GREMLIN Database
YFHF - Epimerase family protein YfhF
UniProt: O31574 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (281)
Sequences: 65402 (46076)
Seq/√Len: 2748.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
237_T290_E2.9541.00
8_G29_I2.9011.00
19_V206_Q2.5431.00
2_N26_H2.5101.00
86_S90_N2.4751.00
207_M223_V2.4201.00
219_G276_K2.3381.00
112_A208_I2.2961.00
63_V212_V2.2841.00
19_V209_R2.2291.00
55_E101_K2.1991.00
80_T83_H2.1211.00
19_V23_Q2.0961.00
30_L47_W2.0891.00
241_V294_S2.0821.00
108_T158_R2.0371.00
66_N111_Q1.9961.00
221_M279_T1.9761.00
232_K236_K1.9651.00
127_T130_S1.9611.00
206_Q285_T1.9491.00
240_R290_E1.9321.00
28_Y61_I1.9311.00
65_I212_V1.8941.00
93_R148_E1.8731.00
149_G159_T1.8691.00
50_E53_A1.8691.00
4_A61_I1.8681.00
237_T240_R1.8631.00
28_Y45_V1.8401.00
6_T66_N1.8371.00
2_N28_Y1.8291.00
28_Y43_T1.8281.00
164_F208_I1.7811.00
230_D233_Q1.7721.00
23_Q209_R1.7641.00
278_I283_R1.7361.00
26_H43_T1.7301.00
162_A211_A1.7271.00
47_W53_A1.7181.00
202_E295_Q1.7161.00
51_G97_R1.7011.00
143_H147_K1.6911.00
226_P278_I1.6911.00
55_E98_L1.6651.00
206_Q210_Y1.6611.00
5_M17_T1.6591.00
93_R97_R1.6101.00
85_L144_L1.5921.00
209_R213_E1.5831.00
168_L292_A1.5791.00
90_N93_R1.5651.00
62_D107_K1.5421.00
274_P278_I1.5241.00
92_T145_W1.5211.00
3_I25_H1.5211.00
23_Q213_E1.5201.00
51_G55_E1.5131.00
16_L65_I1.5071.00
49_S86_S1.4991.00
200_H295_Q1.4981.00
210_Y214_N1.4911.00
179_L183_F1.4821.00
19_V22_R1.4671.00
237_T241_V1.4611.00
16_L67_L1.4551.00
108_T160_V1.4431.00
82_Q86_S1.4401.00
128_E276_K1.4381.00
53_A56_Q1.4281.00
16_L205_A1.4231.00
164_F204_A1.3891.00
19_V205_A1.3761.00
12_L167_M1.3641.00
64_W99_I1.3601.00
56_Q60_H1.3591.00
132_T143_H1.3431.00
251_P254_F1.3421.00
188_T249_P1.3391.00
67_L112_A1.3331.00
112_A164_F1.3321.00
277_A280_S1.3241.00
33_N44_Y1.3221.00
100_Q155_M1.3221.00
51_G94_E1.3201.00
195_W228_P1.3191.00
147_K150_Q1.3141.00
180_P185_A1.3071.00
59_P102_Q1.2951.00
55_E102_Q1.2941.00
17_T29_I1.2601.00
150_Q161_Y1.2571.00
113_S117_I1.2561.00
96_Q152_I1.2461.00
286_Y295_Q1.2401.00
63_V108_T1.2341.00
111_Q145_W1.2331.00
165_G272_A1.2291.00
25_H213_E1.2261.00
8_G17_T1.2101.00
233_Q236_K1.2011.00
200_H292_A1.1981.00
65_I208_I1.1871.00
138_L142_A1.1851.00
148_E151_H1.1841.00
201_V205_A1.1821.00
18_G171_K1.1801.00
58_L61_I1.1791.00
162_A208_I1.1791.00
123_E130_S1.1651.00
140_H144_L1.1621.00
127_T273_L1.1621.00
76_W80_T1.1491.00
276_K279_T1.1481.00
97_R100_Q1.1451.00
88_R141_T1.1371.00
3_I63_V1.1371.00
4_A30_L1.1361.00
66_N92_T1.1321.00
56_Q59_P1.1271.00
123_E127_T1.1271.00
111_Q149_G1.1211.00
291_F294_S1.1141.00
199_I204_A1.1131.00
20_L209_R1.1091.00
19_V202_E1.1021.00
45_V60_H1.1001.00
3_I20_L1.0921.00
126_F130_S1.0881.00
193_R230_D1.0881.00
193_R232_K1.0831.00
29_I42_M1.0761.00
210_Y280_S1.0751.00
207_M277_A1.0731.00
291_F295_Q1.0721.00
173_A177_M1.0721.00
129_D276_K1.0671.00
239_A245_P1.0661.00
118_Y222_N1.0651.00
98_L101_K1.0621.00
219_G279_T1.0611.00
15_H202_E1.0521.00
