GREMLIN Database
RECX - Regulatory protein RecX
UniProt: O31575 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (208)
Sequences: 843 (727)
Seq/√Len: 50.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_T102_N5.9671.00
25_Y28_S4.0891.00
78_K82_D3.9951.00
73_R112_F3.4271.00
105_K108_N3.0081.00
110_Q147_E2.9991.00
76_S112_F2.9181.00
81_E95_A2.8121.00
10_Q18_N2.7191.00
77_T81_E2.3791.00
46_D49_D2.3241.00
65_R87_K2.3181.00
108_N111_E2.2921.00
4_I39_L2.2861.00
62_G97_V2.2621.00
45_L50_I2.1961.00
181_K185_Q2.1751.00
93_V97_V2.0891.00
161_A165_V2.0721.00
17_F31_A2.0411.00
43_K49_D2.0371.00
65_R83_H1.9841.00
128_P157_Q1.9731.00
76_S140_I1.9060.99
168_L187_Q1.8600.99
161_A197_V1.8590.99
10_Q28_S1.8220.99
77_T107_L1.7600.99
10_Q25_Y1.7350.99
18_N28_S1.7250.99
129_D132_F1.7150.99
162_V201_A1.6980.98
114_A151_S1.6810.98
136_R142_D1.6610.98
161_A201_A1.6520.98
37_F56_G1.6480.98
18_N25_Y1.6030.98
113_A140_I1.6010.98
62_G89_T1.5960.98
63_F100_R1.5580.97
111_E114_A1.5470.97
113_A117_V1.5210.97
158_T200_A1.5100.97
162_V204_Q1.4970.97
126_K130_V1.4930.97
19_I27_F1.4870.96
29_V34_L1.4710.96
58_E90_S1.4700.96
117_V148_A1.4590.96
134_E137_A1.4400.96
158_T201_A1.4390.96
116_Y120_H1.4320.96
10_Q16_R1.4260.96
30_D60_K1.4200.95
186_L190_R1.4180.95
80_V101_L1.4140.95
69_F83_H1.4140.95
32_D35_V1.4010.95
37_F53_I1.4010.95
165_V205_I1.3960.95
20_F25_Y1.3800.95
40_K43_K1.3790.95
5_T22_D1.3390.94
59_V96_E1.3350.94
102_N107_L1.3330.94
8_S20_F1.3260.93
16_R20_F1.3060.93
16_R28_S1.3060.93
168_L171_K1.3030.93
187_Q191_K1.2970.93
130_V134_E1.2960.93
119_T123_T1.2700.92
178_K181_K1.2590.91
82_D86_K1.2430.91
77_T98_I1.2250.90
162_V166_E1.1830.89
69_F75_R1.1770.88
182_Q186_L1.1700.88
47_D51_I1.1520.87
72_Y75_R1.1490.87
73_R79_E1.1310.86
17_F34_L1.1300.86
198_I202_M1.1050.85
132_F136_R1.0960.85
185_Q198_I1.0910.84
16_R25_Y1.0890.84
172_D184_A1.0790.84
91_P95_A1.0710.83
3_F44_E1.0600.82
5_T21_L1.0590.82
19_I29_V1.0560.82
98_I102_N1.0530.82
189_Q198_I1.0420.81
144_T148_A1.0310.81
70_L80_V1.0290.81
63_F104_Y1.0280.81
125_G163_K1.0280.81
119_T140_I0.9950.78
66_A97_V0.9770.77
69_F80_V0.9770.77
113_A148_A0.9770.77
178_K182_Q0.9760.77
10_Q20_F0.9740.77
117_V131_L0.9680.76
27_F50_I0.9630.76
81_E94_I0.9600.76
75_R79_E0.9550.75
113_A144_T0.9480.75
126_K134_E0.9390.74
93_V96_E0.9290.73
31_A35_V0.9230.73
51_I105_K0.9190.73
182_Q185_Q0.9160.72
21_L45_L0.9160.72
63_F101_L0.9070.72
121_K156_D0.9060.71
73_R76_S0.9030.71
175_L179_E0.9000.71
165_V170_K0.8970.71
99_H103_D0.8920.70
33_V37_F0.8860.70
33_V56_G0.8830.69
100_R104_Y0.8780.69
16_R57_D0.8720.68
5_T23_D0.8710.68
74_M115_A0.8690.68
57_D61_K0.8670.68
20_F26_A0.8670.68
110_Q148_A0.8640.68
74_M116_Y0.8620.68
33_V57_D0.8620.68
112_F138_K0.8590.67
194_S197_V0.8580.67
13_N25_Y0.8580.67
74_M111_E0.8580.67
185_Q199_S0.8560.67
110_Q114_A0.8500.66
27_F57_D0.8480.66
156_D159_R0.8430.66
147_E196_D0.8360.65
132_F146_K0.8350.65
153_S156_D0.8310.65
83_H86_K0.8280.64
55_Y93_V0.8240.64
7_I19_I0.8190.64
76_S139_G0.8110.63
145_I149_L0.8110.63
93_V106_Y0.8050.62
63_F67_L0.7960.61
140_I144_T0.7950.61
59_V97_V0.7940.61
158_T162_V0.7930.61
165_V201_A0.7910.61
189_Q195_F0.7800.60
94_I98_I0.7760.59
116_Y131_L0.7750.59
85_K94_I0.7740.59
21_L26_A0.7710.59
135_L140_I0.7680.59
136_R145_I0.7620.58
9_T17_F0.7610.58
116_Y135_L0.7590.58
96_E99_H0.7570.58
15_E31_A0.7520.57
