GREMLIN Database
YFHH - Uncharacterized protein YfhH
UniProt: O31576 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 104 (99)
Sequences: 175 (123)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_A98_S5.0081.00
56_Y73_I4.8161.00
52_N55_D3.5690.99
10_P14_N3.5610.99
16_E20_L2.3820.87
51_L56_Y2.0330.77
51_L97_I1.9280.73
44_T99_V1.8790.71
17_I34_N1.8650.70
51_L55_D1.8530.70
21_S25_R1.8390.69
53_P97_I1.8210.68
48_A76_L1.7840.67
64_V95_L1.7130.64
39_L99_V1.7030.63
5_Y20_L1.6470.60
73_I81_A1.5880.57
21_S43_I1.4940.53
85_R93_E1.4810.52
34_N38_V1.4430.50
10_P48_A1.3530.46
2_E59_G1.3390.45
5_Y42_K1.3190.44
70_E86_T1.2990.43
3_K12_E1.2960.43
40_E97_I1.2650.41
11_H14_N1.2620.41
23_K39_L1.2370.40
40_E98_S1.2200.39
23_K72_T1.2050.38
12_E25_R1.2020.38
5_Y16_E1.1940.38
70_E88_S1.1930.38
55_D98_S1.1810.37
23_K85_R1.1570.36
61_T88_S1.1340.35
36_L84_Y1.1180.34
25_R39_L1.1090.34
7_Q18_A1.0790.32
32_I38_V1.0760.32
63_R79_V1.0710.32
36_L73_I1.0600.32
73_I80_F1.0550.31
61_T72_T1.0520.31
21_S47_K1.0470.31
57_S60_E1.0380.31
63_R77_N1.0360.30
74_S87_S1.0180.30
19_L54_E1.0150.30
3_K56_Y0.9830.28
3_K8_M0.9670.28
43_I50_L0.9670.28
3_K10_P0.9650.28
87_S90_Q0.9600.27
26_K31_G0.9570.27
7_Q10_P0.9550.27
67_T99_V0.9320.26
43_I47_K0.9240.26
14_N60_E0.9180.26
18_A73_I0.9170.26
33_I68_E0.9090.25
4_R33_I0.9080.25
3_K7_Q0.9070.25
39_L70_E0.9070.25
15_T19_L0.8850.24
61_T70_E0.8800.24
65_E101_Q0.8640.24
40_E48_A0.8600.23
4_R99_V0.8590.23
61_T74_S0.8480.23
64_V85_R0.8470.23
15_T68_E0.8420.23
42_K95_L0.8380.23
21_S32_I0.8300.22
47_K64_V0.8240.22
11_H50_L0.8170.22
36_L92_E0.7980.21
26_K35_E0.7910.21
47_K65_E0.7820.21
61_T91_Q0.7820.21
31_G80_F0.7610.20
47_K77_N0.7530.20
7_Q86_T0.7500.20
22_E28_E0.7390.19
2_E12_E0.7330.19
7_Q12_E0.7310.19
48_A97_I0.7230.19
22_E36_L0.7180.19
11_H101_Q0.7070.18
30_H99_V0.7070.18
61_T86_T0.7050.18
61_T90_Q0.6930.18
52_N87_S0.6920.18
40_E53_P0.6910.18
30_H79_V0.6810.18
24_A45_M0.6760.17
28_E41_R0.6720.17
21_S51_L0.6680.17
27_A98_S0.6640.17
63_R68_E0.6630.17
54_E57_S0.6470.17
45_M48_A0.6460.17
6_S53_P0.6460.17
6_S56_Y0.6390.16
66_N69_D0.6390.16
24_A80_F0.6360.16
5_Y9_T0.6340.16
72_T86_T0.6310.16
6_S71_F0.6230.16
24_A29_Q0.6200.16
23_K84_Y0.6130.16
72_T79_V0.6120.16
44_T47_K0.6100.16
43_I88_S0.6090.16
58_P65_E0.6060.15
75_Y80_F0.6060.15
77_N98_S0.6060.15
8_M77_N0.5930.15
19_L87_S0.5860.15
45_M80_F0.5820.15
4_R49_Y0.5800.15
4_R77_N0.5790.15
44_T101_Q0.5730.15
86_T90_Q0.5730.15
18_A26_K0.5680.14
27_A85_R0.5620.14
26_K29_Q0.5570.14
39_L69_D0.5560.14
10_P38_V0.5510.14
14_N44_T0.5470.14
67_T84_Y0.5460.14
86_T92_E0.5440.14
38_V50_L0.5380.14
5_Y33_I0.5360.14
32_I76_L0.5340.14
57_S73_I0.5300.14
43_I70_E0.5300.14
61_T101_Q0.5290.13
3_K51_L0.5270.13
13_L54_E0.5150.13
58_P76_L0.5150.13
84_Y92_E0.5150.13
42_K66_N0.5120.13
53_P71_F0.5030.13
29_Q41_R0.5030.13
37_A40_E0.5020.13
8_M88_S0.5010.13
22_E98_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sf9A 1 1 100 0.051 Contact Map
2yxyA 1 0.9904 100 0.064 Contact Map
2p4vA 1 0.9712 45.9 0.925 Contact Map
1e52A 2 0.5192 37.5 0.929 Contact Map
2d7dA 2 0.3654 30.7 0.932 Contact Map
1grjA 1 0.9423 20.8 0.937 Contact Map
2f23A 1 0.9423 12.7 0.943 Contact Map
3mq7A 6 0.4423 9.3 0.947 Contact Map
4bpe4 1 0.4808 8.8 0.947 Contact Map
4qccA 6 0.2019 7.3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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