GREMLIN Database
YFHP - Uncharacterized protein YfhP
UniProt: O31583 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (294)
Sequences: 895 (716)
Seq/√Len: 41.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_P92_F5.2991.00
147_A164_L4.4941.00
120_I128_V4.3731.00
133_I172_Y4.2971.00
115_Y260_F3.7281.00
299_G303_T3.5061.00
76_S100_L3.4741.00
140_I168_L3.0811.00
54_N57_V2.8921.00
179_Q199_I2.8501.00
80_P96_W2.8151.00
196_S213_T2.7721.00
166_I170_G2.7701.00
7_V37_T2.7021.00
83_L99_T2.6451.00
51_K58_Y2.5351.00
36_A99_T2.5291.00
290_Y294_A2.4551.00
35_I87_Y2.4501.00
60_R256_A2.4381.00
174_V178_M2.4141.00
2_D5_T2.3961.00
3_T42_Q2.3761.00
134_N203_M2.3641.00
169_V173_L2.3211.00
174_V205_F2.2621.00
112_F130_L2.2531.00
72_V107_V2.1821.00
137_D171_Y2.1460.99
132_L176_L2.1340.99
1_M5_T2.1290.99
66_T103_V2.1270.99
6_H40_G2.0460.99
43_A46_I2.0340.99
73_L100_L2.0130.99
173_L177_I1.9980.99
114_A284_Y1.9900.99
144_H165_Y1.9070.99
111_I128_V1.8930.99
113_N141_F1.8280.98
111_I130_L1.7980.98
2_D6_H1.7980.98
118_Q121_R1.7400.98
150_I160_T1.7340.98
32_A36_A1.7170.97
133_I261_S1.6970.97
82_I300_H1.6900.97
49_V99_T1.6720.97
7_V42_Q1.6140.96
8_V12_A1.6070.96
108_F112_F1.6020.96
5_T64_G1.5890.96
179_Q183_K1.5850.96
16_I165_Y1.5770.96
34_M38_L1.5630.95
1_M6_H1.5500.95
6_H105_L1.5270.95
6_H140_I1.5110.94
140_I169_V1.5060.94
220_V284_Y1.5050.94
183_K199_I1.4960.94
107_V119_A1.4800.94
276_E295_I1.4780.94
136_F141_F1.4460.93
284_Y290_Y1.4370.93
100_L104_V1.4300.93
43_A79_I1.4160.92
150_I155_G1.4130.92
254_I296_V1.4090.92
125_K128_V1.4070.92
79_I99_T1.3890.91
13_L37_T1.3830.91
175_R205_F1.3770.91
295_I298_I1.3700.91
217_A236_R1.3350.90
60_R259_S1.3220.89
4_G141_F1.3170.89
158_G162_L1.3060.89
46_I143_S1.3020.89
293_V296_V1.2860.88
11_I148_I1.2700.87
14_G18_T1.2600.87
243_D246_H1.2400.86
241_E245_M1.2360.86
91_D191_H1.2350.86
115_Y135_T1.2320.86
92_F96_W1.1990.84
68_S121_R1.1960.84
113_N127_W1.1880.84
162_L166_I1.1820.83
290_Y296_V1.1800.83
186_L223_S1.1790.83
113_N259_S1.1730.83
83_L241_E1.1710.83
131_G261_S1.1710.83
5_T278_R1.1610.82
14_G96_W1.1510.82
124_S128_V1.1480.81
181_R185_K1.1450.81
111_I117_T1.1430.81
300_H305_R1.1370.81
120_I146_A1.1340.81
150_I178_M1.1260.80
81_A142_I1.1240.80
284_Y291_P1.1240.80
76_S80_P1.1200.80
73_L76_S1.1030.79
190_I212_V1.1020.79
261_S279_F1.1020.79
156_S164_L1.0980.78
53_K58_Y1.0950.78
114_A131_G1.0870.78
69_I73_L1.0830.77
202_T222_R1.0830.77
300_H303_T1.0810.77
170_G192_D1.0800.77
150_I153_A1.0760.77
291_P294_A1.0700.76
143_S164_L1.0690.76
216_H219_Y1.0560.76
177_I181_R1.0560.76
160_T262_P1.0540.75
74_F166_I1.0380.74
91_D167_I1.0310.74
6_H42_Q1.0300.74
59_I66_T1.0210.73
214_T219_Y1.0180.73
48_T107_V1.0140.73
296_V304_I1.0140.73
150_I246_H1.0120.72
76_S120_I1.0060.72
4_G7_V0.9910.71
146_A255_A0.9870.70
105_L109_V0.9800.70
62_H68_S0.9780.70
34_M37_T0.9760.70
77_V265_R0.9750.70
44_P106_H0.9750.70
50_L108_F0.9730.69
234_F237_V0.9730.69
144_H209_R0.9730.69
3_T48_T0.9730.69
59_I131_G0.9720.69
192_D289_H0.9720.69
272_K275_Y0.9720.69
154_G160_T0.9680.69
216_H295_I0.9610.68
75_W103_V0.9570.68
113_N117_T0.9560.68
