GREMLIN Database
YFIY - Probable siderophore-binding lipoprotein YfiY
UniProt: O31567 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (286)
Sequences: 13700 (10892)
Seq/√Len: 644.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_T168_K4.1061.00
252_D286_K3.9921.00
158_A167_G3.9901.00
151_K175_D3.8141.00
163_K166_K3.4311.00
177_R315_D3.2011.00
159_N164_A3.1391.00
286_K290_S3.1081.00
59_V65_T2.9051.00
155_T171_I2.7111.00
179_S183_N2.6821.00
166_K169_E2.6501.00
168_K172_A2.5681.00
216_L221_F2.5451.00
172_A176_K2.5401.00
111_A114_E2.4421.00
247_S250_D2.3871.00
58_V112_I2.2271.00
42_H47_S2.2121.00
192_T222_K2.1741.00
57_I161_V2.1041.00
68_L161_V2.1011.00
175_D179_S2.0611.00
176_K180_D2.0581.00
277_T291_G2.0051.00
56_R76_V1.9911.00
213_G217_D1.9711.00
73_I161_V1.9661.00
67_A154_L1.9591.00
254_D286_K1.9431.00
180_D184_K1.9411.00
274_N278_S1.9131.00
133_Q136_A1.8821.00
73_I163_K1.8551.00
169_E173_D1.8351.00
41_K47_S1.8261.00
37_T49_N1.7871.00
131_Y135_N1.7821.00
39_T49_N1.7821.00
121_I157_Y1.7451.00
255_V292_N1.7371.00
46_T135_N1.7301.00
77_G115_L1.7211.00
255_V294_H1.7081.00
285_L288_V1.6981.00
42_H46_T1.6871.00
165_D169_E1.6551.00
286_K289_K1.6401.00
152_D155_T1.6301.00
179_S182_K1.6111.00
177_R311_N1.5871.00
107_P112_I1.5671.00
38_R159_N1.5471.00
132_D136_A1.5171.00
173_D177_R1.4911.00
41_K46_T1.4881.00
284_N289_K1.4811.00
191_K255_V1.4661.00
58_V115_L1.4641.00
166_K170_V1.4581.00
193_V221_F1.4561.00
274_N277_T1.4501.00
282_W288_V1.4321.00
99_K111_A1.4311.00
181_L314_L1.4291.00
273_A277_T1.4171.00
245_K279_S1.4161.00
113_A137_I1.4131.00
149_N152_D1.4121.00
108_N111_A1.4101.00
128_E132_D1.4011.00
256_L287_A1.3941.00
58_V77_G1.3821.00
190_N222_K1.3761.00
152_D156_L1.3671.00
202_E242_T1.3581.00
110_E246_E1.3401.00
79_V82_W1.3301.00
151_K171_I1.3261.00
59_V68_L1.3151.00
315_D319_T1.3141.00
183_N186_G1.3131.00
164_A168_K1.3021.00
132_D135_N1.3011.00
50_I53_N1.2961.00
76_V115_L1.2901.00
181_L318_E1.2891.00
247_S251_M1.2831.00
294_H320_Y1.2821.00
71_L163_K1.2781.00
141_V160_A1.2741.00
176_K179_S1.2681.00
122_G142_F1.2571.00
177_R180_D1.2571.00
54_P118_D1.2511.00
165_D168_K1.2491.00
127_Q130_I1.2451.00
68_L73_I1.2451.00
13_M16_M1.2391.00
316_D319_T1.2251.00
192_T254_D1.2221.00
141_V156_L1.2201.00
89_D92_K1.2191.00
172_A175_D1.2191.00
180_D183_N1.2161.00
154_L167_G1.2051.00
39_T47_S1.1981.00
170_V173_D1.1951.00
155_T175_D1.1911.00
227_Q251_M1.1911.00
156_L159_N1.1841.00
88_Y91_L1.1801.00
311_N315_D1.1711.00
171_I175_D1.1691.00
195_V216_L1.1621.00
56_R116_K1.1591.00
225_E251_M1.1531.00
14_A17_V1.1511.00
178_V314_L1.1421.00
39_T46_T1.1411.00
109_V133_Q1.1401.00
184_K318_E1.1351.00
119_L141_V1.1341.00
55_K118_D1.1301.00
182_K218_Q1.1221.00
224_P251_M1.1151.00
173_D176_K1.1091.00
221_F321_F1.1041.00
208_T217_D1.1031.00
57_I119_L1.1011.00
191_K292_N1.0681.00
42_H131_Y1.0681.00
130_I133_Q1.0661.00
222_K226_K1.0631.00
21_C24_S1.0561.00
194_S253_A1.0501.00
37_T52_A1.0471.00
255_V321_F1.0441.00
70_A170_V1.0411.00
55_K74_K1.0351.00
194_S205_I1.0171.00
145_S148_G1.0141.00
