YFIQ - BACSU - GREMLIN Contacts

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YFIQ - Putative membrane-bound acyltransferase YfiQ

UniProt:	O31559	Sequences: MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSFRTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAMGGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFVVTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQYRWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKIMMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNKFKYGYLFVGKIYQPKQKKVTVEVRDHAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	362 (314)
Sequences:	13344 (11802)
Seq/√Len:	666.0

ECOLI - OPGC YCFT YIAH
BACSU - YFIQ YRHL YKRP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
326_I	330_W	3.604	1.00
279_F	283_Y	3.580	1.00
290_L	328_T	3.469	1.00
64_A	202_Y	3.328	1.00
18_V	287_I	3.316	1.00
80_G	84_F	3.071	1.00
76_L	140_M	3.015	1.00
13_S	54_A	2.984	1.00
283_Y	326_I	2.951	1.00
279_F	326_I	2.932	1.00
330_W	334_K	2.894	1.00
128_F	132_I	2.732	1.00
7_F	282_N	2.664	1.00
72_P	76_L	2.630	1.00
11_C	281_S	2.536	1.00
87_F	126_G	2.519	1.00
321_C	325_P	2.430	1.00
279_F	330_W	2.358	1.00
73_D	77_K	2.290	1.00
84_F	88_L	2.274	1.00
61_F	208_Y	2.264	1.00
53_P	197_Y	2.237	1.00
117_A	121_L	2.113	1.00
72_P	140_M	2.103	1.00
90_I	290_L	2.072	1.00
22_I	295_M	2.069	1.00
327_M	331_A	2.033	1.00
222_V	226_A	2.014	1.00
286_S	329_S	1.938	1.00
56_I	131_V	1.923	1.00
11_C	284_S	1.904	1.00
71_V	74_G	1.872	1.00
286_S	328_T	1.834	1.00
225_A	229_S	1.828	1.00
65_R	205_G	1.828	1.00
64_A	139_H	1.825	1.00
194_W	197_Y	1.809	1.00
90_I	289_L	1.802	1.00
7_F	278_M	1.771	1.00
86_P	289_L	1.769	1.00
6_I	58_I	1.759	1.00
287_I	321_C	1.758	1.00
63_L	139_H	1.730	1.00
11_C	280_I	1.721	1.00
287_I	325_P	1.718	1.00
14_C	287_I	1.668	1.00
65_R	69_D	1.660	1.00
62_L	65_R	1.649	1.00
337_Y	340_L	1.633	1.00
329_S	334_K	1.619	1.00
89_F	332_L	1.605	1.00
162_T	165_Y	1.596	1.00
283_Y	325_P	1.594	1.00
77_K	81_K	1.587	1.00
232_L	236_V	1.546	1.00
118_N	121_L	1.545	1.00
70_G	74_G	1.531	1.00
64_A	68_P	1.488	1.00
274_P	277_M	1.484	1.00
111_F	114_K	1.470	1.00
329_S	333_N	1.461	1.00
279_F	282_N	1.459	1.00
20_L	48_L	1.459	1.00
67_Y	139_H	1.459	1.00
63_L	136_Y	1.455	1.00
283_Y	287_I	1.445	1.00
278_M	282_N	1.436	1.00
57_F	204_C	1.432	1.00
9_I	54_A	1.414	1.00
223_Y	226_A	1.413	1.00
62_L	66_S	1.399	1.00
283_Y	286_S	1.381	1.00
130_L	134_Q	1.378	1.00
