GREMLIN Database
YFIU - Uncharacterized MFS-type transporter YfiU
UniProt: O31563 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 518 (407)
Sequences: 29961 (20240)
Seq/√Len: 1003.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_Q103_L5.0771.00
89_G178_A4.4921.00
87_L114_G3.6691.00
96_A172_L3.5421.00
211_S247_F3.2621.00
94_L107_S3.2111.00
207_L253_Y3.0411.00
102_P106_I2.9741.00
392_A400_A2.8321.00
355_L369_A2.7081.00
269_S396_N2.6991.00
56_L109_L2.6871.00
100_S103_L2.5631.00
218_G240_I2.5521.00
77_R128_A2.5021.00
210_L246_C2.4931.00
325_G375_I2.4721.00
203_A253_Y2.4671.00
321_A371_V2.3881.00
215_V243_G2.3581.00
45_V101_F2.3091.00
82_L186_A2.2771.00
201_D204_G2.2061.00
248_A252_S2.1471.00
64_S113_L2.1461.00
95_V107_S2.1391.00
60_G109_L2.1051.00
307_P310_K2.0961.00
267_A396_N2.0871.00
183_V187_C2.0731.00
393_A396_N2.0721.00
82_L182_V2.0671.00
134_K137_K2.0541.00
185_G189_I2.0541.00
91_G114_G2.0491.00
35_A161_L1.9901.00
237_Y241_I1.9561.00
352_G373_A1.9451.00
160_L169_W1.9051.00
103_L107_S1.8951.00
91_G110_I1.8951.00
164_T169_W1.8421.00
250_L254_E1.8311.00
84_E117_G1.8171.00
284_L411_G1.8141.00
211_S243_G1.8031.00
222_L231_L1.7891.00
301_E311_A1.7731.00
299_Y304_L1.7731.00
21_G81_F1.7691.00
166_S169_W1.7551.00
46_S49_W1.7301.00
68_V117_G1.6941.00
91_G107_S1.6851.00
19_T145_M1.6851.00
199_R263_D1.6681.00
214_A239_C1.6671.00
93_L97_L1.6651.00
12_K134_K1.6541.00
362_E365_E1.6481.00
73_D398_G1.6271.00
49_W101_F1.6191.00
291_A419_Y1.6141.00
45_V49_W1.5871.00
290_L412_L1.5841.00
238_G242_F1.5741.00
23_F149_A1.5721.00
331_A335_K1.5691.00
130_L138_A1.5661.00
261_G264_P1.5601.00
162_D309_A1.5601.00
251_I255_K1.5571.00
14_A129_T1.5551.00
92_S174_N1.5521.00
63_V209_S1.5401.00
56_L105_L1.5271.00
218_G243_G1.5241.00
78_K82_L1.5201.00
82_L185_G1.5171.00
214_A246_C1.5161.00
306_V314_W1.5161.00
101_F105_L1.5151.00
38_T41_E1.5081.00
234_P238_G1.5021.00
163_W166_S1.4991.00
79_K191_E1.4991.00
211_S246_C1.4911.00
132_K135_Q1.4631.00
271_L277_Q1.4411.00
136_G334_D1.4351.00
131_P134_K1.4351.00
95_V104_F1.4331.00
363_K367_V1.4311.00
352_G376_G1.4301.00
221_N229_H1.4281.00
255_K269_S1.4261.00
98_S107_S1.4191.00
279_T388_L1.4181.00
310_K313_Y1.4131.00
348_I376_G1.4131.00
86_C182_V1.4061.00
35_A170_L1.4011.00
70_K74_R1.3951.00
207_L246_C1.3881.00
127_L135_Q1.3871.00
350_C354_A1.3841.00
28_D31_I1.3791.00
214_A242_F1.3791.00
93_L175_L1.3651.00
71_L80_L1.3541.00
53_G104_F1.3511.00
98_S103_L1.3491.00
72_S77_R1.3461.00
243_G247_F1.3361.00
159_F163_W1.3301.00
83_I87_L1.3271.00
306_V310_K1.3241.00
352_G369_A1.3211.00
