YHBB - BACSU - GREMLIN Contacts

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YHBB - Uncharacterized protein YhbB

UniProt:	O31589	Sequences: MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKKKLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEERMAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEKFWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSMKMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQTYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (272)
Sequences:	474 (404)
Seq/√Len:	24.5

BACSU - YHBB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
175_N	276_Q	14.598	1.00
251_E	257_N	5.466	1.00
183_C	261_I	4.543	1.00
218_M	259_T	4.220	1.00
159_E	282_M	4.065	1.00
195_P	201_W	4.050	1.00
169_Y	185_H	3.926	1.00
157_Y	166_N	3.639	1.00
165_R	279_D	3.055	1.00
265_K	271_P	2.961	1.00
247_C	259_T	2.871	1.00
154_A	261_I	2.545	0.99
242_P	263_V	2.492	0.99
175_N	188_G	2.471	0.99
213_T	217_S	2.427	0.98
46_L	286_S	2.384	0.98
248_Y	285_W	2.288	0.98
249_D	257_N	2.151	0.96
180_I	261_I	2.110	0.96
174_D	179_F	2.085	0.96
196_N	218_M	1.974	0.94
215_A	247_C	1.937	0.94
161_F	166_N	1.905	0.93
248_Y	260_T	1.840	0.92
170_K	203_M	1.826	0.91
177_T	259_T	1.818	0.91
166_N	182_Q	1.807	0.91
153_G	156_Q	1.784	0.90
172_F	208_W	1.773	0.90
159_E	274_N	1.773	0.90
216_H	255_R	1.740	0.89
44_K	175_N	1.735	0.89
270_M	284_Y	1.733	0.89
252_G	277_T	1.731	0.89
189_A	229_L	1.728	0.89
215_A	285_W	1.681	0.88
160_K	230_R	1.644	0.86
249_D	254_G	1.627	0.86
161_F	167_P	1.625	0.86
189_A	192_R	1.622	0.86
165_R	171_N	1.612	0.85
189_A	228_G	1.599	0.85
225_S	228_G	1.591	0.84
164_K	279_D	1.581	0.84
218_M	222_L	1.570	0.84
172_F	207_S	1.519	0.82
159_E	281_R	1.516	0.81
177_T	261_I	1.514	0.81
223_S	302_F	1.504	0.81
266_D	272_L	1.487	0.80
215_A	248_Y	1.479	0.80
274_N	282_M	1.464	0.79
194_H	203_M	1.461	0.79
39_V	303_H	1.456	0.79
133_Y	136_A	1.445	0.78
238_E	304_I	1.436	0.78
179_F	276_Q	1.435	0.78
160_K	169_Y	1.423	0.77
192_R	225_S	1.413	0.76
176_C	181_S	1.377	0.75
220_M	224_N	1.365	0.74
50_R	281_R	1.360	0.74
181_S	258_H	1.358	0.74
161_F	164_K	1.332	0.72
222_L	245_V	1.316	0.71
162_W	271_P	1.300	0.70
210_Y	217_S	1.295	0.70
280_S	283_R	1.271	0.68
157_Y	182_Q	1.261	0.68
150_D	153_G	1.253	0.67
219_K	225_S	1.246	0.67
244_D	269_N	1.243	0.67
275_A	280_S	1.242	0.67
181_S	212_W	1.240	0.66
189_A	222_L	1.227	0.66
128_T	132_D	1.222	0.65
56_K	180_I	1.221	0.65
176_C	258_H	1.190	0.63
174_D	180_I	1.187	0.63
246_I	274_N	1.185	0.63
180_I	183_C	1.184	0.63
152_L	156_Q	1.173	0.62
157_Y	161_F	1.168	0.62
158_A	183_C	1.168	0.62
246_I	285_W	1.168	0.62
277_T	297_I	1.166	0.62
219_K	223_S	1.164	0.61