107_T	110_A	1.378	1.00
70_G	78_K	1.370	1.00
108_F	111_F	1.365	1.00
66_S	70_G	1.341	1.00
200_L	260_I	1.339	1.00
61_F	205_G	1.336	1.00
115_Y	118_N	1.333	1.00
74_G	78_K	1.321	1.00
8_M	273_V	1.319	1.00
94_D	293_Y	1.309	1.00
86_P	328_T	1.303	1.00
93_I	290_L	1.284	1.00
110_A	114_K	1.280	1.00
48_L	51_S	1.276	1.00
53_P	194_W	1.273	1.00
319_A	323_A	1.269	1.00
226_A	230_G	1.268	1.00
64_A	206_K	1.265	1.00
317_L	321_C	1.248	1.00
275_K	279_F	1.233	1.00
139_H	198_F	1.225	1.00
283_Y	330_W	1.220	1.00
223_Y	227_I	1.218	1.00
258_S	261_F	1.217	1.00
75_F	136_Y	1.213	1.00
276_I	280_I	1.211	1.00
298_G	317_L	1.200	1.00
11_C	15_L	1.188	1.00
165_Y	170_S	1.186	1.00
83_I	136_Y	1.184	1.00
132_I	136_Y	1.178	1.00
90_I	126_G	1.178	1.00
258_S	262_L	1.177	1.00
106_V	109_L	1.174	1.00
166_L	169_F	1.172	1.00
63_L	66_S	1.172	1.00
256_S	259_M	1.171	1.00
286_S	333_N	1.170	1.00
294_F	324_G	1.168	1.00
74_G	77_K	1.164	1.00
287_I	322_T	1.160	1.00
84_F	133_F	1.157	1.00
337_Y	341_F	1.155	1.00
16_S	51_S	1.153	1.00
260_I	264_F	1.152	1.00
76_L	133_F	1.148	1.00
85_V	89_F	1.146	1.00
229_S	233_V	1.142	1.00
125_I	292_A	1.139	1.00
56_I	132_I	1.139	1.00
13_S	51_S	1.138	1.00
109_L	113_Q	1.131	1.00
295_M	317_L	1.130	1.00
137_M	140_M	1.127	1.00
11_C	277_M	1.124	1.00
168_Y	172_A	1.120	1.00
315_L	319_A	1.114	1.00
125_I	293_Y	1.114	1.00
90_I	94_D	1.112	1.00
127_Y	131_V	1.104	1.00
285_F	289_L	1.101	1.00
259_M	262_L	1.098	1.00
48_L	52_T	1.096	1.00
300_V	304_N	1.092	1.00
157_I	161_V	1.091	1.00
328_T	332_L	1.091	1.00
116_L	119_V	1.091	1.00
18_V	318_F	1.091	1.00
64_A	205_G	1.089	1.00
311_V	315_L	1.087	1.00
135_F	198_F	1.086	1.00
86_P	286_S	1.086	1.00
116_L	120_F	1.082	1.00
260_I	263_C	1.067	1.00
255_Y	258_S	1.066	1.00
291_H	295_M	1.065	1.00
80_G	133_F	1.063	1.00
144_E	148_K	1.056	1.00
156_S	159_F	1.055	1.00
248_K	251_D	1.053	1.00
155_L	158_S	1.053	1.00
249_R	252_I	1.049	1.00
75_F	140_M	1.045	1.00
291_H	321_C	1.045	1.00
17_V	52_T	1.045	1.00
81_K	338_G	1.036	1.00
6_I	62_L	1.033	1.00
87_F	285_F	1.030	1.00
160_V	164_A	1.027	1.00
261_F	265_H	1.025	1.00
139_H	202_Y	1.024	1.00
312_P	315_L	1.024	1.00
331_A	335_F	1.023	1.00
18_V	291_H	1.020	1.00
96_L	100_S	1.010	1.00
17_V	51_S	1.007	1.00
190_P	193_G	1.007	1.00
92_A	96_L	1.003	1.00
117_A	120_F	0.993	1.00
156_S	160_V	0.986	1.00
250_P	253_M	0.986	1.00
298_G	302_L	0.984	1.00
245_I	248_K	0.981	1.00
198_F	202_Y	0.980	1.00
192_A	196_F	0.976	1.00
