GREMLIN Database
YFIZ - Probable siderophore transport system permease protein YfiZ
UniProt: O31568 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (319)
Sequences: 13884 (9958)
Seq/√Len: 557.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_N277_D4.3751.00
72_A286_A3.7341.00
108_G123_S3.6051.00
23_A295_C3.5321.00
80_L210_C3.4551.00
24_V64_A3.2961.00
233_K236_L3.2151.00
73_S203_A3.0851.00
80_L241_M3.0391.00
68_T290_A2.9601.00
67_A188_V2.8721.00
270_A288_L2.8001.00
39_Q52_E2.7071.00
66_V191_R2.6091.00
76_A286_A2.5301.00
73_S248_L2.5001.00
73_S252_A2.4831.00
39_Q42_Q2.4431.00
24_V68_T2.4331.00
103_F165_L2.3691.00
224_E238_K2.3671.00
20_L291_I2.2661.00
70_V252_A2.2431.00
19_I291_I2.2361.00
79_A285_S2.2141.00
76_A207_L2.1741.00
274_V284_F2.1741.00
29_V37_W2.0951.00
70_V256_A2.0541.00
68_T294_V2.0481.00
20_L68_T2.0431.00
216_K237_L2.0071.00
49_G52_E2.0041.00
69_V200_F1.9851.00
103_F162_F1.9801.00
36_S39_Q1.9691.00
202_Y251_S1.9501.00
107_A111_F1.9161.00
63_R297_D1.8951.00
27_S64_A1.8771.00
83_A278_Y1.8751.00
81_M245_V1.8711.00
218_N278_Y1.8591.00
23_A291_I1.8521.00
213_L216_K1.8271.00
219_L232_Q1.8161.00
38_R42_Q1.8151.00
106_V166_T1.7941.00
13_L284_F1.7911.00
209_I244_C1.7711.00
206_A248_L1.7081.00
53_H57_K1.6821.00
191_R195_L1.6751.00
213_L240_V1.6341.00
50_T53_H1.6001.00
236_L240_V1.5891.00
79_A281_V1.5701.00
65_L196_L1.5531.00
128_A250_G1.5431.00
299_G303_I1.5391.00
26_A29_V1.5391.00
197_M201_P1.5291.00
262_I293_L1.5291.00
192_S195_L1.5261.00
105_I124_S1.5151.00
213_L237_L1.5011.00
43_A57_K1.4981.00
206_A247_M1.4881.00
23_A294_V1.4671.00
132_A246_V1.4571.00
16_L287_V1.4541.00
20_L287_V1.4491.00
26_A30_Y1.4381.00
300_A311_V1.4361.00
104_F123_S1.4091.00
188_V293_L1.3881.00
12_V284_F1.3831.00
299_G314_M1.3751.00
27_S298_I1.3711.00
280_W283_P1.3641.00
16_L284_F1.3531.00
206_A244_C1.3341.00
201_P205_A1.3321.00
77_A248_L1.3281.00
41_Y45_T1.3211.00
270_A284_F1.3211.00
270_A281_V1.2991.00
102_G166_T1.2811.00
66_V255_I1.2751.00
16_L288_L1.2681.00
209_I213_L1.2631.00
161_M320_M1.2491.00
213_L241_M1.2491.00
197_M200_F1.2441.00
228_K235_G1.2381.00
69_V196_L1.2361.00
54_V58_D1.2351.00
131_T162_F1.2331.00
98_N249_A1.2321.00
20_L290_A1.2301.00
266_I292_L1.2271.00
75_A266_I1.2021.00
266_I288_L1.2001.00
236_L239_F1.1931.00
278_Y281_V1.1881.00
104_F127_G1.1881.00
219_L230_L1.1771.00
84_L241_M1.1771.00
13_L280_W1.1681.00
16_L291_I1.1661.00
226_V229_G1.1631.00
256_A259_I1.1621.00
199_M255_I1.1561.00
51_N54_V1.1511.00
43_A53_H1.1511.00
34_G37_W1.1401.00
102_G184_L1.1381.00
