GREMLIN Database
YHBJ - Putative efflux system component YhbJ
UniProt: O31593 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (183)
Sequences: 25261 (20225)
Seq/√Len: 1495.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_E201_S3.1051.00
84_T95_D3.0821.00
70_D87_K2.9841.00
149_S163_D2.5611.00
131_Y199_K2.4931.00
80_K101_D2.4761.00
72_D87_K2.4031.00
87_K95_D2.2691.00
84_T97_K2.2501.00
164_G200_I2.2431.00
151_D163_D2.2261.00
63_P93_T2.1671.00
80_K83_D2.1661.00
151_D161_T2.1131.00
78_T103_T2.0691.00
72_D84_T2.0461.00
105_V125_I2.0451.00
133_T197_P2.0211.00
36_A39_Y2.0101.00
54_A133_T2.0041.00
134_A217_V1.9721.00
160_T208_K1.9701.00
134_A200_I1.8691.00
150_V200_I1.8491.00
129_N201_S1.8241.00
132_I215_A1.7911.00
173_T196_V1.7631.00
149_S165_T1.7451.00
165_T203_K1.6971.00
81_K101_D1.6861.00
154_V215_A1.6831.00
34_G38_Y1.6471.00
168_E199_K1.6261.00
126_D129_N1.6141.00
84_T87_K1.5921.00
107_N110_K1.5881.00
165_T201_S1.5641.00
68_V109_V1.5241.00
133_T199_K1.4971.00
74_D77_K1.4961.00
116_Q119_T1.4851.00
68_V86_A1.4511.00
135_N197_P1.4251.00
33_A37_Y1.4201.00
152_V202_I1.4141.00
35_G39_Y1.4091.00
90_G94_V1.4021.00
36_A40_Y1.3981.00
59_A120_T1.3841.00
104_I122_A1.3841.00
69_S89_K1.3831.00
177_F194_Q1.3661.00
73_L83_D1.3651.00
170_G197_P1.3551.00
98_S124_T1.3301.00
153_V161_T1.3161.00
151_D218_K1.3081.00
53_V132_I1.3011.00
137_K140_D1.2991.00
33_A36_A1.2981.00
56_D126_D1.2901.00
70_D111_N1.2821.00
153_V218_K1.2811.00
86_A96_V1.2701.00
59_A123_Q1.2671.00
85_V122_A1.2601.00
141_I196_V1.2581.00
32_I36_A1.2571.00
157_D162_F1.2221.00
65_A117_A1.2151.00
63_P67_K1.2091.00
34_G37_Y1.2011.00
106_K123_Q1.1961.00
132_I152_V1.1951.00
132_I217_V1.1731.00
47_K51_A1.1701.00
46_V218_K1.1661.00
57_M123_Q1.1591.00
102_G124_T1.1411.00
177_F193_T1.1121.00
174_N177_F1.1011.00
74_D107_N1.1001.00
154_V157_D1.1001.00
69_S87_K1.0911.00
107_N122_A1.0871.00
78_T101_D1.0791.00
35_G38_Y1.0761.00
145_E148_N1.0671.00
31_I34_G1.0641.00
98_S101_D1.0551.00
131_Y201_S1.0501.00
78_T127_M1.0471.00
87_K90_G1.0441.00
66_G88_I1.0321.00
65_A116_Q1.0221.00
108_E123_Q1.0121.00
86_A122_A1.0031.00
62_A96_V1.0021.00
136_I144_I0.9981.00
73_L122_A0.9961.00
166_V198_V0.9911.00
34_G39_Y0.9901.00
167_E199_K0.9851.00
71_W86_A0.9831.00
73_L107_N0.9821.00
115_V121_I0.9811.00
86_A121_I0.9701.00
153_V159_D0.9691.00
75_E106_K0.9681.00
108_E120_T0.9531.00
153_V216_S0.9461.00
157_D160_T0.9381.00
163_D203_K0.9371.00
204_N207_D0.9361.00
53_V209_V0.9321.00
136_I198_V0.9171.00
135_N195_K0.9111.00
174_N197_P0.8941.00
152_V164_G0.8891.00
140_D143_D0.8881.00
69_S72_D0.8881.00
100_M124_T0.8861.00
62_A86_A0.8851.00
68_V115_V0.8851.00
48_T218_K0.8781.00
71_W111_N0.8761.00
166_V200_I0.8761.00
131_Y167_E0.8701.00
130_L211_P0.8641.00
49_D134_A0.8631.00
39_Y42_S0.8631.00
90_G95_D0.8611.00
152_V215_A0.8611.00
67_K114_T0.8581.00
79_V83_D0.8521.00
57_M125_I0.8491.00
77_K83_D0.8381.00
154_V209_V0.8361.00
58_A100_M0.8291.00
92_Q97_K0.8251.00
62_A115_V0.8231.00
48_T216_S0.8221.00
78_T207_D0.8201.00
144_I219_I0.8161.00