120_I199_I0.9450.67
108_F130_L0.9380.66
51_K55_N0.9340.66
46_I205_F0.9340.66
209_R260_F0.9330.66
123_F174_V0.9310.66
25_S227_H0.9300.66
244_V302_L0.9290.66
3_T6_H0.9280.66
114_A200_S0.9270.66
117_T137_D0.9260.65
156_S159_I0.9250.65
36_A105_L0.9170.65
191_H194_I0.9140.64
56_A261_S0.9080.64
76_S123_F0.9010.63
38_L167_I0.8970.63
48_T291_P0.8950.63
131_G198_I0.8920.63
107_V264_Y0.8920.63
46_I82_I0.8850.62
249_K276_E0.8820.62
129_A262_P0.8800.61
146_A169_V0.8780.61
47_D67_H0.8740.61
134_N284_Y0.8720.61
170_G184_R0.8700.61
114_A211_A0.8630.60
302_L305_R0.8610.60
142_I275_Y0.8590.60
95_L107_V0.8580.60
244_V250_Q0.8570.59
76_S202_T0.8560.59
111_I124_S0.8540.59
278_R293_V0.8500.59
147_A160_T0.8490.59
18_T25_S0.8480.59
135_T260_F0.8470.59
39_A43_A0.8470.59
149_A301_D0.8450.58
6_H169_V0.8410.58
83_L148_I0.8410.58
127_W258_L0.8390.58
280_I284_Y0.8390.58
133_I175_R0.8370.58
76_S96_W0.8370.58
142_I154_G0.8350.57
25_S226_G0.8340.57
43_A72_V0.8330.57
287_K290_Y0.8320.57
75_W79_I0.8320.57
3_T69_I0.8320.57
111_I119_A0.8310.57
214_T217_A0.8290.57
185_K189_M0.8050.55
159_I190_I0.8040.55
8_V141_F0.8000.54
275_Y300_H0.7990.54
42_Q141_F0.7970.54
159_I162_L0.7960.54
111_I120_I0.7940.54
220_V261_S0.7940.54
66_T297_H0.7900.53
46_I66_T0.7900.53
195_E213_T0.7880.53
190_I219_Y0.7870.53
149_A153_A0.7860.53
301_D305_R0.7790.52
6_H175_R0.7780.52
15_G165_Y0.7770.52
9_M12_A0.7740.52
74_F100_L0.7710.51
45_D110_D0.7700.51
146_A250_Q0.7660.51
8_V238_P0.7660.51
196_S211_A0.7660.51
212_V252_D0.7660.51
184_R233_T0.7640.51
54_N151_W0.7620.51
148_I155_G0.7610.51
107_V118_Q0.7610.51
6_H101_L0.7590.50
178_M205_F0.7590.50
186_L212_V0.7580.50
4_G42_Q0.7550.50
77_V92_F0.7550.50
117_T136_F0.7530.50
212_V219_Y0.7530.50
186_L210_I0.7530.50
82_I187_H0.7520.50
248_A279_F0.7510.50
215_A246_H0.7500.50
45_D62_H0.7490.49
68_S281_D0.7470.49
190_I234_F0.7460.49
214_T246_H0.7390.48
54_N254_I0.7390.48
68_S137_D0.7390.48
9_M109_V0.7350.48
116_G208_W0.7320.48
129_A175_R0.7320.48
218_F254_I0.7310.48
127_W290_Y0.7270.47
15_G161_F0.7250.47
210_I221_G0.7210.47
99_T104_V0.7200.47
68_S120_I0.7200.47
130_L199_I0.7190.47
293_V298_I0.7160.46
249_K300_H0.7160.46
255_A305_R0.7150.46
183_K197_I0.7150.46
180_L184_R0.7120.46
95_L237_V0.7120.46
54_N256_A0.7120.46
102_A132_L0.7100.46
194_I197_I0.7100.46
69_I196_S0.7060.45
236_R273_D0.7050.45
109_V172_Y0.7020.45
88_P162_L0.7000.45
127_W256_A0.6940.44
6_H9_M0.6930.44
159_I166_I0.6880.44
91_D267_E0.6880.44
34_M120_I0.6860.44
129_A145_L0.6850.43
76_S99_T0.6850.43
164_L168_L0.6840.43
78_I142_I0.6830.43
135_T200_S0.6830.43
101_L163_S0.6820.43
146_A167_I0.6810.43
117_T209_R0.6790.43
261_S266_W0.6770.43
162_L249_K0.6760.43
132_L175_R0.6760.43
146_A300_H0.6680.42
298_I304_I0.6680.42
45_D63_R0.6670.42
127_W228_V0.6650.42
153_A300_H0.6650.42
17_A98_W0.6650.42
113_N294_A0.6620.41
159_I163_S0.6610.41
187_H301_D0.6600.41
202_T210_I0.6600.41
96_W100_L0.6590.41
220_V280_I0.6590.41
173_L215_A0.6590.41
5_T183_K0.6590.41
72_V100_L0.6590.41
117_T129_A0.6570.41
146_A185_K0.6540.41
63_R135_T0.6530.41
35_I230_I0.6520.40
174_V187_H0.6510.40
184_R244_V0.6510.40
298_I302_L0.6470.40
