GREMLIN Database
YFHQ - Probable A/G-specific adenine glycosylase YfhQ
UniProt: O31584 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (335)
Sequences: 2953 (2214)
Seq/√Len: 121.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_T73_A4.7041.00
116_D119_D4.0821.00
25_E185_K3.9091.00
67_Q81_K3.5811.00
257_H270_E2.9551.00
30_V35_E2.7891.00
99_Q103_K2.7621.00
159_S218_S2.7061.00
185_K188_E2.6351.00
67_Q85_A2.6051.00
224_T227_E2.5891.00
224_T228_L2.5821.00
44_V65_V2.4941.00
115_P141_K2.4761.00
38_D41_K2.4341.00
214_Q220_F2.3361.00
80_E347_A2.2841.00
84_K87_E2.2651.00
248_T323_F2.2591.00
62_L66_E2.2531.00
311_V316_V2.2031.00
68_F85_A2.1911.00
100_S124_K2.1891.00
117_E143_I2.1531.00
207_S210_L2.1191.00
120_F135_L2.0321.00
104_E124_K2.0181.00
117_E121_G1.9991.00
19_D216_H1.9791.00
157_I216_H1.9381.00
104_E108_E1.9331.00
28_Q195_E1.9241.00
218_S222_E1.9221.00
16_F213_V1.9191.00
41_K65_V1.9081.00
72_E106_K1.9051.00
255_Y335_L1.9021.00
167_P171_T1.8991.00
49_L54_V1.8821.00
38_D42_V1.8811.00
136_S190_N1.8681.00
239_I318_N1.8591.00
159_S222_E1.8391.00
238_G315_L1.8301.00
248_T325_K1.8121.00
21_I188_E1.7671.00
109_Y122_G1.7641.00
237_P316_V1.7601.00
159_S228_L1.7561.00
72_E76_D1.7481.00
159_S224_T1.7301.00
132_G144_P1.7241.00
44_V98_L1.7191.00
162_D172_I1.7191.00
25_E188_E1.7181.00
36_D42_V1.7141.00
256_I346_F1.7011.00
158_L176_A1.6611.00
157_I213_V1.6561.00
79_E103_K1.6451.00
339_T342_E1.6441.00
112_I115_P1.6321.00
79_E83_L1.5971.00
160_I176_A1.5921.00
162_D169_T1.5901.00
121_G128_P1.5841.00
240_K315_L1.5731.00
93_S97_N1.5721.00
59_P62_L1.5701.00
128_P174_E1.5691.00
225_E228_L1.5561.00
61_F65_V1.5481.00
135_L141_K1.5371.00
135_L143_I1.5331.00
342_E345_Q1.5221.00
79_E99_Q1.5201.00
101_A123_L1.5101.00
350_V353_Q1.5091.00
78_D81_K1.5071.00
144_P178_R1.5041.00
220_F225_E1.5031.00
36_D41_K1.4991.00
24_F191_Q1.4981.00
202_T207_S1.4811.00
109_Y119_D1.4781.00
349_P352_H1.4721.00
119_D122_G1.4621.00
21_I25_E1.4571.00
104_E109_Y1.4561.00
20_L213_V1.4281.00
256_I348_F1.4241.00
161_W224_T1.4191.00
113_V120_F1.4181.00
165_A232_S1.3901.00
239_I316_V1.3861.00
20_L192_G1.3791.00
17_R182_S1.3741.00
195_E199_L1.3671.00
135_L139_Y1.3621.00
117_E141_K1.3591.00
241_T318_N1.3561.00
97_N100_S1.3561.00
309_E318_N1.3521.00
338_V346_F1.3401.00
244_A319_I1.3351.00
309_E316_V1.3261.00
100_S103_K1.3131.00
154_M193_L1.3051.00
74_L82_V1.3031.00
82_V99_Q1.2991.00
115_P139_Y1.2951.00
260_P263_G1.2951.00
95_V98_L1.2771.00
144_P181_I1.2681.00
101_A104_E1.2590.99
71_V113_V1.2590.99
307_V320_S1.2580.99
161_W228_L1.2580.99
161_W230_V1.2520.99
321_V355_I1.2430.99
181_I193_L1.2420.99
253_Q339_T1.2410.99
189_F193_L1.2360.99
155_S173_F1.2330.99
