GREMLIN Database
COIA - Putative competence protein CoiA
UniProt: O31604 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (321)
Sequences: 332 (282)
Seq/√Len: 15.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_Q120_G5.3501.00
64_Q166_Y4.5341.00
61_G104_Y3.7681.00
113_V116_K3.7421.00
61_G106_C3.7171.00
9_Q12_K3.5530.99
52_E59_L3.5430.99
30_K38_H3.4210.99
76_P91_V3.2280.99
82_I92_M2.9190.98
106_C133_G2.9090.98
80_P92_M2.8410.97
26_E42_K2.7470.97
20_C23_C2.7030.96
260_F277_Q2.6480.96
32_G38_H2.5270.95
12_K18_F2.4850.94
222_I226_R2.4320.94
132_M154_F2.4070.93
82_I89_P2.2300.90
69_L93_A2.1860.89
101_A126_I2.1460.88
55_S89_P2.1440.88
9_Q13_L2.0690.86
256_P334_L2.0300.85
85_I124_E1.9880.84
23_C41_H1.9070.81
92_M121_F1.8800.80
69_L179_I1.8730.80
277_Q330_Y1.8240.78
265_K329_Q1.8230.78
53_P78_L1.8170.78
103_E130_W1.8130.78
105_Q130_W1.8130.78
90_D105_Q1.8130.78
90_D130_W1.8130.78
90_D103_E1.8130.78
23_C39_F1.8060.78
78_L104_Y1.7960.77
27_L37_P1.7810.76
89_P92_M1.7710.76
20_C41_H1.7500.75
80_P89_P1.7340.74
62_K79_E1.7280.74
107_A335_C1.7150.74
269_F326_A1.6960.73
76_P93_A1.6950.73
54_E62_K1.6690.72
52_E106_C1.6660.71
20_C39_F1.6430.70
194_I204_L1.6270.70
101_A120_G1.5920.68
57_Y167_C1.5880.68
263_V269_F1.5850.67
109_I114_F1.5770.67
218_W262_P1.5440.65
13_L18_F1.5330.65
58_H130_W1.5290.65
58_H105_Q1.5290.65
58_H103_E1.5290.65
58_H90_D1.5290.65
68_W72_Q1.5240.64
91_V152_W1.5030.63
30_K35_K1.4980.63
18_F29_V1.4930.63
104_Y166_Y1.4880.62
79_E105_Q1.4800.62
79_E130_W1.4800.62
79_E90_D1.4800.62
79_E103_E1.4800.62
38_H47_C1.4740.62
131_I173_F1.4730.62
109_I129_Q1.4720.62
89_P101_A1.4700.61
93_A100_L1.4590.61
54_E79_E1.4520.60
64_Q171_R1.4500.60
54_E58_H1.4480.60
9_Q31_L1.4450.60
41_H58_H1.4390.60
47_C121_F1.4200.59
145_Y176_L1.4060.58
152_W176_L1.4030.58
101_A128_P1.3960.57
260_F276_W1.3690.56
41_H54_E1.3470.55
81_Y85_I1.3450.54
39_F58_H1.3440.54
242_L246_E1.3260.53
70_K248_R1.3090.52
9_Q18_F1.3050.52
30_K52_E1.2940.51
105_Q117_R1.2880.51
117_R130_W1.2880.51
90_D117_R1.2880.51
103_E117_R1.2880.51
23_C58_H1.2800.51
55_S107_A1.2800.51
61_G166_Y1.2780.51
27_L70_K1.2730.50
23_C32_G1.2620.50
32_G47_C1.2560.49
39_F54_E1.2490.49
263_V277_Q1.2480.49
165_C269_F1.2470.49
88_R256_P1.2410.48
61_G165_C1.2220.47
87_Q101_A1.2220.47
240_L269_F1.2150.47
62_K117_R1.1990.46
58_H79_E1.1960.46
166_Y173_F1.1900.46
23_C54_E1.1870.45
25_G45_K1.1860.45
27_L125_G1.1850.45
55_S326_A1.1670.44
150_F330_Y1.1600.44
57_Y168_P1.1600.44
32_G41_H1.1550.44
20_C58_H1.1500.43
55_S283_F1.1490.43