39_Y43_T0.8141.00
146_V167_E0.8141.00
129_N203_K0.8071.00
136_I219_I0.7971.00
103_T127_M0.7891.00
73_L104_I0.7841.00
125_I211_P0.7831.00
79_V85_V0.7761.00
86_A107_N0.7751.00
62_A121_I0.7751.00
73_L77_K0.7711.00
156_G213_M0.7671.00
146_V169_I0.7651.00
210_L213_M0.7631.00
155_D216_S0.7611.00
171_Y210_L0.7571.00
56_D110_K0.7511.00
37_Y40_Y0.7501.00
194_Q214_N0.7381.00
69_S90_G0.7301.00
53_V130_L0.7251.00
144_I166_V0.7211.00
55_G131_Y0.7191.00
55_G129_N0.7111.00
60_I99_I0.7061.00
152_V217_V0.6981.00
32_I35_G0.6891.00
109_V121_I0.6851.00
40_Y43_T0.6791.00
68_V71_W0.6781.00
96_V121_I0.6721.00
30_A34_G0.6711.00
22_I25_L0.6691.00
114_T118_G0.6681.00
65_A114_T0.6681.00
25_L29_L0.6661.00
92_Q95_D0.6631.00
135_N174_N0.6631.00
55_G201_S0.6631.00
68_V121_I0.6621.00
105_V171_Y0.6591.00
134_A198_V0.6591.00
59_A113_Q0.6581.00
51_A215_A0.6531.00
173_T194_Q0.6521.00
81_K99_I0.6481.00
120_T123_Q0.6451.00
152_V200_I0.6431.00
132_I202_I0.6411.00
105_V170_G0.6391.00
157_D208_K0.6351.00
52_K194_Q0.6341.00
62_A88_I0.6341.00
147_G165_T0.6331.00
75_E107_N0.6311.00
67_K89_K0.6311.00
103_T210_L0.6301.00
150_V164_G0.6291.00
53_V215_A0.6281.00
169_I198_V0.6261.00
64_A93_T0.6231.00
125_I172_A0.6211.00
62_A65_A0.6191.00
115_V119_T0.6161.00
64_A94_V0.6151.00
110_K113_Q0.6121.00
40_Y44_N0.6111.00
200_I217_V0.6101.00
33_A39_Y0.6081.00
160_T206_S0.6061.00
130_L204_N0.6061.00
109_V115_V0.6051.00
37_Y41_Q0.6051.00
127_M207_D0.6021.00
55_G126_D0.5991.00
72_D75_E0.5951.00
106_K168_E0.5951.00
41_Q44_N0.5911.00
58_A124_T0.5891.00
162_F208_K0.5891.00
175_S194_Q0.5891.00
196_V213_M0.5881.00
28_V31_I0.5821.00
38_Y42_S0.5821.00
163_D204_N0.5671.00
72_D83_D0.5661.00
159_D162_F0.5631.00
127_M130_L0.5611.00
58_A62_A0.5591.00
54_A131_Y0.5581.00
71_W107_N0.5581.00
173_T214_N0.5571.00
58_A99_I0.5551.00
56_D100_M0.5541.00
138_E214_N0.5521.00
22_I26_I0.5511.00
91_E94_V0.5511.00
35_G40_Y0.5511.00
29_L32_I0.5511.00
54_A57_M0.5471.00
162_F206_S0.5451.00
79_V124_T0.5421.00
106_K120_T0.5401.00
82_G97_K0.5401.00
78_T83_D0.5391.00
27_V34_G0.5351.00
26_I30_A0.5341.00
27_V30_A0.5341.00
38_Y41_Q0.5321.00
63_P89_K0.5311.00
60_I100_M0.5271.00
61_T120_T0.5271.00
113_Q119_T0.5261.00
49_D52_K0.5261.00
25_L32_I0.5261.00
162_F209_V0.5251.00
31_I35_G0.5221.00
136_I217_V0.5201.00
69_S111_N0.5121.00
174_N195_K0.5111.00
100_M126_D0.5101.00
127_M211_P0.5071.00
154_V158_P0.5061.00
125_I171_Y0.5061.00
138_E156_G0.5051.00
174_N194_Q0.5031.00
29_L33_A0.5021.00
128_D207_D0.5021.00
38_Y43_T0.5021.00
49_D140_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ne5B 3 0.7376 100 0.328 Contact Map
4tkoB 1 0.724 100 0.345 Contact Map
4kkuA 1 0.7919 100 0.379 Contact Map
3fppA 3 0.7647 100 0.391 Contact Map
2f1mA 2 0.724 100 0.391 Contact Map
4dk0A 5 0.7964 100 0.4 Contact Map
3lnnA 6 0.8688 100 0.404 Contact Map
4l8jA 2 0.8054 100 0.417 Contact Map
1vf7A 5 0.7466 99.9 0.429 Contact Map
2k32A 1 0.3846 99.6 0.631 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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