GREMLIN Database
YJBE - Uncharacterized membrane protein YjbE
UniProt: O31603 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (204)
Sequences: 4371 (2455)
Seq/√Len: 171.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_V207_I3.4861.00
36_D39_R3.3961.00
75_G178_I3.3421.00
55_I135_V3.1371.00
53_M113_L2.9811.00
49_I109_V2.9521.00
82_G171_A2.3781.00
96_K99_T2.2911.00
12_I123_V2.2861.00
95_I98_S2.2371.00
9_L140_V2.2001.00
9_L136_I2.1251.00
42_A108_I2.0711.00
55_I59_S2.0651.00
15_I126_A2.0601.00
199_P206_V2.0461.00
40_Q150_K2.0301.00
132_S136_I1.9971.00
95_I99_T1.9891.00
202_T206_V1.9521.00
192_G196_T1.9481.00
37_K41_Q1.9331.00
83_Y87_I1.9181.00
45_L49_I1.8711.00
192_G195_E1.8401.00
4_D8_S1.8271.00
192_G207_I1.7881.00
34_L104_A1.7671.00
13_V140_V1.7541.00
38_Q41_Q1.7171.00
150_K154_I1.7011.00
7_I11_V1.6801.00
203_V206_V1.6531.00
49_I53_M1.6381.00
94_H98_S1.6361.00
40_Q44_I1.6351.00
204_A207_I1.6051.00
204_A208_L1.6031.00
195_E199_P1.5921.00
35_P38_Q1.5691.00
84_Q87_I1.5691.00
84_Q88_E1.5581.00
71_Q180_R1.5471.00
94_H99_T1.5361.00
51_V139_C1.5081.00
80_Y84_Q1.5041.00
59_S131_F1.4911.00
195_E207_I1.4741.00
192_G203_V1.4711.00
72_C181_D1.4661.00
79_L174_G1.4561.00
10_L14_G1.4121.00
189_A193_T1.3971.00
199_P203_V1.3941.00
193_T207_I1.3771.00
34_L42_A1.3731.00
52_A56_G1.3681.00
86_L164_Y1.3571.00
198_L205_F1.3471.00
16_D20_G1.3371.00
195_E198_L1.3211.00
64_L70_L1.3191.00
5_Y133_L1.3151.00
193_T199_P1.3141.00
136_I140_V1.3061.00
48_F52_A1.2981.00
88_E91_D1.2981.00
192_G206_V1.2961.00
200_I204_A1.2721.00
201_L205_F1.2451.00
193_T196_T1.2391.00
193_T203_V1.2331.00
199_P202_T1.2101.00
41_Q45_L1.2081.00
194_V198_L1.2011.00
193_T198_L1.1981.00
195_E206_V1.1901.00
199_P207_I1.1881.00
127_S133_L1.1861.00
45_L105_I1.1791.00
41_Q101_L1.1721.00
58_T138_L1.1511.00
182_K185_S1.1431.00
193_T197_L1.1251.00
154_I158_K1.1241.00
175_G179_V1.1201.00
185_S188_M1.1141.00
75_G174_G1.1091.00
56_G60_A1.1031.00
5_Y130_E1.0781.00
191_H195_E1.0751.00
87_I91_D1.0691.00
196_T206_V1.0661.00
196_T207_I1.0611.00
53_M109_V1.0601.00
202_T205_F1.0450.99
59_S63_Y1.0450.99
32_R157_E1.0440.99
192_G198_L1.0380.99
24_A27_I1.0350.99
194_V203_V1.0330.99
172_Y176_E1.0260.99
179_V184_L1.0200.99
195_E203_V1.0150.99
196_T199_P1.0060.99
198_L203_V1.0060.99
200_I203_V1.0030.99
164_Y168_G0.9930.99
190_Q198_L0.9800.99
191_H205_F0.9770.99
192_G200_I0.9700.99
205_F208_L0.9680.99
60_A64_L0.9570.99
6_L10_L0.9560.99
192_G197_L0.9560.99
106_R110_L0.9560.99
102_W106_R0.9530.99
188_M191_H0.9480.99
8_S133_L0.9410.99
189_A192_G0.9390.99
83_Y171_A0.9390.99
87_I161_L0.9390.99
61_A113_L0.9360.99
124_A127_S0.9360.99
191_H197_L0.9350.99
44_I48_F0.9330.99
206_V209_A0.9290.99
197_L201_L0.9200.99
12_I133_L0.9170.99
39_R154_I0.9040.98
105_I108_I0.9020.98
11_V126_A0.9010.98
13_V17_L0.8900.98
190_Q193_T0.8830.98
77_F117_L0.8720.98
127_S130_E0.8720.98
53_M56_G0.8710.98
62_V124_A0.8670.98
193_T200_I0.8650.98
194_V197_L0.8630.98
127_S132_S0.8570.98
5_Y8_S0.8520.98
16_D58_T0.8490.98
191_H194_V0.8460.98
187_F191_H0.8440.98
55_I138_L0.8440.98
24_A177_M0.8400.98
176_E180_R0.8380.97
28_A105_I0.8260.97
191_H199_P0.8230.97
93_K99_T0.8100.97
28_A153_H0.8100.97
164_Y205_F0.8100.97
197_L200_I0.8070.97
4_D7_I0.8000.97
191_H196_T0.7910.96
93_K98_S0.7820.96
130_E133_L0.7820.96
189_A195_E0.7810.96
5_Y132_S0.7770.96
165_A203_V0.7750.96