25_S29_M0.6460.40
204_K207_Q0.6450.40
124_S264_Y0.6440.40
147_A150_I0.6400.39
86_F170_G0.6380.39
11_I18_T0.6380.39
139_F167_I0.6370.39
127_W259_S0.6350.39
299_G305_R0.6340.39
134_N264_Y0.6330.39
127_W284_Y0.6330.39
34_M215_A0.6330.39
180_L189_M0.6320.39
188_E272_K0.6300.38
110_D122_P0.6280.38
276_E297_H0.6280.38
42_Q113_N0.6280.38
76_S151_W0.6280.38
228_V231_L0.6270.38
180_L192_D0.6270.38
170_G174_V0.6250.38
56_A259_S0.6220.38
204_K224_M0.6210.38
101_L104_V0.6200.38
33_V167_I0.6180.37
32_A35_I0.6170.37
63_R137_D0.6160.37
112_F128_V0.6150.37
29_M65_F0.6140.37
70_P201_P0.6140.37
131_G200_S0.6120.37
199_I258_L0.6110.37
207_Q227_H0.6110.37
139_F143_S0.6100.37
115_Y209_R0.6090.37
1_M10_G0.6080.37
248_A282_L0.6080.37
12_A15_G0.6060.36
287_K293_V0.6020.36
112_F132_L0.6020.36
187_H229_V0.6000.36
65_F121_R0.6000.36
34_M217_A0.5990.36
142_I192_D0.5970.36
164_L188_E0.5970.36
15_G33_V0.5950.35
6_H107_V0.5930.35
249_K258_L0.5930.35
212_V221_G0.5910.35
50_L54_N0.5890.35
113_N140_I0.5880.35
97_L148_I0.5870.35
71_A75_W0.5870.35
17_A27_P0.5850.35
184_R301_D0.5850.35
166_I214_T0.5840.34
37_T98_W0.5840.34
85_L149_A0.5820.34
45_D122_P0.5800.34
284_Y294_A0.5780.34
118_Q127_W0.5770.34
106_H110_D0.5770.34
112_F131_G0.5760.34
47_D110_D0.5760.34
243_D277_V0.5760.34
192_D235_N0.5720.33
179_Q198_I0.5700.33
96_W146_A0.5700.33
230_I234_F0.5700.33
213_T218_F0.5670.33
12_A27_P0.5660.33
180_L183_K0.5660.33
67_H110_D0.5650.33
191_H216_H0.5650.33
101_L156_S0.5620.33
218_F266_W0.5620.33
82_I125_K0.5600.32
15_G151_W0.5550.32
161_F164_L0.5550.32
14_G98_W0.5550.32
207_Q224_M0.5550.32
81_A85_L0.5530.32
113_N121_R0.5530.32
148_I152_Y0.5530.32
52_L64_G0.5520.32
91_D94_H0.5500.32
196_S218_F0.5470.31
163_S192_D0.5460.31
113_N199_I0.5450.31
59_I262_P0.5410.31
14_G201_P0.5410.31
62_H110_D0.5400.31
93_L148_I0.5380.31
167_I173_L0.5370.31
133_I202_T0.5370.31
43_A75_W0.5370.31
84_Y92_F0.5340.30
196_S200_S0.5340.30
71_A127_W0.5330.30
117_T128_V0.5330.30
5_T253_N0.5320.30
52_L226_G0.5320.30
184_R246_H0.5320.30
118_Q260_F0.5310.30
105_L118_Q0.5290.30
49_V79_I0.5290.30
78_I93_L0.5280.30
3_T103_V0.5280.30
139_F193_E0.5260.30
35_I217_A0.5260.30
45_D106_H0.5240.30
98_W114_A0.5230.30
293_V302_L0.5210.29
191_H255_A0.5180.29
120_I303_T0.5180.29
82_I181_R0.5170.29
115_Y284_Y0.5160.29
45_D67_H0.5150.29
18_T148_I0.5130.29
145_L255_A0.5130.29
4_G48_T0.5130.29
260_F292_F0.5120.29
93_L216_H0.5100.29
49_V146_A0.5100.29
212_V282_L0.5090.28
64_G279_F0.5060.28
197_I212_V0.5050.28
40_G54_N0.5050.28
166_I177_I0.5050.28
151_W161_F0.5020.28
14_G194_I0.5010.28
62_H208_W0.5010.28
5_T9_M0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tweA 2 0.0795 7.2 0.972 Contact Map
3h90A 3 0.7339 6.9 0.972 Contact Map
4p6vB 1 0.2385 6.2 0.973 Contact Map
4i0uA 4 0.2202 5.7 0.973 Contact Map
3zdlB 1 0.0428 5.4 0.973 Contact Map
4w8pB 1 0.0214 5.2 0.974 Contact Map
4ev6A 3 0.2263 4.8 0.974 Contact Map
4phzA 3 0.3884 4.8 0.974 Contact Map
2ftxA 1 0.2202 4.2 0.975 Contact Map
4a2nB 1 0.419 3.6 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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