202_A206_F1.3171.00
217_Y221_N1.3171.00
31_I170_L1.3121.00
17_L184_F1.3061.00
72_S121_I1.3051.00
184_F188_F1.2971.00
64_S116_G1.2941.00
242_F246_C1.2911.00
364_W368_I1.2851.00
251_I268_Y1.2841.00
40_N50_G1.2801.00
17_L188_F1.2781.00
19_T141_L1.2691.00
194_A197_A1.2641.00
253_Y261_G1.2601.00
57_Y115_G1.2601.00
277_Q281_I1.2461.00
94_L103_L1.2411.00
347_I351_A1.2381.00
158_S308_A1.2331.00
310_K314_W1.2311.00
204_G253_Y1.2301.00
162_D307_P1.2301.00
345_S379_F1.2261.00
267_A399_T1.2231.00
15_I130_L1.2231.00
90_L94_L1.2151.00
218_G236_V1.2141.00
89_G182_V1.2071.00
207_L249_A1.2021.00
102_P105_L1.2021.00
318_L374_G1.2021.00
81_F185_G1.1991.00
331_A334_D1.1981.00
300_V314_W1.1961.00
252_S255_K1.1911.00
60_G112_A1.1901.00
321_A325_G1.1861.00
325_G378_G1.1811.00
17_L181_L1.1771.00
179_V183_V1.1761.00
229_H235_E1.1751.00
337_G340_K1.1661.00
85_V181_L1.1611.00
82_L86_C1.1541.00
67_I205_I1.1511.00
210_L214_A1.1461.00
352_G372_A1.1451.00
364_W367_V1.1451.00
345_S380_L1.1351.00
273_N277_Q1.1341.00
216_M413_T1.1281.00
20_I181_L1.1271.00
169_W176_P1.1271.00
99_Q102_P1.1271.00
26_A146_N1.1231.00
28_D174_N1.1201.00
24_M178_A1.1191.00
354_A358_L1.1131.00
29_N58_T1.1081.00
97_L172_L1.1071.00
89_G93_L1.1001.00
330_G334_D1.1001.00
329_G379_F1.0991.00
354_A357_P1.0801.00
274_H278_R1.0781.00
221_N228_L1.0771.00
344_L379_F1.0751.00
332_L336_K1.0691.00
340_K343_I1.0681.00
133_E137_K1.0671.00
365_E369_A1.0601.00
368_I371_V1.0601.00
55_T220_T1.0571.00
349_S376_G1.0521.00
126_I142_L1.0461.00
244_I248_A1.0451.00
280_L407_V1.0441.00
247_F251_I1.0401.00
31_I157_G1.0381.00
229_H236_V1.0341.00
218_G239_C1.0341.00
127_L397_K1.0301.00
249_A252_S1.0251.00
76_G79_K1.0211.00
273_N393_A1.0201.00
286_S380_L1.0191.00
240_I244_I1.0141.00
229_H233_N1.0091.00
95_V171_F1.0081.00
266_L403_T1.0051.00
355_L358_L1.0001.00
276_F280_L1.0001.00
79_K83_I0.9961.00
89_G175_L0.9951.00
87_L91_G0.9941.00
235_E238_G0.9941.00
52_W56_L0.9901.00
276_F400_A0.9881.00
273_N396_N0.9861.00
156_I159_F0.9801.00
187_C190_A0.9801.00
274_H277_Q0.9801.00
122_G142_L0.9791.00
295_F420_A0.9781.00
358_L369_A0.9771.00
78_K186_A0.9761.00
56_L60_G0.9701.00
80_L117_G0.9701.00
103_L106_I0.9691.00
168_H172_L0.9671.00
71_L75_Y0.9671.00
206_F210_L0.9661.00
94_L97_L0.9651.00
184_F187_C0.9631.00
198_K263_D0.9611.00
361_T365_E0.9581.00
314_W363_K0.9541.00
255_K268_Y0.9531.00
422_F426_G0.9501.00
200_L205_I0.9491.00
300_V366_F0.9491.00
365_E368_I0.9401.00
32_I53_G0.9351.00
77_R191_E0.9331.00
66_P208_L0.9311.00
136_G330_G0.9311.00
318_L373_A0.9291.00
106_I109_L0.9241.00
