GREMLIN Database
YFHC - Putative NAD(P)H nitroreductase YfhC
UniProt: O31571 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (162)
Sequences: 13272 (9639)
Seq/√Len: 757.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_P35_V3.3441.00
38_D137_K3.1821.00
33_S61_S2.5691.00
33_S37_L2.3911.00
57_F126_L2.3871.00
58_I106_V2.3801.00
39_M134_A2.2571.00
19_S135_W2.1001.00
106_V164_E2.0851.00
35_V137_K2.0841.00
140_G175_P2.0821.00
70_I97_G1.9691.00
131_Q141_M1.9631.00
139_I174_Y1.9201.00
41_E44_K1.8881.00
57_F103_L1.8171.00
42_T133_L1.7971.00
15_D19_S1.7851.00
127_I168_A1.7671.00
68_N157_A1.7361.00
67_A97_G1.7211.00
35_V139_I1.6961.00
27_K176_D1.6791.00
43_A130_L1.6191.00
25_K176_D1.6071.00
155_H166_F1.5891.00
127_I170_I1.5641.00
63_E67_A1.5621.00
29_E174_Y1.5481.00
105_V127_I1.5331.00
65_G68_N1.5231.00
12_V15_D1.5211.00
103_L130_L1.4811.00
13_L17_I1.4711.00
108_Q163_N1.4591.00
14_R38_D1.4281.00
39_M130_L1.4101.00
131_Q143_W1.4021.00
14_R18_R1.3741.00
134_A172_T1.3611.00
109_E165_R1.3511.00
121_A124_S1.3501.00
59_Y101_G1.3311.00
72_T153_E1.3231.00
30_P61_S1.3211.00
18_R45_Y1.3091.00
125_S128_Q1.3051.00
131_Q170_I1.2941.00
104_L169_I1.2931.00
106_V160_L1.2921.00
13_L16_I1.2911.00
61_S101_G1.2771.00
72_T157_A1.2651.00
11_S15_D1.2611.00
139_I172_T1.2571.00
135_W140_G1.2571.00
107_F119_D1.2541.00
153_E156_Q1.2451.00
35_V174_Y1.2431.00
56_R164_E1.1971.00
123_T167_A1.1961.00
57_F105_V1.1951.00
35_V38_D1.1921.00
67_A71_N1.1711.00
185_T189_D1.1641.00
39_M172_T1.1571.00
150_Y153_E1.1551.00
105_V130_L1.1351.00
102_F169_I1.1261.00
105_V123_T1.1231.00
62_S65_G1.1121.00
36_I101_G1.1121.00
104_L166_F1.1071.00
65_G157_A1.0961.00
143_W168_A1.0941.00
69_L154_V1.0911.00
37_L188_R1.0831.00
63_E66_K1.0751.00
46_A129_N1.0631.00
18_R41_E1.0561.00
11_S136_E1.0531.00
133_L137_K1.0511.00
22_S142_V1.0481.00
103_L172_T1.0481.00
39_M139_I1.0441.00
153_E157_A1.0371.00
14_R42_T1.0331.00
110_D163_N1.0311.00
134_A141_M1.0291.00
60_V104_L1.0231.00
42_T137_K1.0201.00
15_D18_R1.0181.00
118_D145_S1.0171.00
141_M170_I1.0081.00
56_R108_Q1.0061.00
128_Q132_L0.9941.00
37_L41_E0.9911.00
64_T67_A0.9861.00
37_L187_I0.9801.00
107_F123_T0.9681.00
141_M172_T0.9611.00
129_N132_L0.9571.00
26_F171_Q0.9551.00
31_V139_I0.9551.00
49_H118_D0.9531.00
133_L136_E0.9511.00
40_L59_Y0.9501.00
44_K190_R0.9461.00
59_Y103_L0.9451.00
64_T68_N0.9411.00
14_R137_K0.9391.00
34_A37_L0.9311.00
40_L43_A0.9301.00
68_N71_N0.9261.00
12_V136_E0.9161.00
28_Q98_R0.8991.00
13_L136_E0.8971.00
105_V170_I0.8941.00
144_K171_Q0.8921.00
101_G172_T0.8871.00
152_K156_Q0.8791.00
71_N75_A0.8721.00
127_I143_W0.8691.00
13_L132_L0.8681.00
142_V171_Q0.8661.00
186_P189_D0.8641.00
130_L170_I0.8621.00
125_S143_W0.8591.00