111_Q161_Y1.0511.00
110_I162_A1.0501.00
9_T31_S1.0471.00
55_E59_P1.0431.00
239_A246_H1.0401.00
90_N94_E1.0391.00
163_R220_P1.0391.00
94_E97_R1.0351.00
99_I109_L1.0281.00
95_V109_L1.0251.00
224_T272_A1.0211.00
87_S91_A1.0201.00
150_Q159_T1.0201.00
18_G22_R1.0191.00
229_V289_L1.0181.00
229_V233_Q1.0161.00
96_Q109_L1.0161.00
15_H201_V1.0161.00
97_R101_K1.0111.00
236_K239_A1.0101.00
6_T95_V1.0081.00
150_Q220_P1.0061.00
54_P98_L1.0021.00
197_S226_P0.9981.00
186_G249_P0.9901.00
228_P271_R0.9891.00
70_K87_S0.9891.00
274_P284_F0.9881.00
98_L102_Q0.9871.00
206_Q282_F0.9871.00
146_E163_R0.9841.00
21_T42_M0.9841.00
290_E294_S0.9811.00
89_I144_L0.9791.00
34_A46_Q0.9711.00
85_L90_N0.9661.00
228_P269_G0.9631.00
33_N36_E0.9621.00
11_F169_G0.9591.00
85_L89_I0.9591.00
21_T41_N0.9561.00
195_W230_D0.9551.00
58_L98_L0.9401.00
176_L180_P0.9391.00
15_H18_G0.9351.00
200_H286_Y0.9271.00
195_W269_G0.9231.00
210_Y213_E0.9231.00
100_Q157_I0.9211.00
167_M204_A0.9191.00
31_S44_Y0.9191.00
30_L57_E0.9191.00
286_Y291_F0.9171.00
250_V253_F0.9171.00
250_V254_F0.9151.00
58_L64_W0.9141.00
176_L179_L0.9131.00
67_L208_I0.9111.00
84_I141_T0.9081.00
11_F201_V0.9071.00
2_N62_D0.9061.00
51_G101_K0.9051.00
109_L149_G0.8921.00
206_Q209_R0.8871.00
14_Q171_K0.8841.00
162_A223_V0.8821.00
96_Q149_G0.8821.00
2_N25_H0.8801.00
144_L147_K0.8801.00
241_V290_E0.8741.00
15_H19_V0.8721.00
52_A55_E0.8681.00
221_M276_K0.8661.00
239_A244_R0.8591.00
160_V211_A0.8521.00
94_E98_L0.8501.00
233_Q237_T0.8501.00
45_V57_E0.8491.00
64_W95_V0.8481.00
207_M282_F0.8461.00
52_A56_Q0.8381.00
200_H203_D0.8351.00
92_T149_G0.8351.00
30_L53_A0.8331.00
202_E286_Y0.8331.00
17_T27_V0.8301.00
70_K83_H0.8291.00
206_Q286_Y0.8281.00
203_D225_A0.8241.00
224_T274_P0.8231.00
16_L20_L0.8201.00
168_L200_H0.8201.00
2_N61_I0.8191.00
124_K130_S0.8181.00
163_R222_N0.8171.00
100_Q156_G0.8101.00
53_A57_E0.8081.00
58_L102_Q0.8051.00
33_N46_Q0.8041.00
30_L54_P0.7951.00
21_T27_V0.7941.00
6_T68_A0.7941.00
147_K151_H0.7931.00
177_M180_P0.7891.00
28_Y60_H0.7871.00
150_Q153_E0.7851.00
179_L182_K0.7841.00
167_M199_I0.7811.00
96_Q148_E0.7791.00
26_H41_N0.7781.00
102_Q105_K0.7731.00
3_I65_I0.7711.00
192_G232_K0.7701.00
172_G175_P0.7691.00
249_P252_E0.7671.00
115_V272_A0.7631.00
97_R152_I0.7611.00
226_P274_P0.7601.00
115_V165_G0.7591.00
66_N95_V0.7541.00
186_G247_W0.7521.00
83_H86_S0.7491.00
3_I212_V0.7491.00
81_K140_H0.7471.00
161_Y220_P0.7461.00
151_H154_A0.7431.00
113_S146_E0.7421.00
85_L141_T0.7371.00
136_D139_S0.7371.00
210_Y282_F0.7351.00
107_K158_R0.7351.00
49_S87_S0.7341.00
275_K278_I0.7331.00
241_V293_L0.7331.00
203_D206_Q0.7301.00
32_R48_L0.7281.00
144_L148_E0.7251.00
50_E54_P0.7251.00
152_I155_M0.7231.00
182_K185_A0.7221.00
100_Q152_I0.7201.00
181_Y239_A0.7151.00
64_W109_L0.7151.00
92_T96_Q0.7151.00
91_A94_E0.7131.00
248_L251_P0.7121.00
15_H205_A0.7071.00
33_N38_E0.7041.00
286_Y292_A0.7021.00
102_Q106_P0.7011.00
70_K84_I0.7011.00
99_I105_K0.7001.00
54_P94_E0.6961.00
137_F140_H0.6961.00
