SPX - BACSU - GREMLIN Contacts

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SPX - Regulatory protein Spx

UniProt:	O31602	Sequences: MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRKVRSFQLREAQRLAN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	131 (111)
Sequences:	2570 (1821)
Seq/√Len:	172.8

ECOLI - YFFB ARSC YFGD
BACSU - SPX MGSR YUSI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
21_E	27_F	3.289	1.00
39_I	81_R	2.692	1.00
46_L	80_Y	2.618	1.00
6_T	29_E	2.378	1.00
33_F	88_G	2.354	1.00
95_I	110_I	2.239	1.00
4_L	17_R	2.148	1.00
97_D	100_R	2.125	1.00
39_I	43_K	2.098	1.00
8_P	31_N	1.996	1.00
43_K	80_Y	1.850	1.00
31_N	34_S	1.755	1.00
19_W	105_Y	1.642	1.00
63_V	86_H	1.607	1.00
38_S	41_E	1.585	1.00
62_K	66_K	1.585	1.00
47_R	76_L	1.479	1.00
44_Q	48_M	1.463	1.00
75_P	78_D	1.438	1.00
63_V	67_L	1.436	1.00
106_N	109_E	1.434	1.00
19_W	23_H	1.400	1.00
54_D	59_T	1.396	1.00
61_S	88_G	1.389	1.00
3_T	28_V	1.376	1.00
55_E	60_R	1.341	1.00
13_C	32_I	1.339	1.00
46_L	56_I	1.335	1.00
17_R	29_E	1.330	1.00
62_K	65_Q	1.325	1.00
51_D	56_I	1.320	1.00
96_I	101_L	1.303	1.00
4_L	13_C	1.291	1.00
8_P	34_S	1.278	1.00
30_R	36_P	1.270	1.00
102_Q	113_F	1.267	1.00
17_R	21_E	1.261	1.00
42_I	84_N	1.254	1.00
41_E	96_I	1.247	1.00
9_S	14_R	1.242	1.00
30_R	41_E	1.219	1.00
73_S	78_D	1.215	1.00
108_D	111_R	1.209	1.00
5_Y	30_R	1.203	1.00
57_I	83_I	1.202	1.00
41_E	44_Q	1.179	1.00
39_I	80_Y	1.150	1.00
6_T	17_R	1.138	1.00
55_E	103_V	1.133	1.00
41_E	45_I	1.131	1.00
48_M	101_L	1.127	1.00
63_V	66_K	1.109	1.00
8_P	17_R	1.099	1.00
51_D	103_V	1.096	1.00
53_T	79_L	1.080	1.00
60_R	106_N	1.077	1.00
109_E	112_R	1.076	1.00
83_I	89_L	1.055	1.00
13_C	17_R	1.046	0.99
71_V	74_M	1.046	0.99
43_K	47_R	1.004	0.99
83_I	90_L	1.004	0.99
28_V	35_E	0.996	0.99
19_W	111_R	0.986	0.99
7_S	13_C	0.982	0.99
76_L	80_Y	0.982	0.99
36_P	90_L	0.972	0.99
4_L	95_I	0.966	0.99
42_I	80_Y	0.964	0.99
3_T	30_R	0.954	0.99
52_G	79_L	0.946	0.99
18_A	22_E	0.945	0.99
102_Q	114_L	0.942	0.99
51_D	55_E	0.926	0.99
46_L	53_T	0.925	0.99
109_E	113_F	0.924	0.99
107_E	111_R	0.920	0.99
45_I	94_I	0.920	0.99
39_I	77_Q	0.907	0.99
70_N	78_D	0.899	0.98
52_G	55_E	0.893	0.98
71_V	79_L	0.889	0.98
43_K	76_L	0.877	0.98
64_F	89_L	0.875	0.98
23_H	111_R	0.872	0.98
64_F	74_M	0.861	0.98
51_D	101_L	0.854	0.98
14_R	18_A	0.854	0.98
94_I	103_V	0.850	0.98
13_C	89_L	0.844	0.98
46_L	52_G	0.836	0.97
30_R	35_E	0.836	0.97
2_V	25_I	0.832	0.97
67_L	82_L	0.822	0.97
102_Q	110_I	0.820	0.97
16_A	20_L	0.818	0.97
43_K	77_Q	0.817	0.97
100_R	113_F	0.815	0.97
46_L	76_L	0.814	0.97
108_D	112_R	0.813	0.97
45_I	101_L	0.809	0.97
32_I	94_I	0.779	0.96
81_R	85_E	0.778	0.96
44_Q	96_I	0.764	0.96
110_I	114_L	0.753	0.95
74_M	78_D	0.732	0.95
61_S	66_K	0.729	0.95
76_L	79_L	0.721	0.94
32_I	90_L	0.714	0.94
2_V	97_D	0.713	0.94
34_S	61_S	0.710	0.94
4_L	20_L	0.708	0.94
56_I	103_V	0.708	0.94
95_I	102_Q	0.704	0.93
21_E	26_P	0.700	0.93
7_S	88_G	0.688	0.93
40_D	43_K	0.684	0.92
6_T	31_N	0.670	0.92
66_K	86_H	0.666	0.91
48_M	100_R	0.666	0.91
57_I	87_P	0.666	0.91
11_T	18_A	0.660	0.91
74_M	79_L	0.660	0.91
33_F	63_V	0.652	0.91
8_P	13_C	0.648	0.90
18_A	21_E	0.644	0.90
74_M	82_L	0.641	0.90
30_R	37_L	0.637	0.90
70_N	74_M	0.637	0.90
14_R	17_R	0.625	0.89
57_I	79_L	0.621	0.88
37_L	84_N	0.620	0.88
17_R	27_F	0.619	0.88
53_T	76_L	0.615	0.88
48_M	99_K	0.612	0.88
9_S	31_N	0.611	0.87
64_F	70_N	0.611	0.87
39_I	84_N	0.610	0.87
63_V	88_G	0.608	0.87
51_D	94_I	0.604	0.87
54_D	79_L	0.602	0.87
32_I	37_L	0.600	0.87
95_I	114_L	0.593	0.86
37_L	41_E	0.587	0.85
70_N	85_E	0.587	0.85
2_V	114_L	0.586	0.85
16_A	105_Y	0.583	0.85
56_I	94_I	0.578	0.84
102_Q	109_E	0.572	0.84
96_I	99_K	0.570	0.84
79_L	83_I	0.560	0.83
5_Y	41_E	0.556	0.82
10_C	92_R	0.555	0.82
98_E	102_Q	0.533	0.79
11_T	14_R	0.530	0.79
4_L	29_E	0.529	0.79
19_W	79_L	0.527	0.79
58_S	65_Q	0.527	0.79
16_A	110_I	0.521	0.78
12_S	61_S	0.519	0.78
45_I	96_I	0.518	0.77
64_F	71_V	0.516	0.77
33_F	61_S	0.512	0.77
5_Y	36_P	0.510	0.76
42_I	90_L	0.510	0.76
69_V	73_S	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1z3eA	1	0.9008	100	0.267	Contact Map
3l78A	1	0.8931	100	0.305	Contact Map
3fz4A	1	0.8702	100	0.32	Contact Map
3gkxA	2	0.8702	100	0.328	Contact Map
1s3cA	2	1	100	0.329	Contact Map
2mu0A	1	0.8702	100	0.337	Contact Map
3f0iA	1	0.8702	100	0.339	Contact Map
3rdwA	1	0.8702	100	0.341	Contact Map
1rw1A	1	0.8626	100	0.344	Contact Map
2m46A	1	0.8779	100	0.345	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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