GREMLIN Database
YFIQ - Putative membrane-bound acyltransferase YfiQ
UniProt: O31559 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (314)
Sequences: 13344 (11802)
Seq/√Len: 666.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
326_I330_W3.6041.00
279_F283_Y3.5801.00
290_L328_T3.4691.00
64_A202_Y3.3281.00
18_V287_I3.3161.00
80_G84_F3.0711.00
76_L140_M3.0151.00
13_S54_A2.9841.00
283_Y326_I2.9511.00
279_F326_I2.9321.00
330_W334_K2.8941.00
128_F132_I2.7321.00
7_F282_N2.6641.00
72_P76_L2.6301.00
11_C281_S2.5361.00
87_F126_G2.5191.00
321_C325_P2.4301.00
279_F330_W2.3581.00
73_D77_K2.2901.00
84_F88_L2.2741.00
61_F208_Y2.2641.00
53_P197_Y2.2371.00
117_A121_L2.1131.00
72_P140_M2.1031.00
90_I290_L2.0721.00
22_I295_M2.0691.00
327_M331_A2.0331.00
222_V226_A2.0141.00
286_S329_S1.9381.00
56_I131_V1.9231.00
11_C284_S1.9041.00
71_V74_G1.8721.00
286_S328_T1.8341.00
225_A229_S1.8281.00
65_R205_G1.8281.00
64_A139_H1.8251.00
194_W197_Y1.8091.00
90_I289_L1.8021.00
7_F278_M1.7711.00
86_P289_L1.7691.00
6_I58_I1.7591.00
287_I321_C1.7581.00
63_L139_H1.7301.00
11_C280_I1.7211.00
287_I325_P1.7181.00
14_C287_I1.6681.00
65_R69_D1.6601.00
62_L65_R1.6491.00
337_Y340_L1.6331.00
329_S334_K1.6191.00
89_F332_L1.6051.00
162_T165_Y1.5961.00
283_Y325_P1.5941.00
77_K81_K1.5871.00
232_L236_V1.5461.00
118_N121_L1.5451.00
70_G74_G1.5311.00
64_A68_P1.4881.00
274_P277_M1.4841.00
111_F114_K1.4701.00
329_S333_N1.4611.00
279_F282_N1.4591.00
20_L48_L1.4591.00
67_Y139_H1.4591.00
63_L136_Y1.4551.00
283_Y287_I1.4451.00
278_M282_N1.4361.00
57_F204_C1.4321.00
9_I54_A1.4141.00
223_Y226_A1.4131.00
62_L66_S1.3991.00
283_Y286_S1.3811.00
130_L134_Q1.3781.00
107_T110_A1.3781.00
70_G78_K1.3701.00
108_F111_F1.3651.00
66_S70_G1.3411.00
200_L260_I1.3391.00
61_F205_G1.3361.00
115_Y118_N1.3331.00
74_G78_K1.3211.00
8_M273_V1.3191.00
94_D293_Y1.3091.00
86_P328_T1.3031.00
93_I290_L1.2841.00
110_A114_K1.2801.00
48_L51_S1.2761.00
53_P194_W1.2731.00
319_A323_A1.2691.00
226_A230_G1.2681.00
64_A206_K1.2651.00
317_L321_C1.2481.00
275_K279_F1.2331.00
139_H198_F1.2251.00
283_Y330_W1.2201.00
223_Y227_I1.2181.00
258_S261_F1.2171.00
75_F136_Y1.2131.00
276_I280_I1.2111.00
298_G317_L1.2001.00
11_C15_L1.1881.00
165_Y170_S1.1861.00
83_I136_Y1.1841.00
132_I136_Y1.1781.00
90_I126_G1.1781.00
258_S262_L1.1771.00
106_V109_L1.1741.00
166_L169_F1.1721.00
63_L66_S1.1721.00
256_S259_M1.1711.00
286_S333_N1.1701.00
294_F324_G1.1681.00
74_G77_K1.1641.00
287_I322_T1.1601.00
84_F133_F1.1571.00
337_Y341_F1.1551.00