54_P58_L0.6931.00
174_L177_M0.6911.00
99_I106_P0.6901.00
39_Q42_M0.6871.00
119_G133_S0.6841.00
148_E152_I0.6831.00
243_H246_H0.6771.00
25_H62_D0.6751.00
249_P254_F0.6751.00
211_A280_S0.6741.00
16_L208_I0.6741.00
195_W271_R0.6731.00
236_K240_R0.6721.00
125_T271_R0.6721.00
232_K250_V0.6711.00
117_I132_T0.6681.00
229_V234_F0.6681.00
164_F167_M0.6671.00
83_H87_S0.6631.00
170_E200_H0.6631.00
210_Y281_G0.6631.00
125_T273_L0.6631.00
237_T289_L0.6621.00
77_T84_I0.6581.00
106_P158_R0.6541.00
278_I284_F0.6541.00
140_H147_K0.6531.00
188_T251_P0.6511.00
121_S126_F0.6501.00
159_T218_S0.6481.00
211_A277_A0.6481.00
223_V277_A0.6451.00
128_E277_A0.6441.00
51_G98_L0.6421.00
134_D139_S0.6391.00
58_L99_I0.6361.00
127_T275_K0.6321.00
14_Q18_G0.6281.00
170_E295_Q0.6271.00
175_P179_L0.6241.00
145_W149_G0.6241.00
12_L204_A0.6231.00
175_P180_P0.6231.00
205_A209_R0.6191.00
165_G224_T0.6171.00
122_L130_S0.6161.00
177_M181_Y0.6151.00
81_K137_F0.6121.00
25_H63_V0.6121.00
173_A181_Y0.6101.00
78_E137_F0.6081.00
20_L212_V0.6081.00
23_Q210_Y0.6071.00
63_V110_I0.6061.00
99_I102_Q0.6061.00
11_F15_H0.6031.00
178_I182_K0.6001.00
239_A242_K0.5991.00
24_G27_V0.5981.00
85_L140_H0.5981.00
43_T60_H0.5981.00
152_I157_I0.5951.00
17_T21_T0.5881.00
234_F289_L0.5881.00
15_H171_K0.5871.00
4_A47_W0.5871.00
158_R217_I0.5861.00
89_I93_R0.5831.00
102_Q107_K0.5811.00
4_A58_L0.5811.00
235_G239_A0.5811.00
184_L244_R0.5801.00
229_V237_T0.5771.00
66_N109_L0.5761.00
194_Q231_M0.5731.00
110_I212_V0.5711.00
116_G139_S0.5711.00
204_A208_I0.5701.00
141_T145_W0.5701.00
63_V107_K0.5691.00
5_M20_L0.5671.00
124_K269_G0.5641.00
69_G88_R0.5611.00
23_Q206_Q0.5601.00
110_I208_I0.5601.00
4_A64_W0.5511.00
29_I44_Y0.5501.00
172_G176_L0.5501.00
96_Q100_Q0.5491.00
117_I146_E0.5471.00
184_L187_G0.5441.00
132_T147_K0.5431.00
9_T33_N0.5411.00
183_F186_G0.5391.00
31_S35_R0.5381.00
197_S228_P0.5351.00
285_T291_F0.5341.00
4_A57_E0.5291.00
121_S124_K0.5251.00
173_A180_P0.5241.00
45_V53_A0.5241.00
99_I107_K0.5231.00
216_G279_T0.5231.00
57_E60_H0.5211.00
70_K88_R0.5201.00
162_A207_M0.5191.00
35_R38_E0.5161.00
277_A284_F0.5141.00
140_H151_H0.5141.00
110_I211_A0.5141.00
151_H155_M0.5131.00
93_R144_L0.5121.00
180_P188_T0.5121.00
93_R151_H0.5111.00
92_T111_Q0.5091.00
128_E222_N0.5091.00
146_E161_Y0.5081.00
166_V196_L0.5071.00
173_A176_L0.5061.00
160_V221_M0.5061.00
237_T293_L0.5061.00
267_V270_Q0.5041.00
161_Y218_S0.5031.00
58_L95_V0.5031.00
54_P57_E0.5001.00
31_S34_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkxA 3 0.9472 100 0.218 Contact Map
3m2pA 2 0.934 100 0.222 Contact Map
1sb8A 2 0.9703 100 0.225 Contact Map
3rufA 2 0.9571 100 0.228 Contact Map
1rpnA 4 0.9604 100 0.238 Contact Map
3slgA 4 0.9604 100 0.238 Contact Map
2c20A 2 0.9604 100 0.241 Contact Map
1orrA 3 0.9604 100 0.241 Contact Map
2pk3A 2 0.9538 100 0.242 Contact Map
2pzmA 2 0.9373 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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