GREMLIN Database
YFHB - Uncharacterized isomerase YfhB
UniProt: O31570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (264)
Sequences: 4108 (3064)
Seq/√Len: 188.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_K267_E3.6421.00
82_Y285_Y3.6361.00
32_T35_E3.3791.00
177_M198_P3.2531.00
227_V262_G3.0861.00
170_S173_A2.7361.00
172_E176_K2.6741.00
9_Y83_A2.5941.00
51_I80_S2.5321.00
61_L100_T2.4481.00
97_S104_I2.4421.00
29_D53_K2.4221.00
8_K287_E2.2951.00
14_S282_T2.2411.00
181_N223_I2.2311.00
60_E99_Q2.2231.00
15_S18_K2.2211.00
95_T108_K2.0161.00
71_N101_K2.0091.00
236_G266_I1.9901.00
267_E278_N1.9791.00
54_S60_E1.9161.00
171_L175_K1.9071.00
95_T106_P1.8841.00
251_I263_K1.8441.00
5_E290_I1.8271.00
253_E261_D1.8241.00
169_K173_A1.7901.00
10_E42_R1.7751.00
212_G232_S1.7681.00
5_E288_T1.7611.00
39_I291_L1.7421.00
180_D183_Q1.7291.00
110_S117_H1.7021.00
58_D99_Q1.6951.00
49_S80_S1.6811.00
26_L51_I1.6781.00
13_T18_K1.6691.00
251_I265_E1.6621.00
227_V264_V1.6441.00
115_R282_T1.6151.00
54_S99_Q1.6091.00
228_T231_A1.5901.00
117_H280_T1.5851.00
139_D183_Q1.5681.00
31_Y39_I1.5591.00
36_M62_R1.5581.00
183_Q186_E1.5511.00
119_T276_K1.5411.00
232_S252_I1.5261.00
236_G268_M1.5131.00
168_L173_A1.5101.00
6_V287_E1.5021.00
141_L166_V1.4981.00
7_L83_A1.4931.00
13_T284_V1.4871.00
60_E101_K1.4791.00
163_T194_A1.4751.00
40_A48_T1.4471.00
269_N278_N1.4381.00
31_Y35_E1.4341.00
163_T214_H1.4331.00
253_E263_K1.4251.00
35_E39_I1.4051.00
115_R265_E1.4031.00
72_L230_T1.4021.00
33_E36_M1.3941.00
171_L202_E1.3881.00
143_I168_L1.3861.00
252_I264_V1.3771.00
168_L174_S1.3751.00
58_D104_I1.3651.00
61_L80_S1.3441.00
216_S221_G1.3321.00
99_Q104_I1.3271.00
7_L288_T1.3141.00
256_Q261_D1.3111.00
85_C109_I1.3041.00
158_S162_W1.3011.00
73_C76_A1.3001.00
8_K45_Y1.2991.00
147_D169_K1.2831.00
110_S113_D1.2651.00
240_K268_M1.2611.00
22_A79_A1.2611.00
118_I121_E1.2601.00
167_P199_F1.2541.00
62_R69_E1.2441.00
82_Y86_E1.2221.00
37_Q40_A1.2191.00
171_L200_T1.2181.00
195_S214_H1.2101.00
108_K278_N1.2071.00
23_G43_A1.2051.00
18_K261_D1.2031.00
6_V43_A1.2011.00
107_V118_I1.1951.00
33_E37_Q1.1951.00
216_S222_T1.1871.00
265_E280_T1.1871.00
210_L235_M1.1831.00
264_V279_M1.1791.00
135_K139_D1.1751.00
249_K265_E1.1431.00
197_H232_S1.1401.00
147_D176_K1.1391.00
167_P238_Y1.1201.00
171_L211_H1.1171.00
143_I177_M1.1171.00
7_L26_L1.1161.00
232_S264_V1.1121.00
30_D52_R1.0971.00
46_S226_P1.0901.00
165_I234_V1.0851.00
255_G261_D1.0851.00
122_Q125_P1.0851.00
68_H220_S1.0841.00
135_K145_D1.0801.00
137_L164_A1.0791.00
21_P45_Y1.0791.00
114_G282_T1.0751.00
218_P222_T1.0711.00
140_A183_Q1.0711.00
140_A184_F1.0671.00
34_D38_I1.0671.00
214_H231_A1.0621.00
4_A25_V1.0611.00
212_G252_I1.0511.00
107_V116_I1.0461.00
8_K43_A1.0451.00
11_A22_A1.0451.00
81_L98_I1.0441.00
85_C116_I1.0411.00