158_L180_F1.2320.99
219_A225_E1.2180.99
105_V113_V1.2110.99
41_K61_F1.2100.99
176_A179_A1.2060.99
20_L193_L1.2060.99
146_V173_F1.2030.99
319_I351_S1.2020.99
53_R56_T1.2020.99
243_A322_F1.2010.99
48_M57_V1.1900.99
55_E58_I1.1880.99
101_A126_V1.1830.99
103_K107_Q1.1650.99
208_C217_C1.1610.99
218_S221_E1.1520.99
303_D323_F1.1520.99
126_V134_V1.1500.99
21_I185_K1.1460.99
106_K109_Y1.1440.99
260_P266_A1.1430.99
140_N187_S1.1430.99
117_E131_K1.1380.99
246_V271_F1.1370.99
63_R85_A1.1370.99
58_I62_L1.1300.99
143_I178_R1.1300.99
270_E273_N1.1250.99
258_K267_N1.1240.99
116_D141_K1.1190.99
171_T175_D1.1170.99
43_W47_V1.1040.99
42_V138_A1.1000.99
76_D106_K1.0970.99
188_E192_G1.0900.99
142_P183_K1.0790.98
145_A174_E1.0680.98
246_V355_I1.0580.98
120_F143_I1.0570.98
80_E258_K1.0530.98
120_F134_V1.0520.98
306_G358_M1.0510.98
137_I187_S1.0480.98
208_C211_C1.0380.98
177_I189_F1.0330.98
167_P170_R1.0310.98
196_L212_P1.0300.98
257_H334_K1.0290.98
211_C217_C1.0230.98
269_W337_K1.0150.98
20_L196_L1.0140.98
242_M273_N1.0100.98
172_I176_A1.0070.98
21_I192_G1.0050.98
182_S186_P1.0020.97
37_Q140_N1.0000.97
132_G145_A0.9930.97
201_C211_C0.9930.97
24_F34_R0.9890.97
117_E135_L0.9860.97
154_M177_I0.9860.97
77_A82_V0.9850.97
154_M180_F0.9800.97
79_E261_S0.9790.97
336_K346_F0.9770.97
264_L315_L0.9740.97
151_M164_I0.9630.97
201_C208_C0.9580.97
17_R183_K0.9550.97
68_F77_A0.9510.97
252_G340_K0.9480.96
338_V343_L0.9410.96
256_I338_V0.9380.96
105_V120_F0.9380.96
241_T320_S0.9300.96
120_F126_V0.9210.96
186_P190_N0.9190.96
150_V195_E0.9180.96
165_A233_K0.9180.96
18_D22_S0.9140.96
201_C217_C0.9130.96
24_F28_Q0.9040.95
151_M170_R0.9030.95
248_T252_G0.9010.95
258_K334_K0.8970.95
245_I274_L0.8950.95
182_S189_F0.8940.95
142_P178_R0.8930.95
166_K169_T0.8920.95
187_S192_G0.8890.95
265_L312_F0.8890.95
263_G266_A0.8860.95
39_P139_Y0.8820.95
247_L255_Y0.8810.95
68_F81_K0.8720.94
33_W57_V0.8700.94
235_K313_T0.8680.94
118_K122_G0.8520.94
108_E122_G0.8520.94
195_E198_A0.8510.94
242_M319_I0.8480.94
264_L312_F0.8470.93
48_M56_T0.8460.93
129_Y146_V0.8420.93
31_L54_V0.8410.93
122_G135_L0.8380.93
269_W336_K0.8360.93
82_V95_V0.8310.93
307_V318_N0.8310.93
24_F192_G0.8290.93
129_Y145_A0.8190.92
54_V57_V0.8160.92
196_L200_I0.8120.92
15_Q19_D0.8110.92
73_A76_D0.8080.92
242_M317_W0.8070.92
79_E93_S0.8040.92
248_T254_V0.8040.92
164_I230_V0.8020.91
19_D215_Q0.8010.91
47_V134_V0.7990.91
37_Q42_V0.7980.91
174_E178_R0.7970.91
332_T335_L0.7900.91
350_V354_K0.7890.91
259_R270_E0.7880.91
29_R198_A0.7860.91
43_W71_V0.7850.91
271_F356_W0.7840.91
21_I24_F0.7830.90
37_Q137_I0.7810.90
306_G321_V0.7810.90
84_K346_F0.7790.90
170_R174_E0.7790.90
172_I175_D0.7780.90
