GREMLIN Database
YFHA - Probable siderophore transport system permease protein YfhA
UniProt: O31569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 343 (320)
Sequences: 13902 (9998)
Seq/√Len: 558.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_N287_S4.5791.00
77_V296_A3.7941.00
113_L134_A3.6481.00
28_V305_T3.5761.00
85_I220_C3.5201.00
29_L69_I3.4191.00
243_A246_R3.2761.00
78_C213_S3.1251.00
85_I251_L3.0671.00
73_L300_A3.0361.00
72_A198_V2.9111.00
280_A298_I2.8401.00
44_D57_D2.7571.00
71_T201_S2.6391.00
78_C262_A2.5391.00
78_C258_L2.5261.00
81_A296_A2.4871.00
29_L73_L2.4831.00
44_D47_K2.4381.00
108_V174_M2.4021.00
234_E248_R2.3851.00
25_T301_L2.3611.00
75_A262_A2.2661.00
24_L301_L2.2471.00
81_A217_L2.2101.00
84_A295_S2.2061.00
284_V294_A2.1081.00
34_G42_P2.0671.00
73_L304_L2.0651.00
75_A266_A2.0631.00
108_V171_A2.0521.00
54_S57_D2.0321.00
25_T73_L2.0211.00
226_N247_N1.9981.00
74_C210_I1.9651.00
68_R307_D1.9601.00
32_S69_I1.9541.00
41_P44_D1.9471.00
212_L261_C1.9331.00
228_N288_Y1.9291.00
112_L116_F1.9181.00
88_G288_Y1.8661.00
86_L255_S1.8531.00
229_I242_S1.8141.00
223_A226_N1.8071.00
18_F294_A1.7921.00
111_V175_T1.7911.00
28_V301_L1.7821.00
43_W47_K1.7781.00
219_I254_L1.7441.00
201_S205_H1.7151.00
216_L258_L1.6851.00
223_A250_F1.6361.00
58_E62_M1.6091.00
55_K58_E1.6041.00
309_V313_L1.5821.00
246_R250_F1.5771.00
70_L206_V1.5621.00
31_I34_G1.5571.00
139_A260_G1.5521.00
110_V135_A1.5381.00
272_V303_V1.5281.00
207_K211_I1.5191.00
84_A291_L1.5171.00
216_L257_A1.5071.00
223_A247_N1.4961.00
202_N205_H1.4921.00
25_T297_L1.4851.00
310_G321_A1.4851.00
21_L297_L1.4791.00
48_T62_M1.4721.00
109_A134_A1.4491.00
28_V304_L1.4481.00
143_G256_T1.4401.00
31_I35_L1.4361.00
198_V303_V1.4121.00
17_V294_A1.4061.00
309_V324_F1.3951.00
46_A50_F1.3911.00
216_L254_L1.3791.00
82_A258_L1.3641.00
32_S308_I1.3531.00
211_I215_I1.3371.00
290_A293_P1.3351.00
21_L294_A1.3271.00
280_A291_L1.3231.00
142_V171_A1.3161.00
280_A294_A1.3071.00
71_T265_V1.3041.00
107_A175_T1.2951.00
207_K210_I1.2911.00
219_I223_A1.2791.00
170_S330_A1.2751.00
21_L298_I1.2591.00
103_T259_T1.2541.00
276_A302_L1.2461.00
223_A251_L1.2451.00
80_A276_A1.2301.00
74_C206_V1.2251.00
59_L63_S1.1961.00
48_T58_E1.1961.00
18_F290_A1.1941.00
276_A298_I1.1891.00
25_T300_A1.1861.00
238_A245_Q1.1861.00
89_L251_L1.1701.00
246_R249_F1.1661.00
109_A138_G1.1651.00
107_A194_I1.1641.00
236_I239_G1.1631.00
247_N250_F1.1591.00
21_L301_L1.1541.00
288_Y291_L1.1531.00
266_A269_I1.1481.00
39_F42_P1.1471.00
209_A265_V1.1361.00
