GREMLIN Database
SSPH - Small, acid-soluble spore protein H
UniProt: O31552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 59 (58)
Sequences: 147 (112)
Seq/√Len: 14.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_Q40_Y4.2611.00
38_R48_E3.2400.99
28_Q48_E2.8880.97
28_Q38_R2.5590.94
26_Y42_L2.5330.94
10_V16_K2.5120.93
15_M26_Y2.0890.85
20_Y39_I2.0690.84
13_P42_L1.8060.75
40_Y48_E1.8040.75
31_N46_Q1.7610.73
2_N48_E1.4690.58
31_N35_G1.3140.50
10_V14_D1.2050.44
11_E14_D1.1950.43
15_M42_L1.1810.43
7_K31_N1.1710.42
22_G31_N1.1440.41
35_G53_L1.0810.37
3_I35_G1.0670.37
36_T50_E1.0590.36
31_N38_R1.0220.34
8_E42_L0.9920.33
44_E47_E0.9830.32
5_R27_I0.9790.32
11_E50_E0.9630.31
41_P46_Q0.9250.30
13_P26_Y0.9240.30
29_H38_R0.9220.29
12_S49_H0.9190.29
19_T54_N0.9030.29
4_Q16_K0.8910.28
3_I32_E0.8850.28
38_R50_E0.8560.27
8_E15_M0.8550.26
7_K38_R0.8550.26
11_E40_Y0.8440.26
11_E24_P0.8380.26
47_E54_N0.8290.25
39_I46_Q0.8260.25
27_I39_I0.8250.25
33_E36_T0.8160.25
42_L45_P0.8000.24
14_D25_I0.7970.24
4_Q26_Y0.7810.23
2_N38_R0.7730.23
37_A53_L0.7680.23
17_K22_G0.7640.23
7_K32_E0.7570.22
26_Y41_P0.7560.22
22_G44_E0.7500.22
4_Q42_L0.7420.22
41_P49_H0.7250.21
2_N28_Q0.6960.20
31_N55_S0.6940.20
41_P48_E0.6910.20
39_I55_S0.6880.20
7_K53_L0.6730.19
8_E11_E0.6640.19
3_I47_E0.6610.19
21_N47_E0.6590.19
31_N36_T0.6570.19
25_I36_T0.6540.19
12_S16_K0.6530.19
47_E52_Q0.6200.18
9_I19_T0.6090.17
39_I52_Q0.6090.17
33_E43_D0.6090.17
33_E53_L0.6080.17
17_K34_T0.6000.17
40_Y54_N0.5980.17
33_E57_K0.5900.17
21_N29_H0.5870.17
49_H52_Q0.5780.16
19_T34_T0.5740.16
32_E35_G0.5720.16
23_V44_E0.5630.16
21_N35_G0.5490.15
19_T44_E0.5370.15
22_G50_E0.5370.15
50_E57_K0.5290.15
4_Q35_G0.5150.14
15_M23_V0.5150.14
7_K43_D0.5150.14
17_K49_H0.5120.14
8_E24_P0.5090.14
13_P43_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pmhX 1 0.6102 18 0.899 Contact Map
4nl7A 1 0.9831 10.3 0.91 Contact Map
1ixhA 1 0.4237 8.4 0.913 Contact Map
2jesA 5 0 8.3 0.913 Contact Map
4aw7A 1 0.8814 6.8 0.917 Contact Map
2mlwA 1 0.7119 6.2 0.918 Contact Map
4anjA 1 0.8814 5.9 0.919 Contact Map
2w7aA 1 0.5085 5.8 0.919 Contact Map
2v26A 1 0.8475 5.8 0.92 Contact Map
4i43B 1 0.8983 5.1 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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