192_G199_P0.7740.96
79_L83_Y0.7710.96
68_P72_C0.7690.96
197_L204_A0.7680.96
202_T207_I0.7670.96
199_P209_A0.7640.96
71_Q173_T0.7620.96
198_L207_I0.7600.96
85_L167_S0.7590.96
28_A152_I0.7580.95
193_T208_L0.7570.95
189_A204_A0.7530.95
31_S153_H0.7510.95
9_L13_V0.7490.95
60_A63_Y0.7460.95
190_Q194_V0.7450.95
154_I157_E0.7450.95
28_A156_L0.7450.95
196_T203_V0.7440.95
198_L201_L0.7360.95
12_I127_S0.7340.95
191_H198_L0.7320.95
191_H204_A0.7290.94
104_A111_A0.7280.94
201_L204_A0.7250.94
128_H131_F0.7210.94
17_L143_P0.7210.94
82_G174_G0.7160.94
94_H97_S0.7100.94
100_S103_R0.7030.93
51_V146_I0.7020.93
198_L206_V0.7010.93
156_L177_M0.7000.93
51_V142_V0.7000.93
93_K96_K0.6990.93
196_T200_I0.6990.93
29_M163_I0.6970.93
193_T206_V0.6970.93
21_G24_A0.6940.93
192_G208_L0.6940.93
190_Q203_V0.6930.93
65_L120_V0.6930.93
190_Q196_T0.6850.92
189_A199_P0.6810.92
193_T204_A0.6780.92
123_V126_A0.6760.92
86_L90_K0.6750.92
24_A152_I0.6750.92
195_E202_T0.6750.92
138_L141_S0.6740.92
30_A108_I0.6710.92
105_I109_V0.6710.92
20_G148_G0.6700.92
42_A101_L0.6670.91
110_L114_F0.6670.91
193_T205_F0.6650.91
98_S103_R0.6620.91
34_L38_Q0.6600.91
200_I207_I0.6590.91
159_I162_L0.6560.91
12_I134_V0.6550.91
184_L188_M0.6550.91
113_L120_V0.6520.90
70_L73_A0.6510.90
117_L120_V0.6490.90
194_V208_L0.6450.90
135_V139_C0.6440.90
103_R106_R0.6430.90
192_G205_F0.6390.90
194_V202_T0.6370.89
34_L105_I0.6360.89
80_Y83_Y0.6330.89
72_C178_I0.6310.89
85_L163_I0.6270.89
47_T146_I0.6220.88
123_V134_V0.6210.88
190_Q205_F0.6200.88
198_L202_T0.6190.88
30_A111_A0.6180.88
31_S42_A0.6170.88
77_F81_L0.6170.88
31_S108_I0.6130.88
31_S150_K0.6130.88
161_L164_Y0.6100.87
77_F80_Y0.6070.87
39_R149_S0.6070.87
194_V206_V0.6020.87
189_A203_V0.6020.87
125_G173_T0.6010.86
144_V152_I0.6000.86
141_S152_I0.5970.86
125_G180_R0.5970.86
34_L101_L0.5960.86
102_W105_I0.5900.85
92_T98_S0.5870.85
5_Y136_I0.5850.85
43_I146_I0.5760.84
156_L169_L0.5750.84
141_S153_H0.5750.84
36_D40_Q0.5720.84
5_Y9_L0.5710.84
194_V207_I0.5690.83
74_G121_I0.5690.83
197_L205_F0.5680.83
195_E208_L0.5680.83
11_V15_I0.5670.83
69_F72_C0.5650.83
44_I109_V0.5620.83
82_G170_L0.5620.83
114_F117_L0.5620.83
191_H207_I0.5610.83
24_A28_A0.5590.82
152_I155_A0.5580.82
138_L142_V0.5570.82
75_G164_Y0.5560.82
62_V66_N0.5540.82
93_K97_S0.5520.82
11_V16_D0.5510.81
16_D134_V0.5510.81
58_T173_T0.5500.81
205_F209_A0.5500.81
190_Q200_I0.5500.81
71_Q177_M0.5480.81
16_D115_M0.5480.81
20_G57_L0.5470.81
59_S135_V0.5450.81
39_R157_E0.5420.80
196_T204_A0.5400.80
188_M192_G0.5340.79
204_A209_A0.5320.79
20_G134_V0.5300.79
24_A166_G0.5270.78
85_L164_Y0.5200.78
194_V209_A0.5200.78
18_I173_T0.5190.77
91_D94_H0.5120.76
86_L167_S0.5110.76
190_Q206_V0.5090.76
168_G199_P0.5090.76
49_I105_I0.5050.76
50_A112_D0.5040.75
149_S153_H0.5040.75
182_K188_M0.5040.75
167_S171_A0.5020.75
24_A137_G0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.9817 39.6 0.941 Contact Map
3o7qA 1 0.9771 39.2 0.941 Contact Map
1pw4A 1 0.9495 35 0.942 Contact Map
4xnjA 1 0.9725 34.1 0.943 Contact Map
3wdoA 1 0.9862 30.5 0.944 Contact Map
2cfqA 1 0.4725 29.4 0.944 Contact Map
4w6vA 1 0.4037 18.7 0.949 Contact Map
4uvmA 1 0.422 15 0.952 Contact Map
3giaA 1 0.9358 13.8 0.952 Contact Map
2m20A 2 0.1651 13.2 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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