120_F167_A0.8521.00
108_Q164_E0.8341.00
121_A145_S0.8331.00
32_P174_Y0.8321.00
106_V166_F0.8311.00
58_I164_E0.8281.00
39_M137_K0.8241.00
25_K177_E0.8241.00
154_V157_A0.8231.00
155_H165_R0.8221.00
107_F167_A0.8191.00
124_S143_W0.8141.00
67_A70_I0.8141.00
30_P100_P0.8131.00
109_E163_N0.8111.00
130_L172_T0.8041.00
31_V174_Y0.7881.00
17_I129_N0.7861.00
161_Q164_E0.7821.00
104_L158_F0.7721.00
38_D41_E0.7681.00
48_N55_W0.7651.00
116_R165_R0.7601.00
27_K174_Y0.7561.00
38_D42_T0.7481.00
94_N98_R0.7361.00
14_R136_E0.7361.00
17_I132_L0.7341.00
152_K155_H0.7291.00
102_F171_Q0.7241.00
11_S16_I0.7231.00
30_P63_E0.7231.00
30_P101_G0.7191.00
14_R133_L0.7121.00
36_I40_L0.7051.00
31_V100_P0.7041.00
95_T98_R0.7021.00
125_S129_N0.7011.00
151_D155_H0.6921.00
94_N97_G0.6901.00
49_H145_S0.6891.00
160_L164_E0.6851.00
25_K98_R0.6851.00
41_E187_I0.6841.00
55_W123_T0.6821.00
108_Q111_E0.6821.00
179_P182_K0.6801.00
31_V35_V0.6791.00
151_D166_F0.6731.00
73_F96_L0.6681.00
16_I132_L0.6681.00
29_E32_P0.6661.00
36_I172_T0.6611.00
60_V65_G0.6561.00
56_R106_V0.6561.00
73_F76_F0.6501.00
43_A57_F0.6491.00
121_A125_S0.6471.00
120_F124_S0.6431.00
48_N53_E0.6391.00
68_N72_T0.6381.00
16_I136_E0.6371.00
66_K102_F0.6241.00
99_V102_F0.6181.00
112_N115_A0.6141.00
31_V34_A0.6071.00
73_F169_I0.6071.00
93_K97_G0.6041.00
151_D165_R0.6041.00
49_H122_A0.5931.00
122_A145_S0.5931.00
96_L171_Q0.5921.00
26_F29_E0.5821.00
117_D120_F0.5811.00
26_F142_V0.5771.00
41_E45_Y0.5761.00
44_K187_I0.5741.00
39_M43_A0.5701.00
58_I158_F0.5691.00
13_L133_L0.5661.00
66_K70_I0.5651.00
36_I103_L0.5631.00
40_L103_L0.5621.00
24_R95_T0.5621.00
155_H162_D0.5591.00
149_L169_I0.5561.00
18_R38_D0.5561.00
34_A38_D0.5541.00
23_I175_P0.5531.00
24_R142_V0.5481.00
128_Q131_Q0.5471.00
40_L190_R0.5441.00
55_W126_L0.5411.00
185_T190_R0.5381.00
38_D133_L0.5381.00
20_R47_P0.5381.00
66_K101_G0.5361.00
27_K100_P0.5301.00
96_L102_F0.5301.00
120_F165_R0.5291.00
27_K177_E0.5281.00
43_A126_L0.5271.00
116_R120_F0.5271.00
60_V69_L0.5241.00
65_G69_L0.5231.00
23_I140_G0.5211.00
36_I59_Y0.5211.00
69_L102_F0.5171.00
35_V39_M0.5131.00
160_L166_F0.5131.00
70_I75_A0.5061.00
60_V158_F0.5061.00
28_Q63_E0.5041.00
47_P128_Q0.5021.00
65_G158_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eofA 2 0.8557 100 0.185 Contact Map
1noxA 2 0.8608 100 0.185 Contact Map
4qlxA 2 0.9124 100 0.186 Contact Map
1f5vA 2 0.866 100 0.187 Contact Map
3of4A 3 0.8505 100 0.188 Contact Map
1icrA 2 0.8711 100 0.189 Contact Map
1zchA 2 0.866 100 0.189 Contact Map
1bkjA 2 0.8608 100 0.19 Contact Map
3n2sA 2 0.8608 100 0.19 Contact Map
3bemA 2 0.8763 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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