160_K	164_K	1.161	0.61
125_H	129_S	1.159	0.61
217_S	274_N	1.147	0.60
246_I	303_H	1.144	0.60
231_A	238_E	1.139	0.60
116_E	123_G	1.136	0.59
215_A	259_T	1.134	0.59
185_H	293_Y	1.133	0.59
240_L	271_P	1.126	0.59
174_D	270_M	1.113	0.58
183_C	275_A	1.111	0.58
250_F	297_I	1.103	0.57
150_D	156_Q	1.097	0.57
108_D	111_L	1.094	0.57
166_N	240_L	1.084	0.56
192_R	195_P	1.079	0.55
65_H	77_S	1.077	0.55
190_P	275_A	1.059	0.54
181_S	243_G	1.056	0.54
162_W	292_A	1.055	0.54
270_M	286_S	1.046	0.53
200_G	273_V	1.039	0.53
94_Y	104_A	1.037	0.52
176_C	212_W	1.031	0.52
212_W	258_H	1.022	0.51
158_A	179_F	1.021	0.51
178_N	181_S	1.013	0.51
195_P	202_W	1.013	0.51
155_V	263_V	1.009	0.50
208_W	281_R	1.009	0.50
77_S	103_M	1.003	0.50
208_W	211_S	1.001	0.50
76_L	134_S	0.998	0.50
215_A	297_I	0.990	0.49
264_A	272_L	0.986	0.49
222_L	271_P	0.979	0.48
126_E	130_I	0.978	0.48
260_T	273_V	0.972	0.48
272_L	275_A	0.964	0.47
181_S	187_G	0.964	0.47
115_Q	120_K	0.961	0.47
263_V	274_N	0.961	0.47
250_F	257_N	0.954	0.47
220_M	256_F	0.950	0.46
151_R	154_A	0.949	0.46
214_V	217_S	0.948	0.46
99_I	115_Q	0.941	0.46
180_I	245_V	0.940	0.46
67_R	213_T	0.933	0.45
66_V	103_M	0.930	0.45
69_E	137_E	0.920	0.44
175_N	278_Y	0.918	0.44
103_M	106_L	0.917	0.44
151_R	274_N	0.917	0.44
166_N	169_Y	0.911	0.43
222_L	244_D	0.909	0.43
158_A	263_V	0.907	0.43
48_E	99_I	0.903	0.43
192_R	221_Y	0.902	0.43
249_D	283_R	0.900	0.43
272_L	287_Y	0.899	0.43
215_A	249_D	0.896	0.42
273_V	287_Y	0.896	0.42
158_A	180_I	0.895	0.42
262_V	271_P	0.891	0.42
67_R	141_E	0.890	0.42
49_K	169_Y	0.885	0.42
263_V	269_N	0.879	0.41
151_R	285_W	0.876	0.41
162_W	283_R	0.873	0.41
176_C	243_G	0.873	0.41
202_W	262_V	0.871	0.41
272_L	284_Y	0.871	0.41
159_E	217_S	0.867	0.40
223_S	246_I	0.867	0.40
154_A	189_A	0.866	0.40
197_R	277_T	0.864	0.40
52_V	88_E	0.859	0.40
50_R	274_N	0.856	0.40
243_G	258_H	0.856	0.40
84_Y	98_H	0.854	0.40
247_C	297_I	0.846	0.39
47_L	80_I	0.845	0.39
177_T	183_C	0.839	0.38
110_I	119_K	0.832	0.38
252_G	285_W	0.830	0.38
249_D	253_D	0.823	0.37
36_D	39_V	0.822	0.37
158_A	258_H	0.821	0.37
218_M	245_V	0.819	0.37
284_Y	287_Y	0.819	0.37
159_E	263_V	0.818	0.37
89_Q	262_V	0.818	0.37
169_Y	215_A	0.817	0.37
203_M	212_W	0.812	0.37
149_Y	183_C	0.812	0.37
155_V	242_P	0.808	0.36
148_Q	303_H	0.807	0.36
116_E	121_P	0.807	0.36
115_Q	122_A	0.807	0.36
109_H	138_E	0.806	0.36
116_E	119_K	0.806	0.36
178_N	258_H	0.805	0.36
149_Y	154_A	0.797	0.36
57_A	84_Y	0.794	0.35
179_F	258_H	0.787	0.35
211_S	214_V	0.783	0.35
283_R	287_Y	0.782	0.35
162_W	280_S	0.779	0.35
32_S	35_G	0.779	0.35
30_Q	282_M	0.775	0.34
176_C	187_G	0.775	0.34
49_K	124_F	0.774	0.34
49_K	63_I	0.770	0.34
