GREMLIN Database
YFHO - Uncharacterized protein YfhO
UniProt: O31582 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 861 (804)
Sequences: 911 (850)
Seq/√Len: 30.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_G845_S11.1851.00
801_N824_N10.9321.00
798_L807_I5.8911.00
798_L828_L5.6271.00
798_L817_F5.5181.00
191_F243_G5.3721.00
799_K829_T4.9111.00
841_I845_S4.8001.00
779_H823_D4.4131.00
798_L815_I4.4001.00
128_S132_F4.3751.00
799_K827_E4.3741.00
810_A816_G4.2071.00
807_I815_I4.1421.00
179_A213_I4.1341.00
786_I817_F3.8681.00
485_M554_Y3.7971.00
245_I845_S3.7191.00
51_F55_T3.6491.00
252_A839_A3.5421.00
180_E216_Y3.5361.00
764_A776_F3.5091.00
797_E804_T3.4671.00
251_A841_I3.4561.00
83_F123_L3.4481.00
788_L828_L3.4441.00
178_G194_A3.4031.00
190_W194_A3.3811.00
795_G833_P3.3611.00
82_S85_F3.3251.00
249_I849_A3.2271.00
433_S437_A3.2021.00
259_Y834_Y3.1521.00
102_G105_D3.0771.00
178_G190_W3.0501.00
775_T827_E3.0191.00
195_C246_S3.0121.00
196_S249_I2.9891.00
210_L243_G2.9111.00
324_H347_L2.9111.00
196_S246_S2.8641.00
485_M553_K2.8411.00
191_F195_C2.8391.00
437_A441_Q2.8001.00
498_P505_G2.7701.00
592_T784_Q2.7421.00
42_Q78_Y2.6971.00
332_V336_F2.6481.00
180_E220_R2.6451.00
176_V349_F2.6361.00
14_L125_I2.6291.00
323_F333_F2.6131.00
800_I819_A2.5560.99
799_K804_T2.5270.99
845_S848_L2.5190.99
42_Q77_Y2.4520.99
831_Y836_K2.4280.99
401_L404_L2.4020.99
43_M162_W2.3910.99
11_A14_L2.3740.99
131_V176_V2.3710.99
786_I819_A2.3560.99
249_I846_L2.3450.99
11_A122_S2.3330.99
199_L210_L2.3210.99
587_L759_N2.3120.99
120_K167_D2.3120.99
129_A142_S2.3030.99
588_P763_K2.2850.99
461_S464_Y2.2660.99
676_G746_E2.2290.99
181_K185_E2.2270.99
191_F239_F2.2200.99
125_I150_G2.2180.98
60_F832_P2.1930.98
458_Y461_S2.1720.98
120_K165_F2.1240.98
618_I816_G2.1200.98
543_R611_E2.1070.98
788_L815_I2.1010.98
79_F82_S2.0850.98
680_V744_L2.0740.98
520_F814_F2.0580.98
173_P342_R2.0550.98
10_A14_L2.0480.97
590_V788_L2.0260.97
404_L408_I2.0160.97
213_I239_F2.0040.97
70_G793_E1.9980.97
81_A85_F1.9910.97
208_I333_F1.9500.97
589_F789_P1.9440.96
778_Y819_A1.9270.96
191_F210_L1.9150.96
795_G834_Y1.8920.96
248_G841_I1.8910.96
188_P192_I1.8870.96
291_V294_A1.8870.96
70_G832_P1.8850.96
209_N345_Y1.8830.96
245_I849_A1.8820.96
77_Y202_N1.8770.96
46_F77_Y1.8560.95
81_A167_D1.8420.95
516_D809_K1.8400.95
192_I249_I1.8220.95
520_F525_L1.7980.95
231_K234_I1.7890.94
503_F591_K1.7880.94
785_Y816_G1.7860.94
796_W828_L1.7860.94
777_S825_H1.7710.94
119_F123_L1.7690.94
520_F550_L1.7590.94
11_A125_I1.7490.94
124_I149_Y1.7490.94
801_N820_Q1.7380.93
145_G359_L1.7360.93
590_V776_F1.7150.93
195_C210_L1.7120.93
807_I817_F1.7110.93
175_L246_S1.7040.93
