GREMLIN Database
YHZB - Uncharacterized protein YhzB
UniProt: O31588 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (197)
Sequences: 1020 (716)
Seq/√Len: 51.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_G166_N8.7331.00
131_S142_S4.8741.00
125_H145_N4.3901.00
111_K188_S4.1691.00
19_A186_L3.6521.00
156_N159_P3.3961.00
146_G157_H3.0401.00
65_Q83_E3.0091.00
118_I160_V2.9171.00
108_F188_S2.8551.00
81_P117_M2.7791.00
128_V148_F2.6021.00
191_K195_Q2.5011.00
62_K66_K2.4141.00
129_R144_E2.3121.00
79_T87_V2.2471.00
89_I110_L2.1821.00
7_S11_E2.1231.00
17_H182_A2.0571.00
73_P138_I2.0501.00
44_E48_F1.9971.00
105_I118_I1.9941.00
24_E166_N1.9861.00
101_A167_M1.9801.00
141_F172_F1.8750.99
180_S184_N1.8560.99
125_H144_E1.7530.99
132_L139_L1.7430.99
120_D123_K1.7400.99
187_S191_K1.7300.99
37_G41_L1.7140.99
126_E144_E1.6990.99
6_D129_R1.6900.99
143_D146_G1.6160.98
133_G140_L1.6020.98
108_F185_L1.5770.98
120_D164_T1.5590.97
23_Y193_F1.5090.97
183_V187_S1.5000.97
45_S111_K1.4880.97
127_P144_E1.4870.97
33_Q37_G1.4740.96
181_S184_N1.4570.96
69_K76_E1.4550.96
108_F189_L1.4540.96
81_P149_G1.4450.96
178_E181_S1.4400.96
138_I152_K1.4240.96
112_Y185_L1.4070.95
75_F87_V1.3970.95
4_K191_K1.3780.95
164_T167_M1.3250.94
119_Y149_G1.3240.94
124_L148_F1.3210.93
54_G57_D1.3070.93
117_M149_G1.2710.92
119_Y172_F1.2680.92
105_I149_G1.2570.92
179_K183_V1.2460.91
66_K70_Q1.2340.91
40_R43_Q1.2300.91
32_P100_S1.2250.91
12_R132_L1.2100.90
7_S10_T1.2050.90
15_G176_S1.1970.90
17_H179_K1.1950.89
112_Y188_S1.1840.89
108_F192_M1.1370.87
105_I172_F1.1140.86
188_S192_M1.1110.86
22_I121_A1.1030.85
5_L10_T1.1010.85
34_M37_G1.0790.84
79_T154_S1.0680.83
7_S33_Q1.0670.83
34_M195_Q1.0640.83
101_A193_F1.0510.82
163_E191_K1.0470.82
55_I90_S1.0340.81
119_Y151_F1.0290.81
73_P77_G1.0270.81
130_I141_F1.0220.81
124_L158_Y1.0140.80
173_F182_A1.0090.80
123_K161_S1.0020.79
74_S77_G1.0020.79
9_I16_L0.9950.79
138_I150_D0.9920.79
119_Y141_F0.9730.77
47_F94_F0.9710.77
88_P154_S0.9680.77
64_W172_F0.9680.77
189_L193_F0.9600.76
118_I158_Y0.9540.76
15_G70_Q0.9330.74
118_I130_I0.9220.73
36_K97_S0.9210.73
124_L127_P0.9170.73
192_M196_I0.9170.73
21_V190_T0.9100.72
72_N75_F0.9080.72
64_W115_P0.9050.72
65_Q76_E0.8980.71
73_P152_K0.8830.70
51_A54_G0.8820.70
45_S48_F0.8750.69
28_V159_P0.8730.69
43_Q95_M0.8720.69
57_D134_E0.8720.69
145_N163_E0.8650.68
188_S191_K0.8620.68
25_N166_N0.8600.68
23_Y169_Q0.8550.67
20_A168_L0.8520.67
64_W139_L0.8500.67
64_W153_N0.8420.66
42_F107_F0.8380.66
121_A124_L0.8300.65
84_D171_I0.8260.65
106_D109_A0.8240.65
58_E113_S0.8080.63
28_V101_A0.8060.63
149_G172_F0.8060.63
99_D162_N0.8040.63
74_S149_G0.8020.62
84_D88_P0.8010.62
61_V65_Q0.8010.62
105_I151_F0.8000.62
138_I153_N0.7960.62
124_L168_L0.7900.61
26_I167_M0.7790.60
74_S80_T0.7790.60
64_W151_F0.7760.60
76_E82_M0.7750.60
22_I166_N0.7740.60
119_Y154_S0.7700.59
111_K192_M0.7640.59
33_Q41_L0.7620.58
106_D117_M0.7620.58
65_Q79_T0.7590.58
75_F88_P0.7580.58
5_L18_A0.7440.57
85_M109_A0.7430.57
61_V86_L0.7380.56
150_D172_F0.7360.56
190_T194_E0.7330.56
46_L107_F0.7320.55
17_H173_F0.7290.55
81_P109_A0.7250.55
86_L110_L0.7240.55
4_K45_S0.7190.54
84_D149_G0.7180.54
45_S110_L0.7100.53
29_G163_E0.7100.53
190_T199_G0.7090.53
71_L151_F0.7080.53