109_I126_I1.1480.43
226_R244_F1.1400.43
120_G276_W1.1100.41
87_Q109_I1.1100.41
168_P173_F1.1090.41
317_E331_I1.1020.41
104_Y168_P1.0990.40
276_W330_Y1.0980.40
34_Q37_P1.0930.40
152_W255_L1.0890.40
20_C32_G1.0800.39
168_P277_Q1.0760.39
269_F303_C1.0700.39
58_H107_A1.0640.38
81_Y89_P1.0640.38
88_R262_P1.0540.38
20_C54_E1.0530.38
259_V281_Y1.0500.38
91_V216_S1.0480.38
41_H117_R1.0460.38
151_H278_G1.0460.38
9_Q262_P1.0450.37
118_T128_P1.0400.37
78_L128_P1.0370.37
136_R165_C1.0360.37
261_V277_Q1.0330.37
23_C117_R1.0290.37
32_G39_F1.0250.36
90_D107_A1.0120.36
103_E107_A1.0120.36
107_A130_W1.0120.36
229_P241_R1.0090.36
85_I120_G1.0070.35
58_H117_R1.0040.35
61_G88_R1.0030.35
88_R133_G1.0010.35
149_T252_F0.9940.35
179_I294_I0.9920.35
56_A125_G0.9910.35
89_P121_F0.9910.35
25_G179_I0.9910.35
62_K130_W0.9910.35
62_K103_E0.9910.35
62_K105_Q0.9910.35
62_K90_D0.9910.35
126_I129_Q0.9900.35
312_I315_R0.9890.34
53_P255_L0.9890.34
109_I113_V0.9820.34
38_H41_H0.9700.34
39_F117_R0.9650.33
57_Y135_S0.9650.33
79_E117_R0.9600.33
91_V135_S0.9560.33
161_R226_R0.9560.33
18_F66_Y0.9380.32
27_L68_W0.9360.32
218_W226_R0.9360.32
77_I80_P0.9340.32
21_P89_P0.9340.32
164_I269_F0.9310.32
61_G276_W0.9310.32
183_Y252_F0.9300.31
172_S193_T0.9280.31
88_R106_C0.9270.31
164_I266_G0.9260.31
181_P315_R0.9240.31
69_L164_I0.9240.31
158_S205_F0.9210.31
101_A129_Q0.9200.31
21_P58_H0.9190.31
79_E245_Y0.9180.31
53_P266_G0.9180.31
54_E117_R0.9150.31
155_I179_I0.9130.31
20_C117_R0.9110.31
109_I287_L0.9100.31
203_D212_S0.9070.30
260_F273_V0.9060.30
23_C27_L0.9050.30
177_S201_A0.9030.30
104_Y109_I0.8970.30
225_F266_G0.8940.30
76_P114_F0.8830.29
82_I126_I0.8790.29
27_L102_V0.8770.29
61_G65_L0.8670.28
240_L275_V0.8670.28
22_V50_D0.8610.28
61_G256_P0.8560.28
21_P41_H0.8560.28
13_L131_I0.8560.28
131_I172_S0.8530.28
240_L278_G0.8480.28
82_I123_Q0.8460.27
41_H105_Q0.8440.27
41_H130_W0.8440.27
41_H90_D0.8440.27
41_H103_E0.8440.27
131_I160_Y0.8400.27
109_I252_F0.8360.27
40_A277_Q0.8350.27
256_P272_P0.8280.27
166_Y276_W0.8260.27
57_Y85_I0.8230.26
23_C130_W0.8220.26
23_C105_Q0.8220.26
23_C90_D0.8220.26
23_C103_E0.8220.26
164_I175_R0.8190.26
22_V123_Q0.8190.26
245_Y255_L0.8160.26
102_V242_L0.8140.26
258_E271_S0.8130.26
100_L308_H0.8130.26
99_M126_I0.8120.26
255_L281_Y0.8110.26
132_M176_L0.8100.26
155_I196_I0.8090.26
224_R303_C0.8020.26
29_V55_S0.7940.25
164_I276_W0.7910.25
102_V207_T0.7900.25
238_N274_F0.7900.25
89_P126_I0.7840.25
18_F262_P0.7830.25
30_K259_V0.7830.25
206_F214_Q0.7830.25
66_Y149_T0.7820.25