312_L315_G1.6990.93
800_I820_Q1.6960.93
188_P242_S1.6920.93
67_L550_L1.6830.92
195_C243_G1.6790.92
89_S102_G1.6770.92
481_D553_K1.6690.92
592_T786_I1.6630.92
130_S177_L1.6620.92
711_Y719_T1.6600.92
205_F345_Y1.6580.92
15_V122_S1.6490.92
764_A786_I1.6450.91
800_I805_Q1.6430.91
476_L487_I1.6410.91
78_Y511_S1.6340.91
590_V764_A1.6240.91
776_F824_N1.6220.91
148_L152_S1.6130.91
249_I845_S1.6130.91
798_L805_Q1.6110.91
192_I242_S1.6090.90
43_M82_S1.6090.90
295_F299_L1.6060.90
152_S348_A1.6030.90
198_T209_N1.5990.90
773_R827_E1.5970.90
175_L178_G1.5900.90
434_L437_A1.5720.89
168_T205_F1.5700.89
592_T778_Y1.5620.89
46_F78_Y1.5620.89
182_I191_F1.5600.89
208_I345_Y1.5580.89
481_D485_M1.5580.89
14_L151_V1.5270.88
43_M165_F1.5250.88
45_V264_N1.5250.88
191_F203_F1.5220.88
830_Y833_P1.5120.87
808_E816_G1.5080.87
401_L408_I1.4980.87
241_V245_I1.4960.87
256_P838_S1.4890.87
521_Y527_I1.4840.86
175_L209_N1.4800.86
127_T170_V1.4740.86
175_L845_S1.4640.86
134_Y181_K1.4590.85
131_V180_E1.4540.85
290_I299_L1.4420.85
753_K757_M1.4400.85
145_G356_A1.4390.85
484_L589_F1.4370.85
128_S149_Y1.4330.84
551_Y586_M1.4320.84
82_S162_W1.4250.84
277_N280_D1.4140.84
433_S441_Q1.4120.84
83_F87_A1.4110.83
175_L194_A1.4090.83
337_S340_Q1.4060.83
834_Y838_S1.4060.83
121_L155_Y1.4000.83
127_T130_S1.3970.83
476_L572_H1.3930.83
131_V216_Y1.3910.83
773_R829_T1.3840.82
776_F801_N1.3800.82
592_T780_L1.3760.82
122_S125_I1.3680.82
245_I848_L1.3680.82
458_Y462_E1.3650.81
143_F146_A1.3620.81
179_A191_F1.3580.81
475_R573_L1.3460.80
239_F247_F1.3410.80
792_Y809_K1.3410.80
594_D782_K1.3380.80
592_T819_A1.3350.80
757_M760_K1.3330.80
774_L790_I1.3280.80
805_Q817_F1.3240.79
77_Y164_F1.3200.79
243_G247_F1.3180.79
804_T826_I1.3150.79
678_Y746_E1.3130.79
585_Y753_K1.3050.78
18_L121_L1.3000.78
571_K579_A1.2920.78
441_Q444_A1.2910.78
129_A146_A1.2890.77
44_I113_A1.2880.77
13_L857_K1.2810.77
607_A681_S1.2720.76
248_G259_Y1.2710.76
235_Q238_L1.2700.76
79_F85_F1.2670.76
381_Y385_I1.2550.76
614_M811_D1.2550.76
770_N773_R1.2540.75
211_I332_V1.2540.75
87_A116_I1.2530.75
809_K814_F1.2490.75
39_G113_A1.2470.75
548_S583_N1.2450.75
178_G182_I1.2440.75
483_P572_H1.2410.75
571_K581_Y1.2410.75
551_Y789_P1.2380.74
171_W197_L1.2360.74
399_S403_L1.2360.74
212_F349_F1.2340.74
171_W201_N1.2330.74
165_F205_F1.2230.74
162_W165_F1.2220.74
380_L384_H1.2160.73
236_I240_L1.2140.73
437_A446_S1.2120.73
312_L318_L1.2090.73
214_G243_G1.2080.73
291_V299_L1.2070.73
49_L71_T1.2060.73
514_N793_E1.2050.72
807_I828_L1.2020.72
82_S88_V1.1980.72
550_L814_F1.1960.72
545_N615_L1.1940.72
66_G537_Y1.1890.71
77_Y335_G1.1880.71
506_F552_G1.1840.71
200_I252_A1.1840.71
542_D546_L1.1790.71