166_L	170_S	0.971	1.00
324_G	328_T	0.969	1.00
309_P	312_P	0.968	1.00
227_I	231_A	0.968	1.00
336_K	339_Y	0.964	1.00
234_V	238_Y	0.962	1.00
338_G	341_F	0.961	1.00
275_K	278_M	0.958	1.00
8_M	274_P	0.957	1.00
199_C	202_Y	0.956	1.00
8_M	277_M	0.956	1.00
115_Y	121_L	0.952	1.00
290_L	293_Y	0.951	1.00
52_T	55_F	0.950	1.00
226_A	237_S	0.948	1.00
59_S	132_I	0.945	1.00
257_T	261_F	0.945	1.00
126_G	289_L	0.944	1.00
107_T	111_F	0.937	1.00
248_K	252_I	0.935	1.00
231_A	235_T	0.933	1.00
257_T	260_I	0.933	1.00
282_N	334_K	0.930	1.00
234_V	237_S	0.928	1.00
233_V	237_S	0.925	1.00
323_A	327_M	0.925	1.00
259_M	263_C	0.924	1.00
141_M	145_Y	0.922	1.00
255_Y	259_M	0.915	1.00
233_V	236_V	0.914	1.00
81_K	84_F	0.913	1.00
170_S	173_S	0.909	1.00
298_G	313_A	0.907	1.00
158_S	162_T	0.904	1.00
224_G	228_A	0.903	1.00
108_F	112_V	0.899	1.00
155_L	159_F	0.898	1.00
309_P	313_A	0.895	1.00
280_I	322_T	0.888	1.00
14_C	128_F	0.884	1.00
336_K	340_L	0.871	1.00
226_A	229_S	0.867	1.00
230_G	233_V	0.866	1.00
68_P	206_K	0.863	1.00
131_V	194_W	0.861	1.00
10_R	58_I	0.857	1.00
14_C	55_F	0.847	1.00
20_L	49_M	0.845	1.00
125_I	288_Y	0.844	1.00
82_V	132_I	0.842	1.00
188_W	194_W	0.827	1.00
5_E	8_M	0.824	1.00
79_R	136_Y	0.824	1.00
186_F	190_P	0.821	1.00
330_W	335_F	0.821	1.00
247_S	252_I	0.819	1.00
106_V	110_A	0.817	1.00
164_A	167_G	0.815	1.00
10_R	128_F	0.815	1.00
231_A	234_V	0.812	1.00
290_L	324_G	0.812	1.00
276_I	279_F	0.811	1.00
283_Y	329_S	0.803	1.00
145_Y	149_A	0.802	1.00
167_G	170_S	0.801	1.00
149_A	152_K	0.799	1.00
93_I	97_L	0.795	1.00
83_I	285_F	0.795	1.00
228_A	232_L	0.794	1.00
97_L	101_A	0.791	1.00
67_Y	143_H	0.791	1.00
16_S	20_L	0.786	1.00
313_A	316_L	0.784	1.00
275_K	282_N	0.784	1.00
59_S	63_L	0.783	1.00
205_G	208_Y	0.782	1.00
109_L	114_K	0.781	1.00
229_S	236_V	0.777	1.00
228_A	231_A	0.777	1.00
96_L	99_T	0.775	1.00
230_G	234_V	0.774	1.00
7_F	281_S	0.767	1.00
325_P	329_S	0.765	1.00
169_F	173_S	0.764	1.00
229_S	232_L	0.763	1.00
54_A	259_M	0.763	1.00
53_P	193_G	0.763	1.00
147_K	151_P	0.762	1.00
314_V	318_F	0.762	1.00
87_F	91_A	0.760	1.00
210_R	213_A	0.758	1.00
214_L	217_Q	0.755	1.00
167_G	171_A	0.754	1.00
221_V	225_A	0.751	1.00
94_D	98_M	0.750	1.00
247_S	250_P	0.749	1.00
79_R	85_V	0.746	1.00
115_Y	120_F	0.746	1.00
113_Q	117_A	0.746	1.00
94_D	125_I	0.745	1.00
154_V	157_I	0.743	1.00
232_L	235_T	0.743	1.00
168_Y	171_A	0.743	1.00
57_F	197_Y	0.742	1.00
251_D	255_Y	0.739	1.00