162_W	240_L	0.767	0.34
162_W	253_D	0.762	0.33
162_W	250_F	0.759	0.33
256_F	260_T	0.759	0.33
189_A	226_K	0.758	0.33
42_R	50_R	0.756	0.33
187_G	258_H	0.752	0.33
134_S	137_E	0.751	0.33
174_D	247_C	0.751	0.33
199_S	286_S	0.750	0.33
242_P	265_K	0.748	0.33
184_L	187_G	0.747	0.32
200_G	222_L	0.746	0.32
108_D	170_K	0.745	0.32
207_S	215_A	0.742	0.32
202_W	209_S	0.741	0.32
87_K	159_E	0.740	0.32
241_M	264_A	0.739	0.32
177_T	245_V	0.739	0.32
274_N	281_R	0.738	0.32
254_G	262_V	0.737	0.32
155_V	166_N	0.736	0.32
256_F	302_F	0.735	0.32
57_A	303_H	0.733	0.32
165_R	179_F	0.732	0.32
217_S	222_L	0.732	0.32
273_V	285_W	0.732	0.32
185_H	203_M	0.729	0.31
76_L	101_E	0.729	0.31
87_K	193_G	0.727	0.31
36_D	117_I	0.726	0.31
154_A	301_F	0.724	0.31
86_C	174_D	0.724	0.31
162_W	249_D	0.722	0.31
142_A	184_L	0.720	0.31
218_M	256_F	0.719	0.31
162_W	177_T	0.717	0.31
136_A	140_R	0.716	0.31
43_K	195_P	0.714	0.30
274_N	285_W	0.712	0.30
105_F	110_I	0.707	0.30
186_A	262_V	0.702	0.30
208_W	214_V	0.701	0.30
61_A	171_N	0.701	0.30
169_Y	279_D	0.700	0.30
265_K	279_D	0.700	0.30
209_S	261_I	0.699	0.30
76_L	115_Q	0.699	0.30
159_E	277_T	0.698	0.29
102_R	183_C	0.696	0.29
185_H	207_S	0.696	0.29
29_R	35_G	0.695	0.29
60_K	137_E	0.692	0.29
34_V	38_K	0.690	0.29
128_T	131_I	0.685	0.29
271_P	299_Y	0.683	0.29
115_Q	119_K	0.682	0.29
264_A	303_H	0.681	0.28
122_A	128_T	0.681	0.28
40_M	48_E	0.678	0.28
121_P	169_Y	0.678	0.28
63_I	199_S	0.675	0.28
211_S	229_L	0.674	0.28
231_A	242_P	0.673	0.28
104_A	282_M	0.669	0.28
202_W	299_Y	0.666	0.28
246_I	273_V	0.664	0.27
31_E	36_D	0.664	0.27
163_N	294_T	0.662	0.27
208_W	217_S	0.661	0.27
179_F	221_Y	0.660	0.27
141_E	144_G	0.659	0.27
44_K	77_S	0.657	0.27
122_A	131_I	0.657	0.27
275_A	287_Y	0.656	0.27
272_L	285_W	0.653	0.27
92_S	268_G	0.653	0.27
162_W	210_Y	0.652	0.27
78_Y	172_F	0.652	0.27
151_R	246_I	0.652	0.27
117_I	123_G	0.648	0.27
80_I	255_R	0.645	0.26
240_L	252_G	0.645	0.26
125_H	130_I	0.645	0.26
219_K	297_I	0.641	0.26
101_E	110_I	0.641	0.26
249_D	256_F	0.641	0.26
156_Q	279_D	0.640	0.26
130_I	136_A	0.639	0.26
222_L	246_I	0.638	0.26
157_Y	181_S	0.633	0.26
71_D	76_L	0.631	0.26
76_L	106_L	0.629	0.26
69_E	141_E	0.629	0.26
185_H	278_Y	0.628	0.25
43_K	46_L	0.627	0.25
91_D	184_L	0.627	0.25
50_R	266_D	0.625	0.25
126_E	136_A	0.623	0.25
275_A	283_R	0.622	0.25
195_P	225_S	0.622	0.25
92_S	207_S	0.621	0.25
109_H	139_E	0.620	0.25
260_T	275_A	0.618	0.25
115_Q	165_R	0.618	0.25
125_H	128_T	0.618	0.25
157_Y	243_G	0.617	0.25
248_Y	272_L	0.616	0.25
111_L	114_D	0.615	0.25
63_I	170_K	0.615	0.25
161_F	174_D	0.615	0.25
291_T	297_I	0.613	0.25
74_T	102_R	0.612	0.25
95_I	269_N	0.612	0.25
260_T	272_L	0.612	0.25