111_V190_A1.1291.00
229_I240_A1.1231.00
311_R318_E1.1191.00
245_Q248_R1.1151.00
56_L59_L1.1121.00
133_A137_I1.1041.00
144_L148_L1.1011.00
134_A138_G1.1001.00
84_A292_L1.0971.00
38_R60_M1.0941.00
108_V112_L1.0901.00
72_A304_L1.0881.00
136_F257_A1.0871.00
72_A303_V1.0871.00
71_T206_V1.0851.00
84_A288_Y1.0821.00
233_G237_A1.0801.00
105_G138_G1.0781.00
219_I250_F1.0771.00
74_C209_A1.0761.00
77_V300_A1.0721.00
220_C254_L1.0701.00
115_M178_L1.0691.00
16_I19_L1.0661.00
53_G58_E1.0641.00
105_G142_V1.0511.00
146_V167_F1.0491.00
151_Y245_Q1.0491.00
218_F222_V1.0471.00
77_V80_A1.0471.00
209_A213_S1.0341.00
293_P296_A1.0321.00
70_L203_W1.0311.00
245_Q249_F1.0291.00
307_D311_R1.0271.00
168_S172_Q1.0201.00
216_L261_C1.0141.00
104_G171_A1.0071.00
35_L312_T1.0041.00
29_L304_L1.0031.00
309_V312_T1.0001.00
177_L181_K0.9981.00
48_T61_I0.9971.00
127_S130_W0.9961.00
301_L305_T0.9941.00
62_M66_M0.9901.00
269_I303_V0.9861.00
152_K155_A0.9831.00
141_A145_I0.9781.00
284_V290_A0.9781.00
15_W18_F0.9781.00
112_L178_L0.9751.00
23_G27_A0.9741.00
30_I34_G0.9721.00
22_L26_A0.9711.00
34_G45_V0.9711.00
15_W19_L0.9671.00
310_G324_F0.9641.00
326_A331_P0.9631.00
33_A69_I0.9611.00
103_T268_T0.9461.00
208_I211_I0.9441.00
227_M251_L0.9431.00
215_I218_F0.9391.00
291_L295_S0.9351.00
48_T57_D0.9351.00
276_A280_A0.9331.00
314_F317_V0.9321.00
247_N251_L0.9301.00
69_I308_I0.9301.00
48_T53_G0.9211.00
115_M182_G0.9211.00
28_V308_I0.9181.00
211_I214_V0.9181.00
142_V146_V0.9171.00
47_K51_G0.9131.00
108_V175_T0.9101.00
262_A266_A0.9081.00
290_A294_A0.9061.00
203_W206_V0.9061.00
148_L151_Y0.9031.00
52_A58_E0.9031.00
331_P335_Y0.8981.00
45_V61_I0.8841.00
58_E63_S0.8811.00
242_S247_N0.8811.00
235_D238_A0.8791.00
36_G65_R0.8791.00
332_Y335_Y0.8751.00
182_G186_R0.8741.00
287_S290_A0.8701.00
83_G277_P0.8651.00
17_V20_V0.8651.00
108_V178_L0.8631.00
16_I20_V0.8601.00
40_I61_I0.8591.00
30_I42_P0.8591.00
126_I130_W0.8591.00
283_L298_I0.8541.00
47_K50_F0.8531.00
305_T309_V0.8511.00
22_L297_L0.8491.00
102_I139_A0.8491.00
82_A255_S0.8471.00
228_N289_G0.8431.00
77_V217_L0.8431.00
74_C213_S0.8421.00
17_V21_L0.8421.00
110_V131_L0.8411.00
190_A194_I0.8381.00
310_G320_P0.8371.00
114_M131_L0.8341.00
234_E238_A0.8331.00
78_C82_A0.8231.00
249_F253_L0.8171.00
69_I304_L0.8081.00
212_L216_L0.8081.00
98_D103_T0.8081.00
312_T315_A0.8081.00
224_L289_G0.8071.00
281_R291_L0.8041.00
223_A254_L0.8001.00
288_Y293_P0.8001.00
219_I222_V0.7991.00
136_F140_S0.7981.00
214_V218_F0.7981.00
313_L316_P0.7961.00
68_R311_R0.7941.00
188_S191_N0.7941.00