38_T42_S0.9231.00
160_L164_T0.9211.00
325_G329_G0.9211.00
325_G379_F0.9191.00
275_M391_E0.9181.00
80_L83_I0.9171.00
388_L404_L0.9171.00
280_L403_T0.9131.00
235_E239_C0.9111.00
269_S272_R0.9091.00
301_E308_A0.9091.00
249_A253_Y0.9081.00
248_A251_I0.9081.00
175_L179_V0.9081.00
327_W331_A0.9061.00
328_L331_A0.9051.00
205_I209_S0.9051.00
73_D77_R0.9041.00
199_R262_G0.9021.00
345_S376_G0.9011.00
84_E114_G0.9011.00
128_A397_K0.9001.00
232_G237_Y0.8971.00
25_A118_I0.8961.00
182_V186_A0.8951.00
160_L173_I0.8931.00
97_L107_S0.8891.00
69_G73_D0.8861.00
245_L249_A0.8801.00
33_S54_I0.8791.00
284_L407_V0.8791.00
54_I294_I0.8761.00
204_G254_E0.8721.00
356_F359_W0.8721.00
320_L324_I0.8691.00
60_G64_S0.8691.00
212_I406_L0.8671.00
411_G415_A0.8661.00
339_V343_I0.8661.00
344_L348_I0.8651.00
73_D399_T0.8631.00
325_G328_L0.8621.00
99_Q107_S0.8601.00
63_V213_L0.8601.00
191_E194_A0.8601.00
136_G140_G0.8581.00
45_V50_G0.8581.00
231_L236_V0.8541.00
159_F309_A0.8521.00
273_N391_E0.8491.00
53_G101_F0.8451.00
163_W309_A0.8411.00
368_I372_A0.8411.00
83_I86_C0.8391.00
214_A243_G0.8341.00
283_G404_L0.8321.00
211_S251_I0.8311.00
343_I347_I0.8291.00
300_V304_L0.8251.00
244_I247_F0.8241.00
209_S213_L0.8241.00
367_V371_V0.8231.00
284_L414_L0.8211.00
329_G378_G0.8201.00
272_R277_Q0.8181.00
336_K341_T0.8161.00
77_R124_S0.8151.00
358_L365_E0.8141.00
36_L50_G0.8141.00
18_F122_G0.8121.00
353_F373_A0.8091.00
359_W369_A0.8081.00
313_Y317_P0.8081.00
212_I410_I0.8071.00
346_G380_L0.8051.00
125_H129_T0.8021.00
21_G85_V0.7971.00
210_L242_F0.7961.00
162_D308_A0.7941.00
93_L172_L0.7901.00
353_F357_P0.7891.00
49_W102_P0.7871.00
91_G94_L0.7861.00
22_V146_N0.7851.00
385_L404_L0.7781.00
106_I110_I0.7781.00
39_I104_F0.7771.00
205_I265_I0.7761.00
124_S398_G0.7741.00
39_I50_G0.7741.00
348_I372_A0.7701.00
78_K191_E0.7701.00
210_L213_L0.7701.00
217_Y239_C0.7691.00
85_V182_V0.7661.00
79_K82_L0.7651.00
17_L185_G0.7651.00
357_P360_V0.7651.00
86_C90_L0.7631.00
99_Q168_H0.7611.00
298_S302_Q0.7601.00
26_A149_A0.7601.00
43_F101_F0.7571.00
208_L265_I0.7571.00
27_L31_I0.7561.00
241_I245_L0.7511.00
144_A148_M0.7501.00
300_V306_V0.7491.00
193_K196_E0.7491.00
232_G235_E0.7471.00
343_I346_G0.7451.00
236_V239_C0.7431.00
157_G161_L0.7431.00
351_A354_A0.7411.00
336_K340_K0.7411.00
94_L110_I0.7401.00
72_S124_S0.7391.00
153_G157_G0.7371.00
333_T383_A0.7361.00
355_L365_E0.7341.00
203_A207_L0.7341.00
89_G179_V0.7331.00
176_P180_L0.7321.00
240_I243_G0.7291.00
21_G118_I0.7281.00
58_T413_T0.7271.00
242_F249_A0.7271.00
123_S142_L0.7271.00
276_F388_L0.7261.00