145_A150_V0.7760.90
132_G174_E0.7730.90
44_V95_V0.7730.90
253_Q342_E0.7730.90
312_F315_L0.7720.90
121_G131_K0.7710.90
146_V174_E0.7690.90
34_R129_Y0.7680.90
33_W49_L0.7680.90
21_I137_I0.7650.89
71_V105_V0.7650.89
153_V196_L0.7600.89
78_D99_Q0.7600.89
142_P186_P0.7590.89
120_F141_K0.7550.89
16_F157_I0.7540.89
162_D230_V0.7510.89
255_Y337_K0.7430.88
243_A276_T0.7410.88
63_R67_Q0.7400.88
74_L98_L0.7360.88
74_L95_V0.7330.87
244_A352_H0.7320.87
312_F317_W0.7310.87
200_I210_L0.7280.87
276_T279_G0.7250.87
200_I207_S0.7240.87
304_L322_F0.7210.86
154_M173_F0.7200.86
159_S219_A0.7190.86
336_K342_E0.7160.86
151_M174_E0.7160.86
209_L223_G0.7150.86
137_I194_M0.7150.86
155_S230_V0.7150.86
237_P311_V0.7130.86
24_F188_E0.7080.85
145_A177_I0.7070.85
213_V216_H0.7070.85
128_P170_R0.7050.85
145_A193_L0.7030.85
39_P42_V0.7020.85
244_A270_E0.7020.85
163_D232_S0.7000.85
269_W346_F0.6960.85
71_V102_V0.6950.84
120_F139_Y0.6920.84
100_S104_E0.6890.84
118_K141_K0.6890.84
175_D179_A0.6880.84
181_I186_P0.6830.83
68_F99_Q0.6810.83
181_I190_N0.6800.83
151_M173_F0.6790.83
43_W134_V0.6760.83
112_I139_Y0.6720.82
36_D61_F0.6720.82
77_A99_Q0.6720.82
71_V120_F0.6720.82
304_L320_S0.6690.82
308_V319_I0.6680.82
78_D95_V0.6670.82
256_I343_L0.6670.82
180_F189_F0.6660.82
142_P182_S0.6650.82
45_S49_L0.6630.82
215_Q293_N0.6620.81
128_P178_R0.6610.81
250_E326_V0.6580.81
87_E353_Q0.6580.81
48_M263_G0.6540.81
163_D169_T0.6510.80
84_K347_A0.6490.80
154_M157_I0.6490.80
163_D166_K0.6480.80
353_Q357_K0.6470.80
44_V85_A0.6460.80
87_E347_A0.6450.80
155_S228_L0.6450.80
239_I309_E0.6430.80
44_V101_A0.6410.79
265_L314_H0.6400.79
352_H355_I0.6390.79
113_V126_V0.6330.79
150_V198_A0.6310.78
259_R263_G0.6310.78
312_F350_V0.6310.78
262_K266_A0.6290.78
199_L202_T0.6290.78
162_D168_K0.6280.78
22_S26_R0.6280.78
47_V126_V0.6280.78
264_L317_W0.6270.78
81_K85_A0.6270.78
305_Q323_F0.6270.78
28_Q188_E0.6260.78
137_I188_E0.6230.77
80_E346_F0.6220.77
35_E137_I0.6200.77
64_F123_L0.6200.77
56_T350_V0.6200.77
186_P192_G0.6190.77
158_L177_I0.6170.77
102_V113_V0.6160.77
19_D22_S0.6140.76
68_F82_V0.6140.76
95_V99_Q0.6130.76
187_S190_N0.6130.76
147_D150_V0.6100.76
271_F355_I0.6100.76
163_D233_K0.6090.76
63_R66_E0.6090.76
242_M312_F0.6070.76
107_Q110_G0.6040.75
270_E352_H0.6040.75
227_E230_V0.6030.75
300_D325_K0.6010.75
228_L231_K0.6010.75
33_W54_V0.5990.75
338_V344_E0.5980.75
265_L352_H0.5980.75
71_V106_K0.5970.74
159_S225_E0.5960.74
194_M269_W0.5960.74
145_A151_M0.5950.74
113_V135_L0.5940.74
354_K358_M0.5930.74
244_A265_L0.5920.74
79_E96_R0.5920.74
150_V199_L0.5900.74
93_S266_A0.5900.74
136_S144_P0.5900.74
24_F137_I0.5900.74
101_A120_F0.5890.73
206_P225_E0.5870.73
