GREMLIN Database
YFHJ - Uncharacterized protein YfhJ
UniProt: O31578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 89 (84)
Sequences: 103 (83)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_L57_T3.2810.94
55_I59_W2.6630.84
70_F81_L2.6200.83
11_L61_E2.5540.82
6_E21_Y2.4270.78
72_S81_L2.4130.78
37_A49_E2.3290.75
5_I49_E2.1370.68
30_L75_N2.1130.67
23_Q67_L2.1120.67
38_T55_I1.9940.63
71_Q81_L1.8820.58
58_Q62_N1.7010.50
6_E10_N1.5600.44
47_Q51_M1.5460.43
63_Y70_F1.5440.43
28_V56_V1.5170.42
5_I33_S1.4970.41
35_F48_G1.4580.40
14_E59_W1.3350.35
2_N5_I1.3250.34
32_W52_T1.2880.33
2_N13_L1.2550.32
36_E42_A1.2540.31
58_Q70_F1.2370.31
23_Q84_S1.2340.31
69_L76_D1.2130.30
62_N72_S1.2120.30
71_Q78_N1.1830.29
54_K58_Q1.1710.28
33_S56_V1.1610.28
39_Y69_L1.1230.27
5_I25_K1.1210.27
32_W46_Y1.1210.27
2_N83_Q1.1200.27
2_N82_N1.1060.26
10_N72_S1.0970.26
36_E58_Q1.0950.26
15_K75_N1.0880.26
57_T77_V1.0780.25
33_S49_E1.0760.25
15_K61_E1.0590.25
23_Q45_A1.0480.24
69_L75_N1.0160.23
36_E81_L0.9870.22
13_L22_I0.9750.22
3_M7_K0.9700.22
47_Q50_K0.9660.22
9_T13_L0.9570.21
77_V81_L0.9550.21
3_M17_E0.9480.21
50_K57_T0.9260.21
23_Q39_Y0.9260.21
39_Y51_M0.9230.20
3_M6_E0.9180.20
52_T55_I0.8980.20
75_N81_L0.8810.19
36_E63_Y0.8730.19
10_N13_L0.8520.19
66_Q84_S0.8350.18
80_Y84_S0.8330.18
38_T44_H0.8290.18
7_K19_I0.8080.17
13_L20_S0.8060.17
4_Y65_G0.8060.17
56_V67_L0.8040.17
14_E69_L0.7890.17
3_M20_S0.7840.17
7_K84_S0.7810.17
41_K84_S0.7780.17
54_K70_F0.7740.17
74_R77_V0.7730.17
26_T54_K0.7710.17
17_E44_H0.7620.16
37_A60_I0.7620.16
44_H50_K0.7520.16
26_T63_Y0.7440.16
16_N56_V0.7340.16
30_L77_V0.7230.15
17_E66_Q0.7190.15
54_K57_T0.7150.15
19_I65_G0.7040.15
32_W38_T0.6990.15
38_T52_T0.6930.15
28_V50_K0.6800.14
31_L41_K0.6700.14
31_L35_F0.6590.14
69_L77_V0.6530.14
22_I73_S0.6460.14
52_T59_W0.6440.14
71_Q79_D0.6380.14
9_T28_V0.6350.13
2_N10_N0.6300.13
13_L55_I0.6270.13
3_M10_N0.6260.13
10_N82_N0.6230.13
6_E25_K0.6220.13
9_T50_K0.6140.13
15_K30_L0.6080.13
20_S25_K0.5960.13
16_N19_I0.5950.13
58_Q81_L0.5940.13
62_N83_Q0.5940.13
18_M54_K0.5900.13
18_M50_K0.5870.13
47_Q55_I0.5820.12
1_M68_H0.5770.12
18_M62_N0.5730.12
56_V72_S0.5710.12
11_L51_M0.5690.12
53_E59_W0.5670.12
57_T75_N0.5620.12
20_S78_N0.5600.12
9_T18_M0.5520.12
44_H80_Y0.5520.12
59_W63_Y0.5470.12
29_E41_K0.5340.12
44_H59_W0.5310.12
22_I66_Q0.5210.11
23_Q55_I0.5180.11
35_F38_T0.5160.11
9_T25_K0.5150.11
20_S53_E0.5100.11
42_A63_Y0.5070.11
4_Y51_M0.5040.11
4_Y45_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qtlA 1 0.4719 15.8 0.935 Contact Map
3qe2A 1 0.4831 15.5 0.935 Contact Map
3qfsA 1 0.4719 13.8 0.937 Contact Map
1ddgA 1 0.4719 12.1 0.938 Contact Map
2bpoA 1 0.4719 12.1 0.939 Contact Map
4c4pB 1 0.3034 10.1 0.941 Contact Map
1f20A 1 0.4944 7.3 0.944 Contact Map
1uj8A 1 0.618 6.8 0.945 Contact Map
4lixA 1 0.8427 6.5 0.945 Contact Map
3tsoC 2 0.2921 6.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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