YFHP - BACSU - GREMLIN Contacts

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YFHP - Uncharacterized protein YfhP

UniProt:	O31583	Sequences: MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAPDIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLAVVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGITFLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAFYVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYEVRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (294)
Sequences:	895 (716)
Seq/√Len:	41.8

BACSU - YFHP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
80_P	92_F	5.299	1.00
147_A	164_L	4.494	1.00
120_I	128_V	4.373	1.00
133_I	172_Y	4.297	1.00
115_Y	260_F	3.728	1.00
299_G	303_T	3.506	1.00
76_S	100_L	3.474	1.00
140_I	168_L	3.081	1.00
54_N	57_V	2.892	1.00
179_Q	199_I	2.850	1.00
80_P	96_W	2.815	1.00
196_S	213_T	2.772	1.00
166_I	170_G	2.770	1.00
7_V	37_T	2.702	1.00
83_L	99_T	2.645	1.00
51_K	58_Y	2.535	1.00
36_A	99_T	2.529	1.00
290_Y	294_A	2.455	1.00
35_I	87_Y	2.450	1.00
60_R	256_A	2.438	1.00
174_V	178_M	2.414	1.00
2_D	5_T	2.396	1.00
3_T	42_Q	2.376	1.00
134_N	203_M	2.364	1.00
169_V	173_L	2.321	1.00
174_V	205_F	2.262	1.00
112_F	130_L	2.253	1.00
72_V	107_V	2.182	1.00
137_D	171_Y	2.146	0.99
132_L	176_L	2.134	0.99
1_M	5_T	2.129	0.99
66_T	103_V	2.127	0.99
6_H	40_G	2.046	0.99
43_A	46_I	2.034	0.99
73_L	100_L	2.013	0.99
173_L	177_I	1.998	0.99
114_A	284_Y	1.990	0.99
144_H	165_Y	1.907	0.99
111_I	128_V	1.893	0.99
113_N	141_F	1.828	0.98
111_I	130_L	1.798	0.98
2_D	6_H	1.798	0.98
118_Q	121_R	1.740	0.98
150_I	160_T	1.734	0.98
32_A	36_A	1.717	0.97
133_I	261_S	1.697	0.97
82_I	300_H	1.690	0.97
49_V	99_T	1.672	0.97
7_V	42_Q	1.614	0.96
8_V	12_A	1.607	0.96
108_F	112_F	1.602	0.96
5_T	64_G	1.589	0.96
179_Q	183_K	1.585	0.96
16_I	165_Y	1.577	0.96
34_M	38_L	1.563	0.95
1_M	6_H	1.550	0.95
6_H	105_L	1.527	0.95
6_H	140_I	1.511	0.94
140_I	169_V	1.506	0.94
220_V	284_Y	1.505	0.94
183_K	199_I	1.496	0.94
107_V	119_A	1.480	0.94
276_E	295_I	1.478	0.94
136_F	141_F	1.446	0.93
284_Y	290_Y	1.437	0.93
100_L	104_V	1.430	0.93
43_A	79_I	1.416	0.92
150_I	155_G	1.413	0.92
254_I	296_V	1.409	0.92
125_K	128_V	1.407	0.92
79_I	99_T	1.389	0.91
13_L	37_T	1.383	0.91
175_R	205_F	1.377	0.91
295_I	298_I	1.370	0.91
217_A	236_R	1.335	0.90
60_R	259_S	1.322	0.89
4_G	141_F	1.317	0.89
158_G	162_L	1.306	0.89
46_I	143_S	1.302	0.89
293_V	296_V	1.286	0.88
11_I	148_I	1.270	0.87
14_G	18_T	1.260	0.87
243_D	246_H	1.240	0.86
241_E	245_M	1.236	0.86
91_D	191_H	1.235	0.86
115_Y	135_T	1.232	0.86
92_F	96_W	1.199	0.84
68_S	121_R	1.196	0.84
113_N	127_W	1.188	0.84
162_L	166_I	1.182	0.83
290_Y	296_V	1.180	0.83
186_L	223_S	1.179	0.83
113_N	259_S	1.173	0.83
83_L	241_E	1.171	0.83
131_G	261_S	1.171	0.83
5_T	278_R	1.161	0.82
14_G	96_W	1.151	0.82
