GREMLIN Database
ACOC - Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system
UniProt: O31550 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (385)
Sequences: 7889 (4817)
Seq/√Len: 245.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
296_E300_K3.5651.00
26_V58_D3.4231.00
285_L293_S3.3231.00
243_A385_A3.2841.00
348_D355_E3.2661.00
57_I77_G3.1981.00
299_K303_E3.1091.00
62_K65_E3.0621.00
24_K34_E3.0581.00
172_Q260_P2.9771.00
173_E255_R2.8841.00
352_Y357_I2.7601.00
293_S296_E2.7161.00
58_D75_Y2.6551.00
300_K310_E2.5841.00
234_S264_L2.5631.00
130_A155_L2.5311.00
24_K56_L2.5251.00
250_F259_H2.5121.00
182_V185_A2.5021.00
202_K349_T2.4711.00
244_H385_A2.4421.00
237_A316_F2.4411.00
133_D136_Q2.4381.00
23_N35_S2.4301.00
31_E53_K2.3661.00
352_Y359_R2.3561.00
203_A365_L2.1941.00
21_I63_E2.1761.00
4_K75_Y2.1631.00
348_D361_T2.1571.00
196_Q368_T2.1561.00
204_D360_S2.1471.00
261_H281_H2.1021.00
60_K75_Y2.0741.00
174_I258_T2.0731.00
4_K72_A2.0501.00
314_S337_E2.0241.00
285_L289_E2.0201.00
61_V71_T2.0151.00
265_G276_V1.9581.00
21_I38_S1.9431.00
238_V262_V1.9261.00
29_P55_T1.9221.00
242_Q283_E1.9031.00
241_L316_F1.8821.00
56_L74_C1.8711.00
60_K72_A1.8631.00
176_V251_Y1.8611.00
19_V37_A1.8591.00
148_K152_T1.8471.00
234_S282_A1.8361.00
25_K28_D1.7951.00
353_Q356_E1.7881.00
173_E257_I1.7721.00
56_L59_I1.7721.00
126_I152_T1.7531.00
237_A386_M1.7481.00
32_K53_K1.7391.00
31_E34_E1.7361.00
136_Q154_A1.7301.00
179_M183_I1.7161.00
272_N304_G1.7111.00
220_E226_K1.7021.00
125_K129_K1.6921.00
263_H280_R1.6661.00
182_V186_R1.6581.00
234_S266_M1.6311.00
238_V282_A1.6181.00
186_R189_E1.6111.00
127_A134_L1.6101.00
385_A388_T1.6091.00
353_Q358_V1.6061.00
233_V343_I1.6001.00
301_A306_A1.5991.00
286_S289_E1.5981.00
234_S294_I1.5961.00
68_P71_T1.5871.00
249_S258_T1.5681.00
266_M294_I1.5641.00
281_H284_K1.5471.00
239_L389_Y1.5441.00
279_I293_S1.5341.00
194_S333_L1.5331.00
191_L196_Q1.5281.00
209_A229_I1.5211.00
189_E193_N1.5171.00
172_Q258_T1.5151.00
23_N38_S1.5091.00
207_K210_T1.5011.00
119_I134_L1.4951.00
331_P342_G1.4921.00
249_S373_A1.4851.00
246_V258_T1.4741.00
37_A73_I1.4741.00
61_V67_V1.4551.00
350_P357_I1.4511.00
206_T360_S1.4411.00
214_Q394_A1.4211.00
152_T156_A1.3961.00
38_S47_E1.3781.00
244_H381_A1.3711.00
126_I151_V1.3661.00
316_F339_G1.3641.00
234_S318_I1.3611.00
246_V378_P1.3601.00
180_R183_I1.3561.00
132_L137_L1.3561.00
338_T373_A1.3531.00
294_I298_A1.3521.00
252_Q255_R1.3301.00
