GREMLIN Database
YFHL - Uncharacterized protein YfhL
UniProt: O31580 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (99)
Sequences: 206 (174)
Seq/√Len: 17.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_E94_R6.1291.00
40_Q44_N4.0481.00
14_G58_G3.3971.00
17_I47_N2.1280.90
7_G54_M2.0290.88
13_A29_Y1.9650.87
42_L99_T1.8820.84
65_G90_L1.8490.83
18_K21_P1.7940.81
78_I88_F1.7750.80
40_Q47_N1.7560.79
50_S54_M1.7490.79
55_I59_L1.6950.77
39_D42_L1.6830.76
78_I97_I1.6730.76
35_R95_L1.6490.75
11_I58_G1.6360.74
22_P25_I1.6290.74
93_K97_I1.6130.73
73_F91_T1.5480.70
8_G64_M1.5130.68
49_Y52_S1.5110.68
13_A17_I1.4870.67
12_I56_L1.4870.67
38_S42_L1.4160.63
47_N54_M1.4110.63
51_A54_M1.4050.62
7_G87_T1.4050.62
42_L95_L1.3880.61
55_I85_V1.3470.59
21_P29_Y1.3260.58
27_S41_R1.3230.57
42_L100_H1.2170.51
7_G80_L1.2060.50
34_R61_I1.2000.50
5_V9_L1.1850.49
53_L95_L1.1820.49
85_V89_M1.1530.47
49_Y91_T1.1390.46
12_I83_A1.1350.46
41_R52_S1.1300.46
34_R101_S1.1180.45
38_S82_A1.1100.45
17_I92_E1.0950.44
14_G64_M1.0640.42
57_S91_T1.0600.42
4_L9_L1.0460.41
39_D53_L1.0450.41
17_I29_Y0.9760.37
28_V41_R0.9600.36
14_G55_I0.9570.36
69_G77_L0.9480.35
35_R102_Q0.9460.35
73_F77_L0.9400.35
28_V34_R0.9380.35
25_I67_L0.9360.35
22_P29_Y0.9340.34
91_T94_R0.9280.34
27_S68_L0.9280.34
15_I20_F0.9000.33
45_E49_Y0.8870.32
33_T43_W0.8800.32
7_G51_A0.8790.32
10_M87_T0.8770.31
84_C87_T0.8700.31
12_I16_L0.8390.29
13_A63_G0.8300.29
94_R98_M0.8280.29
45_E98_M0.8270.29
44_N47_N0.8270.29
59_L79_L0.8270.29
8_G96_K0.8210.29
9_L40_Q0.8150.28
8_G60_V0.8110.28
72_L86_I0.8070.28
16_L29_Y0.8000.28
35_R101_S0.7960.27
47_N69_G0.7860.27
64_M75_L0.7740.26
59_L101_S0.7660.26
55_I60_V0.7640.26
62_A96_K0.7630.26
45_E52_S0.7560.25
54_M80_L0.7550.25
11_I53_L0.7510.25
43_W58_G0.7500.25
68_L100_H0.7450.25
40_Q68_L0.7420.25
20_F66_L0.7350.25
49_Y94_R0.7150.24
18_K63_G0.7020.23
49_Y57_S0.6960.23
37_M58_G0.6920.23
12_I67_L0.6900.23
56_L93_K0.6890.23
41_R98_M0.6800.22
16_L102_Q0.6770.22
7_G58_G0.6750.22
13_A100_H0.6730.22
36_S78_I0.6630.21
5_V34_R0.6610.21
23_K96_K0.6600.21
40_Q63_G0.6550.21
71_N74_I0.6490.21
31_Y39_D0.6410.21
38_S102_Q0.6400.21
31_Y92_E0.6240.20
26_N49_Y0.6240.20
62_A98_M0.6230.20
78_I81_I0.6070.19
26_N32_R0.6010.19
37_M89_M0.6000.19
87_T91_T0.5940.19
46_A92_E0.5880.19
16_L74_I0.5870.18
65_G81_I0.5860.18
54_M58_G0.5840.18
8_G69_G0.5790.18
34_R44_N0.5760.18
89_M93_K0.5700.18
40_Q100_H0.5700.18
28_V78_I0.5680.18
16_L60_V0.5670.18
78_I101_S0.5630.18
63_G66_L0.5540.17
63_G102_Q0.5490.17
6_G84_C0.5440.17
60_V76_Q0.5410.17
36_S85_V0.5360.17
50_S68_L0.5360.17
7_G65_G0.5360.17
17_I64_M0.5340.17
21_P98_M0.5340.17
35_R42_L0.5320.17
51_A83_A0.5320.17
49_Y84_C0.5240.16
45_E90_L0.5240.16
39_D68_L0.5230.16
19_L52_S0.5220.16
76_Q95_L0.5220.16
41_R99_T0.5170.16
92_E95_L0.5160.16
9_L16_L0.5080.16
9_L66_L0.5060.16
61_I74_I0.5060.16
72_L102_Q0.5050.16
11_I15_I0.5010.16
71_N82_A0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6yA 2 0.7182 29.6 0.926 Contact Map
4a2nB 1 0.9545 12 0.939 Contact Map
3htsB 2 0.4182 9.7 0.941 Contact Map
4quvA 2 0.9455 5.6 0.947 Contact Map
2xq2A 2 0.8 5.1 0.948 Contact Map
4jmpA 1 0.2 4.8 0.949 Contact Map
4zr1A 1 0.9182 3.8 0.951 Contact Map
3mk7C 2 0.3909 2.7 0.955 Contact Map
3j09A 2 0.7091 2.5 0.956 Contact Map
2y69D 1 0.4 2.3 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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