155_T159_N1.0021.00
182_K186_G1.0021.00
185_L188_Q0.9961.00
69_L95_M0.9901.00
282_W285_L0.9771.00
178_V182_K0.9701.00
36_K162_N0.9691.00
50_I139_P0.9691.00
225_E228_V0.9661.00
146_L149_N0.9621.00
37_T53_N0.9471.00
257_F317_I0.9451.00
194_S197_R0.9431.00
224_P227_Q0.9421.00
120_I138_A0.9421.00
143_A156_L0.9371.00
68_L75_P0.9371.00
68_L121_I0.9321.00
78_A98_V0.9311.00
177_R181_L0.9171.00
21_C25_E0.9151.00
258_Y295_E0.9131.00
167_G171_I0.9111.00
214_I218_Q0.9101.00
75_P98_V0.9091.00
297_D300_V0.9091.00
57_I68_L0.9091.00
214_I217_D0.9051.00
280_S283_K0.9051.00
11_F15_V0.9041.00
286_K292_N0.9041.00
53_N163_K0.9031.00
80_K100_N0.9031.00
301_W304_A0.9031.00
36_K52_A0.9021.00
50_I54_P0.9011.00
157_Y161_V0.8971.00
196_V279_S0.8891.00
288_V293_A0.8891.00
156_L160_A0.8881.00
37_T51_P0.8871.00
16_M19_S0.8841.00
158_A171_I0.8771.00
44_M142_F0.8761.00
53_N162_N0.8741.00
67_A157_Y0.8721.00
174_F218_Q0.8711.00
93_D96_K0.8711.00
275_Q278_S0.8701.00
195_V259_F0.8691.00
121_I160_A0.8611.00
225_E247_S0.8591.00
92_K95_M0.8521.00
124_K144_E0.8451.00
42_H45_G0.8441.00
119_L160_A0.8421.00
71_L170_V0.8411.00
193_V216_L0.8401.00
69_L75_P0.8231.00
54_P119_L0.8211.00
248_I285_L0.8211.00
12_L16_M0.8201.00
277_T293_A0.8191.00
38_R50_I0.8161.00
64_G121_I0.8121.00
66_E308_K0.8111.00
61_T123_N0.8061.00
44_M135_N0.8051.00
157_Y160_A0.8011.00
117_P120_I0.8001.00
52_A55_K0.7931.00
223_R227_Q0.7831.00
283_K288_V0.7831.00
99_K102_G0.7821.00
169_E172_A0.7821.00
185_L318_E0.7821.00
60_L120_I0.7781.00
198_F201_G0.7751.00
249_P285_L0.7731.00
174_F178_V0.7721.00
243_D251_M0.7721.00
193_V257_F0.7691.00
40_V141_V0.7671.00
9_F13_M0.7661.00
168_K171_I0.7661.00
74_K163_K0.7651.00
272_W275_Q0.7641.00
36_K53_N0.7631.00
316_D320_Y0.7621.00
15_V19_S0.7611.00
153_N156_L0.7611.00
155_T158_A0.7601.00
297_D316_D0.7581.00
77_G101_V0.7571.00
196_V199_L0.7521.00
196_V256_L0.7511.00
15_V18_L0.7511.00
315_D318_E0.7511.00
89_D93_D0.7451.00
279_S283_K0.7431.00
206_Y240_F0.7431.00
314_L318_E0.7391.00
151_K155_T0.7371.00
71_L161_V0.7371.00
135_N140_T0.7361.00
151_K178_V0.7351.00
249_P284_N0.7341.00
71_L158_A0.7341.00
91_L95_M0.7331.00
170_V174_F0.7331.00
70_A154_L0.7301.00
139_P142_F0.7291.00
215_I314_L0.7291.00
59_V75_P0.7281.00
177_R312_Y0.7271.00
40_V50_I0.7261.00
180_D315_D0.7231.00
257_F294_H0.7171.00
249_P253_A0.7151.00
71_L166_K0.7151.00
77_G102_G0.7141.00
194_S248_I0.7141.00
191_K221_F0.7101.00
11_F17_V0.7061.00
14_A18_L0.7041.00
78_A100_N0.7041.00
91_L94_D0.7021.00
206_Y210_S0.7011.00
196_V201_G0.7011.00
194_S198_F0.7011.00
244_S247_S0.6971.00
10_V13_M0.6971.00
103_L106_E0.6961.00
90_Y93_D0.6941.00
306_G309_A0.6911.00
154_L170_V0.6871.00
19_S22_N0.6871.00
11_F14_A0.6851.00
120_I137_I0.6851.00
70_A308_K0.6851.00
223_R226_K0.6851.00
181_L185_L0.6841.00
312_Y316_D0.6811.00
208_T228_V0.6811.00
205_I225_E0.6781.00
10_V14_A0.6781.00
72_G163_K0.6771.00
210_S213_G0.6751.00
56_R118_D0.6731.00
184_K187_D0.6711.00
20_A24_S0.6701.00
101_V115_L0.6631.00
66_E306_G0.6631.00
177_R318_E0.6621.00
178_V218_Q0.6601.00
12_L15_V0.6571.00
112_I134_L0.6561.00
