GREMLIN Database
YFHK - Uncharacterized protein YfhK
UniProt: O31579 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (139)
Sequences: 365 (325)
Seq/√Len: 27.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_E62_G4.9841.00
59_N62_G4.3281.00
68_V74_V3.9791.00
157_Y166_T2.8821.00
154_F159_G2.7101.00
157_Y160_V2.6050.99
53_N67_T2.5000.99
147_G150_F2.4440.99
156_D159_G2.2340.98
86_Q93_K2.2200.98
74_V87_I2.1910.98
142_F145_N2.1790.98
155_V160_V2.1660.98
160_V166_T2.1260.97
52_L100_F2.0710.97
148_F157_Y1.9040.95
147_G151_T1.7380.92
85_A98_T1.6370.89
66_G89_F1.6100.88
147_G152_W1.5720.87
153_A162_G1.5690.87
37_V110_T1.5640.87
134_E138_L1.5390.86
163_Y167_K1.5180.85
147_G153_A1.4780.84
76_V101_L1.4470.82
148_F151_T1.4450.82
155_V165_H1.4410.82
47_I52_L1.4390.82
87_I94_A1.4340.82
56_T63_D1.4070.81
140_W154_F1.3860.80
143_S148_F1.3850.79
76_V85_A1.3810.79
111_T119_P1.3670.79
31_P35_I1.3130.76
144_E156_D1.2960.75
85_A101_L1.2890.74
148_F160_V1.2890.74
157_Y163_Y1.2870.74
140_W170_Q1.2800.74
165_H169_L1.2750.73
124_G128_Q1.2660.73
144_E148_F1.2420.71
149_D153_A1.2410.71
45_Y76_V1.2310.71
150_F157_Y1.2240.70
155_V159_G1.1860.68
135_V139_G1.1530.66
147_G161_K1.1310.64
152_W161_K1.1310.64
57_E95_Y1.1300.64
123_N129_L1.1060.62
41_S118_T1.1040.62
150_F161_K1.1010.62
149_D166_T1.0980.62
49_A52_L1.0960.62
77_D169_L1.0900.61
150_F153_A1.0850.61
166_T169_L1.0670.59
83_D98_T1.0640.59
139_G142_F1.0640.59
124_G127_K1.0580.59
46_I64_I1.0480.58
157_Y165_H1.0370.57
95_Y98_T1.0360.57
148_F163_Y1.0240.56
148_F156_D1.0230.56
65_L70_S1.0080.55
74_V101_L1.0010.55
143_S151_T0.9940.54
45_Y85_A0.9890.54
151_T154_F0.9760.53
137_I147_G0.9700.52
140_W151_T0.9600.51
151_T157_Y0.9580.51
134_E143_S0.9550.51
151_T162_G0.9510.51
147_G154_F0.9440.50
152_W155_V0.9400.50
125_K129_L0.9380.50
31_P34_D0.9290.49
34_D59_N0.9010.47
89_F101_L0.8980.47
127_K131_S0.8870.46
149_D160_V0.8840.46
152_W159_G0.8780.45
149_D164_I0.8740.45
144_E163_Y0.8730.45
150_F163_Y0.8730.45
143_S149_D0.8710.45
96_I101_L0.8620.44
96_I99_H0.8600.44
149_D152_W0.8570.44
147_G157_Y0.8540.43
50_G70_S0.8530.43
141_G156_D0.8520.43
152_W165_H0.8430.43
30_A37_V0.8400.42
134_E141_G0.8320.42
161_K167_K0.8320.42
63_D74_V0.8240.41
148_F166_T0.8220.41
154_F162_G0.8180.41
149_D161_K0.8180.41
144_E160_V0.8090.40
145_N148_F0.8020.40
140_W147_G0.7880.39
67_T103_K0.7860.38
54_V89_F0.7800.38
47_I76_V0.7780.38
155_V163_Y0.7710.37
76_V103_K0.7680.37
129_L132_G0.7600.37
83_D99_H0.7510.36
124_G130_S0.7460.36
144_E147_G0.7460.36
138_L145_N0.7310.35
144_E150_F0.7300.34
128_Q131_S0.7280.34
144_E157_Y0.7230.34
52_L83_D0.7180.34
130_S133_T0.7150.33
147_G163_Y0.7140.33
140_W163_Y0.7130.33
123_N126_A0.7120.33
161_K164_I0.7080.33
151_T161_K0.7070.33
117_Y127_K0.7040.33
116_F119_P0.7020.33
68_V102_M0.7000.32
71_E91_G0.7000.32
43_D71_E0.6990.32
153_A159_G0.6980.32
134_E168_D0.6930.32
150_F159_G0.6910.32
137_I151_T0.6890.32
137_I152_W0.6880.32
65_L94_A0.6820.31
151_T155_V0.6780.31
160_V163_Y0.6760.31
54_V98_T0.6740.31
157_Y161_K0.6680.30
68_V85_A0.6670.30
87_I92_K0.6660.30
153_A161_K0.6640.30
140_W144_E0.6570.30
50_G69_S0.6540.29
53_N63_D0.6530.29
160_V165_H0.6420.29
60_H125_K0.6400.29
142_F170_Q0.6350.28
33_H37_V0.6320.28
52_L97_S0.6310.28
48_K102_M0.6310.28
66_G74_V0.6290.28
91_G116_F0.6280.28
42_S91_G0.6240.28
143_S156_D0.6230.28
55_R64_I0.6230.28
140_W148_F0.6130.27
117_Y120_T0.6080.27
115_A118_T0.6040.26
149_D154_F0.6030.26
86_Q95_Y0.6020.26
54_V66_G0.6000.26
163_Y166_T0.5910.26
98_T114_T0.5880.25
157_Y167_K0.5860.25
164_I167_K0.5840.25
59_N75_K0.5820.25
134_E139_G0.5780.25
123_N133_T0.5780.25
83_D167_K0.5750.25
78_R86_Q0.5740.25
77_D138_L0.5730.25
143_S147_G0.5710.24
41_S94_A0.5680.24
150_F154_F0.5680.24
145_N151_T0.5630.24
148_F155_V0.5610.24
105_A113_Q0.5500.23
50_G83_D0.5460.23
41_S45_Y0.5430.23
66_G90_K0.5410.23
128_Q132_G0.5400.23
56_T86_Q0.5400.23
106_S121_P0.5390.23
39_M42_S0.5350.23
145_N149_D0.5330.22
157_Y162_G0.5300.22
140_W156_D0.5290.22
89_F136_T0.5260.22
89_F92_K0.5260.22
113_Q117_Y0.5240.22
149_D157_Y0.5200.22
35_I39_M0.5180.22
152_W170_Q0.5170.22
36_S41_S0.5170.22
91_G94_A0.5140.21
34_D170_Q0.5140.21
51_K69_S0.5130.21
56_T62_G0.5090.21
145_N153_A0.5080.21
67_T131_S0.5040.21
148_F154_F0.5040.21
162_G166_T0.5040.21
46_I125_K0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3npfA 2 0.7965 99.7 0.555 Contact Map
3h41A 1 0.9302 99.6 0.59 Contact Map
3m1uA 2 0.9767 99.4 0.647 Contact Map
2kt8A 1 0.436 99.4 0.65 Contact Map
2hbwA 1 0.6919 99.4 0.65 Contact Map
2kq8A 1 0.407 99.4 0.654 Contact Map
2krsA 1 0.4244 99.3 0.664 Contact Map
4krtA 1 0.593 98.9 0.721 Contact Map
4q4gX 1 0.5988 97.5 0.805 Contact Map
4xcmA 2 0.7326 97.3 0.813 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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