GREMLIN Database
SPX - Regulatory protein Spx
UniProt: O31602 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 131 (111)
Sequences: 2570 (1821)
Seq/√Len: 172.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E27_F3.2891.00
39_I81_R2.6921.00
46_L80_Y2.6181.00
6_T29_E2.3781.00
33_F88_G2.3541.00
95_I110_I2.2391.00
4_L17_R2.1481.00
97_D100_R2.1251.00
39_I43_K2.0981.00
8_P31_N1.9961.00
43_K80_Y1.8501.00
31_N34_S1.7551.00
19_W105_Y1.6421.00
63_V86_H1.6071.00
38_S41_E1.5851.00
62_K66_K1.5851.00
47_R76_L1.4791.00
44_Q48_M1.4631.00
75_P78_D1.4381.00
63_V67_L1.4361.00
106_N109_E1.4341.00
19_W23_H1.4001.00
54_D59_T1.3961.00
61_S88_G1.3891.00
3_T28_V1.3761.00
55_E60_R1.3411.00
13_C32_I1.3391.00
46_L56_I1.3351.00
17_R29_E1.3301.00
62_K65_Q1.3251.00
51_D56_I1.3201.00
96_I101_L1.3031.00
4_L13_C1.2911.00
8_P34_S1.2781.00
30_R36_P1.2701.00
102_Q113_F1.2671.00
17_R21_E1.2611.00
42_I84_N1.2541.00
41_E96_I1.2471.00
9_S14_R1.2421.00
30_R41_E1.2191.00
73_S78_D1.2151.00
108_D111_R1.2091.00
5_Y30_R1.2031.00
57_I83_I1.2021.00
41_E44_Q1.1791.00
39_I80_Y1.1501.00
6_T17_R1.1381.00
55_E103_V1.1331.00
41_E45_I1.1311.00
48_M101_L1.1271.00
63_V66_K1.1091.00
8_P17_R1.0991.00
51_D103_V1.0961.00
53_T79_L1.0801.00
60_R106_N1.0771.00
109_E112_R1.0761.00
83_I89_L1.0551.00
13_C17_R1.0460.99
71_V74_M1.0460.99
43_K47_R1.0040.99
83_I90_L1.0040.99
28_V35_E0.9960.99
19_W111_R0.9860.99
7_S13_C0.9820.99
76_L80_Y0.9820.99
36_P90_L0.9720.99
4_L95_I0.9660.99
42_I80_Y0.9640.99
3_T30_R0.9540.99
52_G79_L0.9460.99
18_A22_E0.9450.99
102_Q114_L0.9420.99
51_D55_E0.9260.99
46_L53_T0.9250.99
109_E113_F0.9240.99
107_E111_R0.9200.99
45_I94_I0.9200.99
39_I77_Q0.9070.99
70_N78_D0.8990.98
52_G55_E0.8930.98
71_V79_L0.8890.98
43_K76_L0.8770.98
64_F89_L0.8750.98
23_H111_R0.8720.98
64_F74_M0.8610.98
51_D101_L0.8540.98
14_R18_A0.8540.98
94_I103_V0.8500.98
13_C89_L0.8440.98
46_L52_G0.8360.97
30_R35_E0.8360.97
2_V25_I0.8320.97
67_L82_L0.8220.97
102_Q110_I0.8200.97
16_A20_L0.8180.97
43_K77_Q0.8170.97
100_R113_F0.8150.97
46_L76_L0.8140.97
108_D112_R0.8130.97
45_I101_L0.8090.97
32_I94_I0.7790.96
81_R85_E0.7780.96
44_Q96_I0.7640.96
110_I114_L0.7530.95
74_M78_D0.7320.95
61_S66_K0.7290.95
76_L79_L0.7210.94
32_I90_L0.7140.94
2_V97_D0.7130.94
34_S61_S0.7100.94
4_L20_L0.7080.94
56_I103_V0.7080.94
95_I102_Q0.7040.93
21_E26_P0.7000.93
7_S88_G0.6880.93
40_D43_K0.6840.92
6_T31_N0.6700.92
66_K86_H0.6660.91
48_M100_R0.6660.91
57_I87_P0.6660.91
11_T18_A0.6600.91
74_M79_L0.6600.91
33_F63_V0.6520.91
8_P13_C0.6480.90
18_A21_E0.6440.90
74_M82_L0.6410.90
30_R37_L0.6370.90
70_N74_M0.6370.90
14_R17_R0.6250.89
57_I79_L0.6210.88
37_L84_N0.6200.88
17_R27_F0.6190.88
53_T76_L0.6150.88
48_M99_K0.6120.88
9_S31_N0.6110.87
64_F70_N0.6110.87
39_I84_N0.6100.87
63_V88_G0.6080.87
51_D94_I0.6040.87
54_D79_L0.6020.87
32_I37_L0.6000.87
95_I114_L0.5930.86
37_L41_E0.5870.85
70_N85_E0.5870.85
2_V114_L0.5860.85
16_A105_Y0.5830.85
56_I94_I0.5780.84
102_Q109_E0.5720.84
96_I99_K0.5700.84
79_L83_I0.5600.83
5_Y41_E0.5560.82
10_C92_R0.5550.82
98_E102_Q0.5330.79
11_T14_R0.5300.79
4_L29_E0.5290.79
19_W79_L0.5270.79
58_S65_Q0.5270.79
16_A110_I0.5210.78
12_S61_S0.5190.78
45_I96_I0.5180.77
64_F71_V0.5160.77
33_F61_S0.5120.77
5_Y36_P0.5100.76
42_I90_L0.5100.76
69_V73_S0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z3eA 1 0.9008 100 0.267 Contact Map
3l78A 1 0.8931 100 0.305 Contact Map
3fz4A 1 0.8702 100 0.32 Contact Map
3gkxA 2 0.8702 100 0.328 Contact Map
1s3cA 2 1 100 0.329 Contact Map
2mu0A 1 0.8702 100 0.337 Contact Map
3f0iA 1 0.8702 100 0.339 Contact Map
3rdwA 1 0.8702 100 0.341 Contact Map
1rw1A 1 0.8626 100 0.344 Contact Map
2m46A 1 0.8779 100 0.345 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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