16_S51_S1.1531.00
260_I264_F1.1521.00
76_L133_F1.1481.00
85_V89_F1.1461.00
229_S233_V1.1421.00
125_I292_A1.1391.00
56_I132_I1.1391.00
13_S51_S1.1381.00
109_L113_Q1.1311.00
295_M317_L1.1301.00
137_M140_M1.1271.00
11_C277_M1.1241.00
168_Y172_A1.1201.00
315_L319_A1.1141.00
125_I293_Y1.1141.00
90_I94_D1.1121.00
127_Y131_V1.1041.00
285_F289_L1.1011.00
259_M262_L1.0981.00
48_L52_T1.0961.00
300_V304_N1.0921.00
157_I161_V1.0911.00
328_T332_L1.0911.00
116_L119_V1.0911.00
18_V318_F1.0911.00
64_A205_G1.0891.00
311_V315_L1.0871.00
135_F198_F1.0861.00
86_P286_S1.0861.00
116_L120_F1.0821.00
260_I263_C1.0671.00
255_Y258_S1.0661.00
291_H295_M1.0651.00
80_G133_F1.0631.00
144_E148_K1.0561.00
156_S159_F1.0551.00
248_K251_D1.0531.00
155_L158_S1.0531.00
249_R252_I1.0491.00
75_F140_M1.0451.00
291_H321_C1.0451.00
17_V52_T1.0451.00
81_K338_G1.0361.00
6_I62_L1.0331.00
87_F285_F1.0301.00
160_V164_A1.0271.00
261_F265_H1.0251.00
139_H202_Y1.0241.00
312_P315_L1.0241.00
331_A335_F1.0231.00
18_V291_H1.0201.00
96_L100_S1.0101.00
17_V51_S1.0071.00
190_P193_G1.0071.00
92_A96_L1.0031.00
117_A120_F0.9931.00
156_S160_V0.9861.00
250_P253_M0.9861.00
298_G302_L0.9841.00
245_I248_K0.9811.00
198_F202_Y0.9801.00
192_A196_F0.9761.00
166_L170_S0.9711.00
324_G328_T0.9691.00
309_P312_P0.9681.00
227_I231_A0.9681.00
336_K339_Y0.9641.00
234_V238_Y0.9621.00
338_G341_F0.9611.00
275_K278_M0.9581.00
8_M274_P0.9571.00
199_C202_Y0.9561.00
8_M277_M0.9561.00
115_Y121_L0.9521.00
290_L293_Y0.9511.00
52_T55_F0.9501.00
226_A237_S0.9481.00
59_S132_I0.9451.00
257_T261_F0.9451.00
126_G289_L0.9441.00
107_T111_F0.9371.00
248_K252_I0.9351.00
231_A235_T0.9331.00
257_T260_I0.9331.00
282_N334_K0.9301.00
234_V237_S0.9281.00
233_V237_S0.9251.00
323_A327_M0.9251.00
259_M263_C0.9241.00
141_M145_Y0.9221.00
255_Y259_M0.9151.00
233_V236_V0.9141.00
81_K84_F0.9131.00
170_S173_S0.9091.00
298_G313_A0.9071.00
158_S162_T0.9041.00
224_G228_A0.9031.00
108_F112_V0.8991.00
155_L159_F0.8981.00
309_P313_A0.8951.00
280_I322_T0.8881.00
14_C128_F0.8841.00
336_K340_L0.8711.00
226_A229_S0.8671.00
230_G233_V0.8661.00
68_P206_K0.8631.00
131_V194_W0.8611.00
10_R58_I0.8571.00
14_C55_F0.8471.00
20_L49_M0.8451.00
125_I288_Y0.8441.00
82_V132_I0.8421.00
188_W194_W0.8271.00
5_E8_M0.8241.00
79_R136_Y0.8241.00
186_F190_P0.8211.00
330_W335_F0.8211.00
247_S252_I0.8191.00
106_V110_A0.8171.00
164_A167_G0.8151.00
10_R128_F0.8151.00
231_A234_V0.8121.00
290_L324_G0.8121.00
276_I279_F0.8111.00
283_Y329_S0.8031.00
145_Y149_A0.8021.00