124_S	128_V	1.148	0.81
181_R	185_K	1.145	0.81
111_I	117_T	1.143	0.81
300_H	305_R	1.137	0.81
120_I	146_A	1.134	0.81
150_I	178_M	1.126	0.80
81_A	142_I	1.124	0.80
284_Y	291_P	1.124	0.80
76_S	80_P	1.120	0.80
73_L	76_S	1.103	0.79
190_I	212_V	1.102	0.79
261_S	279_F	1.102	0.79
156_S	164_L	1.098	0.78
53_K	58_Y	1.095	0.78
114_A	131_G	1.087	0.78
69_I	73_L	1.083	0.77
202_T	222_R	1.083	0.77
300_H	303_T	1.081	0.77
170_G	192_D	1.080	0.77
150_I	153_A	1.076	0.77
291_P	294_A	1.070	0.76
143_S	164_L	1.069	0.76
216_H	219_Y	1.056	0.76
177_I	181_R	1.056	0.76
160_T	262_P	1.054	0.75
74_F	166_I	1.038	0.74
91_D	167_I	1.031	0.74
6_H	42_Q	1.030	0.74
59_I	66_T	1.021	0.73
214_T	219_Y	1.018	0.73
48_T	107_V	1.014	0.73
296_V	304_I	1.014	0.73
150_I	246_H	1.012	0.72
76_S	120_I	1.006	0.72
4_G	7_V	0.991	0.71
146_A	255_A	0.987	0.70
105_L	109_V	0.980	0.70
62_H	68_S	0.978	0.70
34_M	37_T	0.976	0.70
77_V	265_R	0.975	0.70
44_P	106_H	0.975	0.70
50_L	108_F	0.973	0.69
234_F	237_V	0.973	0.69
144_H	209_R	0.973	0.69
3_T	48_T	0.973	0.69
59_I	131_G	0.972	0.69
192_D	289_H	0.972	0.69
272_K	275_Y	0.972	0.69
154_G	160_T	0.968	0.69
216_H	295_I	0.961	0.68
75_W	103_V	0.957	0.68
113_N	117_T	0.956	0.68
120_I	199_I	0.945	0.67
108_F	130_L	0.938	0.66
51_K	55_N	0.934	0.66
46_I	205_F	0.934	0.66
209_R	260_F	0.933	0.66
123_F	174_V	0.931	0.66
25_S	227_H	0.930	0.66
244_V	302_L	0.929	0.66
3_T	6_H	0.928	0.66
114_A	200_S	0.927	0.66
117_T	137_D	0.926	0.65
156_S	159_I	0.925	0.65
36_A	105_L	0.917	0.65
191_H	194_I	0.914	0.64
56_A	261_S	0.908	0.64
76_S	123_F	0.901	0.63
38_L	167_I	0.897	0.63
48_T	291_P	0.895	0.63
131_G	198_I	0.892	0.63
107_V	264_Y	0.892	0.63
46_I	82_I	0.885	0.62
249_K	276_E	0.882	0.62
129_A	262_P	0.880	0.61
146_A	169_V	0.878	0.61
47_D	67_H	0.874	0.61
134_N	284_Y	0.872	0.61
170_G	184_R	0.870	0.61
114_A	211_A	0.863	0.60
302_L	305_R	0.861	0.60
142_I	275_Y	0.859	0.60
95_L	107_V	0.858	0.60
244_V	250_Q	0.857	0.59
76_S	202_T	0.856	0.59
111_I	124_S	0.854	0.59
278_R	293_V	0.850	0.59
147_A	160_T	0.849	0.59
18_T	25_S	0.848	0.59
135_T	260_F	0.847	0.59
39_A	43_A	0.847	0.59
149_A	301_D	0.845	0.58
6_H	169_V	0.841	0.58
83_L	148_I	0.841	0.58
127_W	258_L	0.839	0.58
280_I	284_Y	0.839	0.58
133_I	175_R	0.837	0.58
76_S	96_W	0.837	0.58
142_I	154_G	0.835	0.57
25_S	226_G	0.834	0.57
43_A	72_V	0.833	0.57
287_K	290_Y	0.832	0.57
75_W	79_I	0.832	0.57
3_T	69_I	0.832	0.57
111_I	119_A	0.831	0.57
214_T	217_A	0.829	0.57
185_K	189_M	0.805	0.55
159_I	190_I	0.804	0.55
8_V	141_F	0.800	0.54
275_Y	300_H	0.799	0.54
42_Q	141_F	0.797	0.54
159_I	162_L	0.796	0.54
111_I	120_I	0.794	0.54
220_V	261_S	0.794	0.54
66_T	297_H	0.790	0.53
46_I	66_T	0.790	0.53
195_E	213_T	0.788	0.53
190_I	219_Y	0.787	0.53
149_A	153_A	0.786	0.53
301_D	305_R	0.779	0.52
6_H	175_R	0.778	0.52
15_G	165_Y	0.777	0.52