82_I121_F0.7810.25
47_C106_C0.7790.25
47_C262_P0.7760.24
52_E88_R0.7760.24
91_V164_I0.7730.24
36_A63_R0.7700.24
165_C275_V0.7700.24
329_Q338_G0.7680.24
18_F31_L0.7670.24
55_S175_R0.7670.24
183_Y277_Q0.7670.24
150_F154_F0.7600.24
37_P154_F0.7590.24
22_V49_I0.7580.24
121_F256_P0.7580.24
183_Y260_F0.7580.24
104_Y126_I0.7580.24
39_F103_E0.7570.24
39_F90_D0.7570.24
39_F105_Q0.7570.24
39_F130_W0.7570.24
226_R237_T0.7550.24
69_L76_P0.7540.23
41_H62_K0.7540.23
155_I242_L0.7470.23
324_S336_K0.7430.23
93_A233_N0.7420.23
47_C59_L0.7360.23
155_I238_N0.7320.23
156_N211_P0.7300.22
26_E179_I0.7300.22
78_L134_Y0.7300.22
23_C62_K0.7300.22
179_I187_S0.7270.22
240_L244_F0.7270.22
39_F107_A0.7250.22
181_P266_G0.7240.22
65_L194_I0.7230.22
46_S86_N0.7190.22
26_E36_A0.7170.22
25_G132_M0.7150.22
19_F155_I0.7120.22
156_N166_Y0.7110.22
126_I204_L0.7110.22
218_W315_R0.7090.22
51_I104_Y0.7090.22
83_R209_P0.7060.22
134_Y243_L0.7060.22
9_Q29_V0.7060.22
165_C222_I0.7050.22
182_F188_Y0.7050.22
258_E281_Y0.7050.22
54_E103_E0.7050.22
54_E90_D0.7050.22
54_E130_W0.7050.22
54_E105_Q0.7050.22
58_H62_K0.7050.22
155_I295_R0.7040.21
240_L273_V0.7040.21
256_P262_P0.7030.21
20_C103_E0.7000.21
20_C105_Q0.7000.21
20_C90_D0.7000.21
20_C130_W0.7000.21
30_K40_A0.7000.21
163_L254_F0.6970.21
252_F272_P0.6960.21
199_A204_L0.6940.21
275_V278_G0.6930.21
38_H58_H0.6890.21
23_C38_H0.6870.21
38_H277_Q0.6860.21
119_E220_K0.6860.21
108_T189_S0.6840.21
37_P101_A0.6840.21
117_R121_F0.6840.21
15_R123_Q0.6790.21
268_V295_R0.6770.20
20_C27_L0.6760.20
10_N16_R0.6710.20
15_R239_R0.6680.20
183_Y273_V0.6670.20
47_C88_R0.6660.20
116_K225_F0.6650.20
36_A92_M0.6640.20
39_F62_K0.6630.20
50_D244_F0.6630.20
104_Y173_F0.6620.20
30_K224_R0.6620.20
30_K84_T0.6600.20
238_N255_L0.6600.20
241_R272_P0.6590.20
152_W260_F0.6580.20
62_K245_Y0.6560.20
317_E323_L0.6550.20
266_G277_Q0.6530.20
85_I118_T0.6520.20
21_P90_D0.6510.19
21_P130_W0.6510.19
21_P105_Q0.6510.19
21_P103_E0.6510.19
29_V59_L0.6510.19
152_W187_S0.6500.19
21_P39_F0.6500.19
237_T260_F0.6480.19
237_T241_R0.6480.19
131_I294_I0.6430.19
107_A110_A0.6410.19
189_S277_Q0.6400.19
76_P227_H0.6390.19
156_N164_I0.6360.19
89_P338_G0.6340.19
202_G208_E0.6320.19
104_Y194_I0.6280.19
280_L299_V0.6260.19
148_S228_K0.6260.19
151_H275_V0.6260.19
244_F278_G0.6230.18
26_E306_H0.6220.18
106_C118_T0.6220.18
183_Y258_E0.6210.18
276_W334_L0.6210.18
82_I173_F0.6200.18
181_P260_F0.6200.18
12_K196_I0.6180.18
261_V333_F0.6180.18
128_P262_P0.6170.18
222_I225_F0.6160.18
66_Y150_F0.6140.18