66_S	69_D	0.735	1.00
60_E	202_Y	0.735	1.00
75_F	79_R	0.734	1.00
79_R	128_F	0.733	1.00
18_V	321_C	0.733	1.00
186_F	192_A	0.733	1.00
79_R	132_I	0.731	1.00
328_T	331_A	0.731	1.00
51_S	135_F	0.731	1.00
215_L	218_Y	0.729	1.00
280_I	287_I	0.728	1.00
114_K	117_A	0.728	1.00
262_L	266_L	0.723	1.00
220_W	223_Y	0.722	1.00
22_I	314_V	0.721	1.00
154_V	158_S	0.719	1.00
7_F	10_R	0.717	1.00
206_K	210_R	0.717	1.00
223_Y	230_G	0.715	1.00
14_C	280_I	0.713	1.00
223_Y	229_S	0.712	1.00
219_R	226_A	0.712	1.00
99_T	103_G	0.711	1.00
256_S	267_F	0.710	1.00
56_I	128_F	0.709	1.00
259_M	267_F	0.709	1.00
17_V	128_F	0.709	1.00
290_L	321_C	0.707	1.00
4_K	7_F	0.702	1.00
110_A	113_Q	0.702	1.00
221_V	224_G	0.701	1.00
220_W	224_G	0.701	1.00
235_T	238_Y	0.700	1.00
131_V	135_F	0.698	1.00
14_C	51_S	0.697	1.00
106_V	111_F	0.697	1.00
15_L	19_L	0.697	1.00
63_L	75_F	0.696	1.00
290_L	325_P	0.692	1.00
232_L	237_S	0.690	1.00
274_P	278_M	0.687	1.00
196_F	199_C	0.686	1.00
73_D	76_L	0.684	1.00
114_K	118_N	0.681	1.00
282_N	329_S	0.680	1.00
219_R	223_Y	0.680	1.00
294_F	297_I	0.680	1.00
278_M	281_S	0.679	1.00
188_W	191_F	0.678	1.00
20_L	53_P	0.671	1.00
125_I	291_H	0.671	1.00
164_A	168_Y	0.670	1.00
147_K	150_S	0.670	1.00
11_C	14_C	0.668	1.00
133_F	198_F	0.663	1.00
297_I	300_V	0.660	1.00
109_L	112_V	0.659	1.00
115_Y	119_V	0.659	1.00
298_G	301_L	0.658	1.00
294_F	298_G	0.658	1.00
218_Y	221_V	0.656	1.00
91_A	95_A	0.655	1.00
63_L	133_F	0.653	1.00
190_P	194_W	0.651	1.00
163_A	166_L	0.650	1.00
294_F	317_L	0.650	1.00
24_S	27_L	0.648	1.00
8_M	278_M	0.644	1.00
89_F	93_I	0.643	1.00
133_F	137_M	0.643	1.00
49_M	53_P	0.641	1.00
191_F	194_W	0.638	1.00
265_H	268_S	0.638	1.00
222_V	229_S	0.636	1.00
22_I	321_C	0.636	1.00
62_L	286_S	0.633	1.00
165_Y	168_Y	0.629	1.00
59_S	198_F	0.629	1.00
131_V	134_Q	0.628	1.00
204_C	260_I	0.626	1.00
145_Y	148_K	0.626	1.00
16_S	50_F	0.625	1.00
191_F	195_L	0.623	1.00
8_M	11_C	0.622	1.00
316_L	319_A	0.619	1.00
92_A	95_A	0.619	1.00
84_F	87_F	0.616	1.00
209_K	212_L	0.615	1.00
89_F	328_T	0.613	1.00
14_C	284_S	0.611	1.00
22_I	317_L	0.610	1.00
135_F	139_H	0.610	1.00
159_F	166_L	0.609	1.00
107_T	114_K	0.609	1.00
231_A	236_V	0.608	1.00
158_S	161_V	0.607	1.00
100_S	103_G	0.604	1.00
312_P	316_L	0.603	1.00
296_I	300_V	0.600	1.00
223_Y	234_V	0.600	1.00
207_E	211_F	0.600	1.00
294_F	320_V	0.597	1.00
162_T	166_L	0.596	1.00
226_A	233_V	0.595	1.00
8_M	272_H	0.587	1.00