237_L240_V1.1341.00
116_S119_A1.1201.00
106_V180_V1.1171.00
72_A290_A1.1101.00
67_A294_V1.1071.00
133_A137_A1.1051.00
125_F247_M1.1041.00
100_G127_G1.0951.00
235_G238_K1.0931.00
208_V212_F1.0911.00
100_G131_T1.0911.00
103_F107_A1.0901.00
122_W126_L1.0881.00
110_F169_L1.0881.00
174_E178_A1.0861.00
33_T55_I1.0851.00
69_V199_M1.0831.00
67_A293_L1.0801.00
11_I14_V1.0791.00
223_G227_A1.0791.00
123_S127_G1.0781.00
209_I240_V1.0771.00
79_A282_L1.0681.00
301_R308_E1.0641.00
66_V196_L1.0611.00
72_A75_A1.0611.00
210_C244_C1.0611.00
235_G239_F1.0561.00
65_L193_L1.0541.00
159_A163_S1.0431.00
79_A278_Y1.0401.00
199_M203_A1.0361.00
283_P286_A1.0261.00
99_A162_F1.0161.00
173_N176_E1.0141.00
30_Y302_Y1.0071.00
48_N53_H1.0061.00
140_S235_G1.0011.00
43_A56_I1.0011.00
274_V280_W0.9981.00
135_V158_M0.9901.00
29_V40_V0.9881.00
47_F53_H0.9831.00
57_K61_L0.9821.00
291_I295_C0.9821.00
297_D301_R0.9801.00
280_W284_F0.9801.00
299_G302_Y0.9761.00
168_G172_V0.9761.00
300_A314_M0.9751.00
205_A208_V0.9751.00
206_A251_S0.9731.00
107_A169_L0.9681.00
24_V294_V0.9651.00
25_C29_V0.9601.00
98_N258_P0.9601.00
17_I21_L0.9591.00
43_A48_N0.9581.00
43_A52_E0.9571.00
237_L241_M0.9561.00
217_I241_M0.9521.00
18_F22_T0.9501.00
259_I293_L0.9471.00
277_D280_W0.9451.00
28_V64_A0.9311.00
266_I270_A0.9291.00
198_T201_P0.9281.00
23_A298_I0.9281.00
281_V285_S0.9191.00
115_Q119_A0.9191.00
42_Q46_S0.9171.00
64_A298_I0.9121.00
130_F134_I0.9111.00
201_P204_A0.9081.00
40_V56_I0.9071.00
316_A321_P0.9041.00
321_P325_Y0.9021.00
103_F166_T0.8991.00
12_V15_C0.8921.00
322_V325_Y0.8921.00
11_I15_C0.8911.00
252_A256_A0.8911.00
304_I307_Q0.8901.00
140_S143_R0.8891.00
193_L196_L0.8881.00
25_C37_W0.8841.00
69_V203_A0.8731.00
232_Q237_L0.8711.00
97_I128_A0.8701.00
53_H58_D0.8661.00
225_D228_K0.8651.00
12_V16_L0.8651.00
42_Q47_F0.8571.00
72_A207_L0.8561.00
35_T56_I0.8561.00
273_V288_L0.8551.00
17_I287_V0.8511.00
31_G60_R0.8491.00
218_N279_R0.8471.00
239_F243_L0.8431.00
180_V184_L0.8421.00
135_V139_G0.8411.00
77_A245_V0.8391.00
73_S77_A0.8391.00
105_I120_L0.8361.00
224_E228_K0.8341.00
300_A310_P0.8331.00
136_Y239_F0.8311.00
78_G267_P0.8261.00
209_I212_F0.8251.00
295_C299_G0.8231.00
42_Q45_T0.8221.00
103_F169_L0.8191.00
93_G98_N0.8091.00
109_S120_L0.8071.00
21_L25_C0.8061.00
213_L244_C0.8041.00
64_A294_V0.8011.00
101_A128_A0.7981.00
278_Y283_P0.7941.00
61_L193_L0.7931.00
108_G120_L0.7921.00
174_E177_L0.7921.00
178_A181_L0.7921.00
214_G279_R0.7921.00
20_L24_V0.7921.00
271_R281_V0.7901.00
204_A208_V0.7891.00
302_Y305_M0.7881.00