167_G170_S0.8011.00
149_A152_K0.7991.00
93_I97_L0.7951.00
83_I285_F0.7951.00
228_A232_L0.7941.00
97_L101_A0.7911.00
67_Y143_H0.7911.00
16_S20_L0.7861.00
313_A316_L0.7841.00
275_K282_N0.7841.00
59_S63_L0.7831.00
205_G208_Y0.7821.00
109_L114_K0.7811.00
229_S236_V0.7771.00
228_A231_A0.7771.00
96_L99_T0.7751.00
230_G234_V0.7741.00
7_F281_S0.7671.00
325_P329_S0.7651.00
169_F173_S0.7641.00
229_S232_L0.7631.00
54_A259_M0.7631.00
53_P193_G0.7631.00
147_K151_P0.7621.00
314_V318_F0.7621.00
87_F91_A0.7601.00
210_R213_A0.7581.00
214_L217_Q0.7551.00
167_G171_A0.7541.00
221_V225_A0.7511.00
94_D98_M0.7501.00
247_S250_P0.7491.00
79_R85_V0.7461.00
115_Y120_F0.7461.00
113_Q117_A0.7461.00
94_D125_I0.7451.00
154_V157_I0.7431.00
232_L235_T0.7431.00
168_Y171_A0.7431.00
57_F197_Y0.7421.00
251_D255_Y0.7391.00
66_S69_D0.7351.00
60_E202_Y0.7351.00
75_F79_R0.7341.00
79_R128_F0.7331.00
18_V321_C0.7331.00
186_F192_A0.7331.00
79_R132_I0.7311.00
328_T331_A0.7311.00
51_S135_F0.7311.00
215_L218_Y0.7291.00
280_I287_I0.7281.00
114_K117_A0.7281.00
262_L266_L0.7231.00
220_W223_Y0.7221.00
22_I314_V0.7211.00
154_V158_S0.7191.00
7_F10_R0.7171.00
206_K210_R0.7171.00
223_Y230_G0.7151.00
14_C280_I0.7131.00
223_Y229_S0.7121.00
219_R226_A0.7121.00
99_T103_G0.7111.00
256_S267_F0.7101.00
56_I128_F0.7091.00
259_M267_F0.7091.00
17_V128_F0.7091.00
290_L321_C0.7071.00
4_K7_F0.7021.00
110_A113_Q0.7021.00
221_V224_G0.7011.00
220_W224_G0.7011.00
235_T238_Y0.7001.00
131_V135_F0.6981.00
14_C51_S0.6971.00
106_V111_F0.6971.00
15_L19_L0.6971.00
63_L75_F0.6961.00
290_L325_P0.6921.00
232_L237_S0.6901.00
274_P278_M0.6871.00
196_F199_C0.6861.00
73_D76_L0.6841.00
114_K118_N0.6811.00
282_N329_S0.6801.00
219_R223_Y0.6801.00
294_F297_I0.6801.00
278_M281_S0.6791.00
188_W191_F0.6781.00
20_L53_P0.6711.00
125_I291_H0.6711.00
164_A168_Y0.6701.00
147_K150_S0.6701.00
11_C14_C0.6681.00
133_F198_F0.6631.00
297_I300_V0.6601.00
109_L112_V0.6591.00
115_Y119_V0.6591.00
298_G301_L0.6581.00
294_F298_G0.6581.00
218_Y221_V0.6561.00
91_A95_A0.6551.00
63_L133_F0.6531.00
190_P194_W0.6511.00
163_A166_L0.6501.00
294_F317_L0.6501.00
24_S27_L0.6481.00
8_M278_M0.6441.00
89_F93_I0.6431.00
133_F137_M0.6431.00
49_M53_P0.6411.00
191_F194_W0.6381.00
265_H268_S0.6381.00
222_V229_S0.6361.00
22_I321_C0.6361.00
62_L286_S0.6331.00
165_Y168_Y0.6291.00
59_S198_F0.6291.00
131_V134_Q0.6281.00
204_C260_I0.6261.00
145_Y148_K0.6261.00
16_S50_F0.6251.00
191_F195_L0.6231.00
8_M11_C0.6221.00
316_L319_A0.6191.00
92_A95_A0.6191.00
84_F87_F0.6161.00