505_G517_L1.1790.71
76_G257_V1.1780.71
715_V826_I1.1780.71
83_F119_F1.1770.71
128_S352_A1.1720.70
783_D821_K1.1710.70
78_Y164_F1.1700.70
310_F357_A1.1690.70
252_A802_G1.1690.70
548_S752_L1.1690.70
239_F243_G1.1690.70
266_R337_S1.1660.70
193_V211_I1.1640.70
244_F790_I1.1630.70
21_A24_V1.1630.70
716_N719_T1.1610.70
820_Q824_N1.1600.70
123_L171_W1.1560.69
300_F351_I1.1560.69
780_L786_I1.1540.69
437_A444_A1.1520.69
260_G484_L1.1510.69
608_L681_S1.1480.69
178_G188_P1.1470.69
235_Q826_I1.1470.69
778_Y786_I1.1440.68
157_R345_Y1.1420.68
323_F329_A1.1390.68
567_Y585_Y1.1380.68
196_S200_I1.1370.68
328_Y332_V1.1360.68
50_L505_G1.1360.68
245_I248_G1.1340.68
651_N655_T1.1320.68
81_A120_K1.1320.68
775_T825_H1.1320.68
247_F254_F1.1310.68
79_F88_V1.1300.67
459_L464_Y1.1260.67
313_F316_L1.1240.67
283_L829_T1.1230.67
677_D717_N1.1230.67
60_F835_F1.1230.67
102_G788_L1.1220.67
65_F69_G1.1170.67
39_G334_N1.1170.67
78_Y339_P1.1150.66
842_S845_S1.1130.66
164_F217_V1.1120.66
192_I245_I1.1020.65
35_G39_G1.0990.65
62_N590_V1.0950.65
835_F839_A1.0930.65
175_L198_T1.0920.65
212_F343_F1.0810.64
164_F205_F1.0780.64
756_V760_K1.0770.64
179_A220_R1.0740.63
334_N543_R1.0630.63
434_L752_L1.0610.62
161_Y509_Y1.0610.62
74_Q510_S1.0610.62
460_T463_E1.0600.62
266_R509_Y1.0570.62
198_T206_A1.0570.62
45_V493_V1.0560.62
441_Q446_S1.0550.62
211_I502_G1.0510.62
134_Y185_E1.0500.62
208_I796_W1.0470.61
82_S89_S1.0430.61
289_I509_Y1.0430.61
264_N512_I1.0410.61
776_F786_I1.0390.61
192_I246_S1.0390.61
78_Y202_N1.0380.61
244_F300_F1.0380.61
794_K833_P1.0350.61
551_Y589_F1.0350.61
252_A809_K1.0330.60
70_G830_Y1.0310.60
330_A334_N1.0290.60
11_A23_F1.0280.60
154_I162_W1.0270.60
846_L850_V1.0230.60
164_F345_Y1.0200.59
296_L299_L1.0170.59
63_Y484_L1.0150.59
675_P722_V1.0090.59
248_G848_L1.0070.58
61_Y510_S1.0040.58
217_V730_I1.0020.58
43_M47_K1.0000.58
12_S122_S0.9960.58
67_L316_L0.9950.57
11_A15_V0.9950.57
172_L349_F0.9930.57
132_F356_A0.9930.57
173_P349_F0.9920.57
39_G164_F0.9900.57
438_N441_Q0.9900.57
85_F88_V0.9870.57
170_V216_Y0.9860.57
521_Y550_L0.9860.57
844_V850_V0.9850.57
81_A84_L0.9850.57
435_F467_R0.9850.57
192_I196_S0.9830.57
291_V302_I0.9820.56
83_F120_K0.9800.56
78_Y201_N0.9790.56
11_A126_F0.9770.56
15_V125_I0.9760.56
334_N509_Y0.9750.56
133_H142_S0.9720.56
101_I112_S0.9710.56
123_L127_T0.9700.55
818_K828_L0.9700.55
343_F543_R0.9660.55
308_R844_V0.9640.55
584_Q839_A0.9610.55
211_I504_N0.9610.55
169_M250_S0.9590.55
244_F660_N0.9590.55
122_S151_V0.9560.54
772_N831_Y0.9550.54
46_F163_E0.9510.54
7_M76_G0.9500.54
806_K825_H0.9500.54
135_L220_R0.9500.54
334_N339_P0.9490.54
433_S444_A0.9480.54
176_V179_A0.9470.54
261_F335_G0.9470.54