175_L179_Q0.7821.00
75_A79_A0.7811.00
202_Y206_A0.7811.00
29_V34_G0.7781.00
234_T238_K0.7781.00
303_I306_P0.7771.00
137_A140_S0.7761.00
242_A246_V0.7761.00
224_E234_T0.7741.00
194_D197_M0.7731.00
30_Y34_G0.7691.00
126_L130_F0.7681.00
262_I315_T0.7671.00
99_A102_G0.7671.00
27_S301_R0.7671.00
210_C241_M0.7651.00
50_T54_V0.7641.00
270_A274_V0.7621.00
136_Y235_G0.7611.00
81_M95_F0.7581.00
195_L255_I0.7571.00
304_I309_V0.7561.00
72_A203_A0.7551.00
100_G162_F0.7501.00
63_R301_R0.7501.00
317_I321_P0.7501.00
293_L315_T0.7431.00
21_L24_V0.7421.00
140_S145_G0.7381.00
287_V291_I0.7371.00
119_A122_W0.7361.00
125_F128_A0.7361.00
203_A252_A0.7351.00
270_A273_V0.7341.00
227_A234_T0.7331.00
125_F129_A0.7301.00
35_T52_E0.7281.00
91_S94_I0.7271.00
63_R308_E0.7271.00
211_F214_G0.7221.00
97_I132_A0.7211.00
212_F216_K0.7201.00
107_A165_L0.7191.00
279_R283_P0.7171.00
131_T135_V0.7161.00
46_S53_H0.7141.00
28_V61_L0.7121.00
199_M251_S0.7051.00
216_K232_Q0.7021.00
40_V43_A0.7001.00
140_S146_L0.7001.00
251_S254_A0.7001.00
33_T37_W0.6991.00
77_A249_A0.6971.00
106_V170_L0.6961.00
128_A246_V0.6951.00
54_V57_K0.6931.00
49_G53_H0.6931.00
325_Y329_R0.6911.00
85_T152_T0.6901.00
129_A250_G0.6891.00
76_A210_C0.6891.00
75_A286_A0.6881.00
22_T25_C0.6851.00
200_F204_A0.6841.00
251_S255_I0.6841.00
109_S179_Q0.6841.00
132_A242_A0.6841.00
42_Q48_N0.6841.00
54_V59_V0.6831.00
65_L69_V0.6811.00
293_L311_V0.6811.00
220_L234_T0.6801.00
74_L262_I0.6781.00
102_G258_P0.6741.00
20_L294_V0.6731.00
228_K234_T0.6711.00
199_M202_Y0.6701.00
259_I311_V0.6701.00
290_A294_V0.6691.00
207_L211_F0.6681.00
140_S144_E0.6661.00
66_V199_M0.6661.00
128_A132_A0.6651.00
33_T36_S0.6631.00
116_S121_V0.6621.00
117_P121_V0.6621.00
138_A154_A0.6611.00
272_F326_I0.6601.00
206_A210_C0.6571.00
76_A282_L0.6571.00
269_F272_F0.6551.00
181_L184_L0.6531.00
292_L296_A0.6531.00
83_A221_V0.6521.00
16_L20_L0.6491.00
265_I323_F0.6481.00
269_F288_L0.6461.00
188_V311_V0.6461.00
37_W40_V0.6441.00
163_S184_L0.6401.00
12_V273_V0.6391.00
167_Q183_W0.6371.00
30_Y298_I0.6371.00
24_V28_V0.6321.00
262_I292_L0.6311.00
202_Y247_M0.6311.00
267_P285_S0.6311.00
193_L197_M0.6301.00
118_Q122_W0.6301.00
28_V56_I0.6291.00
170_L181_L0.6291.00
147_T150_K0.6281.00
176_E179_Q0.6271.00
286_A290_A0.6271.00
167_Q171_S0.6251.00
134_I137_A0.6251.00
91_S263_G0.6221.00
107_A112_L0.6201.00
108_G119_A0.6191.00
61_L65_L0.6191.00
35_T43_A0.6181.00
269_F292_L0.6181.00
70_V188_V0.6171.00
15_C19_I0.6161.00
104_F108_G0.6161.00
292_L318_I0.6151.00
56_I61_L0.6141.00
