GREMLIN Database
YJAZ - Uncharacterized protein YjaZ
UniProt: O31596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 261 (240)
Sequences: 336 (260)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_G68_G3.8941.00
111_A140_V3.5641.00
157_D253_A3.3170.99
164_L174_G3.0910.99
167_Y235_K2.9620.98
142_R164_L2.8890.98
138_H165_A2.7890.98
77_L134_T2.6900.97
134_T172_R2.6740.97
23_I27_F2.4080.94
23_I26_L2.3220.93
71_Q75_Q2.2720.92
39_L47_M2.2680.92
142_R174_G2.2450.92
166_E169_V2.2190.91
19_L23_I2.1500.90
77_L248_G2.1120.89
26_L89_V2.0120.87
153_V206_R2.0110.87
155_L204_I2.0010.86
252_P255_T1.9160.84
46_G50_N1.9100.84
37_G40_G1.9000.83
116_M138_H1.8550.82
92_P241_S1.8500.82
40_G47_M1.8280.81
42_L185_Y1.7540.78
88_I118_L1.7500.78
58_V90_T1.7450.77
120_L129_V1.7250.77
83_G169_V1.7150.76
237_Y251_I1.6720.74
189_Q244_S1.6330.73
131_A215_L1.5770.70
166_E224_M1.5590.69
210_L256_F1.5480.68
201_H254_E1.5370.68
170_Y175_R1.5210.67
192_A255_T1.5160.67
143_L157_D1.5140.67
122_S228_A1.5050.66
179_A182_T1.5030.66
38_I41_H1.5000.66
106_S109_G1.4910.65
73_E77_L1.4890.65
142_R226_G1.4720.64
163_G217_G1.4500.63
136_E163_G1.4500.63
163_G227_Y1.4500.63
136_E139_H1.4500.63
135_H227_Y1.4500.63
217_G227_Y1.4500.63
139_H227_Y1.4500.63
139_H163_G1.4500.63
136_E217_G1.4500.63
135_H139_H1.4500.63
139_H217_G1.4500.63
135_H217_G1.4500.63
135_H163_G1.4500.63
136_E227_Y1.4500.63
39_L44_H1.3980.60
251_I255_T1.3940.60
198_I214_L1.3940.60
111_A116_M1.3890.60
70_I129_V1.3840.59
215_L226_G1.3820.59
134_T173_F1.3590.58
92_P115_K1.3450.57
66_F90_T1.3440.57
66_F70_I1.3390.57
25_P61_L1.3110.55
112_F182_T1.3080.55
83_G119_F1.2990.54
20_A27_F1.2970.54
39_L48_F1.2960.54
52_K79_N1.2930.54
105_G204_I1.2860.54
81_W138_H1.2790.53
16_I30_A1.2770.53
186_T194_Y1.2770.53
17_D20_A1.2530.52
235_K239_T1.2420.51
58_V186_T1.2350.51
164_L226_G1.2300.50
97_N184_W1.2190.50
226_G234_V1.2180.50
81_W141_C1.2070.49
16_I20_A1.2050.49
203_D258_D1.1890.48
77_L169_V1.1850.48
157_D161_M1.1820.47
70_I109_G1.1780.47
192_A196_K1.1690.47
163_G222_P1.1640.46
222_P227_Y1.1640.46
217_G222_P1.1640.46
136_E222_P1.1640.46
135_H222_P1.1640.46
139_H222_P1.1640.46
23_I29_G1.1460.45
159_I232_N1.1410.45
158_T211_F1.1370.45
161_M214_L1.1320.45
37_G42_L1.1320.45
130_S134_T1.1190.44
94_D106_S1.1020.43
107_K137_Y1.1010.43
93_V228_A1.0990.43
143_L161_M1.0910.42
16_I22_Y1.0820.42
156_L215_L1.0760.41
22_Y27_F1.0580.40
77_L130_S1.0540.40
136_E162_E1.0500.40
162_E227_Y1.0500.40
135_H162_E1.0500.40
162_E217_G1.0500.40
139_H162_E1.0500.40
129_V159_I1.0490.40
53_E58_V1.0480.40
27_F116_M1.0480.40
111_A218_K1.0440.39