218_P221_G1.0381.00
63_Y76_A1.0381.00
136_K139_D1.0301.00
37_Q41_E1.0301.00
61_L98_I1.0291.00
138_A145_D1.0261.00
147_D173_A1.0221.00
22_A73_C1.0191.00
174_S200_T1.0191.00
84_L88_G1.0121.00
16_P286_S1.0111.00
171_L203_T0.9920.99
47_E228_T0.9880.99
24_V83_A0.9810.99
26_L83_A0.9800.99
172_E175_K0.9760.99
90_L96_Y0.9740.99
23_G45_Y0.9740.99
86_E285_Y0.9680.99
179_P215_F0.9650.99
268_M277_V0.9620.99
47_E226_P0.9580.99
168_L198_P0.9570.99
11_A79_A0.9530.99
201_F210_L0.9470.99
137_L166_V0.9470.99
216_S220_S0.9470.99
163_T195_S0.9450.99
25_V291_L0.9420.99
174_S211_H0.9380.99
6_V289_R0.9370.99
165_I235_M0.9350.99
71_N163_T0.9290.99
27_Q30_D0.9270.99
199_F238_Y0.9180.99
52_R60_E0.9180.99
286_S291_L0.9170.99
228_T254_Q0.9170.99
47_E76_A0.9120.99
238_Y242_Y0.9110.99
144_T147_D0.9100.99
216_S223_I0.9070.99
211_H256_Q0.8960.99
9_Y24_V0.8930.99
197_H231_A0.8890.99
138_A148_F0.8870.99
70_M76_A0.8850.99
119_T278_N0.8780.99
212_G235_M0.8750.99
57_A104_I0.8750.99
40_A66_P0.8730.99
209_D247_Q0.8660.99
51_I84_L0.8650.98
208_S255_G0.8620.98
63_Y73_C0.8570.98
118_I122_Q0.8570.98
4_A30_D0.8560.98
72_L102_A0.8560.98
120_L233_G0.8550.98
54_S58_D0.8540.98
54_S57_A0.8530.98
70_M161_I0.8520.98
9_Y283_A0.8520.98
14_S263_K0.8510.98
83_A87_K0.8450.98
154_I166_V0.8430.98
35_E38_I0.8430.98
137_L140_A0.8420.98
197_H214_H0.8420.98
58_D97_S0.8410.98
43_A287_E0.8410.98
227_V252_I0.8390.98
253_E256_Q0.8390.98
146_E169_K0.8380.98
117_H278_N0.8340.98
122_Q233_G0.8280.98
97_S106_P0.8280.98
175_K211_H0.8250.98
10_E17_G0.8220.98
13_T282_T0.8210.98
49_S61_L0.8200.98
4_A27_Q0.8200.98
9_Y285_Y0.8180.98
141_L198_P0.8160.98
138_A143_I0.8140.98
165_I238_Y0.8130.98
49_S76_A0.8120.98
17_G42_R0.8090.98
267_E280_T0.8050.98
116_I121_E0.8050.98
210_L252_I0.8030.98
202_E206_P0.8010.98
174_S177_M0.7960.97
85_C96_Y0.7960.97
167_P242_Y0.7920.97
36_M64_F0.7870.97
87_K288_T0.7850.97
184_F196_V0.7840.97
11_A63_Y0.7770.97
72_L105_L0.7730.97
25_V43_A0.7730.97
173_A176_K0.7720.97
81_L96_Y0.7720.97
5_E87_K0.7680.97
133_D136_K0.7660.97
82_Y283_A0.7620.97
202_E208_S0.7580.97
182_K185_P0.7500.96
140_A187_V0.7460.96
10_E13_T0.7410.96
140_A196_V0.7390.96
41_E67_G0.7380.96
22_A63_Y0.7370.96
134_R138_A0.7370.96
51_I88_G0.7350.96
78_V230_T0.7330.96
100_T118_I0.7320.96
22_A76_A0.7310.96
30_D33_E0.7290.96
63_Y79_A0.7280.96
63_Y70_M0.7280.96
84_L96_Y0.7240.96
132_G145_D0.7230.95
227_V256_Q0.7220.95
161_I234_V0.7200.95
175_K255_G0.7170.95
38_I41_E0.7170.95
127_F157_G0.7160.95
57_A99_Q0.7150.95
214_H228_T0.7120.95
119_T280_T0.7050.95
42_R260_K0.7030.95
179_P184_F0.7030.95
248_H268_M0.6990.95
285_Y288_T0.6970.95
271_A276_K0.6940.94
17_G260_K0.6850.94
20_N228_T0.6830.94
209_D250_F0.6820.94
33_E62_R0.6820.94
218_P223_I0.6800.94
162_W194_A0.6760.94
121_E276_K0.6760.94
136_K183_Q0.6710.93
181_N184_F0.6700.93