209_K212_L0.6151.00
89_F328_T0.6131.00
14_C284_S0.6111.00
22_I317_L0.6101.00
135_F139_H0.6101.00
159_F166_L0.6091.00
107_T114_K0.6091.00
231_A236_V0.6081.00
158_S161_V0.6071.00
100_S103_G0.6041.00
312_P316_L0.6031.00
296_I300_V0.6001.00
223_Y234_V0.6001.00
207_E211_F0.6001.00
294_F320_V0.5971.00
162_T166_L0.5961.00
226_A233_V0.5951.00
8_M272_H0.5871.00
332_L335_F0.5851.00
13_S52_T0.5851.00
282_N292_A0.5821.00
256_S260_I0.5771.00
294_F321_C0.5751.00
157_I160_V0.5751.00
14_C18_V0.5741.00
52_T128_F0.5741.00
12_I16_S0.5711.00
9_I58_I0.5711.00
135_F140_M0.5691.00
205_G209_K0.5681.00
20_L51_S0.5681.00
63_L198_F0.5671.00
128_F288_Y0.5661.00
162_T199_C0.5641.00
14_C17_V0.5641.00
62_L132_I0.5631.00
311_V314_V0.5611.00
68_P205_G0.5611.00
59_S128_F0.5601.00
248_K253_M0.5601.00
90_I328_T0.5601.00
150_S153_W0.5591.00
84_F115_Y0.5591.00
140_M144_E0.5591.00
252_I263_C0.5561.00
90_I293_Y0.5561.00
225_A232_L0.5551.00
334_K338_G0.5541.00
98_M102_M0.5531.00
202_Y206_K0.5521.00
16_S48_L0.5521.00
154_V165_Y0.5511.00
230_G237_S0.5511.00
63_L132_I0.5501.00
56_I127_Y0.5501.00
313_A317_L0.5501.00
229_S237_S0.5491.00
169_F172_A0.5491.00
17_V21_H0.5481.00
11_C287_I0.5461.00
8_M281_S0.5431.00
128_F285_F0.5431.00
79_R82_V0.5431.00
300_V303_L0.5421.00
251_D256_S0.5401.00
65_R208_Y0.5401.00
11_C283_Y0.5341.00
67_Y70_G0.5341.00
297_I301_L0.5321.00
190_P197_Y0.5321.00
292_A295_M0.5311.00
10_R132_I0.5301.00
61_F65_R0.5291.00
217_Q220_W0.5281.00
148_K152_K0.5281.00
263_C267_F0.5270.99
50_F54_A0.5270.99
247_S251_D0.5260.99
86_P332_L0.5250.99
283_Y322_T0.5250.99
63_L67_Y0.5240.99
149_A153_W0.5240.99
14_C132_I0.5230.99
88_L133_F0.5210.99
199_C203_Y0.5210.99
132_I285_F0.5200.99
126_G129_I0.5170.99
261_F264_F0.5150.99
129_I289_L0.5150.99
265_H269_K0.5140.99
246_S249_R0.5140.99
69_D209_K0.5090.99
301_L304_N0.5090.99
197_Y256_S0.5070.99
226_A236_V0.5070.99
213_A217_Q0.5070.99
144_E147_K0.5040.99
193_G197_Y0.5040.99
83_I133_F0.5030.99
82_V85_V0.5030.99
155_L166_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ldsA 2 0.5359 20.5 0.947 Contact Map
4j72A 2 0.1077 7.6 0.956 Contact Map
2cfqA 1 0.5414 6.6 0.957 Contact Map
4a01A 2 0.1464 5.9 0.958 Contact Map
2kncA 1 0.1464 5.4 0.959 Contact Map
4px7A 1 0.5304 5.1 0.959 Contact Map
4z24A 2 0.163 4.6 0.96 Contact Map
2kncB 1 0.1519 3.6 0.962 Contact Map
1pw4A 1 0.5912 3.5 0.962 Contact Map
2kluA 1 0.1381 3.3 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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