GREMLIN Database
YHBB - Uncharacterized protein YhbB
UniProt: O31589 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (272)
Sequences: 474 (404)
Seq/√Len: 24.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_N276_Q14.5981.00
251_E257_N5.4661.00
183_C261_I4.5431.00
218_M259_T4.2201.00
159_E282_M4.0651.00
195_P201_W4.0501.00
169_Y185_H3.9261.00
157_Y166_N3.6391.00
165_R279_D3.0551.00
265_K271_P2.9611.00
247_C259_T2.8711.00
154_A261_I2.5450.99
242_P263_V2.4920.99
175_N188_G2.4710.99
213_T217_S2.4270.98
46_L286_S2.3840.98
248_Y285_W2.2880.98
249_D257_N2.1510.96
180_I261_I2.1100.96
174_D179_F2.0850.96
196_N218_M1.9740.94
215_A247_C1.9370.94
161_F166_N1.9050.93
248_Y260_T1.8400.92
170_K203_M1.8260.91
177_T259_T1.8180.91
166_N182_Q1.8070.91
153_G156_Q1.7840.90
172_F208_W1.7730.90
159_E274_N1.7730.90
216_H255_R1.7400.89
44_K175_N1.7350.89
270_M284_Y1.7330.89
252_G277_T1.7310.89
189_A229_L1.7280.89
215_A285_W1.6810.88
160_K230_R1.6440.86
249_D254_G1.6270.86
161_F167_P1.6250.86
189_A192_R1.6220.86
165_R171_N1.6120.85
189_A228_G1.5990.85
225_S228_G1.5910.84
164_K279_D1.5810.84
218_M222_L1.5700.84
172_F207_S1.5190.82
159_E281_R1.5160.81
177_T261_I1.5140.81
223_S302_F1.5040.81
266_D272_L1.4870.80
215_A248_Y1.4790.80
274_N282_M1.4640.79
194_H203_M1.4610.79
39_V303_H1.4560.79
133_Y136_A1.4450.78
238_E304_I1.4360.78
179_F276_Q1.4350.78
160_K169_Y1.4230.77
192_R225_S1.4130.76
176_C181_S1.3770.75
220_M224_N1.3650.74
50_R281_R1.3600.74
181_S258_H1.3580.74
161_F164_K1.3320.72
222_L245_V1.3160.71
162_W271_P1.3000.70
210_Y217_S1.2950.70
280_S283_R1.2710.68
157_Y182_Q1.2610.68
150_D153_G1.2530.67
219_K225_S1.2460.67
244_D269_N1.2430.67
275_A280_S1.2420.67
181_S212_W1.2400.66
189_A222_L1.2270.66
128_T132_D1.2220.65
56_K180_I1.2210.65
176_C258_H1.1900.63
174_D180_I1.1870.63
246_I274_N1.1850.63
180_I183_C1.1840.63
152_L156_Q1.1730.62
157_Y161_F1.1680.62
158_A183_C1.1680.62
246_I285_W1.1680.62
277_T297_I1.1660.62
219_K223_S1.1640.61
160_K164_K1.1610.61
125_H129_S1.1590.61
217_S274_N1.1470.60
246_I303_H1.1440.60
231_A238_E1.1390.60
116_E123_G1.1360.59
215_A259_T1.1340.59
185_H293_Y1.1330.59
240_L271_P1.1260.59
174_D270_M1.1130.58
183_C275_A1.1110.58
250_F297_I1.1030.57
150_D156_Q1.0970.57
108_D111_L1.0940.57
166_N240_L1.0840.56
192_R195_P1.0790.55
65_H77_S1.0770.55
190_P275_A1.0590.54
181_S243_G1.0560.54
162_W292_A1.0550.54
270_M286_S1.0460.53
200_G273_V1.0390.53
94_Y104_A1.0370.52
176_C212_W1.0310.52
212_W258_H1.0220.51
158_A179_F1.0210.51
178_N181_S1.0130.51
195_P202_W1.0130.51
155_V263_V1.0090.50
208_W281_R1.0090.50
77_S103_M1.0030.50
208_W211_S1.0010.50
76_L134_S0.9980.50
215_A297_I0.9900.49
264_A272_L0.9860.49
222_L271_P0.9790.48
126_E130_I0.9780.48
260_T273_V0.9720.48
272_L275_A0.9640.47
181_S187_G0.9640.47
115_Q120_K0.9610.47
263_V274_N0.9610.47
250_F257_N0.9540.47
220_M256_F0.9500.46
151_R154_A0.9490.46
214_V217_S0.9480.46
99_I115_Q0.9410.46
180_I245_V0.9400.46
