GREMLIN Database
YFIT - Putative metal-dependent hydrolase YfiT
UniProt: O31562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (146)
Sequences: 1054 (867)
Seq/√Len: 71.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_D97_A5.0401.00
32_E128_R4.9311.00
39_K117_Q4.0651.00
46_T49_Q3.6191.00
134_Q137_R3.4331.00
131_T134_Q3.1631.00
51_D62_R3.1471.00
135_F154_L2.9631.00
79_F150_L2.4921.00
71_S93_Y2.3511.00
37_K162_H2.3491.00
136_K151_E2.3091.00
97_A100_E2.0001.00
116_L161_S1.9661.00
87_T138_G1.9401.00
72_H120_H1.9181.00
66_H112_S1.8981.00
140_Y145_K1.8131.00
79_F127_L1.7901.00
71_S157_Y1.7401.00
81_L88_P1.7221.00
66_H104_S1.7201.00
82_S139_F1.6901.00
130_L135_F1.6491.00
86_E137_R1.6090.99
93_Y157_Y1.5350.99
61_V168_I1.5230.99
24_K151_E1.5170.99
34_V161_S1.4560.99
92_P142_P1.4120.98
49_Q52_T1.3920.98
71_S75_S1.3560.98
42_V65_V1.3460.98
30_V162_H1.3420.98
73_M77_I1.3360.98
50_L109_P1.3200.98
27_W155_G1.3170.98
136_K149_T1.3170.98
75_S153_A1.3080.97
31_L158_V1.2970.97
53_P63_Q1.2750.97
60_T105_K1.2460.97
110_S114_A1.2360.96
53_P57_G1.2280.96
139_F153_A1.1970.96
72_H123_W1.1750.95
148_I153_A1.1720.95
111_G118_E1.1650.95
81_L86_E1.1560.95
69_A112_S1.1540.95
75_S93_Y1.1490.95
115_L118_E1.1390.94
51_D105_K1.1290.94
74_N98_W1.1290.94
41_A44_V1.1220.94
103_D106_T1.1150.94
81_L91_R1.1120.94
81_L92_P1.1070.93
115_L119_L1.0990.93
68_L165_I1.0830.93
39_K110_S1.0780.92
64_V168_I1.0700.92
107_A115_L1.0630.92
29_Q33_E1.0510.92
30_V158_V1.0500.91
24_K135_F1.0410.91
127_L154_L1.0370.91
39_K113_L1.0320.91
40_Q43_E1.0270.91
114_A117_Q1.0200.90
45_M166_A1.0110.90
38_L165_I1.0030.89
87_T140_Y1.0010.89
63_Q99_S0.9940.89
28_I127_L0.9850.89
75_S156_L0.9850.89
107_A111_G0.9700.88
53_P60_T0.9690.88
45_M49_Q0.9570.87
114_A121_G0.9270.85
34_V165_I0.9250.85
69_A115_L0.9200.85
32_E121_G0.9180.85
130_L134_Q0.9100.84
85_E137_R0.8950.83
46_T168_I0.8930.83
29_Q43_E0.8910.83
35_P38_L0.8820.82
133_Q137_R0.8800.82
54_Y159_W0.8790.82
47_D51_D0.8640.81
30_V161_S0.8600.81
80_K126_L0.8560.81
65_V112_S0.8470.80
120_H161_S0.8440.80
29_Q166_A0.8420.79
75_S79_F0.8330.79
71_S156_L0.8320.79
37_K169_T0.8270.78
36_A117_Q0.8220.78
154_L158_V0.8220.78
38_L161_S0.8100.77
41_A165_I0.8090.77
62_R109_P0.8000.76
73_M115_L0.7970.76
31_L161_S0.7940.75
71_S74_N0.7760.74
36_A136_K0.7680.73
53_P61_V0.7680.73
126_L130_L0.7650.73
45_M61_V0.7600.72
85_E88_P0.7590.72
54_Y163_H0.7560.72
83_L130_L0.7470.71
123_W157_Y0.7420.70
36_A40_Q0.7390.70
77_I120_H0.7380.70