244_V248_R0.7911.00
77_V213_S0.7861.00
113_L131_L0.7851.00
25_T29_L0.7831.00
220_C251_L0.7811.00
131_L134_A0.7811.00
104_G107_A0.7801.00
185_Y189_Q0.7791.00
252_L256_T0.7791.00
80_A84_A0.7771.00
234_E244_V0.7711.00
66_M203_W0.7691.00
137_I141_A0.7661.00
86_L100_I0.7661.00
303_V325_T0.7611.00
106_A139_A0.7611.00
26_A30_I0.7611.00
204_Q207_K0.7601.00
32_S311_R0.7581.00
47_K52_A0.7571.00
327_A331_P0.7571.00
151_Y154_G0.7561.00
45_V48_T0.7551.00
205_H265_V0.7551.00
68_R318_E0.7541.00
130_W133_A0.7511.00
26_A29_L0.7501.00
147_Y249_F0.7481.00
280_A283_L0.7471.00
147_Y245_Q0.7471.00
280_A284_V0.7461.00
314_F319_V0.7451.00
237_A244_V0.7441.00
34_G39_F0.7411.00
105_G171_A0.7381.00
35_L39_F0.7351.00
272_V325_T0.7341.00
138_G142_V0.7321.00
297_L301_L0.7291.00
40_I57_D0.7291.00
27_A30_I0.7281.00
111_V179_M0.7281.00
221_F224_L0.7271.00
112_L117_F0.7251.00
80_A296_A0.7241.00
51_G58_E0.7221.00
140_S260_G0.7211.00
151_Y155_A0.7211.00
47_K53_G0.7211.00
96_S99_I0.7211.00
139_A256_T0.7181.00
90_V161_V0.7161.00
79_L272_V0.7151.00
209_A261_C0.7101.00
222_V226_N0.7071.00
213_S262_A0.7051.00
81_A292_L0.7011.00
70_L74_C0.6991.00
55_K59_L0.6991.00
38_R42_P0.6961.00
112_L174_M0.6951.00
226_N242_S0.6911.00
81_A220_C0.6901.00
38_R41_P0.6861.00
59_L62_M0.6861.00
228_N293_P0.6861.00
25_T304_L0.6811.00
114_M189_Q0.6781.00
107_A268_T0.6771.00
182_G187_A0.6761.00
335_Y339_K0.6761.00
143_G252_L0.6761.00
102_I143_G0.6751.00
54_S58_E0.6751.00
146_V150_A0.6731.00
82_A259_T0.6731.00
238_A244_V0.6681.00
302_L306_A0.6671.00
33_A61_I0.6651.00
210_I214_V0.6641.00
279_I298_I0.6631.00
71_T209_A0.6631.00
88_G231_V0.6611.00
17_V283_L0.6611.00
33_A66_M0.6601.00
269_I321_A0.6581.00
230_Q244_V0.6581.00
59_L64_F0.6581.00
261_C265_V0.6561.00
261_C264_S0.6561.00
282_R336_L0.6551.00
191_N194_I0.6541.00
300_A304_L0.6491.00
296_A300_A0.6491.00
143_G147_Y0.6471.00
21_L25_T0.6461.00
217_L221_F0.6441.00
209_A212_L0.6441.00
42_P45_V0.6441.00
179_M191_N0.6431.00
277_P295_S0.6431.00
140_S256_T0.6391.00
279_I282_R0.6391.00
75_A198_V0.6371.00
216_L220_C0.6361.00
275_M333_F0.6301.00
303_V321_A0.6281.00
131_L135_A0.6251.00
96_S273_G0.6231.00
198_V321_A0.6221.00
29_L33_A0.6221.00
103_T106_A0.6201.00
183_P186_R0.6191.00
176_T180_I0.6191.00
203_W207_K0.6181.00
66_M70_L0.6171.00
20_V24_L0.6171.00
129_S133_A0.6151.00
307_D318_E0.6151.00
85_I254_L0.6141.00
272_V302_L0.6141.00
156_S159_R0.6131.00
158_F161_V0.6121.00
212_L257_A0.6121.00
259_T263_V0.6111.00
40_I48_T0.6111.00
77_V81_A0.6101.00
114_M190_A0.6091.00
109_A113_L0.6091.00