67_R213_T0.9330.45
66_V103_M0.9300.45
69_E137_E0.9200.44
175_N278_Y0.9180.44
103_M106_L0.9170.44
151_R274_N0.9170.44
166_N169_Y0.9110.43
222_L244_D0.9090.43
158_A263_V0.9070.43
48_E99_I0.9030.43
192_R221_Y0.9020.43
249_D283_R0.9000.43
272_L287_Y0.8990.43
215_A249_D0.8960.42
273_V287_Y0.8960.42
158_A180_I0.8950.42
262_V271_P0.8910.42
67_R141_E0.8900.42
49_K169_Y0.8850.42
263_V269_N0.8790.41
151_R285_W0.8760.41
162_W283_R0.8730.41
176_C243_G0.8730.41
202_W262_V0.8710.41
272_L284_Y0.8710.41
159_E217_S0.8670.40
223_S246_I0.8670.40
154_A189_A0.8660.40
197_R277_T0.8640.40
52_V88_E0.8590.40
50_R274_N0.8560.40
243_G258_H0.8560.40
84_Y98_H0.8540.40
247_C297_I0.8460.39
47_L80_I0.8450.39
177_T183_C0.8390.38
110_I119_K0.8320.38
252_G285_W0.8300.38
249_D253_D0.8230.37
36_D39_V0.8220.37
158_A258_H0.8210.37
218_M245_V0.8190.37
284_Y287_Y0.8190.37
159_E263_V0.8180.37
89_Q262_V0.8180.37
169_Y215_A0.8170.37
203_M212_W0.8120.37
149_Y183_C0.8120.37
155_V242_P0.8080.36
148_Q303_H0.8070.36
116_E121_P0.8070.36
115_Q122_A0.8070.36
109_H138_E0.8060.36
116_E119_K0.8060.36
178_N258_H0.8050.36
149_Y154_A0.7970.36
57_A84_Y0.7940.35
179_F258_H0.7870.35
211_S214_V0.7830.35
283_R287_Y0.7820.35
162_W280_S0.7790.35
32_S35_G0.7790.35
30_Q282_M0.7750.34
176_C187_G0.7750.34
49_K124_F0.7740.34
49_K63_I0.7700.34
162_W240_L0.7670.34
162_W253_D0.7620.33
162_W250_F0.7590.33
256_F260_T0.7590.33
189_A226_K0.7580.33
42_R50_R0.7560.33
187_G258_H0.7520.33
134_S137_E0.7510.33
174_D247_C0.7510.33
199_S286_S0.7500.33
242_P265_K0.7480.33
184_L187_G0.7470.32
200_G222_L0.7460.32
108_D170_K0.7450.32
207_S215_A0.7420.32
202_W209_S0.7410.32
87_K159_E0.7400.32
241_M264_A0.7390.32
177_T245_V0.7390.32
274_N281_R0.7380.32
254_G262_V0.7370.32
155_V166_N0.7360.32
256_F302_F0.7350.32
57_A303_H0.7330.32
165_R179_F0.7320.32
217_S222_L0.7320.32
273_V285_W0.7320.32
185_H203_M0.7290.31
76_L101_E0.7290.31
87_K193_G0.7270.31
36_D117_I0.7260.31
154_A301_F0.7240.31
86_C174_D0.7240.31
162_W249_D0.7220.31
142_A184_L0.7200.31
218_M256_F0.7190.31
162_W177_T0.7170.31
136_A140_R0.7160.31
43_K195_P0.7140.30
274_N285_W0.7120.30
105_F110_I0.7070.30
186_A262_V0.7020.30
208_W214_V0.7010.30
61_A171_N0.7010.30
169_Y279_D0.7000.30
265_K279_D0.7000.30
209_S261_I0.6990.30
76_L115_Q0.6990.30
159_E277_T0.6980.29
102_R183_C0.6960.29
185_H207_S0.6960.29
29_R35_G0.6950.29
60_K137_E0.6920.29
34_V38_K0.6900.29
128_T131_I0.6850.29
271_P299_Y0.6830.29
115_Q119_K0.6820.29
264_A303_H0.6810.28
122_A128_T0.6810.28
40_M48_E0.6780.28
121_P169_Y0.6780.28
63_I199_S0.6750.28
211_S229_L0.6740.28
231_A242_P0.6730.28
104_A282_M0.6690.28
202_W299_Y0.6660.28
246_I273_V0.6640.27
31_E36_D0.6640.27
163_N294_T0.6620.27
208_W217_S0.6610.27
179_F221_Y0.6600.27
141_E144_G0.6590.27
44_K77_S0.6570.27
122_A131_I0.6570.27
275_A287_Y0.6560.27
272_L285_W0.6530.27
92_S268_G0.6530.27
162_W210_Y0.6520.27
78_Y172_F0.6520.27
151_R246_I0.6520.27
117_I123_G0.6480.27
80_I255_R0.6450.26