216_S226_K1.3171.00
217_P221_E1.3141.00
139_G146_I1.3131.00
237_A382_F1.3081.00
240_A386_M1.3061.00
384_K388_T1.3041.00
348_D359_R1.2951.00
26_V62_K1.2941.00
200_T328_H1.2841.00
5_V74_C1.2791.00
199_I379_A1.2781.00
185_A189_E1.2571.00
188_Q192_A1.2571.00
173_E252_Q1.2561.00
334_N337_E1.2421.00
265_G337_E1.2341.00
149_D153_K1.2271.00
349_T362_I1.2251.00
256_I373_A1.2221.00
205_I208_L1.2221.00
180_R375_D1.2061.00
365_L386_M1.2031.00
141_G150_D1.1911.00
208_L232_F1.1881.00
149_D152_T1.1861.00
175_P255_R1.1831.00
25_K59_I1.1771.00
126_I130_A1.1711.00
55_T77_G1.1671.00
387_K391_E1.1661.00
20_S45_E1.1651.00
139_G145_R1.1641.00
202_K327_E1.1621.00
385_A389_Y1.1611.00
6_V72_A1.1551.00
350_P359_R1.1551.00
261_H283_E1.1531.00
213_K217_P1.1361.00
16_Q66_E1.1301.00
341_L386_M1.1301.00
199_I369_F1.1261.00
198_T368_T1.1251.00
35_S47_E1.1251.00
269_A324_F1.1221.00
235_R239_L1.1211.00
263_H281_H1.1171.00
130_A152_T1.1131.00
218_T395_A1.1081.00
132_L155_L1.1071.00
55_T80_N1.0961.00
269_A381_A1.0941.00
298_A302_R1.0911.00
210_T214_Q1.0801.00
198_T330_T1.0791.00
197_L369_F1.0791.00
213_K216_S1.0781.00
234_S279_I1.0751.00
194_S335_P1.0741.00
204_D353_Q1.0741.00
237_A339_G1.0721.00
217_P220_E1.0701.00
262_V283_E1.0681.00
181_K254_E1.0621.00
307_G310_E1.0621.00
206_T361_T1.0461.00
346_S361_T1.0441.00
251_Y373_A1.0391.00
5_V76_I1.0391.00
199_I326_V1.0351.00
252_Q257_I1.0351.00
341_L367_L1.0341.00
7_M17_G1.0341.00
281_H285_L1.0311.00
210_T213_K1.0311.00
316_F341_L1.0241.00
231_H287_L1.0231.00
26_V59_I1.0231.00
327_E347_Y1.0201.00
223_Y292_Q1.0181.00
247_L374_C1.0181.00
61_V65_E1.0121.00
343_I363_L1.0031.00
117_M146_I1.0021.00
247_L339_G1.0011.00
188_Q194_S1.0001.00
234_S290_L0.9971.00
201_M387_K0.9951.00
263_H278_V0.9931.00
205_I363_L0.9921.00
206_T210_T0.9921.00
367_L383_L0.9881.00
26_V57_I0.9831.00
316_F382_F0.9831.00
205_I346_S0.9771.00
275_V306_A0.9751.00
134_L146_I0.9751.00
153_K157_E0.9661.00
351_V362_I0.9631.00
52_E76_I0.9621.00
30_V56_L0.9571.00
377_A381_A0.9541.00
25_K63_E0.9531.00
14_M17_G0.9531.00
371_H376_G0.9491.00
321_L329_F0.9491.00
10_L17_G0.9491.00
196_Q333_L0.9461.00
296_E299_K0.9411.00
300_K307_G0.9391.00
138_K154_A0.9381.00
5_V36_I0.9371.00
16_Q68_P0.9351.00
22_W59_I0.9351.00
279_I294_I0.9331.00
289_E292_Q0.9291.00
183_I187_M0.9251.00
275_V311_L0.9211.00
269_A377_A0.9201.00
132_L151_V0.9131.00
127_A146_I0.9131.00
351_V360_S0.9091.00
181_K185_A0.9081.00