240_L266_G0.6140.18
88_R121_F0.6130.18
59_L107_A0.6110.18
35_K315_R0.6070.18
104_Y164_I0.6050.18
40_A154_F0.6040.18
20_C62_K0.6030.18
258_E299_V0.6010.18
99_M234_S0.6010.18
92_M126_I0.6000.18
157_A230_H0.5980.18
230_H333_F0.5970.18
128_P266_G0.5970.18
82_I86_N0.5960.18
29_V244_F0.5950.18
333_F336_K0.5890.17
107_A117_R0.5880.17
22_V83_R0.5830.17
71_T115_Q0.5830.17
163_L176_L0.5820.17
16_R55_S0.5820.17
86_N198_R0.5800.17
25_G221_A0.5790.17
254_F278_G0.5780.17
69_L194_I0.5770.17
55_S240_L0.5770.17
100_L205_F0.5740.17
17_R186_H0.5720.17
241_R252_F0.5680.17
113_V150_F0.5680.17
183_Y222_I0.5650.17
226_R238_N0.5640.17
79_E107_A0.5640.17
60_E304_K0.5620.16
18_F118_T0.5590.16
89_P284_M0.5560.16
222_I252_F0.5560.16
241_R260_F0.5550.16
255_L259_V0.5540.16
34_Q331_I0.5530.16
79_E87_Q0.5500.16
108_T150_F0.5500.16
18_F315_R0.5460.16
133_G165_C0.5450.16
24_G48_A0.5440.16
107_A225_F0.5440.16
76_P222_I0.5440.16
184_T260_F0.5430.16
24_G223_H0.5420.16
225_F236_E0.5420.16
65_L76_P0.5410.16
94_R99_M0.5410.16
229_P238_N0.5380.16
271_S310_K0.5370.16
213_I303_C0.5370.16
150_F271_S0.5360.16
27_L325_E0.5340.16
82_I188_Y0.5340.16
94_R196_I0.5300.15
57_Y139_R0.5300.15
55_S200_G0.5290.15
121_F252_F0.5280.15
155_I241_R0.5280.15
76_P94_R0.5270.15
223_H271_S0.5270.15
175_R179_I0.5260.15
123_Q153_Q0.5260.15
248_R288_G0.5240.15
27_L267_A0.5240.15
39_F55_S0.5220.15
146_Q205_F0.5220.15
91_V126_I0.5210.15
155_I336_K0.5210.15
104_Y199_A0.5200.15
53_P170_R0.5190.15
24_G46_S0.5190.15
91_V226_R0.5180.15
165_C176_L0.5160.15
137_L183_Y0.5160.15
266_G326_A0.5150.15
326_A330_Y0.5150.15
81_Y277_Q0.5140.15
24_G70_K0.5140.15
89_P155_I0.5140.15
41_H79_E0.5140.15
27_L110_A0.5140.15
145_Y186_H0.5130.15
32_G58_H0.5120.15
329_Q335_C0.5110.15
152_W248_R0.5090.15
87_Q106_C0.5080.15
20_C38_H0.5080.15
34_Q163_L0.5070.15
30_K154_F0.5060.15
216_S233_N0.5060.15
52_E87_Q0.5050.15
89_P106_C0.5040.15
30_K59_L0.5030.15
262_P277_Q0.5020.15
189_S260_F0.5010.15
70_K125_G0.5010.15
56_A86_N0.5000.15
55_S241_R0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dnxA 2 0.3887 60 0.959 Contact Map
1vq8Z 1 0.1475 34.5 0.964 Contact Map
2fiyA 1 0.3217 33.2 0.965 Contact Map
3j20Y 1 0.118 27.8 0.966 Contact Map
1weuA 1 0.0831 20.9 0.968 Contact Map
3cc2Z 1 0.1689 20.3 0.968 Contact Map
1wenA 1 0.0831 18.3 0.969 Contact Map
2k4xA 1 0.1287 17.4 0.969 Contact Map
1dxgA 2 0.0965 16.7 0.969 Contact Map
3r3pA 3 0.2493 16.1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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