240_L252_G0.6450.26
125_H130_I0.6450.26
219_K297_I0.6410.26
101_E110_I0.6410.26
249_D256_F0.6410.26
156_Q279_D0.6400.26
130_I136_A0.6390.26
222_L246_I0.6380.26
157_Y181_S0.6330.26
71_D76_L0.6310.26
76_L106_L0.6290.26
69_E141_E0.6290.26
185_H278_Y0.6280.25
43_K46_L0.6270.25
91_D184_L0.6270.25
50_R266_D0.6250.25
126_E136_A0.6230.25
275_A283_R0.6220.25
195_P225_S0.6220.25
92_S207_S0.6210.25
109_H139_E0.6200.25
260_T275_A0.6180.25
115_Q165_R0.6180.25
125_H128_T0.6180.25
157_Y243_G0.6170.25
248_Y272_L0.6160.25
111_L114_D0.6150.25
63_I170_K0.6150.25
161_F174_D0.6150.25
291_T297_I0.6130.25
74_T102_R0.6120.25
95_I269_N0.6120.25
260_T272_L0.6120.25
175_N229_L0.6110.25
119_K168_A0.6090.24
34_V148_Q0.6050.24
190_P213_T0.6050.24
109_H146_A0.6020.24
52_V160_K0.6000.24
217_S273_V0.6000.24
71_D129_S0.5990.24
169_Y182_Q0.5980.24
96_E103_M0.5970.24
190_P287_Y0.5970.24
73_T268_G0.5960.24
144_G227_A0.5950.24
66_V140_R0.5940.24
89_Q131_I0.5940.24
46_L195_P0.5940.24
180_I210_Y0.5880.23
168_A186_A0.5860.23
170_K179_F0.5850.23
97_E104_A0.5840.23
262_V266_D0.5780.23
222_L231_A0.5760.23
260_T285_W0.5740.23
163_N219_K0.5740.23
62_V138_E0.5730.23
262_V265_K0.5710.22
285_W294_T0.5710.22
202_W277_T0.5700.22
262_V273_V0.5670.22
126_E133_Y0.5650.22
49_K296_S0.5640.22
99_I103_M0.5620.22
133_Y137_E0.5610.22
172_F256_F0.5610.22
154_A190_P0.5600.22
197_R293_Y0.5600.22
173_S179_F0.5600.22
179_F187_G0.5590.22
147_F303_H0.5580.22
56_K209_S0.5570.22
153_G264_A0.5560.22
43_K193_G0.5550.22
177_T271_P0.5550.22
226_K239_E0.5550.22
50_R222_L0.5520.22
203_M293_Y0.5520.22
69_E142_A0.5510.21
199_S224_N0.5490.21
143_F236_S0.5480.21
32_S242_P0.5450.21
103_M115_Q0.5430.21
218_M291_T0.5410.21
48_E111_L0.5380.21
119_K123_G0.5380.21
138_E184_L0.5370.21
60_K107_Y0.5360.21
191_M266_D0.5340.21
87_K211_S0.5340.21
225_S229_L0.5310.21
38_K169_Y0.5290.20
292_A299_Y0.5280.20
144_G148_Q0.5270.20
143_F148_Q0.5260.20
293_Y297_I0.5260.20
180_I202_W0.5250.20
69_E108_D0.5220.20
86_C99_I0.5220.20
69_E74_T0.5210.20
109_H276_Q0.5210.20
172_F285_W0.5200.20
280_S287_Y0.5190.20
53_D107_Y0.5180.20
200_G299_Y0.5180.20
89_Q132_D0.5160.20
45_K169_Y0.5140.20
56_K106_L0.5130.20
100_E110_I0.5120.20
154_A274_N0.5110.20
51_K142_A0.5110.20
161_F226_K0.5090.20
105_F108_D0.5070.19
200_G287_Y0.5070.19
172_F292_A0.5070.19
188_G276_Q0.5060.19
280_S284_Y0.5040.19
84_Y147_F0.5040.19
44_K211_S0.5040.19
278_Y282_M0.5030.19
162_W287_Y0.5000.19
272_L280_S0.5000.19
89_Q93_L0.5000.19
100_E156_Q0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cgkA 3 0.7814 97.1 0.903 Contact Map
2k1gA 1 0.3955 97 0.906 Contact Map
4hz9A 1 0.3794 96.9 0.907 Contact Map
2k3aA 1 0.4759 96.8 0.908 Contact Map
4eyzA 1 0.6624 96 0.915 Contact Map
4ct3A 4 0.5113 95.9 0.915 Contact Map
4lj1A 1 0.3698 95.7 0.917 Contact Map
3vpiA 1 0.4341 95.1 0.92 Contact Map
4q4gX 1 0.4405 94.8 0.921 Contact Map
2if6A 1 0.2219 94.7 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.