GREMLIN Database
YFHM - AB hydrolase superfamily protein YfhM
UniProt: O31581 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (252)
Sequences: 61102 (48721)
Seq/√Len: 3069.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_A55_R4.5891.00
98_I122_K4.4451.00
62_R84_D4.2441.00
45_Q276_N3.2711.00
235_M261_D2.9951.00
127_N237_D2.7581.00
86_I112_L2.7331.00
271_K274_I2.6351.00
96_K121_E2.5111.00
98_I121_E2.4701.00
258_I278_L2.4361.00
230_R282_Y2.4271.00
126_I275_V2.3731.00
260_V278_L2.3361.00
106_G128_I2.2741.00
89_I97_A2.2631.00
90_T119_Y2.1101.00
112_L116_R2.1081.00
15_T68_D2.0711.00
249_E255_G2.0601.00
53_G280_L2.0201.00
86_I116_R2.0131.00
99_V109_A1.9971.00
83_D115_T1.9651.00
98_I124_I1.9641.00
19_A39_W1.9601.00
235_M259_F1.9321.00
86_I119_Y1.9131.00
18_V88_L1.9041.00
86_I90_T1.8811.00
17_H66_L1.8761.00
33_H64_Y1.8151.00
263_A271_K1.8001.00
109_A123_L1.7991.00
28_L57_I1.7841.00
113_A123_L1.7661.00
48_P276_N1.6811.00
59_P85_I1.6541.00
54_Y98_I1.6511.00
111_H115_T1.6471.00
27_P98_I1.6351.00
124_I279_I1.6341.00
20_A57_I1.6321.00
79_D115_T1.5811.00
33_H61_Q1.5781.00
230_R258_I1.5771.00
98_I283_L1.5751.00
242_R259_F1.5691.00
21_A58_A1.5631.00
28_L94_D1.5331.00
85_I112_L1.5271.00
116_R119_Y1.5211.00
221_K224_Y1.5211.00
277_Q281_E1.5171.00
229_Y252_C1.5091.00
28_L55_R1.5021.00
17_H39_W1.4921.00
32_L109_A1.4861.00
61_Q108_V1.4541.00
37_E41_G1.4461.00
278_L281_E1.4411.00
32_L61_Q1.4341.00
52_A280_L1.4261.00
112_L120_L1.4081.00
77_R80_T1.4071.00
31_L100_I1.3961.00
27_P121_E1.3881.00
247_E251_H1.3851.00
12_N87_G1.3731.00
125_A128_I1.3691.00
57_I88_L1.3431.00
31_L56_V1.3071.00
90_T116_R1.2871.00
32_L85_I1.2841.00
46_I58_A1.2831.00
17_H60_D1.2751.00
235_M262_E1.2711.00
36_P64_Y1.2601.00
82_R111_H1.2591.00
112_L119_Y1.2561.00
94_D97_A1.2551.00
59_P88_L1.2431.00
16_L67_S1.2401.00
48_P280_L1.2381.00
22_G55_R1.2281.00
186_T189_D1.2261.00
89_I94_D1.2191.00
102_H268_N1.2121.00
60_D65_N1.2101.00
39_W66_L1.2011.00
36_P103_D1.1961.00
260_V263_A1.1961.00
30_V89_I1.1941.00
39_W60_D1.1891.00
246_K250_R1.1771.00
274_I278_L1.1751.00
252_C255_G1.1731.00
16_L84_D1.1661.00
124_I230_R1.1571.00
275_V279_I1.1551.00
223_S251_H1.1531.00
14_I62_R1.1521.00
88_L92_F1.1451.00
111_H114_S1.1271.00
21_A46_I1.1221.00
233_W245_A1.1221.00
232_I260_V1.1211.00
232_I278_L1.1161.00
242_R246_K1.1151.00
100_I126_I1.1101.00
48_P273_A1.1031.00
89_I112_L1.1021.00
110_W125_A1.0961.00
103_D265_H1.0841.00
48_P52_A1.0791.00
274_I277_Q1.0661.00
263_A267_I1.0571.00
123_L229_Y1.0381.00
27_P54_Y1.0341.00
247_E250_R1.0311.00
97_A120_L1.0301.00
39_W58_A1.0231.00
114_S221_K1.0221.00
233_W242_R1.0141.00
26_G55_R1.0091.00
57_I92_F1.0041.00
29_I54_Y1.0031.00
273_A277_Q1.0011.00