80_V97_V0.7470.56
110_Q144_T0.7430.56
76_S116_Y0.7420.56
121_K148_A0.7400.56
109_D138_K0.7380.56
7_I40_K0.7350.55
29_V39_L0.7340.55
76_S134_E0.7320.55
75_R83_H0.7320.55
53_I93_V0.7300.55
18_N26_A0.7240.54
200_A203_D0.7240.54
66_A70_L0.7180.54
5_T25_Y0.7170.53
60_K193_F0.7110.53
143_D146_K0.7110.53
67_L106_Y0.7100.53
80_V106_Y0.7070.52
29_V41_K0.7040.52
55_Y106_Y0.7030.52
17_F35_V0.7030.52
74_M119_T0.7020.52
80_V178_K0.6970.51
51_I54_Q0.6960.51
72_Y83_H0.6960.51
81_E98_I0.6950.51
158_T197_V0.6940.51
65_R69_F0.6930.51
169_L184_A0.6890.51
78_K139_G0.6860.50
124_N193_F0.6840.50
154_F200_A0.6820.50
62_G93_V0.6820.50
58_E61_K0.6750.49
118_S151_S0.6740.49
53_I138_K0.6720.49
4_I97_V0.6680.48
6_K53_I0.6640.48
160_E193_F0.6620.48
73_R134_E0.6580.47
168_L172_D0.6560.47
20_F28_S0.6550.47
85_K96_E0.6520.47
37_F175_L0.6480.46
145_I159_R0.6470.46
35_V63_F0.6450.46
6_K20_F0.6410.46
201_A204_Q0.6380.45
28_S57_D0.6380.45
31_A107_L0.6360.45
83_H89_T0.6360.45
83_H184_A0.6350.45
120_H125_G0.6350.45
21_L27_F0.6310.45
86_K196_D0.6290.44
52_E56_G0.6280.44
120_H124_N0.6260.44
101_L109_D0.6250.44
36_K56_G0.6240.44
67_L101_L0.6230.44
34_L41_K0.6210.44
5_T20_F0.6210.44
23_D26_A0.6200.43
83_H87_K0.6170.43
168_L184_A0.6170.43
6_K19_I0.6160.43
115_A118_S0.6130.43
127_G130_V0.6120.43
67_L100_R0.6090.42
31_A34_L0.6090.42
41_K183_R0.6080.42
121_K131_L0.6070.42
142_D193_F0.6060.42
71_S106_Y0.6050.42
18_N27_F0.6040.42
158_T204_Q0.6030.42
48_L92_P0.5980.41
11_K18_N0.5970.41
157_Q197_V0.5940.41
55_Y58_E0.5900.40
81_E199_S0.5890.40
195_F199_S0.5880.40
91_P189_Q0.5870.40
155_E207_Y0.5860.40
15_E40_K0.5860.40
179_E182_Q0.5850.40
139_G201_A0.5840.40
130_V191_K0.5820.40
95_A107_L0.5810.40
165_V184_A0.5740.39
201_A205_I0.5730.39
102_N136_R0.5710.39
44_E196_D0.5680.38
62_G178_K0.5660.38
94_I143_D0.5650.38
31_A40_K0.5650.38
19_I61_K0.5640.38
112_F116_Y0.5640.38
9_T14_T0.5590.37
70_L177_T0.5570.37
80_V83_H0.5570.37
169_L174_K0.5570.37
83_H131_L0.5550.37
136_R182_Q0.5550.37
73_R138_K0.5550.37
121_K160_E0.5520.37
75_R167_K0.5500.37
81_E85_K0.5500.37
146_K150_S0.5500.37
165_V168_L0.5490.36
11_K127_G0.5480.36
177_T181_K0.5480.36
184_A193_F0.5470.36
34_L39_L0.5450.36
105_K146_K0.5440.36
161_A202_M0.5430.36
115_A131_L0.5420.36
19_I25_Y0.5390.36
85_K91_P0.5370.35
143_D147_E0.5340.35
73_R181_K0.5330.35
30_D57_D0.5320.35
181_K203_D0.5320.35
120_H134_E0.5310.35
131_L189_Q0.5280.35
5_T26_A0.5260.34
45_L49_D0.5250.34
63_F193_F0.5250.34
35_V128_P0.5250.34
10_Q26_A0.5240.34
39_L184_A0.5240.34
152_F157_Q0.5240.34
117_V157_Q0.5230.34
5_T18_N0.5220.34
108_N121_K0.5210.34
66_A84_L0.5210.34
4_I40_K0.5210.34
57_D60_K0.5190.34
60_K106_Y0.5190.34
55_Y96_E0.5180.34
115_A119_T0.5120.33
10_Q13_N0.5090.33
141_D144_T0.5080.33
21_L24_K0.5050.32
67_L71_S0.5010.32
62_G180_L0.5000.32
46_D141_D0.5000.32
23_D99_H0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d5lA 1 0.7689 100 0.305 Contact Map
3e3vA 1 0.5833 100 0.471 Contact Map
3dfgA 1 0.5379 100 0.54 Contact Map
3c1dA 2 0.5455 100 0.545 Contact Map
4ejoA 2 0.428 80.4 0.936 Contact Map
3tgnA 2 0.553 78.8 0.937 Contact Map
4eqqA 2 0.3788 77.8 0.937 Contact Map
4l9nA 2 0.5152 77.8 0.937 Contact Map
2g9wA 2 0.4205 72.5 0.94 Contact Map
2frhA 2 0.4621 70.2 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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