296_A314_M0.6131.00
295_C298_I0.6131.00
72_A76_A0.6101.00
109_S180_V0.6091.00
154_A157_A0.6091.00
300_A308_E0.6091.00
98_N101_A0.6081.00
80_L244_C0.6081.00
120_L123_S0.6061.00
129_A246_V0.6061.00
22_T26_A0.6061.00
139_G154_A0.6041.00
99_A159_A0.6041.00
265_I269_F0.6021.00
127_G131_T0.5981.00
163_S167_Q0.5981.00
216_K219_L0.5971.00
132_A136_Y0.5951.00
149_I152_T0.5951.00
85_T88_P0.5951.00
249_A253_V0.5931.00
38_R41_Y0.5911.00
67_A311_V0.5891.00
25_C41_Y0.5871.00
37_W41_Y0.5861.00
198_T202_Y0.5841.00
188_V256_A0.5831.00
12_V274_V0.5831.00
27_S294_V0.5781.00
36_S52_E0.5750.99
203_A207_L0.5740.99
212_F215_Q0.5720.99
40_V45_T0.5720.99
269_F322_V0.5700.99
13_L17_I0.5700.99
297_D308_E0.5700.99
81_M97_I0.5670.99
240_V244_C0.5640.99
241_M245_V0.5640.99
97_I135_V0.5640.99
264_I326_I0.5640.99
130_F133_A0.5640.99
218_N283_P0.5610.99
136_Y140_S0.5610.99
81_M90_A0.5610.99
265_I322_V0.5600.99
250_G254_A0.5590.99
300_A303_I0.5590.99
66_V70_V0.5580.99
44_F56_I0.5570.99
48_N52_E0.5560.99
99_A163_S0.5550.99
240_V243_L0.5550.99
47_F50_T0.5540.99
39_Q48_N0.5530.99
108_G112_L0.5530.99
220_L237_L0.5530.99
218_N221_V0.5510.99
194_D198_T0.5490.99
246_V250_G0.5440.99
298_I302_Y0.5430.99
170_L184_L0.5420.99
154_A158_M0.5400.99
26_A298_I0.5390.99
126_L129_A0.5360.99
80_L245_V0.5340.99
215_Q218_N0.5340.99
29_V41_Y0.5320.99
143_R146_L0.5310.99
205_A209_I0.5310.99
39_Q46_S0.5310.99
325_Y328_R0.5300.99
233_K240_V0.5260.99
23_A26_A0.5230.99
15_C18_F0.5230.99
288_L291_I0.5220.99
134_I158_M0.5220.99
100_G158_M0.5200.99
328_R331_A0.5200.99
146_L150_K0.5160.99
139_G151_L0.5150.99
283_P287_V0.5140.99
19_I23_A0.5140.99
196_L199_M0.5130.99
233_K239_F0.5130.99
207_L210_C0.5130.99
217_I278_Y0.5130.99
268_H271_R0.5120.99
260_S265_I0.5110.99
270_A285_S0.5080.99
294_V298_I0.5080.99
34_G38_R0.5080.99
275_G279_R0.5080.99
20_L64_A0.5070.99
66_V256_A0.5060.99
203_A208_V0.5060.99
75_A289_G0.5050.99
39_Q43_A0.5040.99
164_S265_I0.5030.99
170_L177_L0.5010.99
259_I315_T0.5010.99
86_K224_E0.5010.99
207_L286_A0.5000.99
266_I296_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9219 100 0.182 Contact Map
2qi9A 2 0.9489 100 0.191 Contact Map
4g1uA 2 0.8889 100 0.193 Contact Map
1pw4A 1 0.8739 16.6 0.964 Contact Map
3dh4A 3 0.6126 14.8 0.965 Contact Map
2xq2A 2 0.5856 12.2 0.966 Contact Map
3rlfF 1 0.4024 9.4 0.968 Contact Map
4tquM 1 0.4204 7 0.97 Contact Map
3rlbA 1 0.5045 5.8 0.971 Contact Map
3wdoA 1 0.8739 5.6 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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