246_K259_F0.9981.00
50_V56_V0.9971.00
28_L54_Y0.9881.00
30_V85_I0.9871.00
44_N47_K0.9871.00
102_H266_W0.9841.00
263_A270_E0.9831.00
22_G26_G0.9821.00
50_V53_G0.9771.00
79_D111_H0.9721.00
82_R108_V0.9711.00
86_I115_T0.9651.00
34_G103_D0.9501.00
256_H278_L0.9501.00
54_Y283_L0.9471.00
32_L59_P0.9471.00
32_L99_V0.9461.00
249_E257_L0.9421.00
187_S191_S0.9341.00
233_W257_L0.9321.00
43_K58_A0.9301.00
97_A119_Y0.9271.00
18_V92_F0.9191.00
233_W259_F0.9151.00
246_K257_L0.9151.00
204_T208_N0.9141.00
86_I89_I0.9091.00
29_I100_I0.9091.00
260_V271_K0.9081.00
260_V274_I0.9061.00
27_P96_K0.9051.00
100_I279_I0.9041.00
264_S270_E0.9041.00
30_V97_A0.9031.00
122_K228_P0.9011.00
258_I281_E0.8901.00
29_I56_V0.8901.00
230_R256_H0.8861.00
41_G268_N0.8771.00
243_K246_K0.8731.00
99_V112_L0.8711.00
27_P122_K0.8691.00
93_T96_K0.8521.00
61_Q104_W0.8491.00
111_H221_K0.8491.00
47_K50_V0.8451.00
82_R115_T0.8441.00
126_I268_N0.8431.00
101_G106_G0.8411.00
191_S195_E0.8321.00
87_G91_Q0.8311.00
101_G109_A0.8301.00
33_H59_P0.8281.00
14_I68_D0.8281.00
113_A120_L0.8231.00
192_R195_E0.8221.00
246_K249_E0.8221.00
245_A257_L0.8181.00
36_P104_W0.8141.00
20_A24_E0.8111.00
24_E55_R0.8061.00
75_S80_T0.8021.00
262_E271_K0.7951.00
206_M209_W0.7901.00
83_D86_I0.7901.00
87_G90_T0.7901.00
21_A50_V0.7861.00
28_L97_A0.7841.00
80_T83_D0.7821.00
83_D87_G0.7791.00
232_I275_V0.7781.00
39_W59_P0.7771.00
258_I274_I0.7761.00
57_I94_D0.7711.00
31_L42_W0.7711.00
196_A200_P0.7681.00
209_W212_A0.7651.00
231_M255_G0.7631.00
60_D66_L0.7611.00
101_G105_G0.7601.00
236_E262_E0.7581.00
191_S194_K0.7541.00
25_D55_R0.7521.00
124_I283_L0.7481.00
193_Y196_A0.7421.00
126_I267_I0.7411.00
208_N211_R0.7391.00
30_V99_V0.7351.00
81_L104_W0.7331.00
192_R196_A0.7331.00
234_G267_I0.7311.00
61_Q64_Y0.7311.00
100_I124_I0.7281.00
82_R112_L0.7271.00
122_K282_Y0.7201.00
46_I50_V0.7191.00
120_L227_V0.7191.00
61_Q81_L0.7161.00
194_K198_K0.7161.00
122_K283_L0.7151.00
172_L175_A0.7151.00
169_Y173_D0.7141.00
127_N233_W0.7141.00
195_E199_Q0.7131.00
46_I56_V0.7131.00
170_D173_D0.7121.00
140_L143_P0.7121.00
99_V120_L0.7121.00
155_Q158_D0.7101.00
95_E119_Y0.7081.00
256_H281_E0.7061.00
40_Y43_K0.7051.00
127_N267_I0.7041.00
61_Q85_I0.6991.00
168_D171_T0.6981.00
12_N80_T0.6921.00
171_T175_A0.6901.00
203_L206_M0.6901.00
167_N170_D0.6891.00
16_L62_R0.6861.00
35_F104_W0.6851.00
54_Y280_L0.6841.00
19_A43_K0.6761.00
127_N234_G0.6751.00
45_Q48_P0.6711.00
152_A155_Q0.6711.00
55_R94_D0.6711.00
83_D116_R0.6691.00
235_M242_R0.6651.00
208_N212_A0.6641.00
276_N280_L0.6621.00
151_I154_F0.6561.00
102_H127_N0.6541.00
88_L91_Q0.6531.00
218_L221_K0.6521.00
152_A156_L0.6511.00
29_I49_L0.6501.00
62_R81_L0.6491.00
183_A186_T0.6491.00