81_W168_A1.0430.39
87_P169_V1.0220.38
237_Y243_A1.0200.38
87_P168_A1.0130.38
68_G203_D1.0130.38
239_T250_S1.0090.37
140_V143_L0.9800.36
152_D205_K0.9750.36
144_G174_G0.9740.36
87_P203_D0.9630.35
107_K168_A0.9560.35
110_L249_L0.9510.34
38_I140_V0.9490.34
148_K224_M0.9380.34
73_E173_F0.9240.33
122_S160_I0.9200.33
124_L175_R0.9170.32
180_E221_Q0.9160.32
140_V225_L0.9160.32
18_D30_A0.9140.32
117_F256_F0.9100.32
193_L225_L0.9080.32
170_Y236_K0.9060.32
238_L243_A0.9060.32
245_T248_G0.9050.32
191_Q247_D0.9040.32
79_N243_A0.8970.31
42_L46_G0.8960.31
59_S63_E0.8960.31
16_I39_L0.8950.31
24_I44_H0.8940.31
139_H230_G0.8940.31
136_E230_G0.8940.31
135_H230_G0.8940.31
163_G230_G0.8940.31
227_Y230_G0.8940.31
217_G230_G0.8940.31
185_Y224_M0.8900.31
48_F206_R0.8890.31
69_H130_S0.8880.31
238_L248_G0.8870.31
88_I92_P0.8800.31
245_T249_L0.8770.30
204_I239_T0.8760.30
20_A23_I0.8610.30
85_D186_T0.8590.30
146_L157_D0.8570.29
75_Q255_T0.8550.29
141_C249_L0.8540.29
66_F118_L0.8540.29
176_S229_V0.8530.29
195_E233_I0.8530.29
157_D212_P0.8520.29
84_P249_L0.8470.29
105_G206_R0.8470.29
119_F166_E0.8470.29
46_G118_L0.8460.29
198_I229_V0.8450.29
55_I59_S0.8400.29
72_K233_I0.8370.28
142_R169_V0.8350.28
73_E169_V0.8330.28
166_E231_F0.8330.28
133_M246_A0.8310.28
152_D254_E0.8290.28
198_I201_H0.8260.28
105_G194_Y0.8170.28
134_T150_E0.8130.27
70_I138_H0.8130.27
210_L221_Q0.8070.27
150_E172_R0.8030.27
127_G177_Q0.8020.27
150_E173_F0.8010.27
36_K239_T0.7950.26
138_H216_F0.7920.26
139_H165_A0.7910.26
165_A217_G0.7910.26
136_E165_A0.7910.26
165_A227_Y0.7910.26
135_H165_A0.7910.26
93_V157_D0.7900.26
53_E65_G0.7900.26
96_R232_N0.7890.26
77_L168_A0.7860.26
164_L179_A0.7830.26
111_A224_M0.7770.26
75_Q258_D0.7760.26
169_V181_W0.7670.25
174_G226_G0.7660.25
125_D215_L0.7650.25
37_G257_L0.7570.25
189_Q252_P0.7530.25
116_M226_G0.7530.25
138_H212_P0.7530.25
97_N106_S0.7500.24
95_E122_S0.7440.24
86_V194_Y0.7400.24
119_F137_Y0.7390.24
149_E152_D0.7380.24
79_N191_Q0.7370.24
164_L248_G0.7310.24
176_S243_A0.7310.24
80_K172_R0.7300.24
103_E196_K0.7300.24
201_H233_I0.7290.24
51_I206_R0.7290.24
91_L215_L0.7230.23
21_H39_L0.7210.23
59_S191_Q0.7210.23
59_S65_G0.7200.23
234_V256_F0.7190.23
15_S251_I0.7180.23
158_T215_L0.7170.23
78_K204_I0.7130.23
85_D243_A0.7120.23
216_F231_F0.7080.23
201_H206_R0.7050.23
16_I19_L0.7040.22
203_D255_T0.7010.22
68_G239_T0.7000.22
41_H180_E0.7000.22
97_N256_F0.6990.22
244_S247_D0.6990.22
142_R166_E0.6960.22
155_L201_H0.6940.22
98_R244_S0.6930.22
46_G83_G0.6890.22
76_Y187_P0.6830.22
88_I178_T0.6830.22
47_M50_N0.6820.22
203_D254_E0.6810.22