63_Y98_I0.6680.93
171_L174_S0.6670.93
47_E70_M0.6670.93
136_K186_E0.6660.93
214_H235_M0.6640.93
181_N218_P0.6600.93
168_L177_M0.6580.93
227_V232_S0.6580.93
115_R280_T0.6570.93
7_L285_Y0.6550.92
7_L87_K0.6540.92
71_N161_I0.6540.92
119_T123_A0.6530.92
195_S199_F0.6490.92
138_A144_T0.6480.92
36_M52_R0.6450.92
167_P201_F0.6450.92
199_F202_E0.6440.92
199_F239_M0.6390.92
8_K21_P0.6350.91
210_L255_G0.6320.91
127_F155_V0.6300.91
185_P219_Y0.6290.91
236_G279_M0.6280.91
29_D52_R0.6280.91
11_A76_A0.6260.91
208_S253_E0.6240.91
256_Q262_G0.6240.91
20_N229_G0.6230.91
5_E23_G0.6230.91
47_E66_P0.6220.90
200_T211_H0.6210.90
76_A79_A0.6190.90
108_K117_H0.6170.90
266_I279_M0.6160.90
158_S161_I0.6150.90
21_P46_S0.6070.89
164_A193_K0.6060.89
197_H235_M0.6050.89
65_T70_M0.6050.89
203_T206_P0.6020.89
5_E289_R0.5990.89
25_V48_T0.5990.89
197_H212_G0.5980.89
235_M239_M0.5970.89
110_S115_R0.5960.89
66_P222_T0.5920.88
165_I197_H0.5910.88
214_H234_V0.5900.88
123_A126_Q0.5890.88
110_S267_E0.5890.88
18_K38_I0.5870.88
141_L177_M0.5850.88
157_G165_I0.5850.88
32_T36_M0.5850.88
155_V242_Y0.5840.87
154_I164_A0.5800.87
123_A161_I0.5790.87
147_D167_P0.5790.87
55_E99_Q0.5790.87
226_P262_G0.5770.87
65_T222_T0.5740.87
78_V120_L0.5720.86
14_S18_K0.5720.86
11_A49_S0.5720.86
67_G221_G0.5710.86
250_F266_I0.5700.86
123_A160_G0.5690.86
166_V196_V0.5650.86
141_L196_V0.5640.86
171_L253_E0.5630.86
22_A283_A0.5600.85
75_H229_G0.5580.85
162_W234_V0.5570.85
41_E259_G0.5560.85
9_Y82_Y0.5560.85
22_A61_L0.5550.85
216_S231_A0.5530.85
187_V193_K0.5510.84
6_V286_S0.5500.84
81_L107_V0.5500.84
198_P215_F0.5500.84
100_T103_G0.5480.84
117_H267_E0.5410.83
248_H267_E0.5370.83
11_A73_C0.5370.83
123_A234_V0.5350.83
163_T231_A0.5340.82
127_F237_A0.5330.82
202_E211_H0.5320.82
134_R145_D0.5300.82
73_C77_T0.5300.82
122_Q277_V0.5290.82
63_Y230_T0.5290.82
11_A227_V0.5280.82
215_F222_T0.5270.82
89_M92_S0.5250.81
106_P109_I0.5250.81
84_L90_L0.5240.81
26_L30_D0.5230.81
49_S73_C0.5220.81
23_G73_C0.5200.81
120_L125_P0.5200.81
185_P223_I0.5190.81
63_Y72_L0.5180.81
240_K250_F0.5180.81
71_N194_A0.5170.80
27_Q31_Y0.5160.80
86_E288_T0.5120.80
76_A225_D0.5110.80
43_A286_S0.5110.80
209_D253_E0.5110.80
208_S263_K0.5080.79
36_M50_F0.5060.79
240_K244_N0.5050.79
83_A86_E0.5020.78
207_D263_K0.5010.78
143_I147_D0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ednA 2 0.9966 100 0.244 Contact Map
1qyaA 2 0.9829 100 0.255 Contact Map
1ym5A 2 0.9659 100 0.255 Contact Map
1xubA 2 0.9352 100 0.263 Contact Map
1s7jA 1 0.8874 100 0.292 Contact Map
1u0kA 2 0.9454 100 0.299 Contact Map
4dunA 2 0.8805 100 0.303 Contact Map
4jbdA 2 0.884 100 0.406 Contact Map
3ejxA 5 0.9181 100 0.417 Contact Map
4juuA 2 0.9113 100 0.424 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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