343_F349_F0.9470.54
46_F510_S0.9430.53
298_F303_S0.9400.53
808_E818_K0.9390.53
149_Y173_P0.9380.53
827_E844_V0.9370.53
292_P296_L0.9360.53
780_L819_A0.9360.53
65_F71_T0.9340.53
191_F214_G0.9290.52
543_R546_L0.9290.52
793_E815_I0.9270.52
165_F330_A0.9250.52
246_S816_G0.9250.52
521_Y529_M0.9240.52
43_M120_K0.9230.52
128_S778_Y0.9170.51
266_R535_S0.9170.51
429_I594_D0.9150.51
49_L53_Q0.9140.51
45_V69_G0.9140.51
456_K459_L0.9130.51
199_L206_A0.9120.51
442_K446_S0.9090.51
189_A193_V0.9080.51
82_S87_A0.9080.51
232_R235_Q0.9060.50
63_Y789_P0.9060.50
15_V839_A0.9060.50
47_K117_S0.9020.50
339_P497_T0.8990.50
284_F287_R0.8980.50
266_R343_F0.8970.50
62_N65_F0.8950.50
79_F83_F0.8930.49
319_L329_A0.8930.49
162_W167_D0.8910.49
125_I208_I0.8910.49
204_Y342_R0.8900.49
240_L593_A0.8900.49
173_P679_Y0.8880.49
150_G548_S0.8870.49
819_A851_F0.8840.49
11_A18_L0.8830.49
165_F345_Y0.8790.48
152_S434_L0.8780.48
366_K369_E0.8760.48
589_F791_P0.8750.48
86_L122_S0.8720.48
13_L119_F0.8690.47
642_I857_K0.8680.47
570_K584_Q0.8680.47
478_K754_N0.8650.47
468_E576_E0.8650.47
844_V851_F0.8640.47
199_L510_S0.8620.47
207_Y341_N0.8620.47
421_A424_A0.8550.46
39_G165_F0.8550.46
192_I845_S0.8540.46
319_L430_I0.8520.46
787_M790_I0.8510.46
178_G193_V0.8510.46
507_S593_A0.8500.46
477_Q806_K0.8490.46
339_P510_S0.8470.46
42_Q511_S0.8470.46
203_F497_T0.8470.46
337_S535_S0.8470.46
9_Y279_D0.8460.46
37_G41_A0.8460.46
69_G337_S0.8460.46
588_P752_L0.8410.45
39_G163_E0.8400.45
337_S509_Y0.8390.45
768_N854_R0.8390.45
187_R826_I0.8390.45
201_N830_Y0.8390.45
230_E826_I0.8390.45
81_A162_W0.8380.45
787_M816_G0.8360.45
194_A198_T0.8360.45
243_G507_S0.8350.45
189_A849_A0.8340.45
344_E348_A0.8340.45
61_Y66_G0.8310.45
70_G330_A0.8280.44
375_A400_I0.8250.44
411_L806_K0.8210.44
762_E781_S0.8210.44
146_A221_W0.8180.43
254_F258_V0.8180.43
769_W774_L0.8180.43
120_K163_E0.8170.43
597_Y602_L0.8160.43
841_I850_V0.8160.43
8_I817_F0.8160.43
617_G826_I0.8150.43
121_L164_F0.8140.43
205_F334_N0.8140.43
217_V221_W0.8130.43
554_Y582_E0.8100.43
331_S337_S0.8090.43
186_R523_N0.8090.43
488_D505_G0.8060.43
86_L112_S0.8060.43
616_K774_L0.8040.42
676_G748_N0.8020.42
41_A337_S0.8010.42
218_L242_S0.8010.42
554_Y583_N0.8010.42
38_D68_G0.8000.42
43_M81_A0.8000.42
590_V778_Y0.8000.42
207_Y257_V0.7990.42
169_M205_F0.7990.42
303_S674_A0.7970.42
240_L622_D0.7960.42
574_E803_K0.7960.42
149_Y540_L0.7950.42
131_V245_I0.7940.42
43_M77_Y0.7940.42
281_N331_S0.7930.42
800_I826_I0.7920.41
404_L410_A0.7910.41
203_F247_F0.7890.41
342_R345_Y0.7890.41
75_L80_S0.7890.41
45_V500_I0.7890.41
290_I296_L0.7890.41
168_T209_N0.7870.41
719_T722_V0.7860.41
422_K836_K0.7850.41