166_E185_Y0.6790.21
80_K203_D0.6780.21
59_S160_I0.6780.21
119_F185_Y0.6740.21
25_P202_R0.6700.21
214_L221_Q0.6690.21
61_L90_T0.6690.21
67_Y164_L0.6620.21
154_T205_K0.6580.21
161_M181_W0.6570.21
207_D211_F0.6560.21
121_S245_T0.6520.20
128_S211_F0.6520.20
70_I239_T0.6500.20
93_V100_I0.6490.20
88_I138_H0.6490.20
46_G84_P0.6470.20
75_Q160_I0.6460.20
18_D22_Y0.6440.20
132_L160_I0.6420.20
72_K79_N0.6390.20
138_H219_G0.6390.20
16_I48_F0.6380.20
55_I254_E0.6380.20
16_I67_Y0.6370.20
107_K131_A0.6370.20
120_L190_L0.6360.20
141_C168_A0.6350.20
53_E64_K0.6290.20
42_L47_M0.6290.20
77_L150_E0.6280.20
140_V148_K0.6250.19
58_V258_D0.6210.19
90_T176_S0.6200.19
24_I160_I0.6200.19
60_K63_E0.6190.19
175_R234_V0.6190.19
214_L224_M0.6160.19
169_V224_M0.6160.19
116_M200_P0.6150.19
90_T118_L0.6130.19
104_F157_D0.6120.19
147_T257_L0.6120.19
77_L172_R0.6090.19
219_G233_I0.6050.19
104_F198_I0.6050.19
162_E222_P0.6000.18
36_K40_G0.5960.18
168_A215_L0.5950.18
170_Y231_F0.5940.18
61_L66_F0.5940.18
160_I230_G0.5920.18
53_E203_D0.5910.18
110_L118_L0.5890.18
159_I215_L0.5890.18
90_T117_F0.5840.18
108_S256_F0.5820.18
192_A222_P0.5820.18
59_S76_Y0.5810.18
65_G258_D0.5780.18
50_N178_T0.5760.18
122_S245_T0.5730.18
248_G256_F0.5710.17
104_F224_M0.5700.17
112_F115_K0.5690.17
59_S154_T0.5670.17
109_G166_E0.5600.17
137_Y156_L0.5580.17
68_G253_A0.5560.17
73_E141_C0.5560.17
37_G41_H0.5550.17
16_I23_I0.5550.17
90_T203_D0.5550.17
157_D214_L0.5540.17
68_G186_T0.5530.17
160_I200_P0.5520.17
20_A28_S0.5500.17
81_W92_P0.5490.17
169_V174_G0.5360.16
213_Q218_K0.5360.16
120_L238_L0.5350.16
42_L50_N0.5350.16
206_R210_L0.5320.16
70_I74_E0.5300.16
41_H45_H0.5280.16
39_L49_K0.5280.16
131_A142_R0.5280.16
105_G256_F0.5280.16
18_D25_P0.5270.16
156_L194_Y0.5270.16
214_L231_F0.5240.16
193_L222_P0.5240.16
56_Q71_Q0.5230.16
81_W174_G0.5220.16
153_V159_I0.5180.16
160_I176_S0.5170.16
79_N252_P0.5160.16
83_G176_S0.5140.16
18_D21_H0.5120.16
27_F30_A0.5090.15
21_H105_G0.5050.15
72_K75_Q0.5050.15
141_C252_P0.5040.15
125_D183_T0.5040.15
23_I31_E0.5030.15
169_V177_Q0.5020.15
60_K78_K0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y3uA 1 0.9004 96.8 0.91 Contact Map
4arfA 2 0.8046 96.3 0.915 Contact Map
4ar9A 1 0.8582 96.3 0.915 Contact Map
4areA 1 0.9042 96.1 0.917 Contact Map
3cqbA 4 0.3946 91.7 0.932 Contact Map
4gaaA 2 0.8851 69.3 0.948 Contact Map
4fgmA 4 0.9004 54.8 0.953 Contact Map
1z5hA 3 0.8889 52.4 0.953 Contact Map
4wz9A 2 0.8889 52.1 0.953 Contact Map
4x2uA 1 0.8966 51.3 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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