34_V68_L0.7370.70
133_Q146_E0.7370.70
42_V129_T0.7350.70
42_V50_L0.7270.69
126_L129_T0.7200.68
83_L126_L0.7180.68
35_P64_V0.7170.68
64_V68_L0.7160.68
57_G163_H0.7150.67
119_L126_L0.7130.67
26_K29_Q0.7080.67
138_G149_T0.7020.66
130_L150_L0.6990.66
159_W163_H0.6920.65
62_R112_S0.6910.65
58_G159_W0.6850.64
25_D128_R0.6850.64
27_W56_D0.6830.64
26_K30_V0.6810.64
62_R76_Y0.6800.64
74_N90_I0.6770.63
68_L161_S0.6740.63
76_Y122_R0.6700.62
99_S104_S0.6700.62
116_L120_H0.6700.62
84_T163_H0.6690.62
58_G163_H0.6630.62
80_K98_W0.6530.60
71_S95_E0.6510.60
70_D98_W0.6360.58
41_A169_T0.6330.58
54_Y167_H0.6320.58
119_L123_W0.6270.57
95_E120_H0.6260.57
38_L68_L0.6230.57
35_P116_L0.6230.57
148_I152_N0.6190.56
67_H160_H0.6180.56
27_W37_K0.6180.56
49_Q64_V0.6090.55
55_R159_W0.6070.55
31_L115_L0.6040.55
120_H139_F0.6030.54
35_P161_S0.6020.54
54_Y58_G0.6010.54
82_S150_L0.6000.54
128_R135_F0.5970.54
68_L116_L0.5960.54
72_H167_H0.5860.52
141_H145_K0.5830.52
120_H123_W0.5790.51
55_R58_G0.5760.51
52_T61_V0.5720.51
74_N157_Y0.5720.51
29_Q113_L0.5710.50
117_Q121_G0.5700.50
51_D99_S0.5650.50
107_A125_A0.5610.49
103_D137_R0.5600.49
86_E104_S0.5590.49
121_G125_A0.5560.49
80_K122_R0.5550.49
38_L116_L0.5540.48
82_S87_T0.5530.48
67_H164_H0.5520.48
133_Q136_K0.5520.48
90_I95_E0.5480.48
84_T159_W0.5480.48
53_P58_G0.5460.47
72_H157_Y0.5450.47
29_Q32_E0.5440.47
43_E128_R0.5430.47
150_L157_Y0.5430.47
55_R163_H0.5410.47
30_V34_V0.5410.47
33_E37_K0.5400.47
70_D99_S0.5380.46
63_Q100_E0.5370.46
24_K165_I0.5350.46
29_Q40_Q0.5330.46
27_W30_V0.5320.46
26_K43_E0.5300.45
75_S157_Y0.5280.45
73_M122_R0.5280.45
139_F152_N0.5250.45
94_D114_A0.5250.45
79_F153_A0.5200.44
132_D152_N0.5180.44
36_A51_D0.5140.44
72_H161_S0.5130.43
42_V158_V0.5120.43
85_E91_R0.5110.43
43_E113_L0.5100.43
24_K108_D0.5100.43
125_A137_R0.5090.43
25_D29_Q0.5070.43
123_W161_S0.5060.43
66_H71_S0.5060.43
160_H164_H0.5040.42
28_I39_K0.5040.42
76_Y119_L0.5010.42
68_L158_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rxqA 3 0.9831 100 0.427 Contact Map
2rd9A 4 0.9663 99.9 0.554 Contact Map
2yqyA 2 0.7079 99.9 0.581 Contact Map
2ou6A 2 0.9157 99.7 0.648 Contact Map
3dkaA 2 0.7809 99.7 0.649 Contact Map
3gorA 2 0.8202 99.7 0.65 Contact Map
3di5A 1 0.809 99.7 0.653 Contact Map
2hkvA 2 0.7921 99.7 0.654 Contact Map
4n6cA 1 0.9326 99.7 0.655 Contact Map
3cexA 2 0.8596 99.7 0.66 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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