203_F512_I0.7840.41
183_I220_R0.7840.41
192_I849_A0.7830.41
778_Y824_N0.7820.41
61_Y796_W0.7810.41
211_I214_G0.7810.41
780_L816_G0.7810.41
40_L337_S0.7800.41
402_L408_I0.7800.41
145_G165_F0.7800.41
11_A33_M0.7800.41
780_L826_I0.7800.41
135_L180_E0.7800.41
399_S402_L0.7790.40
195_C239_F0.7790.40
419_K782_K0.7780.40
125_I146_A0.7770.40
66_G517_L0.7770.40
509_Y619_I0.7760.40
291_V296_L0.7730.40
425_V775_T0.7700.40
785_Y808_E0.7700.40
182_I185_E0.7690.40
351_I761_T0.7690.40
780_L801_N0.7690.40
815_I839_A0.7690.40
21_A123_L0.7670.40
64_S69_G0.7670.40
768_N803_K0.7650.39
87_A112_S0.7650.39
798_L809_K0.7630.39
120_K342_R0.7630.39
50_L84_L0.7620.39
291_V303_S0.7610.39
273_I282_I0.7570.39
603_D842_S0.7570.39
72_F253_A0.7570.39
52_D103_E0.7570.39
419_K843_L0.7550.39
79_F120_K0.7540.39
803_K818_K0.7540.39
431_L470_S0.7530.38
799_K805_Q0.7520.38
16_S692_G0.7520.38
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425_V840_I0.5140.23
69_G78_Y0.5140.23
608_L615_L0.5130.23
173_P796_W0.5130.23
197_L502_G0.5130.23
305_Y308_R0.5130.23
675_P850_V0.5130.23
590_V828_L0.5120.23
330_A333_F0.5120.23
65_F514_N0.5120.23
82_S167_D0.5120.23
34_T168_T0.5110.22
49_L52_D0.5110.22
362_L410_A0.5110.22
369_E377_V0.5110.22
504_N695_L0.5110.22
10_A303_S0.5100.22
73_S260_G0.5100.22
41_A161_Y0.5100.22
154_I166_T0.5100.22
598_S785_Y0.5100.22
289_I495_N0.5100.22
281_N536_R0.5090.22
777_S823_D0.5090.22
43_M511_S0.5090.22
128_S441_Q0.5090.22
367_R380_L0.5090.22
208_I679_Y0.5090.22
135_L506_F0.5080.22
244_F375_A0.5080.22
66_G70_G0.5080.22
260_G513_L0.5080.22
327_P330_A0.5080.22
245_I761_T0.5070.22
806_K844_V0.5070.22
165_F620_L0.5070.22
150_G484_L0.5060.22
661_G803_K0.5060.22
200_I350_T0.5050.22
808_E817_F0.5050.22
195_C214_G0.5050.22
248_G251_A0.5050.22
790_I828_L0.5040.22
76_G253_A0.5040.22
203_F495_N0.5040.22
230_E426_Y0.5040.22
421_A805_Q0.5030.22
534_V539_S0.5030.22
63_Y788_L0.5030.22
183_I236_I0.5030.22
250_S304_F0.5020.22
13_L738_E0.5020.22
82_S510_S0.5020.22
157_R339_P0.5010.22
507_S581_Y0.5010.22
131_V666_I0.5010.22
262_L311_R0.5010.22
35_G43_M0.5000.22
383_Y387_R0.5000.22
112_S527_I0.5000.22
288_I497_T0.5000.22
62_N502_G0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.7364 97.1 0.961 Contact Map
3rceA 1 0.7003 96.4 0.964 Contact Map
2j42A 1 0.1429 64.5 0.979 Contact Map
2vzpA 1 0.1254 49 0.981 Contact Map
2waaA 1 0.1417 47.7 0.981 Contact Map
2w87A 1 0.1324 37.7 0.982 Contact Map
4xvhA 1 0.1231 36.9 0.982 Contact Map
3tewA 1 0.1498 33.7 0.982 Contact Map
2jwaA 2 0.0453 32.6 0.983 Contact Map
3sz6A 1 0.1301 29.3 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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