175_N	229_L	0.611	0.25
119_K	168_A	0.609	0.24
34_V	148_Q	0.605	0.24
190_P	213_T	0.605	0.24
109_H	146_A	0.602	0.24
52_V	160_K	0.600	0.24
217_S	273_V	0.600	0.24
71_D	129_S	0.599	0.24
169_Y	182_Q	0.598	0.24
96_E	103_M	0.597	0.24
190_P	287_Y	0.597	0.24
73_T	268_G	0.596	0.24
144_G	227_A	0.595	0.24
66_V	140_R	0.594	0.24
89_Q	131_I	0.594	0.24
46_L	195_P	0.594	0.24
180_I	210_Y	0.588	0.23
168_A	186_A	0.586	0.23
170_K	179_F	0.585	0.23
97_E	104_A	0.584	0.23
262_V	266_D	0.578	0.23
222_L	231_A	0.576	0.23
260_T	285_W	0.574	0.23
163_N	219_K	0.574	0.23
62_V	138_E	0.573	0.23
262_V	265_K	0.571	0.22
285_W	294_T	0.571	0.22
202_W	277_T	0.570	0.22
262_V	273_V	0.567	0.22
126_E	133_Y	0.565	0.22
49_K	296_S	0.564	0.22
99_I	103_M	0.562	0.22
133_Y	137_E	0.561	0.22
172_F	256_F	0.561	0.22
154_A	190_P	0.560	0.22
197_R	293_Y	0.560	0.22
173_S	179_F	0.560	0.22
179_F	187_G	0.559	0.22
147_F	303_H	0.558	0.22
56_K	209_S	0.557	0.22
153_G	264_A	0.556	0.22
43_K	193_G	0.555	0.22
177_T	271_P	0.555	0.22
226_K	239_E	0.555	0.22
50_R	222_L	0.552	0.22
203_M	293_Y	0.552	0.22
69_E	142_A	0.551	0.21
199_S	224_N	0.549	0.21
143_F	236_S	0.548	0.21
32_S	242_P	0.545	0.21
103_M	115_Q	0.543	0.21
218_M	291_T	0.541	0.21
48_E	111_L	0.538	0.21
119_K	123_G	0.538	0.21
138_E	184_L	0.537	0.21
60_K	107_Y	0.536	0.21
191_M	266_D	0.534	0.21
87_K	211_S	0.534	0.21
225_S	229_L	0.531	0.21
38_K	169_Y	0.529	0.20
292_A	299_Y	0.528	0.20
144_G	148_Q	0.527	0.20
143_F	148_Q	0.526	0.20
293_Y	297_I	0.526	0.20
180_I	202_W	0.525	0.20
69_E	108_D	0.522	0.20
86_C	99_I	0.522	0.20
69_E	74_T	0.521	0.20
109_H	276_Q	0.521	0.20
172_F	285_W	0.520	0.20
280_S	287_Y	0.519	0.20
53_D	107_Y	0.518	0.20
200_G	299_Y	0.518	0.20
89_Q	132_D	0.516	0.20
45_K	169_Y	0.514	0.20
56_K	106_L	0.513	0.20
100_E	110_I	0.512	0.20
154_A	274_N	0.511	0.20
51_K	142_A	0.511	0.20
161_F	226_K	0.509	0.20
105_F	108_D	0.507	0.19
200_G	287_Y	0.507	0.19
172_F	292_A	0.507	0.19
188_G	276_Q	0.506	0.19
280_S	284_Y	0.504	0.19
84_Y	147_F	0.504	0.19
44_K	211_S	0.504	0.19
278_Y	282_M	0.503	0.19
162_W	287_Y	0.500	0.19
272_L	280_S	0.500	0.19
89_Q	93_L	0.500	0.19
100_E	156_Q	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cgkA	3	0.7814	97.1	0.903	Contact Map
2k1gA	1	0.3955	97	0.906	Contact Map
4hz9A	1	0.3794	96.9	0.907	Contact Map
2k3aA	1	0.4759	96.8	0.908	Contact Map
4eyzA	1	0.6624	96	0.915	Contact Map
4ct3A	4	0.5113	95.9	0.915	Contact Map
4lj1A	1	0.3698	95.7	0.917	Contact Map
3vpiA	1	0.4341	95.1	0.92	Contact Map
4q4gX	1	0.4405	94.8	0.921	Contact Map
2if6A	1	0.2219	94.7	0.922	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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