319_I352_H0.5860.73
129_Y151_M0.5840.73
317_W352_H0.5820.73
62_L65_V0.5810.72
117_E120_F0.5810.72
250_E327_K0.5800.72
145_A190_N0.5790.72
160_I173_F0.5790.72
153_V195_E0.5780.72
270_E347_A0.5760.72
254_V356_W0.5760.72
173_F177_I0.5740.71
231_K234_K0.5740.71
274_L280_I0.5720.71
161_W227_E0.5710.71
177_I180_F0.5700.71
45_S54_V0.5700.71
295_Y299_A0.5690.71
109_Y112_I0.5690.71
34_R195_E0.5680.71
28_Q129_Y0.5680.71
18_D184_E0.5680.71
312_F352_H0.5660.70
148_G314_H0.5660.70
243_A280_I0.5650.70
128_P173_F0.5640.70
137_I191_Q0.5620.70
294_E297_I0.5620.70
250_E325_K0.5610.70
187_S193_L0.5600.70
291_L299_A0.5600.70
148_G203_P0.5590.70
206_P217_C0.5580.69
154_M176_A0.5580.69
76_D107_Q0.5570.69
273_N352_H0.5570.69
242_M315_L0.5560.69
145_A194_M0.5550.69
244_A355_I0.5540.69
164_I231_K0.5530.69
19_D157_I0.5530.69
117_E174_E0.5530.69
17_R186_P0.5530.69
182_S185_K0.5530.69
122_G141_K0.5510.68
79_E100_S0.5510.68
145_A317_W0.5500.68
129_Y195_E0.5500.68
291_L294_E0.5480.68
297_I301_I0.5480.68
302_S305_Q0.5480.68
276_T280_I0.5480.68
108_E119_D0.5470.68
47_V101_A0.5450.68
277_Q281_K0.5440.67
189_F195_E0.5430.67
317_W351_S0.5380.67
59_P63_R0.5380.67
129_Y174_E0.5380.67
338_V342_E0.5370.66
331_D341_E0.5360.66
40_Y45_S0.5350.66
132_G182_S0.5350.66
42_V47_V0.5340.66
105_V111_G0.5330.66
60_Y148_G0.5330.66
38_D112_I0.5320.66
265_L351_S0.5320.66
83_L99_Q0.5310.66
300_D327_K0.5290.65
289_A293_N0.5270.65
186_P189_F0.5260.65
104_E107_Q0.5250.65
259_R314_H0.5240.65
243_A320_S0.5240.65
72_E107_Q0.5240.65
26_R108_E0.5230.64
301_I305_Q0.5220.64
165_A169_T0.5220.64
206_P211_C0.5210.64
311_V314_H0.5210.64
142_P181_I0.5170.64
266_A315_L0.5160.63
93_S258_K0.5150.63
265_L317_W0.5150.63
181_I189_F0.5140.63
55_E195_E0.5140.63
104_E123_L0.5140.63
79_E258_K0.5130.63
34_R265_L0.5130.63
238_G266_A0.5130.63
169_T230_V0.5100.63
120_F131_K0.5100.63
118_K121_G0.5080.62
138_A141_K0.5070.62
34_R137_I0.5060.62
151_M169_T0.5060.62
336_K339_T0.5040.62
302_S324_G0.5040.62
290_F294_E0.5030.61
296_G302_S0.5030.61
132_G177_I0.5030.61
185_K192_G0.5030.61
115_P119_D0.5030.61
107_Q340_K0.5020.61
163_D317_W0.5020.61
53_R202_T0.5000.61
244_A273_N0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fspA 1 0.9539 100 0.384 Contact Map
1kg2A 1 0.6043 100 0.536 Contact Map
3n5nX 1 0.7046 100 0.54 Contact Map
1keaA 2 0.5854 100 0.578 Contact Map
4unfA 1 0.5935 100 0.602 Contact Map
1ornA 1 0.5772 100 0.612 Contact Map
4uobA 1 0.5935 100 0.615 Contact Map
2abkA 1 0.5691 100 0.63 Contact Map
1pu6A 1 0.5122 100 0.722 Contact Map
3n0uA 1 0.5285 100 0.734 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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