332_L	335_F	0.585	1.00
13_S	52_T	0.585	1.00
282_N	292_A	0.582	1.00
256_S	260_I	0.577	1.00
294_F	321_C	0.575	1.00
157_I	160_V	0.575	1.00
14_C	18_V	0.574	1.00
52_T	128_F	0.574	1.00
12_I	16_S	0.571	1.00
9_I	58_I	0.571	1.00
135_F	140_M	0.569	1.00
205_G	209_K	0.568	1.00
20_L	51_S	0.568	1.00
63_L	198_F	0.567	1.00
128_F	288_Y	0.566	1.00
162_T	199_C	0.564	1.00
14_C	17_V	0.564	1.00
62_L	132_I	0.563	1.00
311_V	314_V	0.561	1.00
68_P	205_G	0.561	1.00
59_S	128_F	0.560	1.00
248_K	253_M	0.560	1.00
90_I	328_T	0.560	1.00
150_S	153_W	0.559	1.00
84_F	115_Y	0.559	1.00
140_M	144_E	0.559	1.00
252_I	263_C	0.556	1.00
90_I	293_Y	0.556	1.00
225_A	232_L	0.555	1.00
334_K	338_G	0.554	1.00
98_M	102_M	0.553	1.00
202_Y	206_K	0.552	1.00
16_S	48_L	0.552	1.00
154_V	165_Y	0.551	1.00
230_G	237_S	0.551	1.00
63_L	132_I	0.550	1.00
56_I	127_Y	0.550	1.00
313_A	317_L	0.550	1.00
229_S	237_S	0.549	1.00
169_F	172_A	0.549	1.00
17_V	21_H	0.548	1.00
11_C	287_I	0.546	1.00
8_M	281_S	0.543	1.00
128_F	285_F	0.543	1.00
79_R	82_V	0.543	1.00
300_V	303_L	0.542	1.00
251_D	256_S	0.540	1.00
65_R	208_Y	0.540	1.00
11_C	283_Y	0.534	1.00
67_Y	70_G	0.534	1.00
297_I	301_L	0.532	1.00
190_P	197_Y	0.532	1.00
292_A	295_M	0.531	1.00
10_R	132_I	0.530	1.00
61_F	65_R	0.529	1.00
217_Q	220_W	0.528	1.00
148_K	152_K	0.528	1.00
263_C	267_F	0.527	0.99
50_F	54_A	0.527	0.99
247_S	251_D	0.526	0.99
86_P	332_L	0.525	0.99
283_Y	322_T	0.525	0.99
63_L	67_Y	0.524	0.99
149_A	153_W	0.524	0.99
14_C	132_I	0.523	0.99
88_L	133_F	0.521	0.99
199_C	203_Y	0.521	0.99
132_I	285_F	0.520	0.99
126_G	129_I	0.517	0.99
261_F	264_F	0.515	0.99
129_I	289_L	0.515	0.99
265_H	269_K	0.514	0.99
246_S	249_R	0.514	0.99
69_D	209_K	0.509	0.99
301_L	304_N	0.509	0.99
197_Y	256_S	0.507	0.99
226_A	236_V	0.507	0.99
213_A	217_Q	0.507	0.99
144_E	147_K	0.504	0.99
193_G	197_Y	0.504	0.99
83_I	133_F	0.503	0.99
82_V	85_V	0.503	0.99
155_L	166_L	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ldsA	2	0.5359	20.5	0.947	Contact Map
4j72A	2	0.1077	7.6	0.956	Contact Map
2cfqA	1	0.5414	6.6	0.957	Contact Map
4a01A	2	0.1464	5.9	0.958	Contact Map
2kncA	1	0.1464	5.4	0.959	Contact Map
4px7A	1	0.5304	5.1	0.959	Contact Map
4z24A	2	0.163	4.6	0.96	Contact Map
2kncB	1	0.1519	3.6	0.962	Contact Map
1pw4A	1	0.5912	3.5	0.962	Contact Map
2kluA	1	0.1381	3.3	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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