317_P321_A0.7231.00
389_V401_L0.7221.00
69_G402_G0.7171.00
39_I43_F0.7111.00
180_L184_F0.7101.00
203_A206_F0.7101.00
233_N237_Y0.7091.00
75_Y80_L0.7081.00
154_P312_G0.7081.00
176_P179_V0.7071.00
72_S398_G0.7061.00
58_T412_L0.7051.00
238_G241_I0.7021.00
340_K344_L0.7011.00
347_I350_C0.7011.00
297_P311_A0.7001.00
211_S214_A0.6991.00
219_M222_L0.6991.00
35_A39_I0.6981.00
183_V186_A0.6981.00
147_G322_S0.6971.00
151_V319_A0.6961.00
379_F383_A0.6941.00
137_K331_A0.6941.00
108_R111_Q0.6941.00
23_F145_M0.6921.00
146_N150_A0.6921.00
233_N236_V0.6911.00
341_T344_L0.6891.00
62_S410_I0.6881.00
321_A375_I0.6871.00
63_V205_I0.6871.00
405_S408_R0.6861.00
200_L204_G0.6851.00
294_I416_P0.6831.00
52_W59_L0.6821.00
271_L276_F0.6811.00
126_I138_A0.6801.00
344_L347_I0.6801.00
169_W172_L0.6791.00
36_L54_I0.6791.00
11_Q134_K0.6771.00
296_I370_S0.6741.00
333_T386_N0.6741.00
255_K272_R0.6741.00
386_N390_S0.6731.00
152_L156_I0.6731.00
158_S312_G0.6701.00
233_N238_G0.6691.00
337_G341_T0.6671.00
61_L409_Q0.6661.00
140_G144_A0.6651.00
374_G378_G0.6641.00
313_Y316_T0.6631.00
306_V363_K0.6631.00
124_S401_L0.6621.00
68_V84_E0.6611.00
328_L332_L0.6611.00
203_A261_G0.6611.00
223_D230_S0.6611.00
208_L212_I0.6601.00
295_F423_I0.6571.00
61_L115_G0.6571.00
127_L139_L0.6561.00
314_W317_P0.6561.00
50_G53_G0.6551.00
282_I346_G0.6551.00
418_L421_G0.6541.00
275_M387_V0.6541.00
14_A17_L0.6541.00
351_A355_L0.6521.00
207_L250_L0.6521.00
60_G113_L0.6521.00
282_I384_P0.6491.00
161_L166_S0.6461.00
348_I375_I0.6461.00
13_W16_S0.6441.00
250_L266_L0.6421.00
234_P237_Y0.6391.00
346_G350_C0.6361.00
31_I173_I0.6351.00
77_R192_T0.6311.00
95_V98_S0.6301.00
18_F129_T0.6301.00
62_S413_T0.6301.00
277_Q280_L0.6301.00
62_S409_Q0.6301.00
280_L404_L0.6301.00
92_S111_Q0.6291.00
69_G121_I0.6291.00
421_G425_A0.6281.00
221_N236_V0.6271.00
12_K130_L0.6261.00
74_R199_R0.6251.00
204_G261_G0.6231.00
34_A311_A0.6211.00
137_K141_L0.6201.00
362_E367_V0.6191.00
152_L155_N0.6181.00
324_I327_W0.6181.00
139_L143_G0.6171.00
68_V120_I0.6121.00
32_I95_V0.6111.00
60_G114_G0.6111.00
186_A190_A0.6101.00
39_I42_S0.6101.00
270_L276_F0.6101.00
289_L377_F0.6081.00
149_A153_G0.6061.00
332_L341_T0.6041.00
211_S215_V0.6041.00
85_V178_A0.6041.00
143_G147_G0.6041.00
275_M278_R0.6031.00
87_L113_L0.6031.00
133_E136_G0.6011.00
97_L103_L0.6011.00
130_L134_K0.6001.00
39_I161_L0.5991.00
42_S168_H0.5981.00
290_L293_V0.5971.00
221_N235_E0.5961.00
155_N313_Y0.5941.00
296_I300_V0.5931.00
309_A313_Y0.5911.00
161_L170_L0.5901.00
223_D228_L0.5901.00
70_K263_D0.5891.00
326_A330_G0.5871.00
349_S352_G0.5871.00