9_M	12_A	0.774	0.52
74_F	100_L	0.771	0.51
45_D	110_D	0.770	0.51
146_A	250_Q	0.766	0.51
8_V	238_P	0.766	0.51
196_S	211_A	0.766	0.51
212_V	252_D	0.766	0.51
184_R	233_T	0.764	0.51
54_N	151_W	0.762	0.51
148_I	155_G	0.761	0.51
107_V	118_Q	0.761	0.51
6_H	101_L	0.759	0.50
178_M	205_F	0.759	0.50
186_L	212_V	0.758	0.50
4_G	42_Q	0.755	0.50
77_V	92_F	0.755	0.50
117_T	136_F	0.753	0.50
212_V	219_Y	0.753	0.50
186_L	210_I	0.753	0.50
82_I	187_H	0.752	0.50
248_A	279_F	0.751	0.50
215_A	246_H	0.750	0.50
45_D	62_H	0.749	0.49
68_S	281_D	0.747	0.49
190_I	234_F	0.746	0.49
214_T	246_H	0.739	0.48
54_N	254_I	0.739	0.48
68_S	137_D	0.739	0.48
9_M	109_V	0.735	0.48
116_G	208_W	0.732	0.48
129_A	175_R	0.732	0.48
218_F	254_I	0.731	0.48
127_W	290_Y	0.727	0.47
15_G	161_F	0.725	0.47
210_I	221_G	0.721	0.47
99_T	104_V	0.720	0.47
68_S	120_I	0.720	0.47
130_L	199_I	0.719	0.47
293_V	298_I	0.716	0.46
249_K	300_H	0.716	0.46
255_A	305_R	0.715	0.46
183_K	197_I	0.715	0.46
180_L	184_R	0.712	0.46
95_L	237_V	0.712	0.46
54_N	256_A	0.712	0.46
102_A	132_L	0.710	0.46
194_I	197_I	0.710	0.46
69_I	196_S	0.706	0.45
236_R	273_D	0.705	0.45
109_V	172_Y	0.702	0.45
88_P	162_L	0.700	0.45
127_W	256_A	0.694	0.44
6_H	9_M	0.693	0.44
159_I	166_I	0.688	0.44
91_D	267_E	0.688	0.44
34_M	120_I	0.686	0.44
129_A	145_L	0.685	0.43
76_S	99_T	0.685	0.43
164_L	168_L	0.684	0.43
78_I	142_I	0.683	0.43
135_T	200_S	0.683	0.43
101_L	163_S	0.682	0.43
146_A	167_I	0.681	0.43
117_T	209_R	0.679	0.43
261_S	266_W	0.677	0.43
162_L	249_K	0.676	0.43
132_L	175_R	0.676	0.43
146_A	300_H	0.668	0.42
298_I	304_I	0.668	0.42
45_D	63_R	0.667	0.42
127_W	228_V	0.665	0.42
153_A	300_H	0.665	0.42
17_A	98_W	0.665	0.42
113_N	294_A	0.662	0.41
159_I	163_S	0.661	0.41
187_H	301_D	0.660	0.41
202_T	210_I	0.660	0.41
96_W	100_L	0.659	0.41
220_V	280_I	0.659	0.41
173_L	215_A	0.659	0.41
5_T	183_K	0.659	0.41
72_V	100_L	0.659	0.41
117_T	129_A	0.657	0.41
146_A	185_K	0.654	0.41
63_R	135_T	0.653	0.41
35_I	230_I	0.652	0.40
174_V	187_H	0.651	0.40
184_R	244_V	0.651	0.40
298_I	302_L	0.647	0.40
25_S	29_M	0.646	0.40
204_K	207_Q	0.645	0.40
124_S	264_Y	0.644	0.40
147_A	150_I	0.640	0.39
86_F	170_G	0.638	0.39
11_I	18_T	0.638	0.39
139_F	167_I	0.637	0.39
127_W	259_S	0.635	0.39
299_G	305_R	0.634	0.39
134_N	264_Y	0.633	0.39
127_W	284_Y	0.633	0.39
34_M	215_A	0.633	0.39
180_L	189_M	0.632	0.39
188_E	272_K	0.630	0.38
110_D	122_P	0.628	0.38
276_E	297_H	0.628	0.38
42_Q	113_N	0.628	0.38
76_S	151_W	0.628	0.38
228_V	231_L	0.627	0.38
180_L	192_D	0.627	0.38
170_G	174_V	0.625	0.38
56_A	259_S	0.622	0.38
204_K	224_M	0.621	0.38
101_L	104_V	0.620	0.38
33_V	167_I	0.618	0.37
32_A	35_I	0.617	0.37
63_R	137_D	0.616	0.37
112_F	128_V	0.615	0.37
29_M	65_F	0.614	0.37
70_P	201_P	0.614	0.37
131_G	200_S	0.612	0.37
199_I	258_L	0.611	0.37
207_Q	227_H	0.611	0.37