66_K69_K0.7070.53
133_G139_L0.7020.52
35_L196_I0.7020.52
34_M196_I0.6900.51
80_T83_E0.6900.51
68_F151_F0.6900.51
7_S134_E0.6890.51
116_I119_Y0.6880.51
37_G70_Q0.6850.51
153_N172_F0.6830.50
28_V162_N0.6820.50
88_P106_D0.6810.50
105_I119_Y0.6770.50
138_I154_S0.6760.50
149_G153_N0.6740.49
171_I185_L0.6730.49
118_I133_G0.6730.49
72_N77_G0.6720.49
6_D131_S0.6700.49
151_F154_S0.6700.49
130_I135_K0.6670.49
101_A164_T0.6640.48
16_L155_V0.6620.48
193_F199_G0.6610.48
138_I172_F0.6610.48
64_W73_P0.6580.48
128_V188_S0.6580.48
11_E132_L0.6570.48
135_K149_G0.6560.48
81_P110_L0.6530.47
126_E143_D0.6530.47
151_F172_F0.6520.47
82_M138_I0.6490.47
79_T84_D0.6470.47
82_M152_K0.6460.47
3_I168_L0.6410.46
55_I86_L0.6400.46
155_V170_I0.6400.46
41_L45_S0.6390.46
118_I121_A0.6340.45
44_E162_N0.6300.45
76_E150_D0.6280.45
37_G48_F0.6280.45
12_R70_Q0.6260.45
148_F154_S0.6250.44
81_P84_D0.6230.44
37_G180_S0.6230.44
50_Y86_L0.6200.44
84_D153_N0.6200.44
44_E47_F0.6200.44
193_F198_G0.6200.44
41_L44_E0.6190.44
45_S49_D0.6170.44
47_F92_E0.6150.43
76_E152_K0.6110.43
11_E44_E0.6110.43
177_I181_S0.6100.43
25_N165_K0.6100.43
122_G165_K0.6090.43
52_D134_E0.6090.43
59_S187_S0.6080.43
145_N180_S0.6020.42
28_V100_S0.6010.42
151_F158_Y0.6010.42
105_I155_V0.6000.42
43_Q97_S0.6000.42
29_G165_K0.5990.42
149_G158_Y0.5980.42
50_Y58_E0.5980.42
64_W96_E0.5970.42
184_N194_E0.5970.42
90_S94_F0.5930.41
72_N87_V0.5930.41
130_I174_P0.5920.41
40_R194_E0.5850.40
6_D60_F0.5810.40
74_S151_F0.5790.40
100_S197_H0.5780.40
169_Q189_L0.5780.40
87_V151_F0.5770.40
36_K40_R0.5770.40
119_Y155_V0.5730.39
115_P172_F0.5700.39
26_I123_K0.5690.39
9_I139_L0.5680.39
70_Q129_R0.5680.39
84_D117_M0.5650.38
147_I157_H0.5640.38
108_F193_F0.5640.38
134_E191_K0.5630.38
27_E165_K0.5610.38
143_D157_H0.5610.38
19_A182_A0.5590.38
76_E91_K0.5590.38
125_H191_K0.5570.38
153_N174_P0.5550.37
119_Y152_K0.5540.37
33_Q36_K0.5540.37
141_F170_I0.5520.37
86_L90_S0.5480.37
78_E104_T0.5480.37
69_K157_H0.5470.37
61_V82_M0.5450.36
114_L171_I0.5450.36
13_A71_L0.5440.36
84_D87_V0.5430.36
18_A141_F0.5420.36
69_K74_S0.5420.36
68_F75_F0.5410.36
141_F151_F0.5410.36
18_A166_N0.5390.36
80_T113_S0.5390.36
173_F179_K0.5380.36
61_V95_M0.5380.36
119_Y150_D0.5360.36
35_L107_F0.5360.36
105_I169_Q0.5340.35
119_Y148_F0.5310.35
103_D164_T0.5300.35
44_E193_F0.5280.35
105_I153_N0.5270.35
81_P88_P0.5240.34
26_I195_Q0.5230.34
30_S100_S0.5230.34
80_T151_F0.5220.34
105_I141_F0.5220.34
27_E100_S0.5200.34
68_F197_H0.5200.34
32_P199_G0.5200.34
128_V131_S0.5170.34
33_Q184_N0.5170.34
126_E157_H0.5170.34
133_G138_I0.5170.34
45_S190_T0.5100.33
31_S100_S0.5070.33
94_F180_S0.5050.33
89_I119_Y0.5020.32
187_S190_T0.5010.32
37_G44_E0.5000.32
69_K77_G0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b7yB 2 0.9807 99.9 0.675 Contact Map
2rhqB 2 0.9952 99.9 0.683 Contact Map
3pcoB 2 0.9807 99.9 0.688 Contact Map
4p72A 2 0.9952 99.9 0.691 Contact Map
3l4gB 2 0.8116 99.2 0.805 Contact Map
2cxiA 3 0.6618 99.2 0.805 Contact Map
3enpA 2 0.6329 52 0.946 Contact Map
3a2kA 1 0.8213 28.9 0.953 Contact Map
4a5oA 2 0.8213 19.7 0.957 Contact Map
3mkbB 1 0.4541 18.3 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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