50_G298_S0.5861.00
318_L370_S0.5861.00
30_G150_A0.5851.00
15_I126_I0.5851.00
24_M174_N0.5831.00
95_V111_Q0.5831.00
397_K401_L0.5831.00
148_M152_L0.5791.00
128_A192_T0.5781.00
77_R125_H0.5771.00
24_M85_V0.5761.00
40_N46_S0.5751.00
231_L237_Y0.5741.00
172_L176_P0.5711.00
41_E44_S0.5681.00
64_S67_I0.5681.00
107_S110_I0.5671.00
230_S233_N0.5661.00
307_P311_A0.5631.00
97_L168_H0.5621.00
402_G406_L0.5611.00
246_C249_A0.5611.00
96_A168_H0.5601.00
213_L217_Y0.5601.00
271_L403_T0.5601.00
208_L250_L0.5591.00
57_Y108_R0.5581.00
174_N178_A0.5551.00
38_T301_E0.5551.00
55_T420_A0.5551.00
283_G287_G0.5541.00
314_W367_V0.5541.00
201_D253_Y0.5531.00
183_V188_F0.5521.00
283_G384_P0.5521.00
255_K262_G0.5511.00
139_L386_N0.5501.00
275_M279_T0.5491.00
75_Y200_L0.5491.00
75_Y79_K0.5471.00
133_E334_D0.5451.00
73_D76_G0.5441.00
126_I129_T0.5441.00
299_Y303_Y0.5441.00
380_L384_P0.5441.00
417_T421_G0.5441.00
371_V375_I0.5431.00
57_Y88_F0.5421.00
23_F27_L0.5421.00
149_A154_P0.5421.00
92_S175_L0.5411.00
316_T319_A0.5391.00
292_A373_A0.5371.00
83_I117_G0.5371.00
40_N45_V0.5371.00
29_N408_R0.5361.00
161_L164_T0.5351.00
28_D173_I0.5341.00
30_G153_G0.5341.00
199_R203_A0.5341.00
33_S294_I0.5341.00
278_R281_I0.5331.00
251_I254_E0.5321.00
321_A367_V0.5321.00
88_F114_G0.5321.00
147_G326_A0.5311.00
281_I285_L0.5311.00
333_T337_G0.5261.00
12_K16_S0.5251.00
51_S220_T0.5251.00
65_V409_Q0.5251.00
137_K334_D0.5241.00
254_E265_I0.5241.00
15_I138_A0.5231.00
356_F369_A0.5231.00
287_G408_R0.5211.00
339_V342_V0.5211.00
342_V384_P0.5211.00
217_Y229_H0.5191.00
32_I54_I0.5161.00
145_M149_A0.5151.00
211_S248_A0.5141.00
192_T195_P0.5131.00
236_V240_I0.5111.00
78_K190_A0.5091.00
65_V405_S0.5091.00
70_K205_I0.5081.00
222_L236_V0.5081.00
123_S401_L0.5081.00
421_G424_T0.5071.00
172_L175_L0.5061.00
356_F370_S0.5051.00
366_F370_S0.5051.00
394_K397_K0.5041.00
270_L273_N0.5031.00
241_I244_I0.5031.00
161_L308_A0.5031.00
80_L121_I0.5031.00
26_A150_A0.5021.00
318_L321_A0.5011.00
151_V316_T0.5011.00
215_V219_M0.5011.00
367_V370_S0.5001.00
243_G248_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.7741 100 0.511 Contact Map
4j05A 3 0.7104 100 0.536 Contact Map
3wdoA 1 0.7529 100 0.538 Contact Map
4xnjA 1 0.8301 100 0.538 Contact Map
4pypA 1 0.7741 100 0.539 Contact Map
2gfpA 2 0.7143 100 0.543 Contact Map
4tphA 2 0.8089 100 0.549 Contact Map
3o7qA 1 0.7394 100 0.549 Contact Map
4w6vA 1 0.834 100 0.556 Contact Map
4gc0A 1 0.8089 100 0.559 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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