30_V50_A0.9061.00
239_L242_Q0.9021.00
200_T330_T0.8951.00
316_F367_L0.8951.00
242_Q262_V0.8941.00
265_G314_S0.8901.00
127_A132_L0.8901.00
239_L396_L0.8901.00
191_L195_A0.8881.00
19_V73_I0.8871.00
199_I383_L0.8871.00
203_A387_K0.8851.00
119_I127_A0.8851.00
139_G144_G0.8831.00
243_A389_Y0.8811.00
36_I74_C0.8801.00
19_V61_V0.8770.99
123_A148_K0.8750.99
18_E66_E0.8750.99
141_G144_G0.8740.99
237_A341_L0.8690.99
191_L194_S0.8690.99
203_A390_L0.8680.99
215_L227_L0.8660.99
122_V148_K0.8640.99
39_I48_I0.8630.99
18_E64_G0.8620.99
67_V71_T0.8600.99
123_A151_V0.8580.99
209_A361_T0.8560.99
231_H290_L0.8550.99
327_E364_P0.8420.99
279_I285_L0.8340.99
339_G367_L0.8320.99
23_N47_E0.8300.99
306_A311_L0.8280.99
7_M39_I0.8230.99
233_V363_L0.8200.99
199_I344_G0.8190.99
348_D354_G0.8170.99
127_A151_V0.8130.99
134_L137_L0.8120.99
127_A137_L0.8110.99
288_I292_Q0.8090.99
36_I50_A0.8080.99
211_L232_F0.8080.99
99_A103_V0.8050.99
263_H314_S0.8050.99
137_L154_A0.8040.99
155_L158_Q0.8040.99
123_A127_A0.8020.99
156_A159_K0.8010.99
33_G49_E0.7970.99
327_E345_A0.7960.99
59_I65_E0.7930.99
140_T144_G0.7920.99
10_L39_I0.7900.99
369_F379_A0.7900.99
24_K28_D0.7840.99
126_I132_L0.7840.99
343_I365_L0.7830.99
151_V154_A0.7810.99
289_E293_S0.7800.99
248_N315_T0.7790.99
190_S196_Q0.7790.99
176_V253_N0.7760.99
97_P101_Q0.7750.99
214_Q392_E0.7750.99
130_A156_A0.7740.99
353_Q360_S0.7740.99
140_T147_V0.7740.99
191_L198_T0.7690.99
119_I123_A0.7680.99
153_K156_A0.7640.99
218_T221_E0.7630.99
191_L368_T0.7630.99
339_G374_C0.7630.99
198_T366_S0.7630.99
9_K12_M0.7620.99
244_H378_P0.7590.99
179_M270_L0.7590.99
186_R334_N0.7520.98
233_V390_L0.7510.98
321_L342_G0.7500.98
348_D352_Y0.7490.98
280_R309_E0.7470.98
95_N98_Q0.7460.98
178_G181_K0.7440.98
393_P396_L0.7430.98
176_V256_I0.7420.98
191_L332_I0.7420.98
30_V76_I0.7420.98
187_M276_V0.7410.98
158_Q161_D0.7410.98
205_I390_L0.7400.98
268_V302_R0.7390.98
227_L231_H0.7380.98
159_K162_Q0.7370.98
139_G150_D0.7360.98
263_H337_E0.7360.98
59_I62_K0.7340.98
239_L243_A0.7340.98
117_M135_K0.7330.98
227_L232_F0.7330.98
179_M272_N0.7320.98
278_V314_S0.7320.98
201_M326_V0.7310.98
97_P100_V0.7300.98
117_M134_L0.7290.98
126_I148_K0.7280.98
205_I361_T0.7280.98
229_I346_S0.7270.98
270_L275_V0.7240.98
218_T222_R0.7220.98
7_M67_V0.7150.98
367_L379_A0.7140.98
17_G39_I0.7130.98
29_P53_K0.7120.98
141_G147_V0.7110.98
23_N26_V0.7100.98
17_G44_I0.7100.98
225_T292_Q0.7090.98
247_L378_P0.7090.98