279_I302_L0.6091.00
306_A324_F0.6061.00
176_T193_Y0.6051.00
43_W46_A0.6041.00
90_V93_P0.6041.00
305_T308_I0.6031.00
104_G168_S0.6001.00
302_L328_I0.5991.00
163_I166_G0.5951.00
226_N229_I0.5931.00
61_I66_M0.5931.00
113_L130_W0.5921.00
150_A163_I0.5911.00
72_A321_A0.5891.00
41_P57_D0.5871.00
289_G293_P0.5871.00
172_Q194_I0.5841.00
42_P46_A0.5841.00
149_L163_I0.5841.00
186_R189_Q0.5821.00
27_A31_I0.5821.00
310_G318_E0.5791.00
228_N231_V0.5740.99
119_D126_I0.5730.99
35_L308_I0.5720.99
222_V225_K0.5710.99
260_G264_S0.5710.99
275_M279_I0.5690.99
17_V284_V0.5670.99
137_I140_S0.5670.99
145_I148_L0.5660.99
250_F254_L0.5640.99
30_I46_A0.5630.99
274_L336_L0.5630.99
86_L102_I0.5630.99
32_S304_L0.5610.99
275_M332_Y0.5610.99
148_L152_K0.5590.99
213_S217_L0.5590.99
308_I312_T0.5580.99
86_L95_A0.5580.99
113_L117_F0.5560.99
172_Q176_T0.5550.99
116_F119_D0.5550.99
28_V31_I0.5510.99
215_I219_I0.5510.99
338_Y341_R0.5500.99
293_P297_L0.5500.99
44_D51_G0.5500.99
208_I212_L0.5480.99
279_I332_Y0.5480.99
213_S218_F0.5470.99
228_N291_L0.5460.99
198_V266_A0.5460.99
104_G172_Q0.5410.99
310_G313_L0.5410.99
304_L308_I0.5400.99
147_Y151_Y0.5400.99
44_D53_G0.5390.99
251_L255_S0.5380.99
243_A250_F0.5340.99
20_V23_G0.5310.99
71_T75_A0.5310.99
52_A55_K0.5300.99
80_A299_G0.5280.99
256_T260_G0.5280.99
187_A190_A0.5250.99
141_A144_L0.5250.99
206_V209_A0.5250.99
18_F22_L0.5240.99
110_V134_A0.5230.99
163_I167_F0.5230.99
45_V49_F0.5230.99
34_G46_A0.5210.99
285_G293_P0.5210.99
179_M187_A0.5200.99
255_S260_G0.5200.99
49_F61_I0.5190.99
31_I308_I0.5190.99
179_M194_I0.5180.99
45_V50_F0.5180.99
250_F253_L0.5170.99
204_Q208_I0.5150.99
230_Q247_N0.5150.99
280_A295_S0.5130.99
84_A280_A0.5120.99
225_K228_N0.5110.99
96_S268_T0.5100.99
29_L70_L0.5100.99
227_M288_Y0.5100.99
270_G275_M0.5100.99
208_I261_C0.5090.99
85_I255_S0.5090.99
102_I197_S0.5090.99
102_I146_V0.5090.99
276_A306_A0.5050.99
18_F297_L0.5040.99
106_A135_A0.5030.99
206_V210_I0.5030.99
105_G167_F0.5030.99
269_I325_T0.5030.99
145_I167_F0.5030.99
278_H281_R0.5030.99
70_L210_I0.5020.99
150_A160_L0.5000.99
25_T69_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.8659 100 0.2 Contact Map
2qi9A 2 0.9417 100 0.2 Contact Map
2nq2A 2 0.898 100 0.203 Contact Map
2m8rA 1 0.1108 38.2 0.958 Contact Map
4huqS 1 0.4606 29.1 0.961 Contact Map
4z7fA 2 0.4781 12.8 0.967 Contact Map
4xtrG 1 0.0641 8.6 0.969 Contact Map
2kogA 1 0.1166 7.6 0.97 Contact Map
3rlbA 1 0.4927 7.2 0.97 Contact Map
4lz6A 1 0.4169 7.1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.