220_E223_S0.6481.00
42_W46_I0.6451.00
45_Q275_V0.6441.00
113_A227_V0.6421.00
31_L49_L0.6411.00
22_G25_D0.6401.00
154_F158_D0.6381.00
31_L58_A0.6371.00
29_I98_I0.6311.00
125_A231_M0.6311.00
43_K47_K0.6311.00
102_H126_I0.6301.00
231_M257_L0.6241.00
196_A199_Q0.6241.00
97_A112_L0.6211.00
110_W130_H0.6201.00
225_E252_C0.6191.00
106_G125_A0.6131.00
114_S224_Y0.6121.00
29_I283_L0.6111.00
187_S190_V0.6111.00
85_I108_V0.6091.00
170_D174_K0.6091.00
261_D274_I0.6081.00
231_M252_C0.6031.00
103_D266_W0.6021.00
231_M249_E0.6011.00
42_W45_Q0.6011.00
277_Q280_L0.6001.00
110_W128_I0.6001.00
272_P276_N0.5991.00
89_I119_Y0.5991.00
70_P76_Y0.5981.00
38_F64_Y0.5981.00
232_I258_I0.5981.00
149_S153_Y0.5971.00
203_L207_L0.5961.00
189_D192_R0.5941.00
207_L211_R0.5901.00
207_L210_Y0.5891.00
107_A129_P0.5871.00
226_T253_P0.5871.00
231_M245_A0.5861.00
96_K119_Y0.5851.00
19_A40_Y0.5851.00
138_T141_Y0.5841.00
97_A121_E0.5821.00
79_D83_D0.5771.00
60_D67_S0.5761.00
53_G56_V0.5761.00
124_I232_I0.5751.00
115_T221_K0.5711.00
188_E192_R0.5701.00
41_G102_H0.5701.00
153_Y157_P0.5691.00
124_I282_Y0.5681.00
188_E191_S0.5661.00
205_A209_W0.5661.00
21_A47_K0.5621.00
167_N174_K0.5611.00
81_L108_V0.5581.00
19_A58_A0.5561.00
268_N275_V0.5551.00
32_L108_V0.5541.00
82_R86_I0.5501.00
78_I111_H0.5481.00
17_H67_S0.5471.00
233_W240_L0.5461.00
226_T254_N0.5431.00
279_I283_L0.5431.00
195_E198_K0.5431.00
149_S152_A0.5411.00
219_A247_E0.5411.00
21_A56_V0.5391.00
153_Y158_D0.5381.00
267_I275_V0.5381.00
168_D176_I0.5361.00
206_M210_Y0.5341.00
126_I232_I0.5331.00
45_Q268_N0.5321.00
151_I155_Q0.5311.00
167_N171_T0.5311.00
102_H267_I0.5311.00
116_R120_L0.5291.00
78_I104_W0.5281.00
152_A157_P0.5271.00
219_A251_H0.5251.00
150_Y154_F0.5251.00
236_E263_A0.5231.00
35_F64_Y0.5221.00
245_A249_E0.5201.00
236_E261_D0.5201.00
122_K230_R0.5181.00
12_N83_D0.5181.00
237_D265_H0.5141.00
69_K76_Y0.5141.00
139_P143_P0.5131.00
203_L210_Y0.5111.00
49_L56_V0.5101.00
205_A208_N0.5091.00
171_T174_K0.5081.00
96_K118_E0.5071.00
63_G76_Y0.5061.00
197_W200_P0.5051.00
150_Y157_P0.5051.00
20_A92_F0.5051.00
183_A187_S0.5051.00
150_Y158_D0.5031.00
33_H42_W0.5031.00
138_T142_P0.5021.00
104_W108_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4inzA 1 0.9685 100 0.107 Contact Map
1ehyA 1 0.9336 100 0.123 Contact Map
3oosA 1 0.9476 100 0.158 Contact Map
4psuA 1 0.9476 100 0.168 Contact Map
3om8A 4 0.9196 100 0.173 Contact Map
2pujA 4 0.9441 100 0.178 Contact Map
2xuaA 2 0.9056 100 0.179 Contact Map
3r40A 2 0.9615 100 0.18 Contact Map
2wueA 4 0.9476 100 0.182 Contact Map
5bovA 2 0.9965 100 0.182 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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