10_L13_A0.7070.98
127_A133_D0.7060.98
202_K347_Y0.7030.98
57_I75_Y0.7020.98
154_A158_Q0.7010.98
32_K50_A0.7010.98
317_S337_E0.6980.97
200_T366_S0.6980.97
20_S64_G0.6950.97
278_V313_G0.6950.97
309_E312_Q0.6940.97
144_G150_D0.6930.97
285_L296_E0.6910.97
199_I321_L0.6900.97
184_A251_Y0.6890.97
296_E310_E0.6870.97
328_H364_P0.6860.97
188_Q191_L0.6860.97
90_P93_E0.6840.97
9_K13_A0.6840.97
241_L262_V0.6830.97
237_A240_A0.6830.97
15_K68_P0.6810.97
263_H310_E0.6810.97
247_L338_T0.6800.97
55_T79_A0.6780.97
300_K305_R0.6770.97
348_D353_Q0.6760.97
202_K362_I0.6730.97
382_F386_M0.6720.97
91_V95_N0.6710.97
207_K360_S0.6710.97
215_L218_T0.6710.97
300_K306_A0.6700.97
101_Q104_K0.6700.97
365_L383_L0.6680.97
308_S312_Q0.6660.97
314_S334_N0.6630.97
241_L247_L0.6620.97
230_T323_A0.6610.97
202_K364_P0.6600.96
392_E395_A0.6570.96
26_V75_Y0.6570.96
266_M318_I0.6560.96
137_L146_I0.6550.96
174_I246_V0.6550.96
50_A76_I0.6550.96
329_F344_G0.6550.96
321_L344_G0.6540.96
140_T150_D0.6530.96
280_R293_S0.6530.96
190_S335_P0.6500.96
220_E223_Y0.6500.96
241_L382_F0.6480.96
247_L382_F0.6460.96
198_T342_G0.6460.96
264_L316_F0.6460.96
324_F380_A0.6440.96
246_V249_S0.6430.96
233_V318_I0.6430.96
10_L48_I0.6370.96
230_T233_V0.6370.96
207_K394_A0.6360.96
321_L326_V0.6330.96
344_G380_A0.6310.95
348_D357_I0.6280.95
4_K60_K0.6240.95
295_S299_K0.6230.95
278_V337_E0.6230.95
96_M99_A0.6220.95
208_L390_L0.6220.95
230_T266_M0.6220.95
381_A384_K0.6210.95
35_S38_S0.6210.95
29_P79_A0.6210.95
89_A92_A0.6200.95
19_V59_I0.6170.95
109_P112_S0.6160.95
50_A53_K0.6150.95
38_S45_E0.6140.95
388_T395_A0.6140.95
119_I146_I0.6140.95
333_L339_G0.6120.95
123_A146_I0.6120.95
240_A385_A0.6100.95
188_Q195_A0.6100.95
165_P171_A0.6100.95
230_T320_N0.6060.94
352_Y355_E0.6060.94
60_K71_T0.6060.94
19_V51_P0.6040.94
209_A346_S0.6030.94
155_L159_K0.6020.94
240_A389_Y0.6000.94
137_L150_D0.5990.94
386_M390_L0.5990.94
206_T351_V0.5980.94
190_S333_L0.5960.94
22_W61_V0.5940.94
137_L141_G0.5920.94
259_H315_T0.5920.94
176_V252_Q0.5910.94
130_A158_Q0.5900.94
307_G312_Q0.5870.93
236_A390_L0.5870.93
269_A378_P0.5860.93
204_D351_V0.5850.93
97_P103_V0.5840.93
41_S44_I0.5840.93
268_V297_N0.5840.93
284_K289_E0.5830.93
212_Q216_S0.5830.93
277_P314_S0.5820.93
57_I79_A0.5820.93
228_T291_A0.5820.93
22_W37_A0.5820.93
132_L136_Q0.5810.93
342_G368_T0.5800.93
17_G41_S0.5790.93
122_V126_I0.5780.93
91_V94_D0.5780.93
91_V97_P0.5770.93
60_K73_I0.5750.93
174_I256_I0.5750.93