139_F	143_S	0.610	0.37
115_Y	209_R	0.609	0.37
1_M	10_G	0.608	0.37
248_A	282_L	0.608	0.37
12_A	15_G	0.606	0.36
287_K	293_V	0.602	0.36
112_F	132_L	0.602	0.36
187_H	229_V	0.600	0.36
65_F	121_R	0.600	0.36
34_M	217_A	0.599	0.36
142_I	192_D	0.597	0.36
164_L	188_E	0.597	0.36
15_G	33_V	0.595	0.35
6_H	107_V	0.593	0.35
249_K	258_L	0.593	0.35
212_V	221_G	0.591	0.35
50_L	54_N	0.589	0.35
113_N	140_I	0.588	0.35
97_L	148_I	0.587	0.35
71_A	75_W	0.587	0.35
17_A	27_P	0.585	0.35
184_R	301_D	0.585	0.35
166_I	214_T	0.584	0.34
37_T	98_W	0.584	0.34
85_L	149_A	0.582	0.34
45_D	122_P	0.580	0.34
284_Y	294_A	0.578	0.34
118_Q	127_W	0.577	0.34
106_H	110_D	0.577	0.34
112_F	131_G	0.576	0.34
47_D	110_D	0.576	0.34
243_D	277_V	0.576	0.34
192_D	235_N	0.572	0.33
179_Q	198_I	0.570	0.33
96_W	146_A	0.570	0.33
230_I	234_F	0.570	0.33
213_T	218_F	0.567	0.33
12_A	27_P	0.566	0.33
180_L	183_K	0.566	0.33
67_H	110_D	0.565	0.33
191_H	216_H	0.565	0.33
101_L	156_S	0.562	0.33
218_F	266_W	0.562	0.33
82_I	125_K	0.560	0.32
15_G	151_W	0.555	0.32
161_F	164_L	0.555	0.32
14_G	98_W	0.555	0.32
207_Q	224_M	0.555	0.32
81_A	85_L	0.553	0.32
113_N	121_R	0.553	0.32
148_I	152_Y	0.553	0.32
52_L	64_G	0.552	0.32
91_D	94_H	0.550	0.32
196_S	218_F	0.547	0.31
163_S	192_D	0.546	0.31
113_N	199_I	0.545	0.31
59_I	262_P	0.541	0.31
14_G	201_P	0.541	0.31
62_H	110_D	0.540	0.31
93_L	148_I	0.538	0.31
167_I	173_L	0.537	0.31
133_I	202_T	0.537	0.31
43_A	75_W	0.537	0.31
84_Y	92_F	0.534	0.30
196_S	200_S	0.534	0.30
71_A	127_W	0.533	0.30
117_T	128_V	0.533	0.30
5_T	253_N	0.532	0.30
52_L	226_G	0.532	0.30
184_R	246_H	0.532	0.30
118_Q	260_F	0.531	0.30
105_L	118_Q	0.529	0.30
49_V	79_I	0.529	0.30
78_I	93_L	0.528	0.30
3_T	103_V	0.528	0.30
139_F	193_E	0.526	0.30
35_I	217_A	0.526	0.30
45_D	106_H	0.524	0.30
98_W	114_A	0.523	0.30
293_V	302_L	0.521	0.29
191_H	255_A	0.518	0.29
120_I	303_T	0.518	0.29
82_I	181_R	0.517	0.29
115_Y	284_Y	0.516	0.29
45_D	67_H	0.515	0.29
18_T	148_I	0.513	0.29
145_L	255_A	0.513	0.29
4_G	48_T	0.513	0.29
260_F	292_F	0.512	0.29
93_L	216_H	0.510	0.29
49_V	146_A	0.510	0.29
212_V	282_L	0.509	0.28
64_G	279_F	0.506	0.28
197_I	212_V	0.505	0.28
40_G	54_N	0.505	0.28
166_I	177_I	0.505	0.28
151_W	161_F	0.502	0.28
14_G	194_I	0.501	0.28
62_H	208_W	0.501	0.28
5_T	9_M	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tweA	2	0.0795	7.2	0.972	Contact Map
3h90A	3	0.7339	6.9	0.972	Contact Map
4p6vB	1	0.2385	6.2	0.973	Contact Map
4i0uA	4	0.2202	5.7	0.973	Contact Map
3zdlB	1	0.0428	5.4	0.973	Contact Map
4w8pB	1	0.0214	5.2	0.974	Contact Map
4ev6A	3	0.2263	4.8	0.974	Contact Map
4phzA	3	0.3884	4.8	0.974	Contact Map
2ftxA	1	0.2202	4.2	0.975	Contact Map
4a2nB	1	0.419	3.6	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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