50_I119_L0.6521.00
161_V164_A0.6521.00
150_W174_F0.6501.00
128_E131_Y0.6481.00
129_K132_D0.6481.00
273_A295_E0.6441.00
72_G166_K0.6431.00
58_V117_P0.6421.00
71_L167_G0.6421.00
308_K312_Y0.6411.00
148_G152_D0.6411.00
59_V64_G0.6371.00
155_T164_A0.6361.00
299_V303_T0.6351.00
99_K115_L0.6341.00
126_R130_I0.6271.00
109_V112_I0.6261.00
216_L219_L0.6251.00
174_F177_R0.6221.00
88_Y92_K0.6211.00
61_T64_G0.6201.00
258_Y293_A0.6181.00
20_A23_S0.6171.00
58_V101_V0.6171.00
300_V303_T0.6131.00
313_L317_I0.6101.00
193_V197_R0.6101.00
307_I311_N0.6091.00
53_N118_D0.6091.00
10_V17_V0.6091.00
154_L171_I0.6091.00
64_G143_A0.6081.00
69_L94_D0.6071.00
194_S224_P0.6061.00
171_I174_F0.6061.00
71_L154_L0.6051.00
17_V20_A0.5971.00
259_F296_V0.5931.00
219_L314_L0.5931.00
68_L157_Y0.5921.00
196_V205_I0.5901.00
50_I160_A0.5891.00
317_I321_F0.5891.00
95_M98_V0.5881.00
109_V137_I0.5861.00
43_A156_L0.5861.00
260_T295_E0.5841.00
253_A256_L0.5841.00
221_F255_V0.5801.00
298_D301_W0.5791.00
192_T255_V0.5781.00
311_N314_L0.5781.00
62_N81_S0.5771.00
245_K282_W0.5771.00
36_K51_P0.5761.00
301_W313_L0.5721.00
193_V196_V0.5691.00
208_T226_K0.5671.00
54_P161_V0.5661.00
58_V120_I0.5641.00
261_Y298_D0.5641.00
248_I251_M0.5631.00
183_N187_D0.5601.00
276_W279_S0.5591.00
300_V316_D0.5571.00
110_E113_A0.5571.00
109_V130_I0.5561.00
182_K219_L0.5551.00
65_T78_A0.5541.00
194_S256_L0.5541.00
257_F321_F0.5541.00
296_V301_W0.5501.00
255_V259_F0.5491.00
46_T49_N0.5471.00
204_R242_T0.5461.00
38_R52_A0.5461.00
46_T131_Y0.5451.00
181_L184_K0.5441.00
243_D248_I0.5441.00
207_Y213_G0.5441.00
34_S37_T0.5421.00
173_D311_N0.5421.00
313_L316_D0.5391.00
151_K218_Q0.5371.00
195_V212_P0.5360.99
12_L17_V0.5350.99
209_D213_G0.5350.99
285_L289_K0.5340.99
197_R200_S0.5340.99
210_S240_F0.5330.99
208_T227_Q0.5330.99
308_K311_N0.5300.99
85_D88_Y0.5300.99
145_S149_N0.5290.99
18_L21_C0.5290.99
75_P78_A0.5280.99
219_L321_F0.5280.99
279_S282_W0.5270.99
182_K185_L0.5270.99
64_G67_A0.5270.99
151_K174_F0.5270.99
37_T50_I0.5260.99
249_P281_L0.5220.99
175_D178_V0.5200.99
64_G157_Y0.5200.99
256_L282_W0.5200.99
96_K99_K0.5180.99
59_V78_A0.5170.99
178_V181_L0.5160.99
309_A313_L0.5160.99
56_R117_P0.5150.99
111_A115_L0.5150.99
213_G226_K0.5150.99
282_W293_A0.5140.99
309_A312_Y0.5120.99
129_K133_Q0.5120.99
44_M131_Y0.5100.99
71_L157_Y0.5100.99
58_V76_V0.5090.99
131_Y142_F0.5070.99
38_R54_P0.5050.99
44_M47_S0.5040.99
51_P139_P0.5030.99
67_A70_A0.5030.99
210_S239_T0.5020.99
94_D97_G0.5010.99
206_Y212_P0.5010.99
67_A307_I0.5010.99
89_D95_M0.5010.99
178_V310_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n01A 1 0.8615 100 0.207 Contact Map
4hn9A 1 0.8585 100 0.236 Contact Map
4mlzA 1 0.8462 100 0.24 Contact Map
3lhsA 1 0.8831 100 0.243 Contact Map
3tnyA 1 0.8615 100 0.25 Contact Map
4ovkA 1 0.8462 100 0.255 Contact Map
3tlkA 1 0.8646 100 0.256 Contact Map
4mo9A 1 0.8523 100 0.256 Contact Map
3mwfA 1 0.8738 100 0.266 Contact Map
3r5tA 1 0.8677 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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