211_L394_A0.5730.93
92_A95_N0.5720.93
79_A82_S0.5720.93
216_S220_E0.5710.92
176_V255_R0.5710.92
290_L297_N0.5700.92
20_S23_N0.5690.92
5_V51_P0.5690.92
293_S297_N0.5690.92
6_V70_G0.5680.92
102_P105_Q0.5680.92
201_M383_L0.5680.92
24_K74_C0.5660.92
238_V242_Q0.5640.92
355_E361_T0.5610.92
314_S335_P0.5600.92
355_E359_R0.5600.92
37_A48_I0.5590.92
230_T318_I0.5580.92
193_N335_P0.5580.92
7_M74_C0.5580.92
14_M69_P0.5580.92
182_V308_S0.5580.92
328_H331_P0.5570.92
33_G53_K0.5570.92
293_S300_K0.5570.92
280_R310_E0.5550.91
152_T155_L0.5550.91
89_A93_E0.5530.91
96_M101_Q0.5520.91
151_V155_L0.5520.91
99_A102_P0.5510.91
353_Q357_I0.5500.91
186_R336_P0.5490.91
35_S49_E0.5470.91
341_L365_L0.5470.91
349_T364_P0.5460.91
94_D98_Q0.5460.91
78_D82_S0.5460.91
389_Y395_A0.5440.91
11_G46_M0.5440.91
328_H366_S0.5440.91
136_Q158_Q0.5430.90
98_Q101_Q0.5430.90
250_F257_I0.5430.90
195_A372_R0.5430.90
40_Q178_G0.5430.90
350_P360_S0.5420.90
126_I155_L0.5410.90
365_L390_L0.5410.90
132_L154_A0.5410.90
216_S224_G0.5400.90
77_G80_N0.5370.90
378_P381_A0.5370.90
120_S145_R0.5360.90
204_D207_K0.5350.90
276_V340_I0.5350.90
14_M344_G0.5340.90
10_L73_I0.5320.90
137_L151_V0.5320.90
267_A274_L0.5320.90
333_L336_P0.5310.89
331_P368_T0.5310.89
77_G83_V0.5290.89
158_Q162_Q0.5260.89
246_V256_I0.5220.89
369_F374_C0.5220.89
200_T364_P0.5220.89
131_G150_D0.5200.88
86_E94_D0.5200.88
148_K151_V0.5200.88
250_F261_H0.5190.88
78_D81_E0.5190.88
239_L385_A0.5190.88
7_M46_M0.5180.88
180_R184_A0.5180.88
19_V67_V0.5160.88
175_P178_G0.5150.88
132_L150_D0.5150.88
348_D356_E0.5140.88
276_V337_E0.5140.88
389_Y396_L0.5130.88
104_K107_N0.5110.88
59_I74_C0.5110.88
249_S256_I0.5100.88
321_L380_A0.5080.87
237_A241_L0.5070.87
29_P56_L0.5070.87
352_Y360_S0.5060.87
262_V315_T0.5060.87
6_V71_T0.5060.87
198_T331_P0.5050.87
95_N99_A0.5050.87
98_Q103_V0.5020.87
321_L343_I0.5020.87
90_P98_Q0.5020.87
338_T374_C0.5000.87
18_E41_S0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dvaI 1 0.1055 100 0.133 Contact Map
1sczA 4 0.5804 100 0.447 Contact Map
4n72A 3 0.6131 100 0.452 Contact Map
1dpbA 4 0.6055 100 0.452 Contact Map
3maeA 3 0.5955 100 0.452 Contact Map
3b8kA 1 0.5955 100 0.458 Contact Map
2ii3A 4 0.5729 100 0.459 Contact Map
3l60A 3 0.5603 100 0.463 Contact Map
3rqcA 4 0.5477 100 0.482 Contact Map
2xt6A 2 0.4724 100 0.507 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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