
97_M110_L1.2600.99
34_L89_W1.2270.99
119_R122_V1.2210.99
18_S47_R1.2170.99
98_D104_G1.2100.99
80_P124_Q1.1870.99
22_D26_E1.1530.99
23_T100_V1.1520.99
72_L117_T1.1520.99
31_H91_S1.1240.98
104_G108_E1.1200.98
46_A50_K1.1140.98
48_K67_H1.0990.98
70_P75_R1.0940.98
51_Q54_T1.0780.98
29_A35_K1.0550.98
20_L96_A1.0420.97
15_E19_Q1.0350.97
6_N10_E1.0270.97
74_A77_L1.0250.97
6_N11_A1.0170.97
8_P106_I1.0150.97
108_E112_G1.0120.97
50_K54_T1.0000.97
33_L88_A0.9990.97
83_N118_A0.9980.97
91_S95_D0.9810.96
27_R92_C0.9750.96
17_L57_L0.9750.96
24_F28_V0.9720.96
34_L85_R0.9610.96
54_T62_L0.9570.96
96_A100_V0.9380.95
12_I16_L0.9270.95
97_M107_R0.9270.95
57_L114_L0.9220.95
18_S22_D0.9190.95
71_M75_R0.9170.95
9_Y14_E0.9050.94
57_L110_L0.8830.94
24_F93_M0.8650.93
108_E111_F0.8520.92
55_Q64_T0.8500.92
109_F112_G0.8490.92
81_I85_R0.8470.92
35_K42_L0.8240.91
33_L92_C0.8000.90
94_K107_R0.7880.89
70_P73_R0.7860.89
84_E88_A0.7670.88
8_P12_I0.7550.87
93_M114_L0.7540.87
51_Q62_L0.7530.87
114_L117_T0.7530.87
64_T69_H0.7520.87
16_L100_V0.7480.86
95_D99_H0.7470.86
83_N122_V0.7390.86
94_K98_D0.7380.86
31_H92_C0.7350.85
23_T96_A0.7340.85
86_A122_V0.7340.85
28_V38_F0.7330.85
90_L114_L0.7170.84
28_V36_P0.7160.84
82_T124_Q0.7110.84
31_H88_A0.7100.83
34_L88_A0.7030.83
20_L93_M0.6890.82
73_R120_H0.6870.81
90_L111_F0.6740.80
75_R79_F0.6660.79
81_I122_V0.6600.79
28_V56_Y0.6590.79
92_C95_D0.6560.78
38_F49_Q0.6520.78
29_A46_A0.6500.78
15_E18_S0.6480.78
115_E118_A0.6430.77
104_G107_R0.6400.77
28_V49_Q0.6390.77
63_Y69_H0.6300.76
8_P109_F0.6290.75
111_F115_E0.6280.75
97_M102_L0.6240.75
25_Y49_Q0.6230.75
29_A43_T0.6230.75
42_L46_A0.6220.75
7_A10_E0.6150.74
11_A105_E0.6140.74
115_E119_R0.6100.73
73_R123_N0.6100.73
47_R50_K0.6090.73
45_T48_K0.6040.72
25_Y52_F0.6030.72
69_H73_R0.6010.72
44_E48_K0.5990.72
89_W93_M0.5960.71
42_L45_T0.5940.71
39_P45_T0.5940.71
90_L115_E0.5920.71
37_I49_Q0.5880.70
27_R96_A0.5870.70
102_L105_E0.5860.70
44_E47_R0.5850.70
69_H72_L0.5840.70
62_L65_E0.5840.70
12_I100_V0.5810.70
18_S46_A0.5800.69
14_E62_L0.5790.69
108_E115_E0.5730.68
98_D111_F0.5720.68
8_P110_L0.5670.68
12_I106_I0.5650.67
34_L37_I0.5640.67
48_K55_Q0.5520.66
34_L81_I0.5460.65
24_F89_W0.5430.64
75_R121_M0.5420.64
19_Q101_G0.5420.64
38_F56_Y0.5380.64
116_L120_H0.5380.64
85_R122_V0.5370.64
12_I57_L0.5360.63
82_T122_V0.5340.63
97_M100_V0.5330.63
36_P85_R0.5310.63
30_S40_S0.5270.62
19_Q23_T0.5270.62
55_Q122_V0.5260.62
12_I17_L0.5260.62
6_N61_P0.5240.62
121_M124_Q0.5190.61
10_E36_P0.5180.61
105_E108_E0.5100.60
11_A103_E0.5070.59
16_L97_M0.5060.59
23_T95_D0.5040.59
61_P64_T0.5020.58
94_K115_E0.5010.58
12_I116_L0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nk2A 2 0.9924 100 0.205 Contact Map
4c0nA 2 0.9697 100 0.219 Contact Map
4uurA 1 0.9091 100 0.226 Contact Map
2xykA 1 0.9545 100 0.263 Contact Map
1ux8A 1 0.8939 100 0.263 Contact Map
4uzvA 2 0.9621 100 0.266 Contact Map
2bmmA 1 0.9167 100 0.291 Contact Map
2bkmA 1 0.9621 100 0.292 Contact Map
1dlyA 1 0.8864 100 0.295 Contact Map
3aq9A 1 0.8712 100 0.307 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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